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1. 发明授权

US5391580A Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation 失效
标题翻译：用于血氧饱和的聚（砜-α-烯烃）复合渗透膜制品
公开(公告)号：US5391580A
公开(公告)日：1995-02-21
申请号：US59558
申请日：1993-05-10
申请人： Mary B. Douglas , Don N. Gray , Barry Watson , Christopher S. Youngen
发明人： Mary B. Douglas , Don N. Gray , Barry Watson , Christopher S. Youngen
IPC分类号： B01D69/12 , B01D71/68 , C08G75/22 , A61M1/14 , C08J5/20
CPC分类号： C08G75/22 , B01D69/12 , B01D71/68
摘要： A biocompatable multi-layer article suitable for use in blood oxygenation is disclosed. The article is made up of a microporous polypropylene tube, a perm-selective, water vapor impermeable, carbon dioxide and oxygen permeable, homogeneous layer directly adhered to the polypropylene tube and active heparin linked through a covalent bond to the permselective layer. The polypropylene tube has an inside diameter from 240 to 400 .mu.m, a wall thickness from 10 to 50 .mu.m, and a porosity from 20 to 80 percent. The perm-selective layer is a polysulfone which has the structure ##STR1## where R is an alkyl group having 16 carbon atoms and n is 3,500 to 35,000. A method for producing a biocompatible multi-layer article suitable for use in blood oxygenation is also disclosed. The method involves the steps of immersing a microporous polypropylene tube which has an inside diameter from 240 to 400 .mu.m, a wall thickness from 10 to 50 .mu.m, and a porosity from 20 to 80 percent in a solution of a polysulfone which has the foregoing structure, and heating the coated polypropylene tube to a temperature that is above the softening point but below the decomposition temperature of the sulfone, e.g., in an oven heated to 70.degree.-150.degree. C.A new poly(sulfone-alpha-olefin) is also disclosed. The new poly olefin has the structure of Formula 2, below: ##STR2## where the R' groups can be the same or different, most of them are C6 to C16 alkyls, n is an integer of at least 6, preferably from 3,500 to 35,000, and some of the repeating groups have the structure of Formula 3, below: ##STR3## where R" is a bromoalkyl group having from 1 to 26 carbons, a methyl or ethyl ester of an alkyl carboxylic acid having from 1 to 26 carbons, or an alkyl aldehyde having from 1 to 26 carbons.
摘要翻译：公开了适用于血氧合的生物相容性多层制品。该制品由微孔聚丙烯管，烫发选择性，水蒸气不渗透，二氧化碳和氧气渗透的均匀层组成，直接粘附到聚丙烯管和通过共价键连接到选择渗透层的活性肝素。聚丙烯管的内径为240〜400μm，壁厚为10〜50μm，孔隙率为20〜80％。烫发选择层是具有结构的聚砜，其中R是具有16个碳原子的烷基，n是3,500至35,000。还公开了一种适用于血氧合的生物相容性多层制品的制造方法。该方法包括以下步骤：在聚砜的溶液中浸入内径为240〜400μm，壁厚为10〜50μm，孔隙率为20〜80％的微孔聚丙烯管，并且将涂覆的聚丙烯管加热到高于软化点但低于砜的分解温度的温度，例如在加热至70-150℃的烘箱中。将新的聚（砜-α-烯烃）也被公开。新的聚烯烃具有下式的结构：其中R'基团可以相同或不同，其中大多数为C6至C16烷基，n为至少6的整数，优选为 3,500至35,000，并且一些重复基团具有下式的结构式：其中R“是具有1至26个碳的溴烷基，具有烷基羧酸的甲基或乙基酯具有 1至26个碳原子的烷基醛或具有1至26个碳的烷基醛。

2. 发明授权

US3970603A Amino acid derivatives of chloromethylated polymers and methods of making the same 失效
公开(公告)号：US3970603A
公开(公告)日：1976-07-20
申请号：US512760
申请日：1974-10-15
申请人： Don N. Gray
发明人： Don N. Gray
IPC分类号： B01J20/22 , C08F8/30 , C08F222/08
CPC分类号： B01J20/22 , C08F8/30
摘要： The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.

3. 发明授权

US3573253A Preparation of cross-linked poly (4-hydroxy - 3 - nitro) (nonsubstituted or alpha and/or beta substituted) stryene 失效
标题翻译：交联聚（4-羟基-3-硝基）（非取代或取代或取代的）碱基的制备
公开(公告)号：US3573253A
公开(公告)日：1971-03-30
申请号：US3573253D
申请日：1968-11-18
申请人： DON N GRAY
发明人： GRAY DON N
IPC分类号： C07K1/04 , C08F2/00 , C08F8/00 , C07C103/52 , C08F7/10 , C08H1/00
CPC分类号： C08F2/00 , C07K1/042 , C08F8/30 , C08F2800/20 , C08F2810/20 , C08F212/14
摘要： THERE IS DISCLOSED A PROCESS FOR PREPARING A SOLID PHASE, POLYMERIC SUBSTRATE COMPRISING A CROSS-LINKED POLY (4HYDROXY-3-NITRO) STYRENE WHICH IS ESPECIALLY SUITABLE FOR THE SYNTHESIS OF POLYPEPTIDES. THE POLYSTYRENE MAY BE NONSUBSTITUTED OR SUBSTITUTED (ALPHA AND/OR BETA).

