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1. 发明授权

US10857533B2 Pipette tip loading and unloading mechanism for single row multichannel pipettors 有权
公开(公告)号：US10857533B2
公开(公告)日：2020-12-08
申请号：US15943604
申请日：2018-04-02
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L3/02 , B01L9/00
摘要： A mechanism that provides an improved method of loading and unloading a row of disposable pipette tips onto a handheld multichannel pipettor. A single button for tip load and unload operations is simpler than the current method of using a separate mechanism for ejecting the tips. The tips are configured in a rigid collar which is held by a clamp on the pipettor. An upward force combined with a sealing gasket that mates with the top of the pipette tips is used to provide the seal between the tips and the pipettor. This eliminates the requirement to “press downward” with excessive force in order to force the pipette tips onto a protruding sealing part. The loading and unloading of tips will be more reliable and repeatable, this providing better pipetting results. The low forces of the loading and unloading operations reduce the chance of repetitive stress injury for the operator.

2. 发明申请

US20180221864A1 Pipette Tip Loading and Unloading Mechanism for Single Row Multichannel Pipettors 审中-公开
公开(公告)号：US20180221864A1
公开(公告)日：2018-08-09
申请号：US15943604
申请日：2018-04-02
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L3/02
CPC分类号： B01L3/0279 , B01L2200/023 , B01L2200/026 , B01L2200/04 , B01L2200/0689 , B01L2300/14
摘要： A mechanism that provides an improved method of loading and unloading a row of disposable pipette tips onto a handheld multichannel pipettor. A single button for tip load and unload operations is simpler than the current method of using a separate mechanism for ejecting the tips. The tips are configured in a rigid collar which is held by a clamp on the pipettor. An upward force combined with a sealing gasket that mates with the top of the pipette tips is used to provide the seal between the tips and the pipettor. This eliminates the requirement to “press downward” with excessive force in order to force the pipette tips onto a protruding sealing part. The loading and unloading of tips will be more reliable and repeatable, this providing better pipetting results. The low forces of the loading and unloading operations reduce the chance of repetitive stress injury for the operator.

3. 发明申请

US20090007702A1 APPARATUS AND METHOD FOR USING A TIP COLLAR ON PIPETTE TIPS PROVIDING STRUCTURAL RIGIDITY 有权
标题翻译：使用提示结构提供结构刚度的管道提示的装置和方法
公开(公告)号：US20090007702A1
公开(公告)日：2009-01-08
申请号：US11774431
申请日：2007-07-06
申请人： FELIX H. YIU
发明人： FELIX H. YIU
IPC分类号： B01L9/00
CPC分类号： B01L9/543 , B01L2300/0829
摘要： The present invention relates to an apparatus for lumping together a plurality of pipette tips using a collar that will provide structural rigidity to the loose plurality of pipette tips; and the method of incorporating such an apparatus. Such rigidity created by the collar apparatus will allow for an innovative method of connecting the plurality of pipette tips to their respective pipettors that will reduce the amount of downward axial force required to impinge a plurality of pipette tips using the traditional connection method.
摘要翻译：本发明涉及一种用于使用将向多个移液器吸头提供结构刚性的套环将多个移液管末端结合在一起的装置; 以及结合这种装置的方法。由套环装置产生的这种刚性将允许将多个移液管尖端连接到它们各自的移液器的创新方法，这将使用传统的连接方法减少冲击多个移液管吸头所需的向下的轴向力的量。

