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1. 发明授权

US07476732B2 Nucleic acid encoding α chain of human IL-11 receptor 失效
标题翻译：编码人IL-11受体α链的核酸
公开(公告)号：US07476732B2
公开(公告)日：2009-01-13
申请号：US11204563
申请日：2005-08-16
申请人： Douglas James Hilton
发明人： Douglas James Hilton
IPC分类号： C12N15/12 , C12N15/63
CPC分类号： C07K14/715
摘要： The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof and their genetic sequences of the present invention are useful in the development of a wide range agonists, antagonists and therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及新型促血细胞生成素受体或其组分或部分，以及用于克隆编码其的遗传序列的方法。更具体地，本发明涉及重组或合成的促血细胞生成素受体或其组分或部分。本发明的受体分子或其组分或其部分及其遗传序列可用于开发基于配体与其受体相互作用的广泛激动剂，拮抗剂和治疗剂以及诊断试剂。

2. 发明授权

US07002000B1 Nucleic acid encoding α chain of human IL-11 receptor 失效
标题翻译：编码人IL-11受体α链的核酸
公开(公告)号：US07002000B1
公开(公告)日：2006-02-21
申请号：US09532263
申请日：2000-03-22
申请人： Douglas James Hilton
发明人： Douglas James Hilton
IPC分类号： C12N15/12 , C12N15/63
CPC分类号： C07K14/715
摘要： The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof and their genetic sequences of the present invention are useful in the development of a wide range of agonists, antagonists and therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及新型促血细胞生成素受体或其组分或部分，以及用于克隆编码其的遗传序列的方法。更具体地，本发明涉及重组或合成的促血细胞生成素受体或其组分或部分。本发明的受体分子或其组分或其部分及其遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂和治疗剂以及诊断试剂。

3. 发明申请

US20110020363A1 MONOCLONAL ANTIBODY AGAINST INTERLEUKIN-13 RECEPTOR ALPHA 1 (IL-13RALPHA1) 有权
标题翻译：白细胞介素-1受体ALPHA 1（IL-13RALPHA1）的单克隆抗体
公开(公告)号：US20110020363A1
公开(公告)日：2011-01-27
申请号：US12828589
申请日：2010-07-01
申请人： Felicity Meredith DUNLOP , Manuel BACA , Andrew Donald NASH , Louis Jerry FABRI , Douglas James HILTON , Nicos A. NICOLA
发明人： Felicity Meredith DUNLOP , Manuel BACA , Andrew Donald NASH , Louis Jerry FABRI , Douglas James HILTON , Nicos A. NICOLA
IPC分类号： A61K39/395 , C07K16/24 , C07K16/46 , A61P29/00 , A61P11/00 , A61P1/00
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.
摘要翻译：本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。更具体地说，本发明为哺乳动物，特别是IL-13R.α提供人源化或人抗体。这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。因此，还提供了筛选IL-13R.alpha.1 /配体相互作用的调节剂的方法。

4. 发明授权

US06274708B1 Mouse interleukin-11 receptor 失效
标题翻译：小鼠白细胞介素-11受体
公开(公告)号：US06274708B1
公开(公告)日：2001-08-14
申请号：US08702665
申请日：1996-12-20
申请人： Douglas James Hilton
发明人： Douglas James Hilton
IPC分类号： C07K100
CPC分类号： C07K14/715
摘要： The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof and their genetic sequences of the present invention are useful in the development of a wide range of agonists, antagonists and therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及新型促血细胞生成素受体或其组分或部分，以及用于克隆编码其的遗传序列的方法。更具体地，本发明涉及重组或合成的促血细胞生成素受体或其组分或部分。本发明的受体分子或其组分或其部分及其遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂和治疗剂以及诊断试剂。

5. 发明授权

US5750654A Leukaemia inhibitory factor 失效
标题翻译：白血病抑制因子
公开(公告)号：US5750654A
公开(公告)日：1998-05-12
申请号：US412769
申请日：1995-03-29
申请人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
发明人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
IPC分类号： A61K38/00 , A61K49/00 , A61P35/02 , C07K1/18 , C07K1/20 , C07K1/22 , C07K4/12 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C12N1/16 , C12N1/19 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/14 , C12N15/19 , C12N15/81 , C12N15/867 , C12P21/02 , C12P21/06 , C12Q1/68 , C12R1/865 , C12R1/91 , G01N33/53 , C07K1/16
CPC分类号： C12N15/86 , C07K14/5415 , C12N15/81 , C12P21/02 , C12P21/06 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N2740/13043
摘要： The present invention provides isolated DNA molecules encoding human and murine LIF, and methods of producing LIF by the expression of the isolated DNA in suitable host cells. The invention further provides human and murine LIF polypeptides, pharmaceutical compositions containing LIF, and methods of use thereof.
摘要翻译：本发明提供了编码人和鼠LIF的分离的DNA分子，以及通过在合适的宿主细胞中表达分离的DNA产生LIF的方法。本发明还提供人和鼠LIF多肽，含有LIF的药物组合物及其使用方法。

