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1. 发明申请

US20080091114A1 Techniques for Correlating Thoracic Impedance with Physiological Status 审中-公开
标题翻译：相关胸部阻力与生理状态的技术
公开(公告)号：US20080091114A1
公开(公告)日：2008-04-17
申请号：US11618266
申请日：2006-12-29
申请人： Xiaoyi Min , Paul A. Levine , Eliot L. Ostrow
发明人： Xiaoyi Min , Paul A. Levine , Eliot L. Ostrow
IPC分类号： A61B5/02
CPC分类号： A61B5/0537 , A61B5/08 , A61B5/4869 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36585
摘要： Exemplary techniques for correlating thoracic impedance values with physiological status are described. One technique involves an implantable medical device (IMD) that includes means for correlating thoracic impedance values with a patient's physiological status and means for interpreting the correlated thoracic impedance values utilizing a patient-based threshold to detect a heart failure condition.
摘要翻译：描述了将胸廓阻抗值与生理状态相关联的示例性技术。一种技术涉及可植入医疗装置（IMD），其包括用于使胸部阻抗值与患者的生理状态相关联的装置，以及利用基于患者的阈值来解释相关的胸部阻抗值以检测心力衰竭状况的装置。

2. 发明授权

US08447400B2 Systems and methods for use by an implantable medical device for controlling multi-site CRT pacing in the presence of atrial tachycardia 有权
标题翻译：用于在存在心房性心动过速时用于控制多部位CRT起搏的可植入医疗装置的系统和方法
公开(公告)号：US08447400B2
公开(公告)日：2013-05-21
申请号：US12822983
申请日：2010-06-24
申请人： Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
发明人： Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3624 , A61N1/3684 , A61N1/3688
摘要： Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to single-site LV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish organized atrial tachycardias (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold that is set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
摘要翻译：系统和方法被提供用于装备用于递送多部位左心室（MSLV）起搏的可植入医疗装置的使用。 MSLV与相对较长的心室后空位（PVAB）相关，可能限制病理性快速组织性房性心动过速（OAT）的检测。在一个示例中，MSLV心脏再同步治疗（CRT）起搏在跟踪模式内递送。基于心房速率超过心房心动过速评估率（ATAR）阈值，可以检测到心房心动过速。然后，该装置切换到单位置LV起搏，从而有效地缩短PVAB以检测可能被模糊的额外的心房事件，从而允许该装置更可靠地区分有组织的心房心动过速（例如心房扑动）和窦性心动过速。设备还可以采用设置为高于ATAR阈值的自动模式切换（AMS）阈值，用于从跟踪模式切换到非跟踪模式。

3. 发明申请

US20110319951A1 Systems and Methods for Use by an Implantable Medical Device for Controlling Multi-Site CRT Pacing in the Presence of Atrial Tachycardia 有权
标题翻译：可植入医疗器械使用的系统和方法用于控制心房心动过速的多站点CRT起搏
公开(公告)号：US20110319951A1
公开(公告)日：2011-12-29
申请号：US12822983
申请日：2010-06-24
申请人： Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
发明人： Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3624 , A61N1/3684 , A61N1/3688
摘要： Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to single-site LV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish organized atrial tachycardias (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold that is set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
摘要翻译：系统和方法被提供用于装备用于递送多部位左心室（MSLV）起搏的可植入医疗装置的使用。 MSLV与相对较长的心室后空泡（PVAB）相关，可能限制病理性快速组织性房性心动过速（OAT）的检测。在一个示例中，MSLV心脏再同步治疗（CRT）起搏在跟踪模式内递送。基于心房速率超过心房心动过速评估率（ATAR）阈值，可以检测到心房心动过速。然后，该装置切换到单位置LV起搏，从而有效地缩短PVAB以检测可能被模糊的额外的心房事件，从而允许该装置更可靠地区分有组织的心房心动过速（例如心房扑动）和窦性心动过速。设备还可以采用设置为高于ATAR阈值的自动模式切换（AMS）阈值，用于从跟踪模式切换到非跟踪模式。

