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1. 发明申请

US20150062447A1 Apparatus and Method for Transmitted Light Illumination for Light Microscopes and Microscope System 审中-公开
标题翻译：用于光显微镜和显微镜系统的透射光照明的装置和方法
公开(公告)号：US20150062447A1
公开(公告)日：2015-03-05
申请号：US14345336
申请日：2012-08-16
申请人： Detlef Hein , Axel Laschke
发明人： Detlef Hein , Axel Laschke
IPC分类号： G02B21/06 , G02B21/02 , G02B21/26
CPC分类号： G02B21/06 , G02B21/025 , G02B21/086 , G02B21/26
摘要： The invention relates to an apparatus for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, and a holding device for holding a sample to be examined, and at least one diaphragm edge for trimming the illuminating light beam bundle, wherein the diaphragm edge is arranged between the holding device and the light source and extends transversely to an optical axis, wherein a beam path of the illuminating light between the diaphragm edge and a sample held by the holding device is free from beam focussing components. The apparatus is characterised in that the means are provided for enquiring concerning a microscope setting and/or a microscope configuration of a light microscope, which means are positionable at the device for transmitted light illumination; means are provided for variable positioning of the diaphragm edge in a direction transverse to the optical axis, and a control device is provided and configured to position the diaphragm edge in the direction transverse to the optical axis via the means for variable positioning. The invention also relates to a method for transmitted light illumination for a light microscope and a microscope system.
摘要翻译：本发明涉及一种用于具有变化的物镜的有效入射光瞳的光学显微镜的透射光照明装置。该装置具有用于发射照明光束的光源和用于保持待检测样品的保持装置和用于修整照明光束的至少一个光阑边缘，其中所述光阑边缘布置在所述保持装置和光源并且横向于光轴延伸，其中在光阑边缘和由保持装置保持的样本之间的照明光的光束路径没有光束聚焦部件。该装置的特征在于提供了用于查询光学显微镜的显微镜设置和/或显微镜配置的装置，该装置可以在用于透射光照明的装置处定位; 提供了用于在横向于光轴的方向上可变地定位光阑边缘的装置，并且提供并配置控制装置，用于经由用于可变定位的装置在垂直于光轴的方向上定位光阑边缘。本发明还涉及一种用于光学显微镜和显微镜系统的透射光照射的方法。

2. 发明申请

US20060275002A1 MODULAR UNIT FOR THE DISTRIBUTION OF THE LIGHT FLOW OF A COLD LIGHT SOURCE 审中-公开
标题翻译：用于分配冷光源的光流的模块化单元
公开(公告)号：US20060275002A1
公开(公告)日：2006-12-07
申请号：US11421598
申请日：2006-06-01
申请人： Johannes Knoblich , Thomas Serfling , Tobias Kaufhold , Detlef Hein
发明人： Johannes Knoblich , Thomas Serfling , Tobias Kaufhold , Detlef Hein
IPC分类号： G02B6/02
CPC分类号： G02B6/0006 , G02B6/266 , G02B21/22 , G02B27/106
摘要： The present invention is directed to a modular unit for the distribution of the light flow of a cold light source which makes it possible to combine different illumination methods in mixed-light operation with only one individual high-power cold light source and to switch between illumination methods. In the modular unit according to the invention for the distribution of the light flow of a cold light source, the light flows of a cold light source which are distributed to a plurality of cross sections can be manipulated individually, and elements provided for the manipulation of the light are constructed in such a way that an adaptation possibility for different types of light guides is provided at the output of each individual cross section. Any combinations of optical elements for beam shaping, beam splitting and/or beam guiding can be used to distribute the light flow. In an advantageous construction, a light guide having a large input cross section and a plurality of smaller, output cross sections is used to distribute the light flow of the cold light source. The proposed modular unit for the distribution of the light flow of a cold light source is provided for microscope applications in particular but is also suitable for other applications in which different illumination methods are to be realized individually and in combination using only one light source.
摘要翻译：本发明涉及一种用于分配冷光源的光流的模块化单元，其使得可以将混合光操作中的不同照明方法与仅一个单独的高功率冷光源组合并且在照明方法。在根据本发明的用于分配冷光源的光流的模块化单元中，分配给多个横截面的冷光源的光流可以单独操作，并且用于操纵以这样的方式构造光，使得在每个单独横截面的输出处提供用于不同类型的光导的适应可能性。用于光束整形，光束分割和/或光束引导的光学元件的任何组合可以用于分配光流。在有利的结构中，使用具有大的输入横截面的导光体和多个较小的输出横截面来分配冷光源的光流。所提出的用于分配冷光源的光流的模块化单元特别用于显微镜应用，但也适用于其中单独实现不同照明方法并且仅使用一个光源组合的其他应用。

