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1. 发明授权

US08671871B2 Temperature-activated time-temperature indicator 有权
标题翻译：温度启动时间温度指示器
公开(公告)号：US08671871B2
公开(公告)日：2014-03-18
申请号：US13238686
申请日：2011-09-21
申请人： Brian S. Huffman , Dawn E. Smith , Carl M. Lentz
发明人： Brian S. Huffman , Dawn E. Smith , Carl M. Lentz
IPC分类号： G01K11/12 , G01K3/04 , G01K11/06
CPC分类号： G01K1/02 , G01K3/04 , G01K11/06
摘要： A temperature-activatable time-temperature indicator that can be used to monitor the historical exposure of a host product to ambient temperatures includes an optically readable, thermally sensitive indicator element. The indicator element can be inactive below a base temperature and is intrinsically thermally responsive at or above an activation temperature which is equal to or greater than the base temperature. The indicator can record cumulative ambient temperature exposure above the activation temperature irreversibly with respect to time. The indicator element can include a synthetic polymeric material, and optionally, a dye. A side-chain crystallizable polymer such as poly(hexadecylmethacrylate), that is solid below the base temperature and is a viscous liquid above the activation temperature can be employed. Intense indicator element colors can be obtained using an appropriate dye or dyes. Various structural configurations of indicator are described and illustrated.
摘要翻译：可用于监测主体产品对环境温度的历史曝光的温度可激活的时间温度指示器包括光学可读的热敏指示元件。指示元件可以在基础温度以下是无效的，并且在等于或大于基础温度的活化温度或更高的本征热响应。该指示器可以相对于时间不可逆地记录高于激活温度的累积环境温度暴露。指示剂元件可以包括合成聚合物材料和任选的染料。可以使用侧链可结晶聚合物如聚（十六烷基甲基丙烯酸酯），其在基体温度以下是固体，并且是高于活化温度的粘性液体。可以使用适当的染料或染料获得强烈的指示剂元素颜色。指示器的各种结构构造被描述和示出。

2. 发明申请

US20120079980A1 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 有权
标题翻译：冷冻指示剂的颜色变化乳液
公开(公告)号：US20120079980A1
公开(公告)日：2012-04-05
申请号：US13246392
申请日：2011-09-27
申请人： Dene H. TAYLOR , Carl M. Lentz , Dawn E. Smith
发明人： Dene H. TAYLOR , Carl M. Lentz , Dawn E. Smith
IPC分类号： G01D21/00 , G01N21/75
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.
摘要翻译：用于冷冻指示剂的变色乳液可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两个反应物相都可以分散在分散介质中。第一反应物相包括疏水性液体和第一反应物，例如着色前体如无色染料。第二反应物相可以包括疏水性液体，并且包括或可以是第二反应物，例如彩色显影剂，例如无色染料显影剂。第一和第二反应物相可以基本上不混合，并且可以共同反应以提供颜色变化。响应于冷冻温度，变色乳液可以不可逆地凝结和变色。通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

3. 发明申请

US20110086995A1 CO-CRYSTALLIZABLE DIACETYLENIC MONOMER COMPOSITIONS, CRYSTAL PHASES AND MIXTURES, AND RELATED METHODS 有权
标题翻译：可结晶的二乙烯单体组合物，晶体相和混合物及相关方法
公开(公告)号：US20110086995A1
公开(公告)日：2011-04-14
申请号：US12730835
申请日：2010-03-24
申请人： Elizabeth CASTILLO MARTINEZ , Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik , Carl M. Lentz
发明人： Elizabeth CASTILLO MARTINEZ , Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik , Carl M. Lentz
IPC分类号： C08F238/00
CPC分类号： C07C275/20 , C08F238/02 , G01N31/229
摘要： Solid polymerizable diacetylenic monomer compositions, including compositions co-crystallized from a diversity of solvent systems under diverse cooling conditions, can exhibit diffraction patterns associated with the color development reactivities of the compositions. High reactivity compositions are disclosed and high reactivity and low reactivity phases can be identified. A low angle powder X-ray diffraction peak can indicate the presence of one or more crystal phases in a composition. A fingerprint region can exhibit fingerprint patterns of diffraction peaks associated with different reactivities. Information about polymerization of the diacetylenic monomers is disclosed using 13C nuclear magnetic resonance (“NMR”) characterization. Diacetylenic monomer compositions useful in ambient condition indicators, for example time-temperature indicators are disclosed.
摘要翻译：固体可聚合二炔单体组合物，包括在不同冷却条件下从多种溶剂体系共结晶的组合物可以显示与组合物的显色反应性相关的衍射图。公开了高反应性组合物，并且可以鉴定出高反应性和低反应性相。低角度粉末X射线衍射峰可以指示组合物中存在一个或多个结晶相。指纹区域可以显示与不同反应性相关的衍射峰的指纹图谱。使用13C核磁共振（“NMR”）表征公开了关于二乙炔单体的聚合的信息。公开了用于环境条件指示剂的二乙炔单体组合物，例如时间 - 温度指示剂。