4. 发明申请

US20110319953A1 SYSTEMS AND METHODS FOR USE BY AN IMPLANTABLE MEDICAL DEVICE FOR CONTROLLING MULTI-SITE CRT PACING IN THE PRESENCE OF ATRIAL TACHYCARDIA 有权
标题翻译：一种用于控制多场CRT显像的可植入医疗器械的系统和方法
公开(公告)号：US20110319953A1
公开(公告)日：2011-12-29
申请号：US13108740
申请日：2011-05-16
申请人： Derrick W. Reed , Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
发明人： Derrick W. Reed , Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
IPC分类号： A61N1/365
CPC分类号： A61N1/3684 , A61N1/3624 , A61N1/3688
摘要： Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. Sequential MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, sequential MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to either single-site LV pacing or simultaneous MSLV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish OATs (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
摘要翻译：系统和方法被提供用于装备用于递送多部位左心室（MSLV）起搏的可植入医疗装置的使用。顺序MSLV与相对较长的心房后心房消融（PVAB）相关，可能限制了病理性快速组织性房性心动过速（OAT）的检测。在一个示例中，顺序MSLV心脏再同步治疗（CRT）起搏在跟踪模式中被递送。基于心房速率超过心房心动过速评估率（ATAR）阈值，可以检测到心房心动过速。然后，该装置切换到单点LV起搏或同步MSLV起搏，从而有效地缩短PVAB以检测可能被模糊的另外的心房事件，从而允许装置更可靠地将OAT（例如心房扑动）与窦心动过速设备还可以采用高于ATAR阈值的自动模式切换（AMS）阈值，用于从跟踪模式切换到非跟踪模式。

5. 发明申请

US20100152806A1 SYSTEMS AND METHODS FOR OPERATING AN IMPLANTABLE DEVICE FOR MEDICAL PROCEDURES 有权
标题翻译：用于操作医疗程序的可植入设备的系统和方法
公开(公告)号：US20100152806A1
公开(公告)日：2010-06-17
申请号：US12332768
申请日：2008-12-11
申请人： Paul A. Levine , Eliot L. Ostrow
发明人： Paul A. Levine , Eliot L. Ostrow
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/3688 , A61N1/3718 , A61N1/37211
摘要： When a medical procedure is performed on a patient in whom an implantable medical device is implanted, the medical procedure may have undesired effects on the medical device, such as triggering a response that initiates therapy by the device that is unnecessary and potentially dangerous to the patient. Systems and methods may facilitate performing of such medical procedures on such patients by temporarily reprogramming the medical device, monitoring for one or more detectable characteristics associated with the medical procedure to be performed, and restoring normal programming of the device based on detection and/or lack of detection of the detectable characteristic(s).
摘要翻译：当对植入了可植入医疗装置的患者执行医疗程序时，医疗程序可能对医疗装置具有不期望的影响，例如触发由该装置引起对患者不必要和潜在危险的治疗的响应。系统和方法可以通过临时重新编程医疗装置，监测与要执行的医疗程序相关联的一个或多个可检测特性，以及基于检测和/或缺乏恢复装置的正常编程来促进对这些患者的这种医疗程序的执行检测可检测特性。

