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    • 1. 发明授权
    • Systems and methods for use by an implantable medical device for controlling multi-site CRT pacing in the presence of atrial tachycardia
    • 用于在存在心房性心动过速时用于控制多部位CRT起搏的可植入医疗装置的系统和方法
    • US08447400B2
    • 2013-05-21
    • US12822983
    • 2010-06-24
    • Rohan A. MoreHeidi HellmanEliot L. OstrowPaul A. Levine
    • Rohan A. MoreHeidi HellmanEliot L. OstrowPaul A. Levine
    • A61N1/368
    • A61N1/368A61N1/3624A61N1/3684A61N1/3688
    • Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to single-site LV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish organized atrial tachycardias (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold that is set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
    • 系统和方法被提供用于装备用于递送多部位左心室(MSLV)起搏的可植入医疗装置的使用。 MSLV与相对较长的心室后空位(PVAB)相关,可能限制病理性快速组织性房性心动过速(OAT)的检测。 在一个示例中,MSLV心脏再同步治疗(CRT)起搏在跟踪模式内递送。 基于心房速率超过心房心动过速评估率(ATAR)阈值,可以检测到心房心动过速。 然后,该装置切换到单位置LV起搏,从而有效地缩短PVAB以检测可能被模糊的额外的心房事件,从而允许该装置更可靠地区分有组织的心房心动过速(例如心房扑动)和窦性心动过速。 设备还可以采用设置为高于ATAR阈值的自动模式切换(AMS)阈值,用于从跟踪模式切换到非跟踪模式。
    • 2. 发明申请
    • Systems and Methods for Use by an Implantable Medical Device for Controlling Multi-Site CRT Pacing in the Presence of Atrial Tachycardia
    • 可植入医疗器械使用的系统和方法用于控制心房心动过速的多站点CRT起搏
    • US20110319951A1
    • 2011-12-29
    • US12822983
    • 2010-06-24
    • Rohan A. MoreHeidi HellmanEliot L. OstrowPaul A. Levine
    • Rohan A. MoreHeidi HellmanEliot L. OstrowPaul A. Levine
    • A61N1/368
    • A61N1/368A61N1/3624A61N1/3684A61N1/3688
    • Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to single-site LV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish organized atrial tachycardias (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold that is set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
    • 系统和方法被提供用于装备用于递送多部位左心室(MSLV)起搏的可植入医疗装置的使用。 MSLV与相对较长的心室后空泡(PVAB)相关,可能限制病理性快速组织性房性心动过速(OAT)的检测。 在一个示例中,MSLV心脏再同步治疗(CRT)起搏在跟踪模式内递送。 基于心房速率超过心房心动过速评估率(ATAR)阈值,可以检测到心房心动过速。 然后,该装置切换到单位置LV起搏,从而有效地缩短PVAB以检测可能被模糊的额外的心房事件,从而允许该装置更可靠地区分有组织的心房心动过速(例如心房扑动)和窦性心动过速。 设备还可以采用设置为高于ATAR阈值的自动模式切换(AMS)阈值,用于从跟踪模式切换到非跟踪模式。
    • 8. 发明授权
    • System and method for generating and using cardiac ischemia diagnostics based on arrhythmia precursors and arrhythmia episodes
    • 基于心律失常前兆和心律失常事件产生和使用心脏缺血诊断的系统和方法
    • US08204592B1
    • 2012-06-19
    • US11949532
    • 2007-12-03
    • Eliot L. OstrowJay SnellXiaoyi Min
    • Eliot L. OstrowJay SnellXiaoyi Min
    • A61N1/36
    • A61B5/0464A61B5/686A61N1/36585A61N1/37258G06F19/00G06F19/3418G06F19/3468G06F19/3481
    • Techniques are described for generating diagnostic information to aid in determining whether cardiac ischemia within a patient is clinically actionable. In one example, a pacemaker or implantable cardioverter/defibrillator (ICD) detects information pertaining to arrhythmia precursors and to episodes of sustained arrhythmias, as well as information pertaining to episodes of cardiac ischemia. The implanted device then correlates the arrhythmia precursors and the sustained arrhythmias with the episodes of cardiac ischemia so as to generate diagnostics permitting a physician reviewing the diagnostics to determine whether the ischemia is clinically actionable. In some implementations, the diagnostics are instead generated by an external system based on raw data provided by the implanted device. In some implementations, the device itself determines whether the ischemia is clinically actionable and automatically controls therapy or generates warning signals accordingly.
