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1. 发明申请

US20110027224A1 USE OF A CYTOKINE FROM THE INTERLEUKIN-6 FAMILY IN THE PREPARATION OF A COMPOSITION FOR COMBINED ADMINISTRATION WITH INTERFERON-ALPHA 审中-公开
标题翻译：来自INTERLEUKIN-6家族的细胞因子在制备与干扰素ALPHA联合给药的组合物中的应用
公开(公告)号：US20110027224A1
公开(公告)日：2011-02-03
申请号：US12887843
申请日：2010-09-22
申请人： Rafael Aldabe Arregui , Esther Larrea Leoz , María Pilar Civeira Murillo , Jesús Prieto Valtueña
发明人： Rafael Aldabe Arregui , Esther Larrea Leoz , María Pilar Civeira Murillo , Jesús Prieto Valtueña
IPC分类号： A61K38/20 , A61P31/12
CPC分类号： C07K14/5412 , A61K38/00 , A61K38/19 , A61K38/212 , C07K14/5415 , C07K14/5431 , A61K2300/00
摘要： The invention relates to the use of at least one cytokine from the IL-6 family −gp130, preferably selected from among IL-11, the leukaemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1, ciliary neurotrophic factor (CNTF), the cardiotrophin-like cytokine (CLC) and combinations thereof or a DNA sequence encoding same, in the preparation of a pharmaceutical composition which is intended for combined administration with at least one IFN-α or a DNA sequence encoding same, for use in the treatment of viral diseases. The invention also relates to a pharmaceutical composition comprising a pharmaceutically-acceptable quantity of at least one cytokin from the IL-6 family −gp130 or a DNA sequence encoding same and a pharmaceutically-acceptable quantity of at least one IFN-α or a DNA sequence encoding same, a pharmaceutical kit and a method for the treatment of viral diseases with the combined administration of the aforementioned cytokines and IFN-α.
摘要翻译：本发明涉及来自IL-6家族-gp130的至少一种细胞因子，优选选自IL-11，白血病抑制因子（LIF），制瘤素M（OSM），心肌营养因子-1，睫状神经营养因子 CNTF），心肌营养素样细胞因子（CLC）及其组合，或编码该DNA序列的DNA序列，用于制备药物组合物，其用于与至少一种IFN-α或其编码的DNA序列组合施用，以供使用在治疗病毒性疾病。本发明还涉及包含药学上可接受量的来自IL-6家族-gp130的至少一种细胞素的药物组合物或其编码的DNA序列和药学上可接受量的至少一种IFN-α或DNA序列编码相同的药物试剂盒，以及通过联合给药上述细胞因子和IFN-α来治疗病毒性疾病的方法。

2. 发明授权

US07691589B2 Method of preventing differentiation of a chicken differentiable cell using chicken leukemia inhibitory factor (LIF) 失效
标题翻译：使用鸡白血病抑制因子（LIF）预防鸡可分化细胞分化的方法
公开(公告)号：US07691589B2
公开(公告)日：2010-04-06
申请号：US11826578
申请日：2007-07-17
申请人： Haruo Matsuda , Shuichi Furusawa , Hiroyuki Horiuchi
发明人： Haruo Matsuda , Shuichi Furusawa , Hiroyuki Horiuchi
IPC分类号： G01N33/53
CPC分类号： C07K14/465 , A01K2217/05 , A01K2227/30 , C07K14/5415 , C12N5/0606 , C12N2501/235 , Y10S514/885
摘要： The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.
摘要翻译：本发明提供一种鸡LIF基因。基于这种遗传信息，可以稳定地提供来源于鸡的LIF蛋白，解决了过去转基因鸡的产生问题。此外，本发明不仅提供了用于测试目的的转基因鸡，而且还提供了第一个实际的转基因种群动物。本发明涉及序列号2所示的白血病抑制因子（LIF），序列号1所示的编码基因及鸡LIF的制造方法。此外，本发明涉及鸡可分化细胞的差分防除剂，鸡差异预防的方法和使用其的鸡可分化细胞的培养方法及其包含的培养基。

