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1. 发明授权

US08671871B2 Temperature-activated time-temperature indicator 有权
标题翻译：温度启动时间温度指示器
公开(公告)号：US08671871B2
公开(公告)日：2014-03-18
申请号：US13238686
申请日：2011-09-21
申请人： Brian S. Huffman , Dawn E. Smith , Carl M. Lentz
发明人： Brian S. Huffman , Dawn E. Smith , Carl M. Lentz
IPC分类号： G01K11/12 , G01K3/04 , G01K11/06
CPC分类号： G01K1/02 , G01K3/04 , G01K11/06
摘要： A temperature-activatable time-temperature indicator that can be used to monitor the historical exposure of a host product to ambient temperatures includes an optically readable, thermally sensitive indicator element. The indicator element can be inactive below a base temperature and is intrinsically thermally responsive at or above an activation temperature which is equal to or greater than the base temperature. The indicator can record cumulative ambient temperature exposure above the activation temperature irreversibly with respect to time. The indicator element can include a synthetic polymeric material, and optionally, a dye. A side-chain crystallizable polymer such as poly(hexadecylmethacrylate), that is solid below the base temperature and is a viscous liquid above the activation temperature can be employed. Intense indicator element colors can be obtained using an appropriate dye or dyes. Various structural configurations of indicator are described and illustrated.
摘要翻译：可用于监测主体产品对环境温度的历史曝光的温度可激活的时间温度指示器包括光学可读的热敏指示元件。指示元件可以在基础温度以下是无效的，并且在等于或大于基础温度的活化温度或更高的本征热响应。该指示器可以相对于时间不可逆地记录高于激活温度的累积环境温度暴露。指示剂元件可以包括合成聚合物材料和任选的染料。可以使用侧链可结晶聚合物如聚（十六烷基甲基丙烯酸酯），其在基体温度以下是固体，并且是高于活化温度的粘性液体。可以使用适当的染料或染料获得强烈的指示剂元素颜色。指示器的各种结构构造被描述和示出。

2. 发明授权

US08529682B2 Process for preparing an indicator composition and indicator compositions 有权
标题翻译：制备指示剂组合物和指示剂组合物的方法
公开(公告)号：US08529682B2
公开(公告)日：2013-09-10
申请号：US13248254
申请日：2011-09-29
申请人： Thaddeus Prusik , Dawn E. Smith , Ray H. Baughman
发明人： Thaddeus Prusik , Dawn E. Smith , Ray H. Baughman
IPC分类号： C09D11/00 , G01N31/00 , G01K1/02 , G01K3/00 , G04F1/00
CPC分类号： C09D11/50
摘要： Indicator inks, indicators formed by printing or otherwise utilizing the inks and host products utilizing the indicators are disclosed. Reactivity-enhancing adjuvants stimulate enhanced thermal reactivity of diacetylenic or other indicator agents capable of responding to ambient thermal conditions with a visual change signaling an end point. The diacetylenic or other agents may be sensitive or relatively insensitive to ambient temperatures. Use of a reactivity-enhancing adjuvant provides a useful means for adapting the reactivities of indicator agents to the response characteristics of prospective host products, for example perishables such as vaccines or fresh fish and maturables such as fruit, cheese and wine. Some exemplary adjuvants include low-temperature polymerization initiators, for example methyl ethyl ketone peroxide and polymerization accelerators, for example cobalt compounds. Such initiators and accelerators can also be used in combination.
摘要翻译：公开了指示剂油墨，通过使用指示剂印刷或以其它方式利用油墨和主体产品形成的指示剂。反应性增强佐剂刺激能够响应于环境热条件的二乙炔或其他指示剂的增强的热反应性，其中以指示终点的视觉改变。二乙炔或其它试剂可能对环境温度敏感或相对不敏感。使用反应性增强佐剂提供了一种有用的方法，用于使指示剂的反应性适应于预期宿主产物的反应特性，例如易腐食物例如疫苗或鲜鱼以及可食用如水果，奶酪和葡萄酒。一些示例性的助剂包括低温聚合引发剂，例如甲基乙基酮过氧化物和聚合促进剂，例如钴化合物。这样的引发剂和促进剂也可以组合使用。

