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1. 发明授权

US06936273B2 Liposomal analgesic formulation and use 有权
标题翻译：脂质体镇痛剂配方及用途
公开(公告)号：US06936273B2
公开(公告)日：2005-08-30
申请号：US10327575
申请日：2002-12-20
申请人： Douglas I. Hepler
发明人： Douglas I. Hepler
IPC分类号： A61K9/00 , A61K9/127 , A61K31/195 , A61K31/355 , A61K31/685 , A61K45/06
CPC分类号： A61K9/0017 , A61K9/127 , A61K31/195 , A61K31/355 , A61K31/685 , A61K45/06
摘要： A liposome formulation containing about 1% diclofenac is an effective topical anti-inflammatory topical treatment for lameness in horses. More particularly it has been discovered that a formulation containing vitamin E, phospholipid and diclofenac salt such as the sodium or potassium salt is a highly effective topical anti-inflammatory formulation that is particularly effective in treating lameness in horses.
摘要翻译：含有约1％双氯芬酸的脂质体制剂是马跛行的有效局部抗炎局部治疗。更具体地，已经发现，含有维生素E，磷脂和双氯芬酸盐（例如钠盐或钾盐）的制剂是高效的局部抗炎制剂，其特别有效地治疗马的跛足。

2. 发明授权

US4973589A Method of preventing the reinfestation of dogs and cats by fleas 失效
标题翻译：防止跳蚤重伤狗和猫的方法
公开(公告)号：US4973589A
公开(公告)日：1990-11-27
申请号：US310257
申请日：1989-02-13
申请人： Sharron H. Barnett , Roland H. Johnson , Douglas I. Hepler
发明人： Sharron H. Barnett , Roland H. Johnson , Douglas I. Hepler
IPC分类号： A61K31/075 , A01N25/00 , A01N43/68 , A01N47/34 , A01N49/00 , A61K31/15 , A61K31/22 , A61K31/27 , A61K31/335 , A61K31/336 , A61K31/357 , A61K45/00 , A61P33/00 , C07C43/164 , C07C43/275 , C07C69/736 , C07D303/22 , C07D317/54 , C07D319/18
CPC分类号： A01N43/68 , A01N25/00 , A01N47/34 , A01N49/00
摘要： The present invention relates to a method of treating dogs and cats having topically disposed fleas. More particularly, the invention relates to such a method of treatment wherein the dog or cat is dosed with a larvicidally or ovicidally effective amount of flea growth inhibiting substance capable of reaching the flea via the hosts blood.
摘要翻译：本发明涉及治疗具有局部放置的跳蚤的狗和猫的方法。更具体地说，本发明涉及这样一种治疗方法，其中狗或猫配有能通过宿主血液到达跳蚤的幼虫或卵巢有效量的跳蚤生长抑制物质。

3. 发明申请

US20100087492A1 SYSTEMIC TREATMENT OF BLOOD-SUCKING AND BLOOD-CONSUMING PARASITES BY ORAL ADMINISTRATION OF A PARASITICIDAL AGENT 有权
标题翻译：通过口服代谢药物进行血液采集和血液消耗的PARASITES的系统治疗
公开(公告)号：US20100087492A1
公开(公告)日：2010-04-08
申请号：US12471129
申请日：2009-05-22
申请人： Roland H. Johnson , Douglas I. Hepler , Kathleen G. Palma , William R. Campbell
发明人： Roland H. Johnson , Douglas I. Hepler , Kathleen G. Palma , William R. Campbell
IPC分类号： A61K31/4439 , A61P33/00 , A61P33/14 , A61P33/10
CPC分类号： A61K31/44 , A61K9/0056
摘要： Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies.
摘要翻译：用于口服递送到哺乳动物的药学上可接受的单一杀虫剂组合物，用于系统地控制靶向吸血或消耗血的寄生虫，例如跳蚤，蜱和某些种类的hel hes和sc疮。