4. 发明授权

US4277560A Enzyme immunoassays using immobilized reagents in a flowing stream 失效
标题翻译：在流动的流中使用固定化试剂的酶免疫测定
公开(公告)号：US4277560A
公开(公告)日：1981-07-07
申请号：US954269
申请日：1978-10-24
申请人： Don N. Gray , Melvin H. Keyes
发明人： Don N. Gray , Melvin H. Keyes
IPC分类号： G01N33/543 , G01N33/551 , G01N33/74 , C12M1/34 , G01N21/00 , G01N33/54
CPC分类号： G01N33/74 , G01N33/54306 , G01N33/551 , Y10S435/962 , Y10S436/806 , Y10S436/807 , Y10S436/815 , Y10S436/817
摘要： This invention relates to a method and apparatus for the rapid quantitative determination of an antigen contained in aqueous biochemical samples, for example, blood. The method comprises a series of sequentially arranged stages through which a buffered stream flows. The sample, containing an unknown concentration of the antigen, is injected into the buffered flowing stream and contacts various reagents in the sequential series of stages. An initial solubilization stage comprises an immobilized antibody on a substrate which antibody is specific to the antigen in the sample. The immobilized antibody has been reacted previously to saturation with an enzyme-antigen complex, the antigen of the complex being the same as the antigen in the sample, and the complex is reversably bound to the immobilized antibody. The antigen in the sample and buffered stream flow through the solubilization stage and a competitive equilibrium reaction takes place between the complex bound to the antibody and the antigen in the sample, resulting in the release of a quantity of the enzyme-antigen complex into the flowing stream. The complex and the stream pass into a conversion stage wherein the complex reacts with an immobilized substrate, such as starch, to produce a measurable product which is a quantitative index of the complex released in the solubilization stage. The measurable product and the stream flow to a detection stage wherein the product is reacted, quantitatively measured and related to the concentration of the antigen in the original sample.
摘要翻译：本发明涉及用于快速定量测定含水生化样品例如血液中的抗原的方法和装置。该方法包括一系列顺序排列的缓冲液流流过的阶段。将含有未知浓度的抗原的样品注入缓冲的流动物流中并在连续的一系列阶段中接触各种试剂。初始增溶阶段包括在底物上的固定化抗体，抗体对样品中的抗原是特异性的。已经将固定的抗体先前与酶 - 抗原复合物反应，复合物的抗原与样品中的抗原相同，并且复合物与固定的抗体可逆地结合。样品和缓冲流中的抗原流过增溶阶段，并且在与抗体结合的复合物和样品中的抗原之间发生竞争性平衡反应，导致一定量的酶 - 抗原复合物释放到流动流。络合物和物流进入转化阶段，其中络合物与固定化的底物如淀粉反应，产生可测量的产物，其是在溶解阶段中释放的复合物的定量指标。可测量的产物和物流流入检测阶段，其中产物反应，定量测量并与原始样品中抗原的浓度相关。

5. 发明授权

US4423930A Polymeric contact lens materials with high oxygen permeability 失效
标题翻译：具有高透氧性的聚合物隐形眼镜材料
公开(公告)号：US4423930A
公开(公告)日：1984-01-03
申请号：US246238
申请日：1981-03-23
申请人： Don N. Gray
发明人： Don N. Gray
IPC分类号： A61F2/24 , A61F13/00 , A61F13/15 , A61L15/26 , A61L27/18 , A61L33/06 , A61M1/12 , C08G75/22 , G02C7/04
CPC分类号： B01D71/68 , A61F13/00 , A61F2/2421 , A61L15/26 , A61L27/18 , A61L33/068 , B01D69/02 , C08G75/22 , A61F2013/00217 , A61F2013/15048 , A61M1/12
摘要： A series of alpha-olefin sulfur dioxide copolymers derived from the C.sub.4 to C.sub.18 alpha-olefins which may be readily processed to an optical article, such as a contact lens, having oxygen and carbon dioxide permeability which make them desirable in uses for contact lenses.
摘要翻译：衍生自C 4 -C 18α-烯烃的一系列α-烯烃二氧化硫共聚物，其可以容易地加工成具有氧和二氧化碳渗透性的光学制品，例如隐形眼镜，使得它们在隐形眼镜的用途中是理想的。

6. 发明授权

US5763586A Extraction of proteins from naturally occuring membranes 失效
标题翻译：从天然膜中提取蛋白质
公开(公告)号：US5763586A
公开(公告)日：1998-06-09
申请号：US747670
申请日：1996-11-12
申请人： Don N. Gray
发明人： Don N. Gray
IPC分类号： C07H15/20 , C07H15/207 , C11D3/22 , C07H1/00 , C07K1/14
CPC分类号： C07H15/20 , C07H15/207 , C11D3/221
摘要： The extraction of proteins from selected naturally occurring membranes without any harmful, adverse, or other deleterious effect(s). In one preferred embodiment the detergent is prepared from the reaction of a cycloalkyl aliphatic alcohol and a saccharide.
摘要翻译：从选定的天然存在的膜中提取蛋白质而没有任何有害的，不利的或其他有害的作用。在一个优选的实施方案中，洗涤剂由环烷基脂族醇和糖的反应制备。

