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1. 发明授权

US08308711B2 Catheter shaft with a lubricious surface 有权
标题翻译：导管轴具有光滑的表面
公开(公告)号：US08308711B2
公开(公告)日：2012-11-13
申请号：US11368659
申请日：2006-03-06
申请人： Jeong S. Lee , Kenneth L. Wantink , Roseminda White
发明人： Jeong S. Lee , Kenneth L. Wantink , Roseminda White
IPC分类号： A61M25/00
CPC分类号： A61L29/085 , A61L29/14 , A61M25/0045 , A61M2025/0046 , C08L83/04 , C08L23/06
摘要： A catheter which has an elongated shaft having a layer of an ultra high molecular weight polyolefin, such as a melt-extruded ultra high molecular weight polyethylene (UHMWPE). The UHMWPE, forming at least in part a surface of the shaft, facilitates sliding a blood/contrast coated device along the shaft surface, and preferably substantially prevents or inhibits agglomerations of blood and contrast from adhering to the surface of the shaft in a patient's body lumen. In a presently preferred embodiment, the layer has a lubricious coating, such that the coated surface of the UHMWPE layer significantly decreases the force produced by the blood/contrast coated device sliding along the coated surface.
摘要翻译：具有细长轴的导管，其具有超高分子量聚烯烃层，例如熔体挤出的超高分子量聚乙烯（UHMWPE）。至少部分地形成轴的表面的UHMWPE有助于沿着轴表面滑动血液/造影剂涂覆的装置，并且优选地基本上防止或抑制血液和对比度的聚集，从而粘附到患者体内的轴的表面流明。在当前优选的实施方案中，该层具有润滑的涂层，使得UHMWPE层的涂覆表面显着降低由涂覆的涂层表面滑动的血液/造影剂装置产生的力。

2. 发明申请

US20070293791A1 Guidewire With Lubricious Proximal Portion 审中-公开
标题翻译：导线与Lubricious近端部分
公开(公告)号：US20070293791A1
公开(公告)日：2007-12-20
申请号：US11424819
申请日：2006-06-16
申请人： Jeong Lee , Aaron Baldwin , Roseminda White , Kristen M. Nolan , Emmanuel C. Biagtan
发明人： Jeong Lee , Aaron Baldwin , Roseminda White , Kristen M. Nolan , Emmanuel C. Biagtan
IPC分类号： A61M25/09
CPC分类号： A61L31/14 , A61L31/10 , A61L2420/08 , A61M25/09 , A61M2025/09091 , C08L27/18 , C08L83/04
摘要： A guidewire has a proximal portion and a distal portion. The distal portion may be coated, as with a hydrophilic or other coating, or may be uncoated. The proximal portion, however, is coated with a specially lubricious coating that serves to reduce resistance and to prevent lock up as the guidewire moves through a guiding catheter. The proximal portion may, for example, be coated with a base layer, such as TEFLON® (polytetrafluoroethylene), and one or more top layers, such as a silicone-based layer. In one approach, two silicone-based top layers are applied. Alternatively, a top layer of spray PTFE, paraffins, olefins, and/or fats may be applied. As an alternative, the base layer may be optional, such that the top layer or layers is coated onto bare metal, or a base other than TEFLON® may be used.
摘要翻译：导线具有近端部分和远端部分。远端部分可以如亲水或其它涂层一样被涂覆，或者可以是未涂覆的。然而，近端部分涂覆有特别润滑的涂层，其用于降低阻力并防止当导丝移动通过导向导管时锁定。近端部分可以例如涂覆有诸如TEFLON（聚四氟乙烯）的基层，以及一个或多个顶层，例如硅氧烷基层。在一种方法中，应用两种基于硅氧烷的顶层。或者，可以施用喷涂PTFE，石蜡，烯烃和/或脂肪的顶层。作为替代，基层可以是任选的，使得顶层或多层涂覆在裸露的金属上，或者可以使用除TEFLON之外的基底。