6. 发明授权

US08332033B2 Systems and methods for use by an implantable medical device for controlling multi-site CRT pacing in the presence of atrial tachycardia 有权
标题翻译：用于在存在心房性心动过速时用于控制多部位CRT起搏的可植入医疗装置的系统和方法
公开(公告)号：US08332033B2
公开(公告)日：2012-12-11
申请号：US13108740
申请日：2011-05-16
申请人： Derrick W. Reed , Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
发明人： Derrick W. Reed , Rohan A. More , Heidi Hellman , Eliot L. Ostrow , Paul A. Levine
IPC分类号： A61N1/368
CPC分类号： A61N1/3684 , A61N1/3624 , A61N1/3688
摘要： Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. Sequential MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, sequential MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding an atrial tachycardia assessment rate (ATAR) threshold. The device then switches to either single-site LV pacing or simultaneous MSLV pacing, thereby effectively shortening the PVAB to detect additional atrial events that might otherwise be obscured, and thereby permitting the device to more reliably distinguish OATs (such as atrial flutter) from sinus tachycardia. The device may also employ an automatic mode switch (AMS) threshold set higher than the ATAR threshold for use in switching from tracking modes to nontracking modes.
摘要翻译：系统和方法被提供用于装备用于递送多部位左心室（MSLV）起搏的可植入医疗装置的使用。顺序MSLV与相对较长的心房后心房消融（PVAB）相关，可能限制了病理性快速组织性房性心动过速（OAT）的检测。在一个示例中，顺序MSLV心脏再同步治疗（CRT）起搏在跟踪模式中被递送。基于心房速率超过心房心动过速评估率（ATAR）阈值，可以检测到心房心动过速。然后，该装置切换到单点LV起搏或同步MSLV起搏，从而有效地缩短PVAB以检测可能被模糊的另外的心房事件，从而允许装置更可靠地将OAT（例如心房扑动）与窦心动过速设备还可以采用高于ATAR阈值的自动模式切换（AMS）阈值，用于从跟踪模式切换到非跟踪模式。

7. 发明授权

US08150516B2 Systems and methods for operating an implantable device for medical procedures 有权
标题翻译：用于操作用于医疗程序的可植入装置的系统和方法
公开(公告)号：US08150516B2
公开(公告)日：2012-04-03
申请号：US12332768
申请日：2008-12-11
申请人： Paul A. Levine , Eliot L. Ostrow
发明人： Paul A. Levine , Eliot L. Ostrow
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/3688 , A61N1/3718 , A61N1/37211
摘要： When a medical procedure is performed on a patient in whom an implantable medical device is implanted, the medical procedure may have undesired effects on the medical device, such as triggering a response that initiates therapy by the device that is unnecessary and potentially dangerous to the patient. Systems and methods may facilitate performing of such medical procedures on such patients by temporarily reprogramming the medical device, monitoring for one or more detectable characteristics associated with the medical procedure to be performed, and restoring normal programming of the device based on detection and/or lack of detection of the detectable characteristic(s).
摘要翻译：当对植入了可植入医疗装置的患者执行医疗程序时，医疗程序可能对医疗装置具有不期望的影响，例如触发由该装置引起对患者不必要和潜在危险的治疗的响应。系统和方法可以通过临时重新编程医疗装置，监测与要执行的医疗程序相关联的一个或多个可检测特性，以及基于检测和/或缺乏恢复装置的正常编程来促进对这些患者的这种医疗程序的执行检测可检测特性。

8. 发明申请

US20110208261A1 SYSTEMS AND METHODS FOR ASSESSING AND REPROGRAMMING SENSING VECTORS FOR USE WITH AN IMPLANTABLE CARDIAC RHYTHM MANAGEMENT DEVICE 审中-公开
标题翻译：用于评估和重现传感矢量的系统和方法，用于使用可移植的心脏治疗仪器
公开(公告)号：US20110208261A1
公开(公告)日：2011-08-25
申请号：US12712037
申请日：2010-02-24
申请人： Paul A. Levine , Eliot L. Ostrow
发明人： Paul A. Levine , Eliot L. Ostrow
IPC分类号： A61N1/08
CPC分类号： A61N1/36507 , A61N1/36521 , A61N1/36542 , A61N1/3684 , A61N1/3686
摘要： Techniques are provided for use with a pacemaker or other implantable medical device capable of sensing electrical signals along a set of programmable sensing vectors. In one example, electrical cardiac signals are sensed within a patient using a primary sensing vector connected to a primary sensing channel for use in controlling the delivery of therapy. If the device detects a significant drop in key signal parameters such as peak signal amplitude or slew rate, an assessment is made whether an alternate sensing vector provides improved cardiac signal sensing. During the assessment, the device can continue to sense signals along the primary channel for the purposes of controlling therapy while alternate vectors are assessed in the background. If it is determined that an alternate sensing vector provides improved cardiac signal sensing, the primary sensing channel can be switched to the alternate sensing vector for use in controlling further therapy.
摘要翻译：提供技术用于能够沿着一组可编程感测向量感测电信号的起搏器或其他可植入医疗装置。在一个示例中，使用连接到主感测通道的主感测矢量在患者体内感测电心电信号，以用于控制治疗的递送。如果设备检测到关键信号参数（如峰值信号幅度或转换速率）的显着下降，则可以评估一个替代传感矢量是否提供改善的心脏信号感测。在评估期间，为了控制治疗的目的，装置可以继续沿着主要信道感测信号，而在背景中评估替代载体。如果确定替代感测向量提供改善的心脏信号感测，则主感测通道可以被切换到用于控制进一步治疗的替代感测矢量。