3. 发明申请

US20090098650A1 COMPOSITIONS FOR THE IN VITRO DERIVATION AND CULTURE OF EMBRYONIC STEM (ES) CELL LINES WITH GERMLINE TRANSMISSION CAPABILITY AND FOR THE CULTURE OF ADULT STEM CELLS 失效
标题翻译：胚胎干细胞（ES）细胞系的组织衍生和培养具有胃肠道传播能力和成熟干细胞培养的组成
公开(公告)号：US20090098650A1
公开(公告)日：2009-04-16
申请号：US12274939
申请日：2008-11-20
申请人： Luc SCHOONJANS
发明人： Luc SCHOONJANS
IPC分类号： C12N5/06 , C12N5/00
CPC分类号： C12N5/0606 , A01K67/0275 , A01K2217/05 , A61K35/51 , A61K2035/124 , C07K14/5415 , C12N5/0634 , C12N5/0647 , C12N2501/10 , C12N2501/2306 , C12N2501/235 , C12N2501/33 , C12N2502/1323 , C12N2502/99
摘要： The present invention describes novel compositions for deriving, maintaining and growing pluripotent and germ-line competent mammalian embryonic stem cells. The compositions of this invention refer to compositions comprising a 1) conditioned medium of a cell line expressing limited amounts of Leukemia Inhibitory Factor (LIF), 2) conditioned medium from a cell line transfected with mammalian LIF and 3) a medium supplemented with recombinant rabbit LIF. The present invention describes novel compositions for deriving, maintaining and growing adult human stem cells and/or adult early progenitor cells, preferably under stroma-free conditions and without added LIF and/or cytokines or growth factors. The media of the present invention are used for the generation of pluripotent and germ-line competent embryonic stem cells of mammals of which these cells were not obtained up to now. The media of the present invention are used for the generation of adult human stem cells and/or adult early progenitor cells. The present invention is also directed to a novel rabbit LIF and to nucleotides encoding the rabbit LIF and methods for the expression of recombinant rabbit LIF in the Pichia pastoris expression system.
摘要翻译：本发明描述了用于衍生，维持和培养多潜能和生殖能力的哺乳动物胚胎干细胞的新型组合物。本发明的组合物是指包含1）表达有限量的白血病抑制因子（LIF）的细胞系的条件培养基，2）来自用哺乳动物LIF转染的细胞系的条件培养基和3）补充有重组兔的培养基 LIF。本发明描述了用于衍生，维持和培养成年人干细胞和/或成年早期祖细胞的新型组合物，优选在无基质条件下并且不加入LIF和/或细胞因子或生长因子。本发明的培养基用于产生目前尚未获得这些细胞的哺乳动物的多潜能和胚胎干细胞的胚胎干细胞。本发明的培养基用于产生成年人干细胞和/或成年早期祖细胞。本发明还涉及新型兔LIF和编码兔LIF的核苷酸和在巴斯德毕赤酵母表达系统中表达重组兔LIF的方法。

4. 发明授权

US07109168B1 Retro-inverso peptides derived from leukemia inhibitory factor 失效
标题翻译：衍生自白血病抑制因子的逆转肽
公开(公告)号：US07109168B1
公开(公告)日：2006-09-19
申请号：US10048307
申请日：2000-06-16
申请人： David E. Wright , D. Elliott Parks
发明人： David E. Wright , D. Elliott Parks
IPC分类号： A61K38/16 , C07K7/08 , C07K14/00 , C07K1/00
CPC分类号： A61K38/10 , A61K38/16 , C07K5/0212 , C07K7/02 , C07K14/5415
摘要： Retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native LIF and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.
摘要翻译：衍生自具有18至约40个氨基酸的白血病抑制因子（LIF）的逆转肽，并且包括SEQ ID NO：1所示的序列。这些肽具有与天然LIF相同的活性并且还具有神经营养活性。由于肽中的D-氨基酸连接，它们在体内不易于蛋白水解降解。

