专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130052894A1 SWIMMING AID 审中-公开
标题翻译：游泳援助
公开(公告)号：US20130052894A1
公开(公告)日：2013-02-28
申请号：US13498123
申请日：2010-09-23
申请人： David Grainger , Gurmail Singh Sidhu
发明人： David Grainger , Gurmail Singh Sidhu
IPC分类号： A63B31/10 , A63B31/00
CPC分类号： A63B31/10 , A63B31/14
摘要： A swimming aid is provided that includes an expandable element and a securing element for securing the swimming aid to a user. The expandable element moves between a collapsed configuration and an expanded configuration. The swimming aid is constructed and arranged such that movement through water in a first direction causes the expandable element to move to the expanded configuration and movement in a second direction, substantially opposite to the first direction, causes the expandable element to move to the collapsed configuration.
摘要翻译：提供了一种游泳辅助装置，其包括可膨胀元件和用于将游泳辅助件固定到使用者的固定元件。可扩展元件在折叠配置和扩展配置之间移动。游泳辅助装置被构造和布置成使得在第一方向上通过水的运动使得可扩张元件移动到膨胀构型并且在与第一方向基本相反的第二方向上的移动使得可扩张元件移动到收缩构型。

2. 发明申请

US20060084696A1 Compounds and therapies for the prevention of vascular and non-vascular pathologies 失效
公开(公告)号：US20060084696A1
公开(公告)日：2006-04-20
申请号：US11270185
申请日：2005-11-09
申请人： David Grainger , James Metcalfe , Sudhakar Kasina
发明人： David Grainger , James Metcalfe , Sudhakar Kasina
IPC分类号： A61K31/381 , A61K31/275
CPC分类号： A61K31/275 , A61K31/381 , C07D333/38 , G01N33/74 , G01N2333/495 , G01N2333/71 , G01N2800/108 , G01N2800/323
摘要： The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compounds that elevate TGF-beta levels, as well as pharmaceutical compositions comprising compounds that elevate TGF-beta levels, and methods for detecting diseases associated with endothelial cell activation.

3. 发明申请

US20050020667A1 Compounds and therapies for the prevention of vascular and non-vascular pathologies 失效
标题翻译：用于预防血管和非血管病变的化合物和疗法
公开(公告)号：US20050020667A1
公开(公告)日：2005-01-27
申请号：US10827602
申请日：2004-04-19
申请人： David Grainger , James Metcalfe , Sudhakar Kasina
发明人： David Grainger , James Metcalfe , Sudhakar Kasina
IPC分类号： A61K31/381 , C07D333/38 , G01N33/74 , A61K31/4025 , A61K31/34 , A61K31/38
CPC分类号： A61K31/275 , A61K31/381 , C07D333/38 , G01N33/74 , G01N2333/495 , G01N2333/71 , G01N2800/108 , G01N2800/323
摘要： The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compounds that elevate TGF-beta levels, as well as pharmaceutical compositions comprising compounds that elevate TGF-beta levels, and methods for detecting diseases associated with endothelial cell activation.
摘要翻译：本发明提供了治疗具有或具有与TGF-β缺乏相关的指征的哺乳动物的方法，包括施用一种或多种有效提高TGF-β水平的试剂。本发明还提供了提高TGF-β水平的新化合物，以及包含提高TGF-β水平的化合物的药物组合物，以及用于检测与内皮细胞活化相关的疾病的方法。

4. 发明申请

US20080045557A1 COMPOUNDS AND METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE 失效
标题翻译：化合物和抑制或损害炎症反应的方法
公开(公告)号：US20080045557A1
公开(公告)日：2008-02-21
申请号：US11682931
申请日：2007-03-07
申请人： David Grainger , Lauren Tatalick
发明人： David Grainger , Lauren Tatalick
IPC分类号： A61K31/4355 , A61P19/00 , A61P31/00 , C07D221/18
CPC分类号： A61K31/13 , A61K31/165 , A61K31/19 , A61K31/445
摘要： Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
摘要翻译：提供了分离和纯化的趋化因子肽，变体及其衍生物，以及趋化因子肽类似物。

5. 发明申请

US20050147758A1 Hydroxyl functional surface coating 失效
标题翻译：羟基官能表面涂层
公开(公告)号：US20050147758A1
公开(公告)日：2005-07-07
申请号：US11035849
申请日：2005-01-13
申请人： Guoqiang Mao , Steven Metzger , Michael Lochhead , David Goldberg , Charles Greef , David Grainger
发明人： Guoqiang Mao , Steven Metzger , Michael Lochhead , David Goldberg , Charles Greef , David Grainger
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , B05D3/02
CPC分类号： G01N33/54393 , A61L27/34 , A61L29/085 , A61L31/10 , G01N33/5306 , G01N2035/00158
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

