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1. 发明授权

US08388640B2 Catheter with a polymide distal tip 有权
公开(公告)号：US08388640B2
公开(公告)日：2013-03-05
申请号：US13323008
申请日：2011-12-12
申请人： Jeong S. Lee , Edwin Wang
发明人： Jeong S. Lee , Edwin Wang
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61L29/085 , A61L2420/08 , A61M25/001 , A61M25/0045 , A61M25/0069 , A61M2025/1093 , C08L79/08 , C08L77/00 , C08L77/12 , C08L75/04
摘要： A catheter having an elongated shaft which has a multilayered distal tip with a first layer formed of a polyimide first material and a second layer formed of a polymeric second material. In one embodiment the multilayered distal tip is a separate member, distal to the distal end of a proximal portion of the shaft. In another embodiment, the shaft has an outer tubular member, and a multilayered inner tubular member with a distal end which forms the multilayered distal tip of the shaft. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. In one embodiment, the polymeric second material is a polyamide material.

2. 发明授权

US08083726B1 Encapsulating cells and lumen 有权
标题翻译：封闭细胞和内腔
公开(公告)号：US08083726B1
公开(公告)日：2011-12-27
申请号：US11240694
申请日：2005-09-30
申请人： Edwin Wang
发明人： Edwin Wang
IPC分类号： A61M31/00 , A61F2/06 , A61F2/02
CPC分类号： A61B1/00082 , A61B1/3137 , A61B17/3478 , A61B2017/00247 , A61L27/16 , A61L27/3834 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61L2430/20 , A61M25/0026 , A61M25/10 , A61M25/104 , A61M2025/0087 , A61M2025/105 , A61M2025/1086 , C08L33/10
摘要： A method including combining a cellular component with a viability enhancer material wherein the combination will inhibit an interaction between the cellular component and a delivery device; and delivering the cellular component through the delivery device. An apparatus including a delivery cannula having dimensions suitable for percutaneous delivery and a lumen therethrough, wherein a portion of a luminal surface of the cannula includes a coating that is amenable to a cellular component delivered through the delivery cannula. A method including percutaneously introducing a delivery cannula into a blood vessel; advancing a distal portion of the delivery cannula to a treatment site; and delivering a cellular component through a lumen of the delivery cannula, wherein a portion of a luminal surface of the cannula includes a coating that is amenable to a cellular component delivered through the delivery cannula.
摘要翻译：一种方法，包括将细胞组分与活力增强剂材料组合，其中所述组合将抑制细胞组分与递送装置之间的相互作用; 以及通过所述递送装置递送所述蜂窝组件。一种装置，包括具有适于经皮输送的尺寸和穿过其中的腔的输送套管，其中套管腔表面的一部分包括适于通过输送套管输送的细胞组分的涂层。一种方法，包括将输送套管经皮导入血管内; 将输送套管的远端部分推进到治疗部位; 以及通过所述输送套管的内腔递送细胞组分，其中所述套管的腔表面的一部分包括适于通过所述递送插管输送的细胞组分的涂层。

3. 发明授权

US08075583B2 Catheter with a polyimide distal tip 有权
标题翻译：导管与聚酰亚胺的远端
公开(公告)号：US08075583B2
公开(公告)日：2011-12-13
申请号：US11237376
申请日：2005-09-28
申请人： Jeong S. Lee , Edwin Wang
发明人： Jeong S. Lee , Edwin Wang
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61L29/085 , A61L2420/08 , A61M25/001 , A61M25/0045 , A61M25/0069 , A61M2025/1093 , C08L79/08 , C08L77/00 , C08L77/12 , C08L75/04
摘要： A catheter having an elongated shaft which has a multilayered distal tip with a first layer formed of a polyimide first material and a second layer formed of a polymeric second material. In one embodiment the multilayered distal tip is a separate member, distal to the distal end of a proximal portion of the shaft. In another embodiment, the shaft has an outer tubular member, and a multilayered inner tubular member with a distal end which forms the multilayered distal tip of the shaft. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. In one embodiment, the polymeric second material is a polyamide material.
摘要翻译：一种具有细长轴的导管，该细长轴具有由聚酰亚胺第一材料形成的第一层和由聚合物第二材料形成的第二层的多层远端。在一个实施例中，多层远侧末端是远离轴的近端部分的远端的分离的构件。在另一个实施例中，轴具有外部管状构件和多层内部管状构件，其具有形成轴的多层远侧末端的远端。在目前优选的实施方案中，聚酰亚胺材料是热固性聚酰亚胺。在一个实施方案中，聚合物第二材料是聚酰胺材料。