5. 发明申请

US20060099689A1 Use of caspase enzymes for maturation of engineered recombinant polypeptide fusions 审中-公开
标题翻译：胱天蛋白酶用于成熟工程重组多肽融合体的使用
公开(公告)号：US20060099689A1
公开(公告)日：2006-05-11
申请号：US10543587
申请日：2004-02-23
申请人： Nico Mertens , Andrew Kelly
发明人： Nico Mertens , Andrew Kelly
IPC分类号： C12P21/04 , C12N9/64 , C12N15/74 , C12N1/21
CPC分类号： C12N9/6475 , C07K14/5415 , C07K14/56 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C07K2319/75 , C12N15/62 , C12P21/06
摘要： The invention relates to methods of producing and isolating recombinant proteins using fusion protein constructs comprising specific recognition sites for a maturating protease. The invention specifically relates to the use of caspase proteases for the maturation of engineered recombinant fusion proteins or polypeptides. These molecules are engineered using recombinant DNA technology to comprise a specific target sequence for a caspase between a first fusion part and the polypeptide of interest. After processing, the desired mature format of the protein or polypeptide is obtained.
摘要翻译：本发明涉及使用包含成熟蛋白酶的特异识别位点的融合蛋白构建体来产生和分离重组蛋白的方法。本发明具体涉及胱天蛋白酶蛋白酶用于工程化重组融合蛋白或多肽的成熟的用途。使用重组DNA技术工程化这些分子，以包含第一融合部分和感兴趣的多肽之间的半胱天冬酶的特异性靶序列。处理后，获得蛋白质或多肽的所需成熟形式。

6. 发明授权

US5641676A Leukaemia inhibitory factor from livestock species and use thereof to enhance implantation and development of embryonic cells 失效
标题翻译：来自家畜物种的白血病抑制因子及其用于增强胚胎细胞的植入和发育的用途
公开(公告)号：US5641676A
公开(公告)日：1997-06-24
申请号：US347688
申请日：1994-12-01
申请人： Nicholas Martin Gough , Tracey Ann Willson , Robert Frederick Seamark
发明人： Nicholas Martin Gough , Tracey Ann Willson , Robert Frederick Seamark
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C07K14/54 , C12N1/19 , C12N5/073 , C12N15/19 , C12P21/02 , C12Q1/68 , C12N5/00 , A61D7/00 , A61K49/00
CPC分类号： C07K14/5415 , C12N5/0604 , A61K38/00 , C12N2501/235
摘要： Disclosed is the in vitro development of mammalian embryos to the implantation stage by culturing the embryos in a medium containing leukemia inhibitory factor (LIF).
摘要翻译：公开了通过在含有白血病抑制因子（LIF）的培养基中培养胚胎来将哺乳动物胚胎体外发育到植入阶段。

7. 发明申请

US20130312127A1 EFFICIENT STERILIZATION OF FISH BY DISRUPTION OF GERM CELL DEVELOPMENT 有权
标题翻译：通过破坏细胞发育来有效灭菌鱼类
公开(公告)号：US20130312127A1
公开(公告)日：2013-11-21
申请号：US13982418
申请日：2011-12-02
申请人： Ten-Tsao Wong , Paul Collodi
发明人： Ten-Tsao Wong , Paul Collodi
IPC分类号： C12N15/85
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/052 , A01K2217/203 , A01K2217/206 , A01K2227/40 , A01K2267/02 , A01K2267/0393 , C07K14/522 , C07K14/5415
摘要： Methods of disrupting germ cell migration and development in a fish embryo by inducing targeted expression of Sdf-1 a or Lif and disruption of the Sdf-1 a gradient or a Lif signaling pathway in the fish embryo have been developed. Plasmid constructs containing a gene encoding Sdf-1 a or Lif and a gene encoding a signaling sequence for targeted expression of Sdf-1 a or Lif have been generated. The plasmids will be administered to a fish or a population of fish to reproductively sterilize the population with efficacy of up to 100%. Transgenic fish of this invention are reproductively incompetent of genetically contaminating a wild fish population.
摘要翻译：已经开发出通过诱导Sdf-1α的靶向表达或者在鱼胚胎中产生Sdf-1梯度或Lif信号通路的Lif和破坏来破坏鱼胚胎中生殖细胞迁移和发育的方法。已经产生了含有编码Sdf-1a或Lif的基因和编码用于靶向表达Sdf-1a或Lif的信号序列的基因的质粒构建体。质粒将被给予鱼或鱼群，以高达100％的效力对人群进行再生灭菌。本发明的转基因鱼在遗传上污染野生鱼群体的生殖能力不足。

