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1. 发明授权

US06562952B1 Precipitation of proteins from organic solutions 失效
标题翻译：从有机溶液中沉淀蛋白质
公开(公告)号：US06562952B1
公开(公告)日：2003-05-13
申请号：US09703221
申请日：2000-10-31
申请人： Roger A. Rajewski , Bala Subramaniam , William K. Snavely , Fenghui Niu
发明人： Roger A. Rajewski , Bala Subramaniam , William K. Snavely , Fenghui Niu
IPC分类号： A23J100
CPC分类号： A61K9/1688
摘要： A process for forming small micron-sized (1-10 &mgr;m) protein particles is provided wherein a protein, a solvent system for the protein and an antisolvent for the protein solvent system are contacted under conditions to at least partially dissolve the protein solvent system in the antisolvent, thereby causing precipitation of the protein. The solvent system is made up of at least in part of a halogenated organic alcohol, most preferably 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). Preferably, a solution of the protein in the solvent system is sprayed through a nozzle into a precipitation zone containing the antisolvent (preferably CO2) under near- or supercritical conditions.
摘要翻译：提供了形成小微米尺寸（1-10μm）蛋白质颗粒的方法，其中蛋白质，用于蛋白质的溶剂体系和蛋白质溶剂体系的抗溶剂在至少部分溶解蛋白质溶剂体系的条件下接触抗溶剂，从而引起蛋白质的沉淀。溶剂系统由至少部分卤代有机醇，最优选1,1,1,3,3,3-六氟-2-丙醇（HFIP）组成。优选地，在近或超临界条件下，将蛋白质在溶剂系统中的溶液通过喷嘴喷射到含有抗溶剂（优选CO 2）的沉淀区中。

2. 发明申请

US20080089944A1 METHOD FOR PRECIPITATION OF SMALL MEDICAMENT PARTICLES INTO USE CONTAINERS 有权
标题翻译：将小剂量颗粒降解成使用容器的方法
公开(公告)号：US20080089944A1
公开(公告)日：2008-04-17
申请号：US11870554
申请日：2007-10-11
申请人： Roger A. Rajewski , Bala Subramaniam , Fenghui Niu
发明人： Roger A. Rajewski , Bala Subramaniam , Fenghui Niu
IPC分类号： A61K9/14
CPC分类号： A61K9/1688 , B01J2/02 , B01J2/04 , B01J2/18
摘要： Commercially feasible methods for lyophobic precipitation of liquid-dispersed or dissolved material (e.g., medicaments) are provided wherein a plurality of individual, open containers (22) each containing a quantity (84) of a solution or dispersion are treated within a common pressurizable chamber (12). In this process, desired near-supercritical or supercritical temperature and pressure conditions are established for a selected antisolvent gas such as carbon dioxide, and an ultrasonic device (14) is actuated to generate high energy ultrasonic waves in the chamber (12). This leads to intense mixing of the antisolvent with the liquid solution or dispersion within the containers (22), with consequent solvent removal and material precipitation.
摘要翻译：提供了用于液体分散或溶解的材料（例如药物）的疏液沉淀的商业上可行的方法，其中每个含有（84）溶液或分散体的多个单独的开放容器（22）在共同的可加压室（12）。在这个过程中，为所选择的反溶剂气体例如二氧化碳建立了所需的近临界或超临界温度和压力条件，并且致动超声波装置（14）以在腔室（12）中产生高能超声波。这导致抗溶剂与容器（22）内的液体溶液或分散体的强烈混合，随后进行溶剂去除和材料沉淀。

3. 发明申请

US20140296140A1 Equipment Assembly for and Method of Processing Particles 有权
标题翻译：加工颗粒的设备组装和方法
公开(公告)号：US20140296140A1
公开(公告)日：2014-10-02
申请号：US14306938
申请日：2014-06-17
申请人： Greg S. JOHNSON , Bala SUBRAMANIAM , Fenghui Niu
发明人： Greg S. JOHNSON , Bala SUBRAMANIAM , Fenghui Niu
IPC分类号： B01J8/00
CPC分类号： B01J8/006 , A61J3/02 , B01D9/0013 , B01D9/0054 , B01D11/0411 , B01D46/0068 , B01J3/008 , B01J4/002 , Y02P20/544
摘要： An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.
摘要翻译：公开了一种用于制备，收集和收集颗粒的设备组件。组件包括具有一个或多个高压过滤器，一个或多个低压过滤器和一个或多个收集容器的串联过滤器系统。可以连续，半连续或间歇式操作来制备，收获和收集颗粒。还公开了一种串联过滤系统及其使用方法。还公开了使用组装制成的颗粒和根据即时方法制备的颗粒。该组件在其它系统上提供改进的颗粒收获和收集，并允许连续的颗粒形成，特别是通过在超临界反溶剂中分散含溶质的工艺流体。

4. 发明授权

US07744923B2 Method for precipitation of small medicament particles into use containers 有权
标题翻译：将小药物颗粒沉淀到使用容器中的方法
公开(公告)号：US07744923B2
公开(公告)日：2010-06-29
申请号：US11870554
申请日：2007-10-11
申请人： Roger A. Rajewski , Bala Subramaniam , Fenghui Niu
发明人： Roger A. Rajewski , Bala Subramaniam , Fenghui Niu
IPC分类号： A61K9/14
CPC分类号： A61K9/1688 , B01J2/02 , B01J2/04 , B01J2/18
摘要： Commercially feasible methods for lyophobic precipitation of liquid-dispersed or dissolved material (e.g., medicaments) are provided wherein a plurality of individual, open containers (22) each containing a quantity (84) of a solution or dispersion are treated within a common pressurizable chamber (12). In this process, desired near-supercritical or supercritical temperature and pressure conditions are established for a selected antisolvent gas such as carbon dioxide, and an ultrasonic device (14) is actuated to generate high energy ultrasonic waves in the chamber (12). This leads to intense mixing of the antisolvent with the liquid solution or dispersion within the containers (22), with consequent solvent removal and material precipitation.
摘要翻译：提供了用于液体分散或溶解的材料（例如药物）的疏液沉淀的商业上可行的方法，其中每个含有（84）溶液或分散体的多个单独的开放容器（22）在共同的可加压室（12）。在这个过程中，为所选择的反溶剂气体例如二氧化碳建立了所需的近临界或超临界温度和压力条件，并且致动超声波装置（14）以在腔室（12）中产生高能超声波。这导致反溶剂与容器（22）内的液体溶液或分散体的强烈混合，随后进行溶剂去除和材料沉淀。

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