4. 发明授权

US08927006B2 Methods and compositions for rapid treatment of otitis externa 有权
标题翻译：治疗外耳炎的方法和组合物
公开(公告)号：US08927006B2
公开(公告)日：2015-01-06
申请号：US12943810
申请日：2010-11-10
申请人： William R. Campbell , Neil E. Paulsen , Roland H. Johnson , Douglas I. Hepler
发明人： William R. Campbell , Neil E. Paulsen , Roland H. Johnson , Douglas I. Hepler
IPC分类号： A61K47/14 , A61K9/107 , A61K9/127 , A61K45/06 , A61K9/00 , A61K31/496 , A61K31/573 , A61K36/752
CPC分类号： A61K45/06 , A61K9/0046 , A61K9/107 , A61K9/127 , A61K31/496 , A61K31/573 , A61K36/752 , A61K47/14 , A61K2300/00
摘要： Methods for treating and preventing otitis externa with a course of treatment consisting of as little as a single dose are provided. The methods are practiced by topical administration of compositions having a lipid carrier, such as liposomes and non-vesicular lipids, to the outer ear canal. Such compositions lack viscocity-enhancing celluloses or adhesives, and are preferably not in the form of a gel. Active agents useful for treating pain, inflammation, fungal or parasitic infestation and/or infections in the outer ear are co-administered in or with the composition.
摘要翻译：提供了一种治疗和预防外耳道的方法，其中包括由单次剂量组成的治疗过程。该方法通过将具有脂质载体（例如脂质体和非囊泡脂质）的组合物局部施用给外耳道来实施。这种组合物不含粘性增强纤维素或粘合剂，并且优选不是凝胶形式。用于治疗疼痛，炎症，真菌或寄生虫侵袭和/或外耳感染的活性剂在组合物中或与组合物共同施用。

5. 发明申请

US20110281809A1 METHODS AND COMPOSITIONS FOR RAPID TREATMENT OF OTITIS EXTERNA 有权
标题翻译：用于快速处理外皮的方法和组合物
公开(公告)号：US20110281809A1
公开(公告)日：2011-11-17
申请号：US12943810
申请日：2010-11-10
申请人： William R. Campbell , Neil E. Paulsen , Roland H. Johnson , Douglas I. Hepler
发明人： William R. Campbell , Neil E. Paulsen , Roland H. Johnson , Douglas I. Hepler
IPC分类号： A61K47/44 , A61K31/7048 , A61K31/545 , A61K31/16 , A61K31/13 , A61K31/137 , A61K31/196 , A61P27/16 , A61P31/00 , A61P33/00 , A61P31/10 , A61P31/12 , A61P29/00 , A61P23/00 , A61K31/43
CPC分类号： A61K45/06 , A61K9/0046 , A61K9/107 , A61K9/127 , A61K31/496 , A61K31/573 , A61K36/752 , A61K47/14 , A61K2300/00
摘要： Methods for treating and preventing otitis externa with a course of treatment consisting of as little as a single dose are provided. The methods are practiced by topical administration of compositions having a lipid carrier, such as liposomes and non-vesicular lipids, to the outer ear canal. Such compositions lack viscocity-enhancing celluloses or adhesives, and are preferably not in the form of a gel. Active agents useful for treating pain, inflammation, fungal or parasitic infestation and/or infections in the outer ear are co-administered in or with the composition.
摘要翻译：提供了一种治疗和预防外耳道的方法，其中包括由单次剂量组成的治疗过程。该方法通过将具有脂质载体（例如脂质体和非囊泡脂质）的组合物局部施用给外耳道来实施。这种组合物不含粘性增强纤维素或粘合剂，并且优选不是凝胶形式。用于治疗疼痛，炎症，真菌或寄生虫侵袭和/或外耳感染的活性剂在组合物中或与组合物共同施用。

6. 发明授权

US06180136B2 Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use 失效
标题翻译：用于缓释药理活性化合物的磷脂包被的微晶及其制造和使用方法
公开(公告)号：US06180136B2
公开(公告)日：2001-01-30
申请号：US09190049
申请日：1998-11-10
申请人： Kenneth A. Larson , William R. Campbell , Douglas I. Hepler
发明人： Kenneth A. Larson , William R. Campbell , Douglas I. Hepler
IPC分类号： A61K9127
CPC分类号： A61K9/5015 , A61K9/0019 , A61K9/127 , A61K9/145 , A61K47/24
摘要： The present invention relates to pharmaceutical compositions for the sustained release of pharmacologically active compounds and methods of their manufacture and use. Sustained release times of 10-12 days have been achieved with the present invention. The present invention provides microcrystal compositions. The microcrystals comprise pharmacologically active compounds and are contained within a phospholipid layer which contains a unique combination of phospholipids. The present invention may be applied to a wide range of pharmaceutical compositions which may be rendered suitable for injection. The microcrystals are of varying sizes. At least 50 percent of the microcrystals are from 0.5 &mgr;m to about 3.0 &mgr;m in diameter, at least ten percent of the microcrystals are from about 3.0 &mgr;m to about 10 &mgr;m in diameter, and the composition contains microcrystals which are greater than 10 &mgr;m in diameter. In preferred embodiments, at least about 1% of the microcrystals are greater than 10 &mgr;m in diameter. The compositions and methods are useful for treating respiratory diseases, infections, inflammation, and pain in a variety of mammals. The compounds and methods are also able to sharply reduce the toxicity of drug compounds.
摘要翻译：本发明涉及用于药物活性化合物缓释的药物组合物及其制造和使用方法。本发明实现了10-12天的持续释放时间。本发明提供微晶组合物。微晶包含药理活性化合物，并且包含在含有磷脂独特组合的磷脂层中。本发明可以应用于可适于注射的广泛范围的药物组合物。微晶具有不同的尺寸。至少50％的微晶直径为0.5μm至约3.0μm，至少10％的微晶直径为约3.0μm至约10μm，组合物含有直径大于10μm的微晶。在优选的实施方案中，至少约1％的微晶直径大于10um。组合物和方法可用于治疗各种哺乳动物的呼吸系统疾病，感染，炎症和疼痛。化合物和方法也能够大大降低药物化合物的毒性。