6. 发明申请

US20060073114A1 Compounds and methods to inhibit or augment an inflammatory response 失效
公开(公告)号：US20060073114A1
公开(公告)日：2006-04-06
申请号：US10241375
申请日：2002-09-11
申请人： David Grainger , Lauren Tatalick , Suzanne Kanaly
发明人： David Grainger , Lauren Tatalick , Suzanne Kanaly
IPC分类号： A61K38/19 , C07K14/52
CPC分类号： C07K14/523 , A61K38/00 , A61K45/06 , A61K47/68 , C07K14/522 , Y02A50/411
摘要： Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.

7. 发明申请

US20080076755A1 Anti-Inflammatory Agents 失效
标题翻译：抗炎药
公开(公告)号：US20080076755A1
公开(公告)日：2008-03-27
申请号：US11573851
申请日：2005-08-10
申请人： David Grainger , David Fox
发明人： David Grainger , David Fox
IPC分类号： A61K31/439 , A61K31/55 , A61P11/06 , A61P17/06 , A61P29/00 , A61P31/12 , A61P37/00 , C07D221/02 , C07D221/04 , C07D487/00 , C07D487/08
CPC分类号： A61K31/55 , A61K31/439 , C07D451/14
摘要： The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein y is any integer from 1 to 8; z is any integer from 1 to 8; with the proviso that y and z cannot both equal 1; X is —C —(Y)k—(R1)n or SO2—(Y)k (R1)n; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or Y is a cycloalkenyl or polycycloalkenyl group.
摘要翻译：本发明提供了通式（I）化合物或其药学上可接受的盐的化合物，组合物和用途，用于制备旨在治疗炎性病症的药物，其中y为1至8的整数; z为1〜8的整数; 条件是y和z不能都等于1; X是-C - （Y） - （R 1）n - 或SO 2 - （Y）（R 1）N k为0或1; Y是环烷基或聚环烷基（例如金刚烷基，金刚烷甲基，双环辛基，环己基，环丙基）; 或Y是环烯基或多环烯基。

8. 发明申请

US20060135560A1 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 审中-公开
标题翻译：用他莫昔芬类似物预防和治疗心血管病变
公开(公告)号：US20060135560A1
公开(公告)日：2006-06-22
申请号：US10729056
申请日：2003-12-05
申请人： David Grainger , James Metcalfe , Lawrence Kunz , Robert Schroff
发明人： David Grainger , James Metcalfe , Lawrence Kunz , Robert Schroff
IPC分类号： A61K31/445 , A61K31/40 , A61K31/138
CPC分类号： A61K31/445 , A61K31/135 , A61K31/138 , A61K31/38 , A61K31/40 , G01N2800/32 , G01N2800/324 , Y10S514/866
摘要： A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individually (C1-C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 is H, R5 is I, O(C1-C4)alkyl or H and R6 is I, O(C1-C4)alkyl or H with the proviso that when R4, R5, and R6 are H, R3 is not ethyl; or a pharmaceutically acceptable salt thereof, effective to elevate the level of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene, toremifene or salts thereof. Further provided is a method for identifying an agent that elevates the level of TGF-beta. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifin or structural analogs thereof, including compounds of formula (I).
摘要翻译：一种治疗或预防心血管病变的方法，其通过给予式（I）化合物：其中Z为C-O或共价键; Y是H或O（C 1 -C 4）烷基，R 1和R 2各自独立地是（ C 1 -C 4烷基或与N一起为饱和杂环基，R 3是乙基或氯乙基，R 4 H，R 5是I，O（C 1 -C 4 -C 4）烷基或H和R 6 是（O）（C 1 -C 4）烷基或H，条件是当R 4，R 0 > 5，且R 6为H，R 3不为乙基; 提供有效地提高TGF-β水平以治疗和/或预防诸如动脉粥样硬化，血栓形成，心肌梗塞和中风的病症的药学上可接受的盐或其药学上可接受的盐。有用的化合物包括异昔芬，托瑞米芬或其盐。还提供了用于鉴定提高TGF-β水平的试剂的方法。本发明的另一个实施方案是用于在体外测定TGF-β的测定或试剂盒。还提供了一种治疗方法，其包括使用给予他莫昔芬或其结构类似物（包括式（I）的化合物）来抑制与程序性血管创伤相关的平滑肌细胞增殖。