4. 发明授权

US06258324B1 Pipette dispensing block 有权
标题翻译：移液器分配块
公开(公告)号：US06258324B1
公开(公告)日：2001-07-10
申请号：US09268244
申请日：1999-03-15
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L302
CPC分类号： B01L3/02 , B01L3/022 , B01L2300/0829 , B01L2400/0487 , G01N35/1065
摘要： A pipette dispensing block has an improved piston seal and lift plate engagement/disengagement means. In a pipette dispensing block where a piston is used to create a pressure differential to aspirate or extract and dispense or eject fluid material, the maintenance of a vacuum or increased pressure is enhanced by a pair of O-ring seals engaging the piston. A reservoir separates the O-rings and is filled with a low vapor pressure lubricant such as silicone oil or grease. The lubricant is maintained in the reservoir by the O-rings and serves to enhance the vacuum seal while maintaining the O-rings in a pliable and resilient manner. The heads of the pistons are engraved or grooved to leave a circular central pillar surrounded above and below by the piston head and a lower intermediate piston pillar section. The individual pistons are arranged in straight rows so that a slat may slip through opposite pairs of opposing piston pillars thereby entrapping the pistons and preventing them from sliding past the lift plate as the lift plate is lifted upwardly. Shoulders present on the pistons below the lift plate serve to allow the lift plate to push the pistons into the cylindrical chambers of the head block so that a pipette dispenser is provided. The lift plate or portions thereof are then trapped between the slats and the piston shoulders, coupling the pistons to the lift plate. Upward and downward control is thereby established and maintained by the lift plate on the pistons.
摘要翻译：移液管分配块具有改进的活塞密封和升降板接合/分离装置。在移液管分配块中，使用活塞来产生压力差以吸出或提取和分配或排出流体材料，通过与活塞接合的一对O形环密封件增强了真空的维持或增加的压力。储存器将O形环分开并填充有低蒸气压润滑剂，例如硅油或油脂。润滑剂通过O形环保持在储存器中，并且用于增强真空密封，同时将O形环保持在柔韧和弹性的方式。活塞的头部被雕刻或开槽以留下由活塞头和下中间活塞柱部分上下包围的圆形中心支柱。单独的活塞被排列成直线，使得板条可以滑过相对的相对的活塞柱对，从而当活塞提升板向上提升时，夹住活塞并阻止它们滑动通过升降板。存在于升降板下方的活塞上的肩部用于允许提升板将活塞推入头部块的圆柱形腔中，从而提供移液管分配器。升降板或其部分然后被捕获在板条和活塞肩部之间，将活塞联接到升降板。由此由活塞上的升降板建立和维持向上和向下的控制。

5. 发明申请

US20170361313A1 Pipette block with molded piston chambers 审中-公开
公开(公告)号：US20170361313A1
公开(公告)日：2017-12-21
申请号：US14631788
申请日：2015-02-25
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/02 , B01L3/0213 , B01L3/0217 , B01L3/022 , B01L9/54 , B01L2200/023 , B01L2200/0689 , B01L2200/12 , B01L2300/0829 , G01N35/10 , G01N35/1074
摘要： The present invention relates to a pipette dispensing block with an improved design for the piston chambers. In a multichannel pipetting block with a grid or array of pipetting piston of any order, the individual piston chambers are individually manufactured using the injection molding process. The individual piston chambers are assembled into a grid or single line array and held together by upper and lower plates in combination with either stabilizing posts or walls. The piston chambers are designed and assembled with a dual o-ring design at the tip and a tip sealing gasket at the bottom to provide the air-tight seal that is required for optimum pipetting performance. When combined with pistons and a motor-driven lifting plate for the pistons, the entire assembly forms a forms a multichannel pipetting block

6. 发明申请

US20170282188A1 Apparatus and method for using a tip collar on a single row of pipette tips 审中-公开
公开(公告)号：US20170282188A1
公开(公告)日：2017-10-05
申请号：US14452447
申请日：2014-08-05
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L9/00 , B01L3/02
CPC分类号： B01L9/543 , B01L3/0275 , B01L2200/025
摘要： An apparatus for assembling together a plurality of pipette tips into a single line using a tip collar that will provide structural rigidity to the plurality of pipette tips and the method of incorporating such an apparatus. Such rigidity created by the tip collar apparatus will allow for an innovative method of connecting a single line of pipette tips to their respective pipettors that will reduce the amount of downward axial force required to impinge the plurality of pipette tips using the traditional connection method. The tips will be maintained in a consistent and straight pattern as required for pipetting, and not susceptible to breakage. The tips can also be customized by the user into any pattern of tips in a single line as needed for specialized applications.

7. 发明授权

US08117925B2 Apparatus and method for using a tip collar on pipette tips providing structural rigidity 有权
标题翻译：在移液管尖端上使用尖端环提供结构刚度的装置和方法
公开(公告)号：US08117925B2
公开(公告)日：2012-02-21
申请号：US11774431
申请日：2007-07-06
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L3/02
CPC分类号： B01L9/543 , B01L2300/0829
摘要： The present invention relates to an apparatus for assembling together a plurality of pipette tips using a tip collar that will provide structural rigidity to the plurality of pipette tips and the method of incorporating such an apparatus. Such rigidity created by the tip collar apparatus will allow for an innovative method of connecting the plurality of pipette tips to their respective pipettors that will reduce the amount of downward axial force required to impinge the plurality of pipette tips using the traditional connection method.
摘要翻译：本发明涉及一种用于使用将为多个移液器吸头提供结构刚度的尖端套圈来组装多个移液管尖端的装置以及结合这种装置的方法。由尖端套环装置产生的这种刚性将允许将多个移液管尖端连接到它们各自的移液器的创新方法，这将使用传统的连接方法减少冲击多个移液管吸头所需的向下的轴向力的量。

