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1. 发明授权

US09050615B2 Apparatus and method for coating substrates for analyte detection by means of an affinity assay method 有权
标题翻译：用于通过亲和测定法涂覆用于分析物检测的底物的装置和方法
公开(公告)号：US09050615B2
公开(公告)日：2015-06-09
申请号：US11919054
申请日：2006-04-22
申请人： Eginhard Schick , Dominic Utinger , Claudio Calonder
发明人： Eginhard Schick , Dominic Utinger , Claudio Calonder
IPC分类号： B01L3/00 , B05B17/06
CPC分类号： B05B17/0615 , B01L3/00
摘要： The invention relates to several embodiments of equipment for coating substrates for detecting one or more analytes by way of an affinity assay method, comprising: a receptacle receiving a liquid to be atomized (“liquid receptacle”) with substances (compounds) to be deposited onto at least one surface of said substrates and an atomized volume produced by the liquid in the operating state; an actuator for triggering the atomization process and; a fixture for receiving and storing the substrates during the coating process. The invention is characterized in that the substrates are not in contact with the surface of the liquid to be atomized. The invention also relates to several embodiments of methods for coating substrates with coupler and/or passivation layers for use in the detection of one or more analytes by way of an affinity assay method.
摘要翻译：本发明涉及用于通过亲和测定方法检测一种或多种分析物的基质用于涂覆基底的设备的几个实施方案，包括：容纳要被雾化的液体（“液体容器”）与要沉积的物质（化合物）的容器所述衬底的至少一个表面和在操作状态下由液体产生的雾化体积; 用于触发雾化过程的致动器; 用于在涂覆过程中接收和存储基底的夹具。本发明的特征在于，基板不与待雾化的液体的表面接触。本发明还涉及用于用用于通过亲和测定方法检测一种或多种分析物的成色剂和/或钝化层涂覆基质的方法的几个实施方案。

2. 发明授权

US07955837B2 Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof 有权
标题翻译：用于确定具有复合组成的生物来源的样品中的一种或多种分析物的方法及其用途
公开(公告)号：US07955837B2
公开(公告)日：2011-06-07
申请号：US12084285
申请日：2005-10-29
申请人： Michael Pawlak , Eginhard Schick , Miro Venturi , Markus Ehrat
发明人： Michael Pawlak , Eginhard Schick , Miro Venturi , Markus Ehrat
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/54373 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N33/54306 , Y10S436/807 , Y10S436/809
摘要： The present invention relates to a process for detecting one or more analytes in one or more samples of biological origin having complex composition. The present invention also relates to a microarray for quantitative determination of one or more analytes in samples of biological origin having complex composition which are immobilized in measurement ranges of microarray, and also to a quantitative detection method based thereon.
摘要翻译：本发明涉及用于检测一种或多种具有复合组成的生物来源的一种或多种样品中的一种或多种分析物的方法。本发明还涉及用于定量测定在生物来源的具有复合组成的样品中的一种或多种分析物的微阵列，其固定在微阵列的测量范围内，以及基于此的定量检测方法。

3. 发明授权

US07645612B2 Kit and method for multi-analyte determination 失效
标题翻译：多分析物测定的试剂盒和方法
公开(公告)号：US07645612B2
公开(公告)日：2010-01-12
申请号：US12062820
申请日：2008-04-04
申请人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
发明人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
IPC分类号： G01N33/543
CPC分类号： G01N21/6452 , B01L3/5085 , G01N21/648 , G01N33/54373 , G01N2021/6441 , G01N2021/6482 , Y10S435/808 , Y10S435/975 , Y10S436/805 , Y10S436/808
摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.
摘要翻译：本发明涉及用于同时定量和/或定量确定多种分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触所述测量区域在所述传感器平台上直接或与其它试剂混合之后。本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