3. 发明申请

US20050215885A1 MRI visible catheter balloon 审中-公开
公开(公告)号：US20050215885A1
公开(公告)日：2005-09-29
申请号：US11094333
申请日：2005-03-29
申请人： Jeong Lee , Edwin Wang , Roseminda White , Jose Romero
发明人： Jeong Lee , Edwin Wang , Roseminda White , Jose Romero
IPC分类号： A61B19/00 , A61F2/958 , A61L29/10 , A61L29/12 , A61L29/18 , A61M29/02 , A61B5/05
CPC分类号： A61F2/95 , A61B2090/3954 , A61L29/106 , A61L29/126 , A61L29/18 , A61M25/10 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/1075 , A61M2025/1079
摘要： Medical devices or components thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, which are formed at least in part of a polymeric material and a ferromagnetic or paramagnetic material, so that the medical device or component thereof is visible on magnetic resonance imaging (MRI) scans. In one embodiment, the medical device is a balloon catheter having an MRI visible balloon. In a presently preferred embodiment, there is an insufficient amount of the ferromagnetic or paramagnetic material within a wall of the balloon or coated onto a wall of the balloon to make the balloon radiopaque.

4. 发明申请

US20070225746A1 Catheter shaft with a lubricious surface 有权
标题翻译：导管轴具有光滑的表面
公开(公告)号：US20070225746A1
公开(公告)日：2007-09-27
申请号：US11368659
申请日：2006-03-06
申请人： Jeong Lee , Kenneth Wantink , Roseminda White
发明人： Jeong Lee , Kenneth Wantink , Roseminda White
IPC分类号： A61M29/00
CPC分类号： A61L29/085 , A61L29/14 , A61M25/0045 , A61M2025/0046 , C08L83/04 , C08L23/06
摘要： A catheter which has an elongated shaft having a layer of an ultra high molecular weight polyolefin, such as a melt-extruded ultra high molecular weight polyethylene (UHMWPE). The UHMWPE, forming at least in part a surface of the shaft, facilitates sliding a blood/contrast coated device along the shaft surface, and preferably substantially prevents or inhibits agglomerations of blood and contrast from adhering to the surface of the shaft in a patient's body lumen. In a presently preferred embodiment, the layer has a lubricious coating, such that the coated surface of the UHMWPE layer significantly decreases the force produced by the blood/contrast coated device sliding along the coated surface.
摘要翻译：具有细长轴的导管，其具有超高分子量聚烯烃层，例如熔体挤出的超高分子量聚乙烯（UHMWPE）。至少部分地形成轴的表面的UHMWPE有助于沿着轴表面滑动血液/造影剂涂覆的装置，并且优选地基本上防止或抑制血液和对比度的聚集，从而粘附到患者体内的轴的表面流明。在当前优选的实施方案中，该层具有润滑的涂层，使得UHMWPE层的涂覆表面显着降低由涂覆的涂层表面滑动的血液/造影剂装置产生的力。

5. 发明申请

US20080021495A1 MRI VISIBLE CATHETER BALLOON 审中-公开
标题翻译： MRI可见气囊
公开(公告)号：US20080021495A1
公开(公告)日：2008-01-24
申请号：US11828921
申请日：2007-07-26
申请人： Jeong Lee , Edwin Wang , Roseminda White , Jose Romero
发明人： Jeong Lee , Edwin Wang , Roseminda White , Jose Romero
IPC分类号： A61M29/00
CPC分类号： A61F2/95 , A61B2090/3954 , A61L29/106 , A61L29/126 , A61L29/18 , A61M25/10 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/1075 , A61M2025/1079
摘要： Medical devices or components thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, which are formed at least in part of a polymeric material and a ferromagnetic or paramagnetic material, so that the medical device or component thereof is visible on magnetic resonance imaging (MRI) scans. In one embodiment, the medical device is a balloon catheter having an MRI visible balloon. In a presently preferred embodiment, there is an insufficient amount of the ferromagnetic or paramagnetic material within a wall of the balloon or coated onto a wall of the balloon to make the balloon radiopaque.
摘要翻译：医疗器械或其组件，特别是用于治疗或诊断用途的体内器件，其至少部分地由聚合物材料和铁磁性或顺磁性材料形成，使得医疗器械或其组件在磁共振成像（MRI））扫描。在一个实施例中，医疗装置是具有MRI可见气囊的气囊导管。在目前优选的实施方案中，在球囊的壁内存在不足量的铁磁性或顺磁性材料，或涂覆在气球的壁上，以使气球不透射线。