8. 发明申请

US20120202745A1 ADULT CEREBELLUM-DERIVED NEURAL STEM CELLS AND COMPOSITIONS AND METHODS FOR PRODUCING OLIGODENDROCYTES 有权
标题翻译：成年细胞衍生的神经干细胞及其组合物和生产寡糖的方法
公开(公告)号：US20120202745A1
公开(公告)日：2012-08-09
申请号：US13375269
申请日：2010-06-08
申请人： Kathy Sue O'Shea , Maria Morell
发明人： Kathy Sue O'Shea , Maria Morell
IPC分类号： A61K38/17 , A61P25/00 , C12N5/079
CPC分类号： C07K14/475 , A61K35/30 , A61K38/00 , C07K14/5415 , C12N5/0622 , C12N5/0623 , C12N2501/155 , C12N2501/235
摘要： This disclosure describes a novel population of cerebellum-derived neural stem cells that can be isolated from the adult brain, expanded, and differentiated into neurons, astrocytes and oligodendrocytes. This disclosure also describes compositions and methods for producing oligodendrocytes. Oligodendrocytes can be produced in vitro (e.g., in culture) or in vivo (e.g., for therapy or in a non-human transgenic animal) using the compositions and methods described herein.
摘要翻译：本公开描述了一种新颖的小脑来源的神经干细胞群，其可以从成年脑分离，扩增并分化为神经元，星形胶质细胞和少突胶质细胞。本公开还描述了用于产生少突胶质细胞的组合物和方法。可以使用本文所述的组合物和方法在体外（例如，培养）或体内（例如，用于治疗或在非人转基因动物中）产生少突胶质细胞。

9. 发明申请

US20080312426A1 Chicken leukemia inhibitory factor (LIF) and GNNE thereof 有权
标题翻译：鸡白血病抑制因子（LIF）及其GNNE
公开(公告)号：US20080312426A1
公开(公告)日：2008-12-18
申请号：US11826577
申请日：2007-07-17
申请人： Haruo Matsuda , Shuichi Furusawa , Hiroyuki Horiuchi
发明人： Haruo Matsuda , Shuichi Furusawa , Hiroyuki Horiuchi
IPC分类号： C07H21/00
CPC分类号： C07K14/465 , A01K2217/05 , A01K2227/30 , C07K14/5415 , C12N5/0606 , C12N2501/235 , Y10S514/885
摘要： The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.
摘要翻译：本发明提供一种鸡LIF基因。基于这种遗传信息，可以稳定地提供来源于鸡的LIF蛋白，解决了过去转基因鸡的产生问题。此外，本发明不仅提供了用于测试目的的转基因鸡，而且还提供了第一个实际的转基因种群动物。本发明涉及序列号2所示的白血病抑制因子（LIF），序列号1所示的编码基因及鸡LIF的制造方法。此外，本发明涉及鸡可分化细胞的差分防除剂，鸡差异预防的方法和使用其的鸡可分化细胞的培养方法及其包含的培养基。

10. 发明申请

US20070049520A1 Method of using retro inverso peptides derived from leukemia inhibitory factor 失效
标题翻译：使用衍生自白血病抑制因子的复发逆转肽的方法
公开(公告)号：US20070049520A1
公开(公告)日：2007-03-01
申请号：US11501975
申请日：2006-08-09
申请人： David Wright , D. Parks
发明人： David Wright , D. Parks
IPC分类号： A61K38/16
CPC分类号： A61K38/10 , A61K38/16 , C07K5/0212 , C07K7/02 , C07K14/5415
摘要： The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native LIF and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.
摘要翻译：本发明提供了使用衍生自具有18至约40个氨基酸的白血病抑制因子（LIF）的逆转换肽的治疗方法，并且包括相对于SEQ ID NO：1的反向逆转序列。本发明的肽具有与天然LIF相同的活性，并具有神经营养活性。由于它们的D-氨基酸连接，本发明的肽也不太容易在体内蛋白水解降解。

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