8. 发明申请

US20170282187A1 Pipette Tips with Vertical Ribs 审中-公开
公开(公告)号：US20170282187A1
公开(公告)日：2017-10-05
申请号：US14452445
申请日：2014-08-05
申请人： FELIX H. YIU
发明人： FELIX H. YIU
IPC分类号： B01L9/00 , B01L3/02
CPC分类号： B01L9/543 , B01L3/0275 , B01L2200/025
摘要： An apparatus for assembling together a plurality of pipette tips into a single line or a rectangular array using a tip collar that will provide structural rigidity to the plurality of pipette tips. The tips are manufactured with vertical ribs and the tip collar is manufactured to achieve a friction fit with the vertical ribs of the tips, thereby producing a tip and collar assembly that is easier to manufacture, lower in cost, and more convenient for the operator.

9. 发明申请

US20100154921A1 METHOD FOR DISPENSING LIQUID UTILIZING FLOW OF LIQUID 审中-公开
标题翻译：用于分配液体利用液体流动的方法
公开(公告)号：US20100154921A1
公开(公告)日：2010-06-24
申请号：US12717066
申请日：2010-03-03
申请人： FELIX H. YIU
发明人： FELIX H. YIU
IPC分类号： B65B3/04
CPC分类号： B01L3/022 , B01L3/0275 , B01L2200/141 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , G01F11/088
摘要： A method for accurately and precisely aspirating and dispensing liquid from a in the nano-liter range without contacting the syringe tip to the target reservoir during dispensing. Such a method utilizes a partially collapsible syringe tip that compresses when subjected to pressurized fluid around its outer surface area to discharge a liquid at the tip of said partially collapsible syringe tip with a high velocity. Such a discharge of liquid at such a high speed allows even the smallest amount of liquid in the nano-liter range to be dispensed to a target reservoir without contacting the target reservoir.
摘要翻译：一种准确和精确地从纳升级范围抽吸和分配液体的方法，而不会在分配期间将注射器尖端接触目标储存器。这种方法利用部分可折叠的注射器针头，其在其外表面区域周围受到加压流体时压缩，以高速度排出部分可折叠的注射器末端的尖端处的液体。以这样高的速度排出这种液体甚至允许将纳米级范围内的最小量的液体分配到目标储存器而不接触目标储存器。

10. 发明申请

US20090035186A1 APPARATUS AND METHOD FOR DISPENSING LIQUID UTILIZING FLOW OF FLUID 审中-公开
标题翻译：用于分配液体利用流体流动的装置和方法
公开(公告)号：US20090035186A1
公开(公告)日：2009-02-05
申请号：US11830683
申请日：2007-07-30
申请人： Felix H. Yiu
发明人： Felix H. Yiu
IPC分类号： B01L3/02 , G01F11/28
CPC分类号： B01L3/022 , B01L3/0275 , B01L2200/141 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , G01F11/088
摘要： An apparatus for accurately and precisely aspirating and dispensing liquid from a in the nano-liter range without contacting the syringe tip to the target reservoir during dispensing; and a method to utilize such an apparatus. Such an apparatus utilizes a partially collapsible syringe tip that compresses when subjected to pressurized fluid around its outer surface area to discharge a liquid at the tip of said partially collapsible syringe tip with a high velocity. Such a discharge of liquid at such a high speed allows even the smallest amount of liquid in the nano-liter range to be dispensed to a target reservoir without contacting the target reservoir.
摘要翻译：一种用于在分配期间准确且精确地从纳升范围吸出和分配液体而不将注射器尖端接触目标储存器的装置; 以及利用这种装置的方法。这样的装置利用部分可折叠的注射器针头，其在其外表面区域周围受到加压流体时压缩，以高速度排出部分可折叠的注射器末端的尖端处的液体。以这样高的速度排出这种液体甚至允许将纳米级范围内的最小量的液体分配到目标储存器而不接触目标储存器。

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