3. 发明授权

US09036254B2 Apparatus and method for transmitted light illumination for light microscopes and microscope system 有权
标题翻译：用于光学显微镜和显微镜系统的透射光照明的装置和方法
公开(公告)号：US09036254B2
公开(公告)日：2015-05-19
申请号：US13978621
申请日：2012-08-16
申请人： Detlef Hein , Juergen Fechti , Gleb Milinovici
发明人： Detlef Hein , Juergen Fechti , Gleb Milinovici
IPC分类号： G02B21/06 , G02B21/08
CPC分类号： G02B21/06 , G02B21/086
摘要： An apparatus for transmitted light illumination for light microscopes A diaphragm edge may be variably positioned in the direction of the optical axis, wherein a position of the diaphragm edge in the direction of the optical axis can be varied irrespectively of a position of the diaphragm edge transversely to the optical axis. A separate sample support table may be mounted on a housing. The housing has a passage opening, through which the diaphragm edge can be moved in the direction of the optical axis. A holding device is formed in the region of the passage opening of the housing or on a separate sample support table and a control device is present which is adapted to position the diaphragm edge in dependence at least upon a determined presence of a sample support table.
摘要翻译：用于光学显微镜的透射光照明的装置光阑边缘可以沿光轴的方向可变地定位，其中光阑边缘在光轴方向上的位置可以随着光阑边缘横向的位置而变化到光轴。单独的样品支撑台可以安装在壳体上。壳体具有通道开口，光阑边缘可以通过该通道开口沿光轴方向移动。保持装置形成在壳体的通道开口的区域中或在单独的样品支撑台上，并且存在控制装置，该控制装置适于至少根据确定的样品支撑台的存在来定位隔膜边缘。

4. 发明申请

US20140192408A1 Apparatus and method for transmitted light illumination for light microscopes and microscope system 有权
公开(公告)号：US20140192408A1
公开(公告)日：2014-07-10
申请号：US13978621
申请日：2012-08-16
申请人： Detlef Hein , Juergen Fechti , Gleb Milinovici
发明人： Detlef Hein , Juergen Fechti , Gleb Milinovici
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/086
摘要： The invention relates to an apparatus for transmitted light illumination for light microscopes, in particular stereo microscopes or macroscopes, having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, a housing, in which the light source is arranged, a holding device for holding a sample to be examined and at least one diaphragm edge for trimming the illuminating light beam, wherein the diaphragm edge extends transversely to an optical axis of a light microscope, which can be positioned in an operating state on the device for transmitted light illumination, and wherein a beam path of the illuminating light between the diaphragm edge and the sample held by the holding device is free from adjustable beam focussing components. The apparatus is characterised according to the invention in that in order to adapt the beam path of the illuminating light to the effective entrance pupil of the objective, means are provided for variable positioning of the diaphragm edge in the direction of the optical axis, wherein a position of the diaphragm edge in the direction of the optical axis can be varied irrespectively of a position of the diaphragm edge transversely to the optical axis, assembly means are provided on the housing for mounting a separate sample support able, means for determining the presence of a sample support table are present, the housing has a passage opening, through which the diaphragm edge can be moved in the direction of the optical axis, the holding device is formed in the region of the passage opening of the housing or on a separate sample support table and a control device is present which is adapted to position the diaphragm edge in dependence at least upon a determined presence of a sample support table. The invention also relates to a method for transmitted light illumination for a light microscope and a microscope system.