9. 发明申请

US20060073611A1 Immunoassay 审中-公开
标题翻译：免疫测定
公开(公告)号：US20060073611A1
公开(公告)日：2006-04-06
申请号：US10547995
申请日：2004-03-10
申请人： David Grainger
发明人： David Grainger
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00533 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00677 , B01J2219/00707 , B01J2219/00725 , C07K1/047 , C12N15/1037 , C40B40/02 , C40B40/10 , C40B50/08 , C40B60/14 , G01N33/53 , G01N33/54313 , G01N33/582 , G01N33/585 , G01N33/6845 , G01N33/6854 , G01N33/6878 , G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： The present invention relates to methods of assaying the levels of proteins or antibodies in a test sample. In particular, the present invention relates to a method of determining the relative abundance of a plurality of proteins in a test sample compared to a reference sample, the method comprising: (a) providing a reference sample comprising a plurality of labelled proteins; (b) incubating a plurality of tagged antibodies capable of binding components of the reference sample with (i) a mixture of the labelled reference sample and the test sample and (ii) the reference sample alone, under conditions suitable for the binding of said antibodies to their targets; (c) comparing the amount of labelled protein bound to individual antibody tags in the presence and absence of the test sample.
摘要翻译：本发明涉及测定样品中蛋白质或抗体水平的方法。特别地，本发明涉及一种确定测试样品中多个蛋白质与参考样品相对丰度的方法，该方法包括：（a）提供包含多个标记蛋白质的参考样品; （b）在适于所述抗体结合的条件下，将能够结合参考样品组分的多个标记抗体与（i）标记参考样品和测试样品的混合物和（ii）参考样品单独孵育，到他们的目标（c）在存在和不存在测试样品的情况下，比较与单个抗体标签结合的标记蛋白质的量。

10. 发明申请

US20060029986A1 Prevention and treatment of cardiovascular pathologies 审中-公开
标题翻译：预防和治疗心血管病变
公开(公告)号：US20060029986A1
公开(公告)日：2006-02-09
申请号：US11231256
申请日：2005-09-20
申请人： David Grainger , Paul Kemp
发明人： David Grainger , Paul Kemp
IPC分类号： G01N33/542 , G01N33/537
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/715 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6927 , A61K47/6937 , A61K47/6957 , C07K14/71 , C07K16/22 , C07K2317/73 , G01N33/6893 , G01N33/74 , G01N2333/495 , G01N2800/32
摘要： A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1-C4)alkyl, R1 and R2 are individually (C1-C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 is H or together with R3 is —CH2—CH2— or —S—, R5 is I, O(C1-C4)alkyl or H and R6 is 1, O(C1-C4)alkyl or H with the proviso that when R4, R5, and R6 are H, R3 is not ethyl; or a pharmaceutically acceptable salt thereof, effective to activate or stimulate production of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene and salts thereof. Further provided is a method for identifying a compound that is a TGF-beta activator or production stimulator is provided. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifen or structural analogs thereof, including compounds of formula (I).
摘要翻译：一种治疗或预防心血管病变的方法，其通过给予式（I）化合物：其中Z为C-O或共价键; Y是H或O（C 1 -C 4）烷基，R 1和R 2各自独立地是（ C 1 -C 4烷基或与N一起为饱和杂环基，R 3是乙基或氯乙基，R 4 H或与R 3一起为-CH 2 - ， - CH 2 - 或-S-，R 5 是（O）（C 1 -C 4 - ）烷基或H，且R 6是1，O（C _{1个C 1 -C 4烷基或H，条件是当R 4，R 5，R 5， 6是H，R 3不是乙基; 提供有效激活或刺激TGF-β的产生以治疗和/或预防诸如动脉粥样硬化，血栓形成，心肌梗死和中风的病症的药学上可接受的盐或其药学上可接受的盐。有用的化合物包括异昔芬及其盐。还提供了鉴定作为TGF-β激活剂或生产刺激剂的化合物的方法。本发明的另一个实施方案是用于在体外测定TGF-β的测定或试剂盒。还提供了一种治疗方法，其包括使用给予他莫昔芬或其结构类似物（包括式（I）的化合物）来抑制与程序性血管创伤相关的平滑肌细胞增殖。}

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式