4. 发明申请

US20090163374A1 Process for Determining One or More Analytes in Samples of Biological Origin Having Complex Composition, and Use Thereof 有权
标题翻译：确定具有复杂组成的生物来源样品中一种或多种分析物的方法及其用途
公开(公告)号：US20090163374A1
公开(公告)日：2009-06-25
申请号：US12084285
申请日：2005-10-29
申请人： Michael Pawlak , Eginhard Schick , Miro Venturi , Markus Ehrat
发明人： Michael Pawlak , Eginhard Schick , Miro Venturi , Markus Ehrat
IPC分类号： C40B30/04 , C40B40/02
CPC分类号： G01N33/54373 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N33/54306 , Y10S436/807 , Y10S436/809
摘要： The present invention relates to a process for detecting one or more analytes in one or more samples of biological origin having complex composition. The present invention also relates to a microarray for quantitative determination of one or more analytes in samples of biological origin having complex composition which are immobilized in measurement ranges of microarray, and also to a quantitative detection method based thereon.
摘要翻译：本发明涉及用于检测一种或多种具有复合组成的生物来源的一种或多种样品中的一种或多种分析物的方法。本发明还涉及用于定量测定在生物来源的具有复合组成的样品中的一种或多种分析物的微阵列，其固定在微阵列的测量范围内，以及基于此的定量检测方法。

5. 发明申请

US20080212070A1 KIT AND METHOD FOR MULTI-ANALYTE DETERMINATION 失效
标题翻译：用于多分析确定的套件和方法
公开(公告)号：US20080212070A1
公开(公告)日：2008-09-04
申请号：US12062820
申请日：2008-04-04
申请人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schurmann-Mader , Martin Andreas Bopp
发明人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schurmann-Mader , Martin Andreas Bopp
IPC分类号： G01N1/00 , G01N21/01 , G01J4/00 , G01N21/41
CPC分类号： G01N21/6452 , B01L3/5085 , G01N21/648 , G01N33/54373 , G01N2021/6441 , G01N2021/6482 , Y10S435/808 , Y10S435/975 , Y10S436/805 , Y10S436/808
摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.
摘要翻译：本发明涉及用于同时定量和/或定量确定多种分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触所述测量区域在所述传感器平台上直接或与其它试剂混合之后。本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

6. 发明申请

US20100130370A1 FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION 有权
标题翻译：流量池阵列及其多用途测定的应用
公开(公告)号：US20100130370A1
公开(公告)日：2010-05-27
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
发明人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样品室的布置包括基板和与基板组合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

7. 发明申请

US20050059014A1 Analytical platform and detection method with the analytes to be determined in a sample as immobilized specific binding partners 审中-公开
标题翻译：分析平台和检测方法与样品中待测定的分析物作为固定化的特异性结合配偶体
公开(公告)号：US20050059014A1
公开(公告)日：2005-03-17
申请号：US10653386
申请日：2003-09-03
申请人： Michael Pawlak , Eginhard Schick , Peter Oroszlan
发明人： Michael Pawlak , Eginhard Schick , Peter Oroszlan
IPC分类号： G01N33/566 , C12M1/00 , C12M1/34 , C12Q1/68 , G01N21/76 , G01N33/53 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54353 , G01N33/54373
摘要： The present invention is related to an analytical platform and a method performed therewith for the analysis of a multitude of “nature-identical” samples for analytes which are contained therein and are of biological relevance as binding partners in specific binding reactions, wherein said samples or dilutions of said samples of the same relative molecular composition as the original samples, with the analytes to be determined contained therein, as a first plurality of specific binding partners, are deposited in discrete measurement areas in at least one one- or two-dimensional array of measurement areas on an evanescent field sensor platform as a solid support without a change in the relative molecular composition, compared with the original relative molecular composition of the sample, one or more tracer compounds as a second plurality of specific binding partners, for the specific determination of analytes out of the first plurality of specific binding partners contained in the samples, are brought into contact with the samples deposited in said discrete measurement areas in a single step or multiple steps of a specific binding reaction, changes in opto-electronic signals, resulting from the binding of tracer compounds to analytes contained in the samples in discrete measurement areas or to specific binding partners bound to the analytes contained in the measurement areas in the evanescent field of the evanescent field sensor platform are measured laterally resolved, and the presence of the analytes to be specifically detected is determined qualitatively and/or quantitatively from the relative amount of the changes in said opto-electronic signals from the corresponding measurement areas.
摘要翻译：本发明涉及一种分析平台及其分析方法，用于分析大量与分析物相似的“自然相同”的样品，其中所含的分析物样品在其中包含并具有生物相关性，作为特异性结合反应中的结合配偶体，其中所述样品或与原始样品相同的相对分子组成的所述样品与其中包含的待测定的分析物作为第一多个特异性结合配偶体的稀释沉积在至少一个一维或二维阵列的离散测量区域中相对于样品的原始相对分子组成，作为第二多个特异性结合配偶体的一个或多个示踪剂化合物，作为固体支持物的ev逝场传感器平台上的测量区域作为固体支持物而没有相对分子组成的变化确定包含在第一个多个具体约束伙伴中的分析物在与单独的步骤或特定结合反应的多个步骤中，沉积在所述离散测量区域中的样品与示踪剂化合物与样品中包含的分析物的离散性的光电子信号的变化相接触测量区域或与消逝场传感器平台的消逝场中测量区域中包含的分析物结合的特异性结合配体进行横向分辨测定，并且特异性检测的分析物的存在是从定性和/或定量的相应测量区域的所述光电信号的相对变化量。