5. 发明授权

US08634132B2 Objective changer having reflected light illumination for light microscopes 有权
标题翻译：具有光学显微镜的反射光照明的物镜更换器
公开(公告)号：US08634132B2
公开(公告)日：2014-01-21
申请号：US12920643
申请日：2009-03-03
申请人： Detlef Hein , Berndt-Joachim Lau , Axel Laschke
发明人： Detlef Hein , Berndt-Joachim Lau , Axel Laschke
IPC分类号： G02B21/00
CPC分类号： G02B21/082 , G02B21/248
摘要： An objective changer having incident-light illumination for light microscopes, including: at least two microscope objectives for examining a specimen, a movable carrier, on which the microscope objectives are mounted, an immovable carrier, which is adapted for mounting on a base body of the microscope, wherein the movable carrier is adapted for defined positioning thereof relatively to the immovable carrier, and at least one illuminating means for illuminating the specimen. The objective changer includes at least one transfer interface for transferring energy for illuminating the specimen is provided on the immovable carrier, at least one energy connector, which is rigidly connected to the movable carrier, is provided for receiving energy to illuminate the specimen, the energy connector is connected to an illuminating means, and by positioning the movable carrier relatively to the immovable carrier, a line engagement can be established between the transfer interface and an energy connector.
摘要翻译：具有用于光学显微镜的入射光照明的物镜更换器，包括：用于检查样本的至少两个显微镜物镜，安装有显微镜物镜的可移动载体，适于安装在基体上的不可移动的载体显微镜，其中可移动的载体适于相对于不可移动的载体的限定的定位，以及用于照射样本的至少一个照明装置。物镜更换器包括至少一个转移界面，用于传递用于照射样本的能量，设置在不可移动的载体上，至少一个刚性地连接到可移动载体的能量连接器用于接收照射样本的能量，能量连接器连接到照明装置，并且通过相对于不可移动的载体定位可移动的载体，可以在传送界面和能量连接器之间建立线接合。

6. 发明授权

US10073257B2 Apparatus and method for transmitted light illumination for light microscopes and microscope system 有权
公开(公告)号：US10073257B2
公开(公告)日：2018-09-11
申请号：US14345336
申请日：2012-08-16
申请人： Detlef Hein , Axel Laschke
发明人： Detlef Hein , Axel Laschke
IPC分类号： G02B21/06 , G02B21/02 , G02B21/26 , G02B21/08
CPC分类号： G02B21/06 , G02B21/025 , G02B21/086 , G02B21/26
摘要： The invention relates to an apparatus for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, and a holding device for holding a sample to be examined, and at least one diaphragm edge for trimming the illuminating light beam bundle, wherein the diaphragm edge is arranged between the holding device and the light source and extends transversely to an optical axis, wherein a beam path of the illuminating light between the diaphragm edge and a sample held by the holding device is free from beam focussing components. The apparatus is characterized in that the means are provided for enquiring concerning a microscope setting and/or a microscope configuration of a light microscope, which means are positionable at the device for transmitted light illumination; means are provided for variable positioning of the diaphragm edge in a direction transverse to the optical axis, and a control device is provided and configured to position the diaphragm edge in the direction transverse to the optical axis via the means for variable positioning. The invention also relates to a method for transmitted light illumination for a light microscope and a microscope system.