7. 发明授权

US4179757A Biocompatible articles having high permeability to gases derived from polysulfones 失效
标题翻译：对来自聚砜的气体具有高渗透性的生物相容性制品
公开(公告)号：US4179757A
公开(公告)日：1979-12-25
申请号：US684683
申请日：1976-05-10
申请人： James E. Crawford , Don N. Gray
发明人： James E. Crawford , Don N. Gray
IPC分类号： A61F2/00 , A61F2/24 , A61F13/00 , A61F13/15 , A61L15/26 , A61L27/18 , A61L33/06 , A61M1/12 , C08G75/22 , A61F1/24 , A61F1/22
CPC分类号： B01D71/68 , A61F13/00008 , A61F2/2421 , A61L15/26 , A61L27/18 , A61L33/068 , B01D69/02 , C08G75/22 , A61F2013/00217 , A61F2013/15048 , A61M1/12
摘要： There is disclosed the preparation of an alpha-olefin-sulfur dioxide copolymer derived from the C.sub.8 to C.sub.18 alpha-olefins. The polymers undergo clean thermal degradation, having high permeabilities to oxygen and carbon dioxide, and are readily processed into a membrane article. Maximum permeabilities are obtained with the C.sub.16 based polymer. New uses of the copolymer are set forth including perfusion membranes, soft contact lenses and biocompatible articles for contact with human body fluids including surgical tubing, wound dressings, and prosthetic devices such as artificial veins, arteries and heart valves.
摘要翻译：公开了衍生自C8-C18α-烯烃的α-烯烃 - 二氧化硫共聚物的制备。聚合物经历清洁的热降解，具有高的氧气和二氧化碳的渗透性，并且易于加工成膜制品。用C16基聚合物获得最大渗透性。提出了共聚物的新用途，包括灌注膜，软性隐形眼镜和用于与人体液体接触的生物相容性制品，包括手术管，伤口敷料和诸如人造静脉，动脉和心脏瓣膜的假体装置。

8. 发明授权

US5674987A Extraction of proteins from naturally occurring membranes 失效
标题翻译：从天然存在的膜提取蛋白质
公开(公告)号：US5674987A
公开(公告)日：1997-10-07
申请号：US279374
申请日：1994-07-22
申请人： Don N. Gray
发明人： Don N. Gray
IPC分类号： C07H15/20 , C07H15/207 , C11D3/22
CPC分类号： C07H15/20 , C07H15/207 , C11D3/221
摘要： The extraction of proteins from selected naturally occurring membranes without any harmful, adverse, or other deleterious effect(s). In one preferred embodiment the detergent is prepared from the reaction of a cycloalkyl aliphatic alcohol and a saccharide.
摘要翻译：从选定的天然存在的膜中提取蛋白质而没有任何有害的，不利的或其他有害的作用。在一个优选的实施方案中，洗涤剂由环烷基脂族醇和糖的反应制备。

9. 发明授权

US4052286A Solid sensor electrode 失效
标题翻译：固体传感器电极
公开(公告)号：US4052286A
公开(公告)日：1977-10-04
申请号：US328360
申请日：1973-01-31
申请人： Don N. Gray , George G. Guilbault
发明人： Don N. Gray , George G. Guilbault
IPC分类号： G01N27/30 , G01N27/46
CPC分类号： G01N27/30
摘要： A noble metal-glass composite is screen printed on an inert substrate such as a low alkali glass and fired to provide a solid sensor electrode.

10. 发明授权

US3985715A Oxazolidone derivatives of chloromethylated polymers and methods of making the same 失效
标题翻译：氯甲基化聚合物的恶唑烷酮衍生物及其制备方法
公开(公告)号：US3985715A
公开(公告)日：1976-10-12
申请号：US511968
申请日：1974-10-15
申请人： Don N. Gray
发明人： Don N. Gray
IPC分类号： C08F8/00 , C08F8/30 , C08F222/08 , C08F226/06
CPC分类号： C08F8/00 , C08F8/30
摘要： The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.
摘要翻译：本申请公开了聚合物及其制备方法，其中聚合物的氯甲基侧基的氯原子，例如苯乙烯和二乙烯基苯的氯甲基化共聚物被α-碳原子上具有被保护的氨基的丙二酸的衍生物所取代和两个羧基或其前体通过几个步骤形成起始聚合物的α-氨基酸衍生物。这些聚合物例如用作离子交换树脂，作为亲和色谱法的底物，以及用作固体肽合成的起始树脂。所得聚合物也用作起始材料，以制备具有在4-位取代的恶唑烷酮-2,5-二酮的衍生物的侧基的聚合物。这些聚合物例如用作固相肽合成的基质和用作固相肽降解的起始树脂。

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