3. 发明申请

US20120079981A1 TEMPERATURE-ACTIVATED TIME-TEMPERATURE INDICATOR 有权
标题翻译：温度激活时间温度指示器
公开(公告)号：US20120079981A1
公开(公告)日：2012-04-05
申请号：US13238686
申请日：2011-09-21
申请人： Brian S. HUFFMAN , Dawn E. SMITH , Carl M. LENTZ
发明人： Brian S. HUFFMAN , Dawn E. SMITH , Carl M. LENTZ
IPC分类号： G01K1/02
CPC分类号： G01K1/02 , G01K3/04 , G01K11/06
摘要： A temperature-activatable time-temperature indicator that can be used to monitor the historical exposure of a host product to ambient temperatures includes an optically readable, thermally sensitive indicator element. The indicator element can be inactive below a base temperature and is intrinsically thermally responsive at or above an activation temperature which is equal to or greater than the base temperature. The indicator can record cumulative ambient temperature exposure above the activation temperature irreversibly with respect to time. The indicator element can include a synthetic polymeric material, and optionally, a dye. A side-chain crystallizable polymer such as poly(hexadecylmethacrylate), that is solid below the base temperature and is a viscous liquid above the activation temperature can be employed. Intense indicator element colors can be obtained using an appropriate dye or dyes. Various structural configurations of indicator are described and illustrated.
摘要翻译：可用于监测主体产品对环境温度的历史曝光的温度可激活的时间温度指示器包括光学可读的热敏指示元件。指示元件可以在基础温度以下是无效的，并且在等于或大于基础温度的活化温度或更高的本征热响应。该指示器可以相对于时间不可逆地记录高于激活温度的累积环境温度暴露。指示剂元件可以包括合成聚合物材料和任选的染料。可以使用侧链可结晶聚合物如聚（十六烷基甲基丙烯酸酯），其在基体温度以下是固体，并且是高于活化温度的粘性液体。可以使用适当的染料或染料获得强烈的指示剂元素颜色。指示器的各种结构构造被描述和示出。

4. 发明授权

US08122844B2 Freeze indicators with a controlled temperature response 有权
标题翻译：冻结温度响应指示器
公开(公告)号：US08122844B2
公开(公告)日：2012-02-28
申请号：US12871034
申请日：2010-08-30
申请人： Dawn E. Smith , Carl M. Lentz , Dene H. Taylor , Yvonne Osunga , Brian Huffman
发明人： Dawn E. Smith , Carl M. Lentz , Dene H. Taylor , Yvonne Osunga , Brian Huffman
IPC分类号： G01K11/12 , G01K11/16 , G01K11/18
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about −1.9° C. or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示剂可以包括具有水性液体介质的指示剂分散体和分散在水性液体介质中的有机材料指示剂颗粒。指示剂分散体在冷冻之前可以具有初始外观，并且在冷冻后具有不可逆的外观，并且可以表现出约-1.9℃或更高的冷冻起始温度。有助于提供相对高的冷冻起始温度的一些因素是使用蛋白质冰成核剂，控制pH，使用蛋白质稳定剂和控制蛋白质稳定剂与冰 - 成核剂的比例。

5. 发明授权

US07624698B2 Freeze indicators suitable for mass production 有权
标题翻译：冷冻指示器适合批量生产
公开(公告)号：US07624698B2
公开(公告)日：2009-12-01
申请号：US12069025
申请日：2008-02-06
申请人： Dene H. Taylor , Thaddeus Prusik , Dawn E. Smith
发明人： Dene H. Taylor , Thaddeus Prusik , Dawn E. Smith
IPC分类号： G01K11/12 , G01K11/14
CPC分类号： G01K1/02 , G01K3/005 , G01K11/06 , G01K11/12 , G01K2207/04 , Y10S252/962
摘要： A freeze indicator employs, as active indicator element, dispersion of solid particles in a liquid medium which can be water or aqueous and which coagulates to provide an irreversible appearance change when subject to freezing. The liquid dispersion can be contained in an indicator volume around which extends a vapor block layer. The vapor block layer can prevent loss of liquid vapor from the dispersion and consequent drying out and dysfunctionality of the freeze indicator. For containing an aqueous medium, bilayer and trilayer laminate materials can be used which have a low water vapor transmission rate. The active indicator element can be a dilute colloidal dispersion of a metal such as gold or silver or other inorganic pigment material in water or an aqueous medium. Some embodiments avoid use of dispersants and the like and employ an active indicator element consisting of inorganic pigment particles, water and optionally an ice nucleating agent. Heavy water, or deuterated water can be components of the water, if desired.
摘要翻译：冷冻指示器使用固体颗粒在液体介质中的分散体作为活性指示剂元素，液体介质可以是水或水，并在凝固时提供不可逆的外观变化。液体分散体可以包含在延伸蒸气阻挡层的指示体积中。蒸气阻挡层可以防止液体蒸气从分散体中的损失，从而导致冷冻指示器的干燥和功能失调。为了含有水性介质，可以使用具有低水蒸气透过率的双层和三层层压材料。活性指示剂元素可以是诸如金或银之类的金属或其它无机颜料材料在水或水介质中的稀释胶体分散体。一些实施方案避免使用分散剂等并且使用由无机颜料颗粒，水和任选的冰核成核剂组成的活性指示剂元件。如果需要，重水或氘代水可以是水的组分。