6. 发明申请

US20050240214A1 Catheter having an improved distal tip 有权
标题翻译：导管具有改进的远端
公开(公告)号：US20050240214A1
公开(公告)日：2005-10-27
申请号：US11172543
申请日：2005-06-29
申请人： Edwin Wang , Roseminda White , Jeong Lee , Tim Kitchen
发明人： Edwin Wang , Roseminda White , Jeong Lee , Tim Kitchen
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/0069 , A61M25/001 , A61M25/10 , A61M2025/1093
摘要： An elongated balloon catheter having a distal tip member on the distal end of the catheter and having a sleeve surrounding and secured at least to the proximal end of the distal tip member.
摘要翻译：一种细长的气囊导管，其具有在导管的远端上的远侧末端构件，并且具有围绕并固定至远侧末端构件的近端的套筒。

7. 发明申请

US20050240213A1 Catheter with a multilayered shaft section having a polyimide layer 有权
标题翻译：具有具有聚酰亚胺层的多层轴部的导管
公开(公告)号：US20050240213A1
公开(公告)日：2005-10-27
申请号：US11038971
申请日：2005-01-18
申请人： Jeong Lee , Edwin Wang , Roseminda White
发明人： Jeong Lee , Edwin Wang , Roseminda White
IPC分类号： A61F2/958 , A61L29/08 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0045 , A61L29/085 , A61M25/0009 , A61M25/104 , C08L77/12 , C08L75/04 , C08L79/08
摘要： A catheter having an multilayered shaft section with a first layer formed of a polyimide first material and a second layer formed of a second material. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. However, in alternative embodiments, a thermoplastic polyimide is used. The thermoset polyimide has a very high glass transition temperature (Tg) of approximately 400° C. (as measured by differential scanning calorimetry), and excellent dimensional stability at the processing temperature of polyamides commonly used in catheter components. As a result, during formation and assembly of the catheter, production of a thin polyimide layer with controlled dimensions is facilitated. The polyimide has a high modulus and provides a thin walled yet highly pushable shaft section, while the second layer provides kink resistance. In one embodiment, the second material is selected from the group consisting of a polyamide material and a polyurethane material.
摘要翻译：一种具有多层轴部的导管，其具有由聚酰亚胺第一材料形成的第一层和由第二材料形成的第二层。在目前优选的实施方案中，聚酰亚胺材料是热固性聚酰亚胺。然而，在替代实施例中，使用热塑性聚酰亚胺。热固性聚酰亚胺具有约400℃的非常高的玻璃化转变温度（Tg）（通过差示扫描量热法测量），以及在导管组件中常用的聚酰胺的加工温度下的优异的尺寸稳定性。结果，在导管的形成和组装过程中，有助于生产具有受控尺寸的薄聚酰亚胺层。聚酰亚胺具有高模量并且提供薄壁且高度可推动的轴部分，而第二层提供扭结阻力。在一个实施方案中，第二材料选自聚酰胺材料和聚氨酯材料。

8. 发明授权

US06520934B1 Catheter assemblies with flexible radiopaque marker 有权
公开(公告)号：US06520934B1
公开(公告)日：2003-02-18
申请号：US09474668
申请日：1999-12-29
申请人： Jeong S. Lee , Vidya Nayak , John Schreiner , Christine Gutting , Edwin Wang , Gary Heinemann , Roseminda White
发明人： Jeong S. Lee , Vidya Nayak , John Schreiner , Christine Gutting , Edwin Wang , Gary Heinemann , Roseminda White
IPC分类号： A61M2900
CPC分类号： A61M25/0108 , A61M2025/1079
摘要： A catheter assembly comprising a shaft and at least one flexible radiopaque marker affixed with the shaft. Flexibility of radiopaque marker is achieved by using a segmented band of radiopaque material or a coiled band formed by winding a wire or hollow tube filled with radiopaque material. The flexible radiopaque marker may be affixed with the shaft by an adhesive, by swaging, by crimping, by soldering, or by spring-action tension fit against the shaft.

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