9. 发明授权

US07248925B2 System and method for determining optimal atrioventricular delay based on intrinsic conduction delays 有权
标题翻译：基于内在传导延迟确定最佳房室延迟的系统和方法
公开(公告)号：US07248925B2
公开(公告)日：2007-07-24
申请号：US10928586
申请日：2004-08-27
申请人： Ken Bruhns , Xiaoyi Min , Paul A. Levine , Euljoon Park
发明人： Ken Bruhns , Xiaoyi Min , Paul A. Levine , Euljoon Park
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A system and method for estimating optimal atrioventricular delay values for use in pacing the ventricles. Both the intrinsic inter-atrial conduction delay and the intrinsic atrioventricular conduction delay are determined for the patient and then the preferred atrioventricular pacing delay is derived therefrom. By taking into account intrinsic inter-atrial delay along with intrinsic atrioventricular delay, a more reliable estimate of the true optimal atrioventricular delay values for the patient can be achieved than with techniques that only take into account intrinsic atrioventricular delay values. In one example, the technique uses intracardiac electrogram (IEGM) signals and surface electrocardiogram (EKG) signals and hence can be performed by an external programmer without requiring Doppler echocardiography or other cardiac performance monitoring techniques. In another example, wherein the implanted device is equipped with a coronary sinus lead, the technique uses only IEGM signals and hence can be performed by the device itself.
摘要翻译：用于估计用于起搏心室的最佳房室延迟值的系统和方法。对于患者确定内在的心房传导延迟和内在的房室传导延迟，然后从其导出优选的房室起搏延迟。通过考虑内在的心房延迟以及内在的房室延迟，可以实现比仅考虑内在房室延迟值的技术更可靠的估计患者的真正最佳房室延迟值。在一个示例中，该技术使用心内电描记图（IEGM）信号和表面心电图（EKG）信号，因此可以由外部编程器执行，而不需要多普勒超声心动图或其他心脏监测技术。在另一示例中，其中植入的装置配备有冠状窦引线，该技术仅使用IEGM信号，因此可以由装置本身执行。

10. 发明申请

US20080086177A1 System and Related Methods for Monitoring Cardiac Disease Using Pacing Latency Measurements 审中-公开
标题翻译：使用起搏延迟测量监测心脏疾病的系统和相关方法
公开(公告)号：US20080086177A1
公开(公告)日：2008-04-10
申请号：US11539824
申请日：2006-10-09
申请人： Xiaoyi Min , Paul A. Levine , Jong Gill
发明人： Xiaoyi Min , Paul A. Levine , Jong Gill
IPC分类号： A61N1/365
CPC分类号： A61N1/37 , A61B5/0452 , A61B5/0809 , A61B5/091 , A61B5/11 , A61N1/3621 , A61N1/3627
摘要： A system and related methods for monitoring cardiac disease. The system includes an implantable medical device having a microcontroller that is configured to measure a pacing latency value for a region of a heart, compare the measured pacing latency value to a previously measured pacing latency value for the region of the heart, and determine a change in an amount of cardiac disease in the region of the heart based on the comparison of the measured pacing latency values.
摘要翻译：用于监测心脏病的系统和相关方法。该系统包括具有微控制器的可植入医疗装置，微控制器被配置为测量心脏区域的起搏延迟值，将测量的起搏延迟值与心脏区域的先前测量的起搏延迟值进行比较，并确定改变基于测量的起搏延迟值的比较，在心脏区域中的心脏病的量。

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