4. 发明授权

US07951413B2 Catheter balloon having a lubricious coating 有权
标题翻译：导管气球具有光滑的涂层
公开(公告)号：US07951413B2
公开(公告)日：2011-05-31
申请号：US11582580
申请日：2006-10-18
申请人： Fozan El-Nounou , Timothy Owens , Florencia Lim , Edwin Wang
发明人： Fozan El-Nounou , Timothy Owens , Florencia Lim , Edwin Wang
IPC分类号： B05D3/10 , B32B3/26 , A61M25/10
CPC分类号： A61M25/104 , A61F2/958 , A61M2025/1075 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249972 , Y10T428/249987 , Y10T428/3154
摘要： A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.
摘要翻译：用于导管的球囊和制造球囊的方法，具有一层具有改良的外表面的多孔聚合物材料和与改性外表面结合的润滑涂层。在一个实施方案中，改性的外表面由浸渍在多孔聚合物材料中的聚合物形成，随后施加的润滑涂层与浸渍聚合物结合。在另一个实施方案中，改性的外表面由沉积在多孔聚合物材料上的官能团形成，其结合到随后施加的光滑涂层上。改进的外表面在光滑涂层和球囊之间提供改进的强结合，以改善导管性能。

5. 发明申请

US20090062835A1 CATHETER HAVING AN IMPROVED DISTAL TIP 有权
标题翻译：具有改进的远程提示的导管
公开(公告)号：US20090062835A1
公开(公告)日：2009-03-05
申请号：US12271726
申请日：2008-11-14
申请人： Edwin Wang , Roseminda J. White , Jeong S. Lee , Tim Kitchen
发明人： Edwin Wang , Roseminda J. White , Jeong S. Lee , Tim Kitchen
IPC分类号： A61M29/02
CPC分类号： A61M25/0069 , A61M25/001 , A61M25/10 , A61M2025/1093
摘要： An elongated balloon catheter having a distal tip member on the distal end of the catheter and having a sleeve surrounding and secured at least to the proximal end of the distal tip member.
摘要翻译：一种细长的气囊导管，其具有在导管的远端上的远侧末端构件，并且具有围绕并固定至远侧末端构件的近端的套筒。

6. 发明授权

US07273471B1 Catheter balloon having a porous layer with ridges 有权
标题翻译：导管球囊具有带脊的多孔层
公开(公告)号：US07273471B1
公开(公告)日：2007-09-25
申请号：US10746621
申请日：2003-12-23
申请人： Edwin Wang , Jon Becker , Florencia Lim
发明人： Edwin Wang , Jon Becker , Florencia Lim
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61M25/1002 , A61M2025/1004
摘要： A balloon catheter having a balloon with a porous polymer layer and one or more filamentary members which are on or in the porous polymer layer and which form ridges protruding outwardly from a surface of the balloon in the inflated configuration. In a presently preferred embodiment, the balloon has a wingless noninflated configuration.
摘要翻译：一种球囊导管，其具有多孔聚合物层的球囊和一个或多个丝状构件，其位于多孔聚合物层中或多孔聚合物层中，并且形成在膨胀构型中从球囊表面向外突出的脊。在目前优选的实施例中，球囊具有无翼无绒构型。

7. 发明申请

US20070032760A1 Catheter balloon having a lubricious coating 有权
标题翻译：导管气球具有光滑的涂层
公开(公告)号：US20070032760A1
公开(公告)日：2007-02-08
申请号：US11582580
申请日：2006-10-18
申请人： Fozan El-Nounou , Timothy Owens , Florencia Lim , Edwin Wang
发明人： Fozan El-Nounou , Timothy Owens , Florencia Lim , Edwin Wang
IPC分类号： A61M29/00 , B32B3/26 , A61M31/00 , A61M37/00
CPC分类号： A61M25/104 , A61F2/958 , A61M2025/1075 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249972 , Y10T428/249987 , Y10T428/3154
摘要： A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.
摘要翻译：用于导管的球囊和制造球囊的方法，具有一层具有改良的外表面的多孔聚合物材料和与修饰的外表面结合的润滑涂层。在一个实施方案中，改性的外表面由浸渍在多孔聚合物材料中的聚合物形成，随后施加的润滑涂层与浸渍聚合物结合。在另一个实施方案中，改性的外表面由沉积在多孔聚合物材料上的官能团形成，其结合到随后施加的光滑涂层上。改进的外表面在光滑涂层和球囊之间提供改进的强结合，以改善导管性能。