7. 发明授权

US09820977B2 Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent 有权
公开(公告)号：US09820977B2
公开(公告)日：2017-11-21
申请号：US12471129
申请日：2009-05-22
申请人： Roland H. Johnson , Douglas I. Hepler , Kathleen G. Palma , William R. Campbell
发明人： Roland H. Johnson , Douglas I. Hepler , Kathleen G. Palma , William R. Campbell
IPC分类号： A61K31/44 , A61K31/4439 , A61K9/00
CPC分类号： A61K31/44 , A61K9/0056
摘要： Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies.

8. 发明授权

US06423338B1 Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use 失效
标题翻译：用于缓释药理活性化合物的磷脂包被的微晶及其制造和使用方法
公开(公告)号：US06423338B1
公开(公告)日：2002-07-23
申请号：US09624556
申请日：2000-07-25
申请人： Kenneth A. Larson , William R. Campbell , Douglas I. Hepler
发明人： Kenneth A. Larson , William R. Campbell , Douglas I. Hepler
IPC分类号： A61K9127
CPC分类号： A61K9/5015 , A61K9/0019 , A61K9/127 , A61K9/145 , A61K47/24
摘要： The present invention relates to pharmaceutical compositions for the sustained release of pharmacologically active compounds, and methods of their manufacture and use. The pharmaceutical compositions contain microcrystals of pharmacologically active compounds which are encapsulated within a phospholipid layer which contain a unique combination of phospholipids. The pharmaceutical compositions may be rendered suitable for injection. The microcrystals are of varying sizes. At least 50 percent of the microcrystals are from 0.5 &mgr;m and 3.0 &mgr;m in diameter, at least ten percent of the microcrystals are from 3.0 &mgr;m to 10 &mgr;m in diameter, and the composition may contain microcrystals which are greater than 10 &mgr;m in diameter. Methods of manufacturing the composition are disclosed, as well as various methods of administration.
摘要翻译：本发明涉及用于缓释药理活性化合物的药物组合物及其制造和使用方法。药物组合物含有药理学活性化合物的微晶，其被包封在含有磷脂独特组合的磷脂层内。药物组合物可适于注射。微晶具有不同的尺寸。至少50％的微晶直径为0.5μm和3.0μm，至少10％的微晶直径为3.0μm至10μm，组合物可含有直径大于10um的微晶。公开了制备组合物的方法，以及各种施用方法。

9. 发明授权

US5416102A Method of preventing the reinfestation of dogs and cats by fleas 失效
标题翻译：防止跳蚤重伤狗和猫的方法
公开(公告)号：US5416102A
公开(公告)日：1995-05-16
申请号：US266153
申请日：1994-06-27
申请人： Sharron H. Barnett , Roland H. Johnson , Douglas I. Hepler , Manfred Boger
发明人： Sharron H. Barnett , Roland H. Johnson , Douglas I. Hepler , Manfred Boger
IPC分类号： A01N25/00 , A01N43/68 , A01N47/34 , A01N49/00 , C07D213/64 , C07D213/643 , A01N43/40 , A01N47/28
CPC分类号： C07D213/643 , A01N25/00 , A01N43/68 , A01N47/34 , A01N49/00
摘要： A method of treating fleas on dogs and cats by orally administering a larvicidally or ovicidally effective amount of flea growth inhibiting benzoylurea.
摘要翻译：通过口服施用杀幼虫或有效量的蚤生长抑制苯甲酰脲来治疗狗和猫的跳蚤的方法。

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