4. 发明授权

US08122844B2 Freeze indicators with a controlled temperature response 有权
标题翻译：冻结温度响应指示器
公开(公告)号：US08122844B2
公开(公告)日：2012-02-28
申请号：US12871034
申请日：2010-08-30
申请人： Dawn E. Smith , Carl M. Lentz , Dene H. Taylor , Yvonne Osunga , Brian Huffman
发明人： Dawn E. Smith , Carl M. Lentz , Dene H. Taylor , Yvonne Osunga , Brian Huffman
IPC分类号： G01K11/12 , G01K11/16 , G01K11/18
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about −1.9° C. or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示剂可以包括具有水性液体介质的指示剂分散体和分散在水性液体介质中的有机材料指示剂颗粒。指示剂分散体在冷冻之前可以具有初始外观，并且在冷冻后具有不可逆的外观，并且可以表现出约-1.9℃或更高的冷冻起始温度。有助于提供相对高的冷冻起始温度的一些因素是使用蛋白质冰成核剂，控制pH，使用蛋白质稳定剂和控制蛋白质稳定剂与冰 - 成核剂的比例。

5. 发明授权

US08430053B2 Color-changing emulsions for freeze indicators 有权
标题翻译：用于冷冻指示剂的变色乳液
公开(公告)号：US08430053B2
公开(公告)日：2013-04-30
申请号：US13246392
申请日：2011-09-27
申请人： Dene H. Taylor , Carl M. Lentz , Dawn E. Smith
发明人： Dene H. Taylor , Carl M. Lentz , Dawn E. Smith
IPC分类号： G01D21/00
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.
摘要翻译：用于冷冻指示剂的变色乳液可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两个反应物相都可以分散在分散介质中。第一反应物相包括疏水性液体和第一反应物，例如着色前体如无色染料。第二反应物相可以包括疏水性液体，并且包括或可以是第二反应物，例如彩色显影剂，例如无色染料显影剂。第一和第二反应物相可以基本上不混合，并且可以共同反应以提供颜色变化。响应于冷冻温度，变色乳液可以不可逆地凝结和变色。通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

6. 发明授权

US08354486B2 Co-crystallizable diacetylenic monomer compositions, crystal phases and mixtures, and related methods 有权
标题翻译：可共结构的二炔单体组合物，结晶相和混合物及相关方法
公开(公告)号：US08354486B2
公开(公告)日：2013-01-15
申请号：US12730835
申请日：2010-03-24
申请人： Elizabeth Castillo Martinez , Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik , Carl M. Lentz
发明人： Elizabeth Castillo Martinez , Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik , Carl M. Lentz
IPC分类号： C08F238/00 , G01D21/00 , C07C275/20 , C08F2/36
CPC分类号： C07C275/20 , C08F238/02 , G01N31/229
摘要： Solid polymerizable diacetylenic monomer compositions, including compositions co-crystallized from a diversity of solvent systems under diverse cooling conditions, can exhibit diffraction patterns associated with the color development reactivities of the compositions. High reactivity compositions are disclosed and high reactivity and low reactivity phases can be identified. A low angle powder X-ray diffraction peak can indicate the presence of one or more crystal phases in a composition. A fingerprint region can exhibit fingerprint patterns of diffraction peaks associated with different reactivities. Information about polymerization of the diacetylenic monomers is disclosed using 13C nuclear magnetic resonance (“NMR”) characterization. Diacetylenic monomer compositions useful in ambient condition indicators, for example time-temperature indicators are disclosed.
摘要翻译：固体可聚合二炔单体组合物，包括在不同冷却条件下从各种溶剂体系共结晶的组合物可以显示与组合物的显色反应性相关的衍射图。公开了高反应性组合物，并且可以鉴定出高反应性和低反应性相。低角度粉末X射线衍射峰可以指示组合物中存在一个或多个结晶相。指纹区域可以显示与不同反应性相关的衍射峰的指纹图谱。使用13C核磁共振（NMR）表征公开了关于二乙炔单体的聚合的信息。公开了用于环境条件指示剂的二乙炔单体组合物，例如时间 - 温度指示剂。

7. 发明授权

US08642807B2 Crystallized diacetylenic indicator compounds and methods of preparing the compounds 有权
标题翻译：结晶二乙炔指示剂化合物及其制备方法
公开(公告)号：US08642807B2
公开(公告)日：2014-02-04
申请号：US13529605
申请日：2012-06-21
申请人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
发明人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
IPC分类号： C07C275/20 , G01K11/12 , G01D21/00
CPC分类号： G01K11/12 , C07C273/02 , C07C275/20 , C09B69/10 , G01K3/04 , G01N21/78 , G01N31/22 , G01N31/229
摘要： Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.
摘要翻译：具有某些晶体学特性的结晶二炔化合物; 二乙炔化合物和从二乙炔溶液中结晶的混合物; 制备和鉴定溶解二乙炔化合物的溶剂体系的方法; 二乙酰溶液; 二乙炔化合物重结晶方法; 2,4-己二炔-1,6-双（烷基脲）化合物的晶体; 环境条件指标和包含结晶二乙炔化合物的时间 - 温度条件指标。