6. 发明授权

US08221755B2 Monoclonal antibody against interleukin-13 receptor alpha 1 (IL-13Ralpha1) 有权
标题翻译：针对白细胞介素-13受体α1（IL-13Rα1）的单克隆抗体
公开(公告)号：US08221755B2
公开(公告)日：2012-07-17
申请号：US12828589
申请日：2010-07-01
申请人： Felicity Meredith Dunlop , Manuel Baca , Andrew Donald Nash , Louis Jerry Fabri , Douglas James Hilton , Nicos A. Nicola
发明人： Felicity Meredith Dunlop , Manuel Baca , Andrew Donald Nash , Louis Jerry Fabri , Douglas James Hilton , Nicos A. Nicola
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.
摘要翻译：本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。更具体地说，本发明为哺乳动物，特别是IL-13R.α提供人源化或人抗体。这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。因此，还提供了筛选IL-13R.alpha.1 /配体相互作用的调节剂的方法。

7. 发明授权

US07785590B2 Monoclonal antibody against interleukin-13 receptor alpha 1 (IL-13Ra1) 有权
标题翻译：针对白细胞介素-13受体α1（IL-13Ra1）的单克隆抗体
公开(公告)号：US07785590B2
公开(公告)日：2010-08-31
申请号：US10850270
申请日：2004-05-20
申请人： Felicity Meredith Dunlop , Manuel Baca , Andrew Donald Nash , Louis Jerry Fabri , Douglas James Hilton , Nicos A Nicola
发明人： Felicity Meredith Dunlop , Manuel Baca , Andrew Donald Nash , Louis Jerry Fabri , Douglas James Hilton , Nicos A Nicola
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor α1 chain (IL-13Rα1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13Rα1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13Rα1/ligand interaction is also provided.
摘要翻译：本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。更具体地说，本发明为哺乳动物，特别是IL-13Rα1提供人源化或人抗体。这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。因此，还提供了筛选IL-13Rα1/配体相互作用的调节剂的方法。

8. 发明授权

US07186883B2 In vitro propagation of embryonic stem cells 失效
标题翻译：胚胎干细胞的体外繁殖
公开(公告)号：US07186883B2
公开(公告)日：2007-03-06
申请号：US10121220
申请日：2002-04-12
申请人： Robert Lindsay Williams , Nicholas Martin Gough , Douglas James Hilton
发明人： Robert Lindsay Williams , Nicholas Martin Gough , Douglas James Hilton
IPC分类号： C12N15/01
CPC分类号： C12N5/0606 , C12N2501/235 , C12N2510/00
摘要： The present invention relates to the use of leukemia inhibitory factor (LIF) in the isolation and propagation of embryonic stem cells in vitro.
摘要翻译：本发明涉及白血病抑制因子（LIF）在体外分离和繁殖胚胎干细胞中的应用。

9. 发明授权

US06414128B1 Haemopoietin receptor and genetic sequences encoding same 失效
标题翻译：促血细胞生成素受体和编码相同的遗传序列
公开(公告)号：US06414128B1
公开(公告)日：2002-07-02
申请号：US09043816
申请日：1998-09-17
申请人： Douglas James Hilton , Tracy Willson , Timothy Gainsford , Warren S Alexander , Donald Metcalf , Ashley Ng , Nicos A Nicola
发明人： Douglas James Hilton , Tracy Willson , Timothy Gainsford , Warren S Alexander , Donald Metcalf , Ashley Ng , Nicos A Nicola
IPC分类号： C12N1512
CPC分类号： C07K14/72 , C07K14/715
摘要： The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.
摘要翻译：本发明涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。受体分子及其衍生物和本发明编码相同基因的序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。本发明特别涉及瘦素受体。

10. 发明授权

US06261548B1 Leukaemia inhibitory factor 失效
标题翻译：白血病抑制因子
公开(公告)号：US06261548B1
公开(公告)日：2001-07-17
申请号：US08839909
申请日：1997-04-21
申请人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
发明人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
IPC分类号： C07K1452
CPC分类号： C12N15/86 , A61K38/00 , C07K14/5415 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N15/81 , C12N2740/13043 , C12P21/02 , C12P21/06
摘要： The present invention provides isolated DNA molecules encoding human and murine LIF and methods of producing LIF by the expression of the isolated DNA and suitable host cells. The invention further provides human and murine LIF polypeptides, pharmaceutical compositions containing LIF, and methods of use thereof.
摘要翻译：本发明提供编码人和鼠LIF的分离的DNA分子和通过分离的DNA和合适的宿主细胞的表达产生LIF的方法。本发明还提供人和鼠LIF多肽，含有LIF的药物组合物及其使用方法。

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