专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08338107B2 Method for producing polymers having a preselected activity 失效
标题翻译：具有预选活性的聚合物的制备方法
公开(公告)号：US08338107B2
公开(公告)日：2012-12-25
申请号：US11560769
申请日：2006-11-16
申请人： William D. Huse , Gregory P. Winter , Lutz Riechmann , Joseph A. Sorge , Richard A. Lerner
发明人： William D. Huse , Gregory P. Winter , Lutz Riechmann , Joseph A. Sorge , Richard A. Lerner
IPC分类号： C12Q1/68
CPC分类号： C07K16/005 , A61K38/00 , C07K16/00 , C07K16/44 , C07K16/468 , C07K2317/55 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

2. 发明授权

US07763248B2 Humanized collagen antibodies and related methods 失效
公开(公告)号：US07763248B2
公开(公告)日：2010-07-27
申请号：US12117642
申请日：2008-05-08
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

3. 发明申请

US20080233133A1 Humanized collagen antibodies and related methods 失效
公开(公告)号：US20080233133A1
公开(公告)日：2008-09-25
申请号：US12070146
申请日：2008-02-15
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00 , C07H21/04
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

4. 发明授权

US07371382B2 Methods of inhibiting αvβ3-mediated binding with αvβ3-specific antibodies 失效
标题翻译：抑制alphavbeta3介导的与alphavbeta3特异性抗体结合的方法
公开(公告)号：US07371382B2
公开(公告)日：2008-05-13
申请号：US10305231
申请日：2002-11-25
申请人： William D Huse , Herren Wu
发明人： William D Huse , Herren Wu
IPC分类号： A61K39/395 , C07K16/28 , C12N15/12
CPC分类号： C07K16/2848 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αVβ3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of αVβ3 by contacting αVβ3 with an enhanced LM609 grafted antibody.
摘要翻译：本发明提供了增强的显示对α3β3的选择性结合亲和力的LM609接枝抗体或其功能片段。本发明还提供编码增强的LM609接枝抗体的核酸分子。另外提供的方法是通过使α3 -V 3β3与增强的3'端接触来抑制α3β3的功能 LM609接枝抗体。

5. 发明授权

US07365167B2 Humanized collagen antibodies and related methods 失效
标题翻译：人源化胶原抗体及相关方法
公开(公告)号：US07365167B2
公开(公告)日：2008-04-29
申请号：US09995529
申请日：2001-11-26
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译：本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性隐形胶原表位的结合活性。本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。

6. 发明授权

US07229619B1 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 有权
标题翻译：给予/给予抗RSV抗体进行预防和治疗的方法
公开(公告)号：US07229619B1
公开(公告)日：2007-06-12
申请号：US09724531
申请日：2000-11-28
申请人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
发明人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
IPC分类号： A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection.
摘要翻译：本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为所述抗体或抗体片段在所述人受试者中实现。本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定所述抗体或抗体片段的血清滴度在所述人受试者中实现。本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法。

7. 发明授权

US07179900B2 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 失效
标题翻译：给予/给予抗RSV抗体进行预防和治疗的方法
公开(公告)号：US07179900B2
公开(公告)日：2007-02-20
申请号：US10403180
申请日：2003-03-31
申请人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
发明人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
IPC分类号： A61K39/42 , A61K39/155
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis of a RSV infection.
摘要翻译：本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为所述抗体或抗体片段在所述人受试者中实现。本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定所述抗体或抗体片段的血清滴度在所述人受试者中实现。本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法。

8. 发明授权

US07101978B2 TNF-α binding molecules 失效
标题翻译： TNF-α结合分子
公开(公告)号：US07101978B2
公开(公告)日：2006-09-05
申请号：US10338552
申请日：2003-01-08
申请人： Jeffry D. Watkins , Alain P. Vasserot , David Marquis , William D. Huse
发明人： Jeffry D. Watkins , Alain P. Vasserot , David Marquis , William D. Huse
IPC分类号： C07K16/00 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , G01N2333/525
摘要： The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
摘要翻译：本发明涉及TNF-α结合分子和编码TNF-α结合分子的核酸序列。特别地，本发明涉及具有高结合亲和力，高缔合率，相对于人TNF-α的低解离速率且能够以低浓度中和TNF-α的TNF-α结合分子。优选地，本发明的TNF-α结合分子包含具有完全人框架（例如人种系框架）的轻链和/或重链可变区。

9. 发明授权

US06258530B1 Surface expression libraries of randomized peptides 失效
标题翻译：随机肽的表面表达文库
公开(公告)号：US06258530B1
公开(公告)日：2001-07-10
申请号：US08367685
申请日：1994-12-30
申请人： William D. Huse
发明人： William D. Huse
IPC分类号： C12Q168
CPC分类号： C40B40/02 , C07K14/005 , C07K14/675 , C07K2319/00 , C12N15/1037 , C12N15/66 , C12N15/70 , C12N2795/14122 , C12Q1/6811
摘要： A composition of matter comprising a plurality of procaryotic cells containing a diverse population of expressible oligonucleotides operationally linked to expression elements, said expressible oligonucleotides having a desirable bias of random codon sequences.
摘要翻译：包含多个含有可操作地与表达元件连接的可表达寡核苷酸群的多种原核细胞的物质组合物，所述可表达的寡核苷酸具有所需的随机密码子序列的偏倚。

10. 发明授权

US5808022A Oligonucleotides having random riplets 失效
标题翻译：具有随机串联的寡核苷酸
公开(公告)号：US5808022A
公开(公告)日：1998-09-15
申请号：US468478
申请日：1995-06-05
申请人： William D. Huse
发明人： William D. Huse
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H21/00
摘要： The invention provides a method of synthesizing oligonucleotides having random tuplets using individual monomers. The steps consist of: (1) sequentially coupling monomers on separate supports to form at least two different tuplets, the coupling is performed in separate reaction vessels; (2) mixing the supports from the reaction vessels; (3) dividing the mixed supports into two or more separate reaction vessels; and (4) repeating steps (1) through (3) one or more times in the reaction vessels of step (3), wherein the last step ends at step (2). Additionally, the oligonucleotides can be cleaved from the supports.
摘要翻译：本发明提供了使用单独单体合成具有随机团的寡核苷酸的方法。步骤包括：（1）在单独的载体上顺序偶联单体以形成至少两个不同的组合，偶联在单独的反应容器中进行; （2）将来自反应容器的载体混合; （3）将混合的载体分成两个或更多个分离的反应容器; 和（4）在步骤（3）的反应容器中重复步骤（1）至（3）一次或多次，其中最后步骤在步骤（2）结束。另外，寡核苷酸可以从载体上裂解。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式