    • 描述了用于产生诊断信息以帮助确定患者心脏缺血是否具有临床可行性的技术。 在一个示例中,起搏器或植入式心律转复除颤器(ICD)检测与心律失常前体有关的信息和持续性心律不齐的发作以及与心脏缺血发作有关的信息。 然后植入的装置将心律失常前体和持续性心律失常与心脏缺血发作相关联,以便产生诊断,允许医师检查诊断以确定缺血是否具有临床可操作性。 在一些实施方式中,诊断代替地由外部系统基于植入设备提供的原始数据生成。 在一些实施方案中,装置本身确定缺血是否具有临床作用并且自动控制治疗或相应地产生警告信号。
    • 9. 发明申请
    • SYSTEMS AND METHODS FOR USE BY AN IMPLANTABLE MEDICAL DEVICE FOR CONTROLLING MULTI-SITE CRT PACING IN THE PRESENCE OF ATRIAL TACHYCARDIA
    • 一种用于控制多场CRT显像的可植入医疗器械的系统和方法
    • US20110319953A1
    • 2011-12-29
    • US13108740
    • 2011-05-16
    • Derrick W. ReedRohan A. MoreHeidi HellmanEliot L. OstrowPaul A. Levine
    • Derrick W. ReedRohan A. MoreHeidi HellmanEliot L. OstrowPaul A. Levine
    • A61N1/365
    • A61N1/3684A61N1/3624A61N1/3688
    • Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. Sequential MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, sequential MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to either single-site LV pacing or simultaneous MSLV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish OATs (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
    • 系统和方法被提供用于装备用于递送多部位左心室(MSLV)起搏的可植入医疗装置的使用。 顺序MSLV与相对较长的心房后心房消融(PVAB)相关,可能限制了病理性快速组织性房性心动过速(OAT)的检测。 在一个示例中,顺序MSLV心脏再同步治疗(CRT)起搏在跟踪模式中被递送。 基于心房速率超过心房心动过速评估率(ATAR)阈值,可以检测到心房心动过速。 然后,该装置切换到单点LV起搏或同步MSLV起搏,从而有效地缩短PVAB以检测可能被模糊的另外的心房事件,从而允许装置更可靠地将OAT(例如心房扑动)与窦 心动过速 设备还可以采用高于ATAR阈值的自动模式切换(AMS)阈值,用于从跟踪模式切换到非跟踪模式。
    • 10. 发明授权
    • Post-exercise arrhythmia detection
    • 运动后心律失常检测
    • US08260408B2
    • 2012-09-04
    • US12492055
    • 2009-06-25
    • Eliot L. Ostrow
    • Eliot L. Ostrow
    • A61B5/0452A61B5/0464
    • A61B5/0452A61B5/0031A61B5/0464A61B5/0816A61B5/1118A61N1/36542
    • Post-exercise arrhythmias are detected by an implantable medical device. In some aspects, post-exercise arrhythmia may be prognostic of a worsening cardiovascular condition. Thus, the detection of post-exercise arrhythmia may be used as an indicator for adjusting the therapy prescribed for a patient. In some aspects post-exercise arrhythmia are detected if a patient is exercising at a level that equals or exceeds a threshold exercise level. In some aspects, therapy for a patient is modified if the detected post-exercise arrhythmia exceeds a threshold arrhythmia level. In some aspects therapy for a patient is modified if ischemia is detected in conjunction with post-exercise arrhythmia.
    • 运动后心律失常由可植入医疗装置检测。 在一些方面,运动后心律失常可能是心血管疾病恶化的预后。 因此,运动后心律失常的检测可以用作调整为患者规定的治疗的指标。 在某些方面,如果患者在等于或超过阈值运动水平的水平上锻炼,则检测到运动后心律失常。 在一些方面,如果检测到的运动后心律失常超过阈值心律失常水平,则修改患者的治疗。 在一些方面,如果与运动后心律失常联合检测到缺血,则修改患者的治疗。