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1. 发明授权

US07566770B2 Humanized collagen antibodies and related methods 失效
标题翻译：人源化胶原抗体及相关方法
公开(公告)号：US07566770B2
公开(公告)日：2009-07-28
申请号：US11486894
申请日：2006-07-14
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides an antibody, or functional fragment thereof, a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译：本发明提供抗体或其功能片段，其接枝抗体或其功能片段，其包含在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的一个或多个互补决定区（CDR），其中抗体或其功能片段对隐窝胶原表位具有特异性结合活性。本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。

2. 发明授权

US07763247B2 Humanized collagen antibodies and related methods 失效
标题翻译：人源化胶原抗体及相关方法
公开(公告)号：US07763247B2
公开(公告)日：2010-07-27
申请号：US12070146
申请日：2008-02-15
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译：本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性隐形胶原表位的结合活性。本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管生成，肿瘤生长和转移的方法。

3. 发明申请

US20080260733A1 HUMANIZED COLLAGEN ANTIBODIES AND RELATED METHODS 失效
公开(公告)号：US20080260733A1
公开(公告)日：2008-10-23
申请号：US12117642
申请日：2008-05-08
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/395 , C07K16/00 , A61P9/00 , G01N33/68 , C07H21/00
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

4. 发明授权

US07390885B2 Humanized collagen antibodies and related methods 失效
公开(公告)号：US07390885B2
公开(公告)日：2008-06-24
申请号：US10011250
申请日：2001-12-06
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

5. 发明申请

US20080050388A1 HUMANIZED COLLAGEN ANTIBODIES AND RELATED METHODS 失效
标题翻译：人类胶原抗体及相关方法
公开(公告)号：US20080050388A1
公开(公告)日：2008-02-28
申请号：US10011250
申请日：2001-12-06
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/395 , G01N33/567 , C07K16/18
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译：本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性隐形胶原表位的结合活性。本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。

6. 发明授权

US07763248B2 Humanized collagen antibodies and related methods 失效
公开(公告)号：US07763248B2
公开(公告)日：2010-07-27
申请号：US12117642
申请日：2008-05-08
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

7. 发明申请

US20080233133A1 Humanized collagen antibodies and related methods 失效
公开(公告)号：US20080233133A1
公开(公告)日：2008-09-25
申请号：US12070146
申请日：2008-02-15
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00 , C07H21/04
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

8. 发明授权

US07365167B2 Humanized collagen antibodies and related methods 失效
标题翻译：人源化胶原抗体及相关方法
公开(公告)号：US07365167B2
公开(公告)日：2008-04-29
申请号：US09995529
申请日：2001-11-26
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译：本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性隐形胶原表位的结合活性。本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。

9. 发明申请

US20050271650A1 Method and composition for angiogenesis inhibition 审中-公开
标题翻译：血管生成抑制的方法和组成
公开(公告)号：US20050271650A1
公开(公告)日：2005-12-08
申请号：US11061370
申请日：2005-02-17
申请人： Bruce Freimark , Daniel Broek , Peter Brooks
发明人： Bruce Freimark , Daniel Broek , Peter Brooks
IPC分类号： A61K38/04 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28
CPC分类号： C07K16/18
摘要： The invention features methods and compositions for inhibiting angiogenesis in a tissue or detecting angiogenesis using antagonists of denatured or proteolyzed forms of laminin.
摘要翻译：本发明的特征在于用于抑制组织中血管发生的方法和组合物或使用层粘连蛋白的变性或蛋白水解形式的拮抗剂检测血管发生。

10. 发明授权

US4658966A Hanging file for blueprints and the like 失效
标题翻译：悬挂文件等蓝图
公开(公告)号：US4658966A
公开(公告)日：1987-04-21
申请号：US845515
申请日：1986-03-28
申请人： Daniel Broek
发明人： Daniel Broek
IPC分类号： B42F15/06 , A47F7/16
CPC分类号： B42F15/06
摘要： The present invention provides a hanging file system for releasably suspending a plurality of relatively large flat pages of blueprints or the like in a hanging relationship to one another including a generally rectangular rack portion having a plurality of pins extending from the lower portion of a rear member of the rack. A binder has an aperture formed in one end for operatively engaging one of the pins and a hanger forming having a slotted channel for operatively receiving the front member of the rack therein for hangably supporting the binder and the plurality of pages contained therein from the rack. The outer front end portion of the binder contains a flared opening for guiding the pages into the channel and between the lower gripping jaws which are resiliently biased by the plastic material itself toward one another for clampably retaining the pages with the hollow channel of the binder. The holder is located a predetermined distance from the apertured end and short of the center of the binder such that the center of gravity causes the binder to attempt to rotate the apertured end clockwise about a pivot formed by the hanger engaging the front rack portion. Motion is prevented since the rear or apertured end of the binder is stopped by the lower surface of the rear rack support of the rack for maintaining the binder in a generally horizontal position for vertically suspending the plurality of pages therefrom. A loose connection of the hanger to the front support of the rack enables the binders to be pivoted in a horizontal manner about the pin-receiving aperture at the end thereof for turning the pages horizontally through an arc to enable the individual pages of a packet or individual packets of different binders to be read or scanned and so that individual pages can be removed from, reinserted in or initially inserted in individual binders without removing the binders from the racks and without moving all of the pages therefrom.
摘要翻译：本发明提供了一种悬挂文件系统，用于可释放地悬挂多个相对较大的蓝图等的平页相互悬挂的关系，包括大致矩形的齿条部分，其具有从后部构件的下部延伸的多个销的架子。粘合剂具有形成在一端中的孔，用于可操作地接合销中的一个和具有开槽通道的衣架形成，用于可操作地接收其中的齿条的前部构件，用于可悬挂地支撑活页夹和从框架容纳在其中的多个页面。粘合剂的外前端部分包含一个扩张开口，用于将页面引导到通道中，并且在下夹持爪之间，塑料材料本身朝向彼此弹性偏压，以用夹具的中空通道夹紧页面。保持器位于与开孔端相距预定距离并且不足于粘合剂的中心，使得重心使得粘合剂试图围绕由悬挂件接合前齿条部分形成的枢轴顺时针旋转有孔端。阻止运动，因为活页夹的后端或有孔端被机架的后架支撑件的下表面阻挡，以将夹具保持在大致水平的位置，以便垂直悬挂多页。悬挂器与机架的前支撑件的松动连接使得粘合剂能够在水平方向上围绕其端部的销接收孔枢转，以使水平地通过弧转动页面，以使分页的各页或要读取或扫描的不同粘合剂的单个包装，并且可以将单独的页面从机架中移除，重新插入或最初插入到单个的粘合剂中，而无需从机架上移除粘合剂并且不从其移动所有页面。

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