7. 发明授权

US09835839B2 Apparatus and method for transmitted light illumination for light microscopes and microscope system 有权
公开(公告)号：US09835839B2
公开(公告)日：2017-12-05
申请号：US14345332
申请日：2012-08-16
申请人： Detlef Hein
发明人： Detlef Hein
IPC分类号： G02B21/06 , G02B21/08 , G02B21/36
CPC分类号： G02B21/06 , G02B21/086 , G02B21/365
摘要： An apparatus and method for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, wherein a beam path of the illuminating light between a diaphragm edge and a sample held by a holding device is free from adjustable beam focussing components. In order to adapt the beam path of the illuminating light to the effective entrance pupil of the objective, the diaphragm edge may be variably positioned in the direction of the optical axis, wherein a position of the diaphragm edge in the direction of the optical axis can be varied irrespectively of a position of the diaphragm edge transversely to the optical axis.

8. 发明申请

US20120270942A1 Spreading Active Agricultural Agents 审中-公开
标题翻译：传播积极农业代理
公开(公告)号：US20120270942A1
公开(公告)日：2012-10-25
申请号：US13503277
申请日：2010-10-21
申请人： Andreas Greiner , Joachim H. Wendorff , Seema Agarwall , Christoph Hellmann , Michael Breuer , Günter Leithold , Hans E. Hummel , Detlef Hein
发明人： Andreas Greiner , Joachim H. Wendorff , Seema Agarwall , Christoph Hellmann , Michael Breuer , Günter Leithold , Hans E. Hummel , Detlef Hein
IPC分类号： A01N37/02 , B29C47/10 , A01P17/00
CPC分类号： D01D5/0084 , A01N25/34 , A01N37/06 , D01F1/10 , D01F6/84 , A01N25/10 , A01N25/18
摘要： Disclosed herein is a device for the application of agricultural active agents, wherein the device is suitable to be brought to the site of action in a manner temporally and spatially separated from the production process, and comprises a dispenser and non-water-soluble nanofibers and/or mesofibers charged with agricultural active agents. The polymers from which the nanofibers and/or mesofibers are made are preferably biodegradable. The agricultural active agents are selected from fungicides, herbicides, batericides, plant growth regulators and plant nutrients. These are preferably pheromones, kairomones and signaling substances. Furthermore, a method for the production of this device is disclosed, wherein the nanofibers and/or mesofibers charged with active agents are produced via electrospinning. The device is suitable to be used to bring agricultural active agents to the site of action in a manner temporally and spatially separated from the production of this device. The application is suitable to be carried out mechanically or automatically. This is preferably agricultural land used for fruit growing, viticulture, gardening or a commercial row crop. The device according to the present invention is particularly suitable to be used for the regulation of arthropods.
摘要翻译：本文公开了一种用于农业活性剂的应用的装置，其中所述装置适于以与生产过程暂时和空间分离的方式带到作用部位，并且包括分配器和非水溶性纳米纤维， /或带有农药活性剂的介体纤维。制备纳米纤维和/或中间纤维的聚合物优选是可生物降解的。农业活性剂选自杀真菌剂，除草剂，杀螨剂，植物生长调节剂和植物营养素。这些优选是信息素，光酮和信号物质。此外，公开了一种制造该装置的方法，其中通过静电纺丝制备装有活性剂的纳米纤维和/或中间纤维。该装置适合用于将农业活性剂以与该装置的生产在时间和空间上分离的方式带到作用部位。该应用适合机械或自动进行。这最好是用于果实生长，葡萄栽培，园艺或商业排列作物的农业用地。根据本发明的装置特别适用于调节节肢动物。