6. 发明授权

US08269042B2 Crystallized diacetylenic indicator compounds and methods of preparing the compounds 有权
标题翻译：结晶二乙炔指示剂化合物及其制备方法
公开(公告)号：US08269042B2
公开(公告)日：2012-09-18
申请号：US12261887
申请日：2008-10-30
申请人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
发明人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
IPC分类号： C07C275/04
CPC分类号： G01K11/12 , C07C273/02 , C07C275/20 , C09B69/10 , G01K3/04 , G01N21/78 , G01N31/22 , G01N31/229
摘要： Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.
摘要翻译：具有某些晶体学特性的结晶二炔化合物; 二乙炔化合物和从二乙炔溶液中结晶的混合物; 制备和鉴定溶解二乙炔化合物的溶剂体系的方法; 二乙酰溶液; 二乙炔化合物重结晶方法; 2,4-己二炔-1,6-双（烷基脲）化合物的晶体; 环境条件指标和包含结晶二乙炔化合物的时间 - 温度条件指标。

7. 发明授权

US08128872B2 Freeze indicators, components therefor and preparative processes 失效
标题翻译：冻结指标，组件和制备过程
公开(公告)号：US08128872B2
公开(公告)日：2012-03-06
申请号：US12511025
申请日：2009-07-28
申请人： Carl Lentz , Dawn E. Smith , Dene H. Taylor
发明人： Carl Lentz , Dawn E. Smith , Dene H. Taylor
IPC分类号： G01N25/20 , G01K11/12
CPC分类号： G01K11/06 , G01K3/04 , Y10S252/962
摘要： Freeze indicators can include an indicator dispersion, a liquid medium, indicator particles dispersed in the liquid medium and a particulate inorganic nucleating agent to inhibit supercooling of the liquid medium. The inorganic nucleating agent can have an ionic surface coating which can help provide a sharp end point. Optionally, freeze indicators can include indicator particles comprising an organic material and a softener to soften the indicator particles and provide the freeze indication with an enhanced visual appearance. Another option is to provide a temperature-sensitive stabilizer to inhibit coagulation of the indicator dispersion at temperatures above the liquid medium frozen state melting point while permitting coagulation of the indicator dispersion at the liquid medium frozen state melting point.
摘要翻译：冷冻指示剂可以包括指示剂分散体，液体介质，分散在液体介质中的指示剂颗粒和颗粒状无机成核剂以抑制液体介质的过冷。无机成核剂可以具有可以帮助提供尖锐终点的离子表面涂层。任选地，冷冻指示器可以包括包含有机材料和柔软剂的指示剂颗粒，以软化指示剂颗粒并提供具有增强的视觉外观的冷冻指示。另一个选择是提供温度敏感的稳定剂，以在高于液体介质冷冻状态熔点的温度下抑制指示剂分散体的凝结，同时允许指示剂分散体在液体介质冷冻状态熔点下凝结。