8. 发明授权

US08053225B2 Flow cell array and the utilization thereof for multianalyte determination 有权
标题翻译：流量池阵列及其在多分辨率测定中的应用
公开(公告)号：US08053225B2
公开(公告)日：2011-11-08
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
发明人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

9. 发明申请

US20090311773A1 Novel apparatus and method for coating substrates for analyte detection by means of an affinity assay method 有权
标题翻译：用于通过亲和测定方法涂覆用于分析物检测的底物的新型装置和方法
公开(公告)号：US20090311773A1
公开(公告)日：2009-12-17
申请号：US11919054
申请日：2006-04-22
申请人： Eginhard Schick , Dominic Utinger , Claudio Calonder
发明人： Eginhard Schick , Dominic Utinger , Claudio Calonder
IPC分类号： C12M1/34 , B05B1/00 , B05D1/02
CPC分类号： B05B17/0615 , B01L3/00
摘要： The invention relates to several embodiments of equipment for coating substrates for detecting one or more analytes by way of an affinity assay method, comprising: a receptacle receiving a liquid to be atomized (“liquid receptacle”) with substances (compounds) to be deposited onto at least one surface of said substrates and an atomized volume produced by the liquid in the operating state; an actuator for triggering the atomization process and; a fixture for receiving and storing the substrates during the coating process. The invention is characterized in that the substrates are not in contact with the surface of the liquid to be atomized. The invention also relates to several embodiments of methods for coating substrates with coupler and/or passivation layers for use in the detection of one or more analytes by way of an affinity assay method.
摘要翻译：本发明涉及用于通过亲和测定方法检测一种或多种分析物的基质用于涂覆基底的设备的几个实施方案，包括：容纳要被雾化的液体（“液体容器”）与要沉积的物质（化合物）的容器所述衬底的至少一个表面和在操作状态下由液体产生的雾化体积; 用于触发雾化过程的致动器; 用于在涂覆过程中接收和存储基底的夹具。本发明的特征在于，基板不与待雾化的液体的表面接触。本发明还涉及用于用用于通过亲和测定方法检测一种或多种分析物的成色剂和/或钝化层涂覆基质的方法的几个实施方案。

10. 发明授权

US07396675B2 Kit and method for determining a plurality of analytes 有权
标题翻译：用于确定多种分析物的试剂盒和方法
公开(公告)号：US07396675B2
公开(公告)日：2008-07-08
申请号：US10296851
申请日：2001-05-25
申请人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
发明人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
IPC分类号： G01N33/543 , G01N33/551
CPC分类号： G01N21/6452 , B01L3/5085 , G01N21/648 , G01N33/54373 , G01N2021/6441 , G01N2021/6482 , Y10S435/808 , Y10S435/975 , Y10S436/805 , Y10S436/808
摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.
摘要翻译：本发明涉及用于同时定性和/或定量测定大量分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触所述测量区域在所述传感器平台上直接或与其它试剂混合之后。本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

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