8. 发明申请

US20060029756A1 Catheter balloon formed of ePTFE and a diene polymer 审中-公开
公开(公告)号：US20060029756A1
公开(公告)日：2006-02-09
申请号：US11198623
申请日：2005-08-05
申请人： Florencia Lim , Chi Long , Charles Claude , Jeong Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
发明人： Florencia Lim , Chi Long , Charles Claude , Jeong Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
IPC分类号： B32B27/32
CPC分类号： A61M25/1034 , A61L29/041 , A61L29/085 , A61L29/126 , A61M25/1006 , A61M25/1025 , A61M25/1029 , A61M2025/1075 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , C08L27/18
摘要： A catheter balloon formed of a polymeric material such as expanded polytetrafluoroethylene (ePTFE) bonded to a second layer formed of a low tensile set polymer and/or impregnated with a low tensile set polymer. In a presently preferred embodiment, the low tensile set polymer is an elastomer selected from the group consisting of a silicone-polyurethane copolymer and a diene polymer. The low tensile set polymer has high strength, low modulus, high elongation, and low tensile set, to provide improved balloon performance. The diene or silicone-polyurethane has a low tensile set, which facilitates deflation of the balloon to a low profile deflated configuration. One aspect of the invention provides improved attachment of the diene to the ePTFE. In one embodiment, the second layer is formed of a diene mixed with a bonding promoter such as a vulcanizing agent which is covalently bonded to the diene.

9. 发明申请

US20050215885A1 MRI visible catheter balloon 审中-公开
公开(公告)号：US20050215885A1
公开(公告)日：2005-09-29
申请号：US11094333
申请日：2005-03-29
申请人： Jeong Lee , Edwin Wang , Roseminda White , Jose Romero
发明人： Jeong Lee , Edwin Wang , Roseminda White , Jose Romero
IPC分类号： A61B19/00 , A61F2/958 , A61L29/10 , A61L29/12 , A61L29/18 , A61M29/02 , A61B5/05
CPC分类号： A61F2/95 , A61B2090/3954 , A61L29/106 , A61L29/126 , A61L29/18 , A61M25/10 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/1075 , A61M2025/1079
摘要： Medical devices or components thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, which are formed at least in part of a polymeric material and a ferromagnetic or paramagnetic material, so that the medical device or component thereof is visible on magnetic resonance imaging (MRI) scans. In one embodiment, the medical device is a balloon catheter having an MRI visible balloon. In a presently preferred embodiment, there is an insufficient amount of the ferromagnetic or paramagnetic material within a wall of the balloon or coated onto a wall of the balloon to make the balloon radiopaque.

10. 发明授权

US06946173B2 Catheter balloon formed of ePTFE and a diene polymer 有权
标题翻译：导管球由ePTFE和二烯聚合物形成
公开(公告)号：US06946173B2
公开(公告)日：2005-09-20
申请号：US10103274
申请日：2002-03-21
申请人： Florencia Lim , Chi Le Long , Charles D. Claude , Jeong S. Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
发明人： Florencia Lim , Chi Le Long , Charles D. Claude , Jeong S. Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
IPC分类号： A61L29/00 , A61F2/958 , A61L29/04 , A61L29/08 , A61L29/12 , A61M25/00 , A61M25/16 , B32B1/08 , A61M25/10 , A61M29/00
CPC分类号： A61M25/1034 , A61L29/041 , A61L29/085 , A61L29/126 , A61M25/1006 , A61M25/1025 , A61M25/1029 , A61M2025/1075 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , C08L27/18
摘要： A catheter balloon formed of a polymeric material such as expanded polytetrafluoroethylene (ePTFE) bonded to a second layer formed of a low tensile set polymer and/or impregnated with a low tensile set polymer. In a presently preferred embodiment, the low tensile set polymer is a silicone-polyurethane copolymer elastomer or a diene polymer elastomer. The low tensile set polymer has high strength, low modulus, high elongation, and low tensile set. The diene or silicone-polyurethane has a low tensile set, which facilitates deflation of the balloon to a low profile deflated configuration. One aspect of the invention provides improved attachment of the diene to the ePTFE. In one embodiment, the second layer is formed of a diene mixed with a bonding promoter such as a vulcanizing agent which is covalently bonded to the diene.
摘要翻译：由诸如膨胀聚四氟乙烯（ePTFE）的聚合物材料形成的导管球囊结合到由低拉伸凝固聚合物形成的第二层和/或用低拉伸固化聚合物浸渍。在目前优选的实施方案中，低拉伸固化聚合物是硅氧烷 - 聚氨酯共聚物弹性体或二烯聚合物弹性体。低强度聚合物具有高强度，低模量，高伸长率和低拉伸强度。二烯或硅氧烷聚氨酯具有低拉伸组合，其有利于将气囊放气至低剖面放气构型。本发明的一个方面提供了改进的二烯与ePTFE的连接。在一个实施方案中，第二层由与二烯混合的二烯混合形成，所述二烯与粘合促进剂例如硫化剂混合。

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