8. 发明申请

US20110086995A1 CO-CRYSTALLIZABLE DIACETYLENIC MONOMER COMPOSITIONS, CRYSTAL PHASES AND MIXTURES, AND RELATED METHODS 有权
标题翻译：可结晶的二乙烯单体组合物，晶体相和混合物及相关方法
公开(公告)号：US20110086995A1
公开(公告)日：2011-04-14
申请号：US12730835
申请日：2010-03-24
申请人： Elizabeth CASTILLO MARTINEZ , Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik , Carl M. Lentz
发明人： Elizabeth CASTILLO MARTINEZ , Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik , Carl M. Lentz
IPC分类号： C08F238/00
CPC分类号： C07C275/20 , C08F238/02 , G01N31/229
摘要： Solid polymerizable diacetylenic monomer compositions, including compositions co-crystallized from a diversity of solvent systems under diverse cooling conditions, can exhibit diffraction patterns associated with the color development reactivities of the compositions. High reactivity compositions are disclosed and high reactivity and low reactivity phases can be identified. A low angle powder X-ray diffraction peak can indicate the presence of one or more crystal phases in a composition. A fingerprint region can exhibit fingerprint patterns of diffraction peaks associated with different reactivities. Information about polymerization of the diacetylenic monomers is disclosed using 13C nuclear magnetic resonance (“NMR”) characterization. Diacetylenic monomer compositions useful in ambient condition indicators, for example time-temperature indicators are disclosed.
摘要翻译：固体可聚合二炔单体组合物，包括在不同冷却条件下从多种溶剂体系共结晶的组合物可以显示与组合物的显色反应性相关的衍射图。公开了高反应性组合物，并且可以鉴定出高反应性和低反应性相。低角度粉末X射线衍射峰可以指示组合物中存在一个或多个结晶相。指纹区域可以显示与不同反应性相关的衍射峰的指纹图谱。使用13C核磁共振（“NMR”）表征公开了关于二乙炔单体的聚合的信息。公开了用于环境条件指示剂的二乙炔单体组合物，例如时间 - 温度指示剂。

9. 发明申请

US20090131718A1 CRYSTALLIZED DIACETYLENIC INDICATOR COMPOUNDS AND METHODS OF PREPARING THE COMPOUNDS 有权
标题翻译：结晶二乙酸指示剂化合物及其制备方法
公开(公告)号：US20090131718A1
公开(公告)日：2009-05-21
申请号：US12261887
申请日：2008-10-30
申请人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
发明人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
IPC分类号： C07C273/02 , C07C275/20 , G01K3/00
CPC分类号： G01K11/12 , C07C273/02 , C07C275/20 , C09B69/10 , G01K3/04 , G01N21/78 , G01N31/22 , G01N31/229
摘要： Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.
摘要翻译：具有某些晶体学特性的结晶二炔化合物; 二乙炔化合物和从二乙炔溶液中结晶的混合物; 制备和鉴定溶解二乙炔化合物的溶剂体系的方法; 二乙酰溶液; 二乙炔化合物重结晶方法; 2,4-己二炔-1,6-双（烷基脲）化合物的晶体; 环境条件指标和包含结晶二乙炔化合物的时间 - 温度条件指标。

10. 发明申请

US20080056329A1 COLOR-RETAINING EXCESS-TEMPERATURE EXPOSURE INDICATOR 有权
标题翻译：彩色保温温度曝光指示器
公开(公告)号：US20080056329A1
公开(公告)日：2008-03-06
申请号：US11844739
申请日：2007-08-24
申请人： Dawn E. SMITH , Thaddeus Prusik , Omar Abbassi
发明人： Dawn E. SMITH , Thaddeus Prusik , Omar Abbassi
IPC分类号： G01K11/00 , G01K3/00
CPC分类号： G01K11/06 , G01K3/04
摘要： An excess temperature indicator can provide a visual indication of past exposure of perishable, maturing and other host products to an elevated temperature exceeding a threshold temperature. The indicator can have an upper layer provided with a viewing window and a wick attached to the upper layer. A reservoir of heat-fusible indicator material can be disposed in contact with the wick, to fuse and move along the wick changing the visual appearance of a first portion of the wick viewable through the window, in response to an excess temperature event. Also, the indicator can have a region of fused upper layer material attaching the wick to the upper layer. Optionally, a window seal can extend around the viewing window to prevent migration of the indicator material. The indicator can be employed to monitor vaccines, foods and other products providing an enduring visual signal of exposure to potentially damaging temperature conditions.
摘要翻译：过温度指示器可以提供易腐烂，成熟和其他主体产品过去暴露于超过阈值温度的高温的视觉指示。指示器可以具有设置有观察窗口的上层和附接到上层的灯芯。热熔指示剂材料的储存器可以布置成与芯接触，以便熔化并沿着芯移动，以响应于过高的温度事件而改变可通过窗口观察的芯的第一部分的视觉外观。此外，指示器可以具有将芯连接到上层的熔融上层材料的区域。可选地，窗口密封件可以围绕观察窗口延伸以防止指示剂材料的迁移。该指标可用于监测疫苗，食品和其他产品，提供暴露于潜在有害温度条件的持久视觉信号。

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