8. 发明授权

US07517146B2 Color-retaining excess-temperature exposure indicator 有权
标题翻译：保色过温曝光指示
公开(公告)号：US07517146B2
公开(公告)日：2009-04-14
申请号：US11844739
申请日：2007-08-24
申请人： Dawn E. Smith , Thaddeus Prusik , Omar Abbassi
发明人： Dawn E. Smith , Thaddeus Prusik , Omar Abbassi
IPC分类号： G01K1/00 , G01K11/00
CPC分类号： G01K11/06 , G01K3/04
摘要： An excess temperature indicator can provide a visual indication of past exposure of perishable, maturing and other host products to an elevated temperature exceeding a threshold temperature. The indicator can have an upper layer provided with a viewing window and a wick attached to the upper layer. A reservoir of heat-fusible indicator material can be disposed in contact with the wick, to fuse and move along the wick changing the visual appearance of a first portion of the wick viewable through the window, in response to an excess temperature event. Also, the indicator can have a region of fused upper layer material attaching the wick to the upper layer. Optionally, a window seal can extend around the viewing window to prevent migration of the indicator material. The indicator can be employed to monitor vaccines, foods and other products providing an enduring visual signal of exposure to potentially damaging temperature conditions.
摘要翻译：过温度指示器可以提供易腐烂，成熟和其他主体产品过去暴露于超过阈值温度的高温的视觉指示。指示器可以具有设置有观察窗口的上层和附接到上层的灯芯。热熔指示剂材料的储存器可以布置成与芯接触，以便熔化并沿着芯移动，以响应于过高的温度事件而改变可通过窗口观察的芯的第一部分的视觉外观。此外，指示器可以具有将芯连接到上层的熔融上层材料的区域。可选地，窗口密封件可以围绕观察窗口延伸以防止指示剂材料的迁移。该指标可用于监测疫苗，食品和其他产品，提供暴露于潜在有害温度条件的持久视觉信号。

9. 发明授权

US08269042B2 Crystallized diacetylenic indicator compounds and methods of preparing the compounds 有权
标题翻译：结晶二乙炔指示剂化合物及其制备方法
公开(公告)号：US08269042B2
公开(公告)日：2012-09-18
申请号：US12261887
申请日：2008-10-30
申请人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
发明人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
IPC分类号： C07C275/04
CPC分类号： G01K11/12 , C07C273/02 , C07C275/20 , C09B69/10 , G01K3/04 , G01N21/78 , G01N31/22 , G01N31/229
摘要： Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.
摘要翻译：具有某些晶体学特性的结晶二炔化合物; 二乙炔化合物和从二乙炔溶液中结晶的混合物; 制备和鉴定溶解二乙炔化合物的溶剂体系的方法; 二乙酰溶液; 二乙炔化合物重结晶方法; 2,4-己二炔-1,6-双（烷基脲）化合物的晶体; 环境条件指标和包含结晶二乙炔化合物的时间 - 温度条件指标。

10. 发明授权

US08128872B2 Freeze indicators, components therefor and preparative processes 失效
标题翻译：冻结指标，组件和制备过程
公开(公告)号：US08128872B2
公开(公告)日：2012-03-06
申请号：US12511025
申请日：2009-07-28
申请人： Carl Lentz , Dawn E. Smith , Dene H. Taylor
发明人： Carl Lentz , Dawn E. Smith , Dene H. Taylor
IPC分类号： G01N25/20 , G01K11/12
CPC分类号： G01K11/06 , G01K3/04 , Y10S252/962
摘要： Freeze indicators can include an indicator dispersion, a liquid medium, indicator particles dispersed in the liquid medium and a particulate inorganic nucleating agent to inhibit supercooling of the liquid medium. The inorganic nucleating agent can have an ionic surface coating which can help provide a sharp end point. Optionally, freeze indicators can include indicator particles comprising an organic material and a softener to soften the indicator particles and provide the freeze indication with an enhanced visual appearance. Another option is to provide a temperature-sensitive stabilizer to inhibit coagulation of the indicator dispersion at temperatures above the liquid medium frozen state melting point while permitting coagulation of the indicator dispersion at the liquid medium frozen state melting point.
摘要翻译：冷冻指示剂可以包括指示剂分散体，液体介质，分散在液体介质中的指示剂颗粒和颗粒状无机成核剂以抑制液体介质的过冷。无机成核剂可以具有可以帮助提供尖锐终点的离子表面涂层。任选地，冷冻指示器可以包括包含有机材料和柔软剂的指示剂颗粒，以软化指示剂颗粒并提供具有增强的视觉外观的冷冻指示。另一个选择是提供温度敏感的稳定剂，以在高于液体介质冷冻状态熔点的温度下抑制指示剂分散体的凝结，同时允许指示剂分散体在液体介质冷冻状态熔点下凝结。

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