9. 发明申请

US20120008193A1 METHOD FOR EQUALIZING ARBITRARY PARFOCAL LENGTHS OF OBJECTIVES WHEN FOCUSING STEREOMICROSCOPES AND MACROSCOPES 审中-公开
标题翻译：当聚焦多普勒和宏观时均衡化目标的仲裁长度的方法
公开(公告)号：US20120008193A1
公开(公告)日：2012-01-12
申请号：US13162765
申请日：2011-06-17
申请人： Gerhard Möller , Axel Laschke , Thomas Serfling , Steffen Leidenbach , Detlef Hein
发明人： Gerhard Möller , Axel Laschke , Thomas Serfling , Steffen Leidenbach , Detlef Hein
IPC分类号： G02B21/22
CPC分类号： G02B21/248 , G02B21/22 , G02B21/241 , G02B21/26
摘要： The invention is directed to a method for equalizing arbitrary parfocal lengths of objectives when focusing stereomicroscopes and macroscopes, including an objective changer (4) equipped with differently parfocalized and/or non-parfocalized objectives (5), and focusing devices for automatic focusing when changing an object or objective. The focusing devices are controlled by control devices according to object and objective changer data and data for the travel path stored previously in a storage device. When changing non-parfocal objectives (5) arranged in an objective changer (4), automatic focusing is carried out. During an objective change, the danger of a collision between objectives (5) arranged in the objective changer (4) and the object or the object carrier (1.1) due to an unfavorable combination of overall length and parfocal length of the objectives (5) with non-parfocal objectives (5) is detected, an error message is outputted and a parfocality manager is blocked in case of an unfavorable combination in a way such that automatic refocusing cannot be carried out.
摘要翻译：本发明涉及一种用于在聚焦立体显微镜和宏观显微镜时均衡任意对焦长度的方法，包括配备有不同的准焦点和/或非参考目标（5）的物镜（4），以及用于当改变时的自动聚焦的聚焦装置一个对象或目标。聚焦装置由控制装置根据物体和物镜更换器数据以及先前存储在存储装置中的旅行路径的数据进行控制。当改变配置在物镜（4）中的非焦距物镜（5）时，进行自动对焦。在客观改变期间，由于目标（5）的总长度和平均焦距的不利组合，布置在物镜（4）中的物镜（5）与物体或物体载体（1.1）之间发生碰撞的危险，检测到非焦点目标（5）时，输出错误消息，并且在不能进行自动重新聚焦的方式中不利组合的情况下，parfocality管理器被阻塞。

10. 发明申请

US20070097498A1 DEVICE FOR VARYING AND ADJUSTING TRANSMITTED ILLUMINATION FOR MICROSCOPES 失效
标题翻译：用于改变和调整显微镜的透射照明的装置
公开(公告)号：US20070097498A1
公开(公告)日：2007-05-03
申请号：US11539002
申请日：2006-10-05
申请人： Johannes Knoblich , Tobias Kaufhold , Detlef Hein
发明人： Johannes Knoblich , Tobias Kaufhold , Detlef Hein
IPC分类号： G02B21/06
CPC分类号： G02B21/125 , G02B21/06
摘要： The present invention serves to vary and adjust the transmitted light illumination in microscopes, particularly with respect to the numerous, different illumination situations. The device, according to the invention, for varying and adjusting the transmitted illumination for microscopes comprises modules for darkfield illumination, brightfield illumination, and/or diffuse illumination and/or for adapting the object field in which an illumination unit can be selectively coupled to different modules and in which actuators are provided for implementing the adjustments within the modules and for producing the desired connections, these actuators being operated by means of operating elements of a control unit. The adjustments within the modules and the implemented connections are detected and are stored in the control unit so as to be reproducible. The proposed solution is provided particularly for varying and adjusting the transmitted illumination in microscopes and makes possible a broad application by means of an ergonomic arrangement of the operating elements and adjusting and/or changing the illumination situations in a simple and reproducible manner.
摘要翻译：本发明用于在显微镜中改变和调节透射光照明，特别是关于许多不同照明情况。根据本发明的用于改变和调整用于显微镜的透射照明的装置包括用于暗场照明，明场照明和/或漫射照明的模块和/或用于调整照明单元可选择地耦合到不同的对象场的模块模块，并且其中提供致动器用于实现模块内的调节并且用于产生期望的连接，这些致动器通过控制单元的操作元件操作。检测模块内的调整和实现的连接，并将其存储在控制单元中以便可再现。提出的解决方案特别用于在显微镜中改变和调整透射照明，并且通过操作元件的人机工程学布置并且以简单且可再现的方式调节和/或改变照明情况成为可能。

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