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1. 发明申请

US20080251081A1 Systems for Removing Dimethyl Sulfoxide (Dmso) or Related Compounds or Odors Associated with Same 有权
标题翻译：用于除去二甲基亚砜（Dmso）或与之相关的相关化合物或气味的系统
公开(公告)号：US20080251081A1
公开(公告)日：2008-10-16
申请号：US12066485
申请日：2006-09-11
申请人： Harvey L. Claussen , Colette Cozean
发明人： Harvey L. Claussen , Colette Cozean
IPC分类号： A61L9/014 , G01N21/62 , A62B7/10 , B01D53/04
CPC分类号： A61M16/0087 , A41D13/1115 , A41D13/1123 , A41D13/1192 , A61L9/014 , A61M16/0093 , A61M16/06 , A61M16/105 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M16/208 , A61M2205/7527 , A62B23/00 , B01D53/02 , B01D53/04 , B01D53/508 , B01D2253/202 , B01D2253/311 , B01D2257/306 , B01D2257/90 , B01D2257/91 , B01D2259/4533 , B01D2259/4541 , B01J20/28085
摘要： Preferred embodiments of the invention relate to systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same. The systems include adsorbents, odor adsorbing fabrics, masks, clean air members and clean air supply assemblies.
摘要翻译：本发明的优选实施方案涉及用于除去二甲基亚砜（DMSO）或相关化合物或与其相关的气味的系统。这些系统包括吸附剂，气味吸附织物，面罩，清洁空气构件和清洁空气供应组件。

2. 发明授权

US5422899A High repetition rate mid-infrared laser 失效
公开(公告)号：US5422899A
公开(公告)日：1995-06-06
申请号：US240255
申请日：1994-05-10
申请人： Robert J. Freiberg , Colette Cozean
发明人： Robert J. Freiberg , Colette Cozean
IPC分类号： A61B18/20 , H01S3/04 , H01S3/042 , H01S3/05 , H01S3/08 , H01S3/091 , H01S3/092 , H01S3/102 , H01S3/16 , H01S3/10
CPC分类号： H01S3/092 , H01S3/042 , H01S3/1022 , A61B18/20 , H01S3/0407 , H01S3/08072 , H01S3/0931 , H01S3/1608
摘要： An optically pumped mid-infrared solid-state laser with high pulse repetition rate is described for use in laser surgery. The laser produces a wavelength between 1.7 and 4.0 microns, and is optically pumped. The rise and fall times of the pump pulses are sufficiently short to avoid thermal lensing induced instability. The laser provides an increased rate of tissue cutting without necessitating an increase in the pulse energy.

3. 发明授权

US5198926A Optics for medical laser 失效
标题翻译：医用激光光学
公开(公告)号：US5198926A
公开(公告)日：1993-03-30
申请号：US644074
申请日：1991-01-18
申请人： Andrew I. Sheinis , Colette Cozean , John F. Forkner , M. John Colles
发明人： Andrew I. Sheinis , Colette Cozean , John F. Forkner , M. John Colles
IPC分类号： A61B18/20 , A61B19/00
CPC分类号： A61B18/201 , A61B34/72 , Y10T292/57
摘要： An optical system for use in a medical laser apparatus comprising an achromat having optical elements selected to cause two substantially different wavelengths, one visible and one infrared, to focus at a common focal point. The achromat comprises a negative lens and a doublet lens formed of a positive bi-convex lens and a negative meniscus lens. The materials of the two lenses which form the doublet have substantially different dispersions and indices of refraction and are chosen to cause a visible helium neon beam and an infrared carbon dioxide beam to focus at the same point. In the preferred embodiment of the present invention, the negative lens is made of zinc selenide, the bi-convex lens of the doublet is made of potassium chloride, and the negative meniscus is made of zinc selenide. The optical system of the present invention can be mounted in a micromanipulator for use in laser surgery. The visible helium neon beam is used as an aiming beam to establish a spot at which the carbon dioxide beam also focuses. The carbon dioxide beam is then employed to vaporize biotic material. A distal end of an articulated arm may couple with the micromanipulator to direct the carbon dioxide beam from the laser through a waveguide and into the micromanipulator. Another aspect of the invention includes introducing the aiming beam into the waveguide through a dichroic mirror positioned in a knuckle joint of the articulated arm. In one embodiment, a laser diode generates the visible light of the aiming beam, and is disposed proximate to the distal end of the articulated arm.
摘要翻译：一种用于医疗激光装置的光学系统，包括具有被选择成使两个基本不同的波长的光学元件的一个消色差，一个可见光和一个红外线聚焦在公共焦点处。消色差包括负透镜和由正双凸透镜和负弯月形透镜形成的双透镜。形成双峰的两个透镜的材料具有基本不同的分散度和折射率，并且被选择为使可见的氦氖光束和红外二氧化碳光束在同一点聚焦。在本发明的优选实施方案中，负透镜由硒化锌制成，双峰的双凸透镜由氯化钾制成，负弯液面由硒化锌制成。本发明的光学系统可以安装在用于激光手术的显微操纵器中。可见氦氖光束用作瞄准光束，以建立二氧化碳光束也聚焦的点。然后使用二氧化碳束来蒸发生物材料。铰接臂的远端可以与显微操纵器耦合以将来自激光器的二氧化碳束引导通过波导并进入显微操纵器。本发明的另一方面包括通过位于关节臂的转向节中的分色镜将瞄准光束引入到波导中。在一个实施例中，激光二极管产生瞄准光束的可见光，并且靠近关节臂的远端设置。

4. 发明申请

US20130018059A1 DIMETHYL SULFOXIDE (DMSO) FORMULATIONS FOR TREATING AUTISM 审中-公开
标题翻译：二甲基亚砜（DMSO）制剂用于治疗药物
公开(公告)号：US20130018059A1
公开(公告)日：2013-01-17
申请号：US13635383
申请日：2011-03-31
申请人： Stanley Jacob , Jesse Cozean , Colette Cozean
发明人： Stanley Jacob , Jesse Cozean , Colette Cozean
IPC分类号： A61K31/10 , A61P1/00 , A61P25/00 , A61K31/519 , A61K31/17
CPC分类号： A61K31/10
摘要： Embodiments of the invention relate generally to formulations comprising dimethyl sulfoxide (DMSO) to treat behavioral disorders, communication delays, and developmental delays. Several formulations disclosed herein are useful for treating broad autism phenotype disorders, including autism spectrum disorders (e.g., autism).
摘要翻译：本发明的实施方案一般涉及包含二甲基亚砜（DMSO）以治疗行为障碍，沟通延迟和发育延迟的制剂。本文公开的几种制剂可用于治疗广泛的自闭症表型障碍，包括自闭症谱系障碍（例如自闭症）。

5. 发明授权

US08298320B2 Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same 有权
标题翻译：用于除去二甲基亚砜（DMSO）或相关化合物或与其相关的气味的系统
公开(公告)号：US08298320B2
公开(公告)日：2012-10-30
申请号：US13099098
申请日：2011-05-02
申请人： Colette Cozean
发明人： Colette Cozean
IPC分类号： A61L9/014 , A62B7/10
CPC分类号： A61M16/0087 , A41D13/1115 , A41D13/1123 , A41D13/1192 , A61L9/014 , A61M16/0093 , A61M16/06 , A61M16/105 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M16/208 , A61M2205/7527 , A62B23/00 , B01D53/02 , B01D53/04 , B01D53/508 , B01D2253/202 , B01D2253/311 , B01D2257/306 , B01D2257/90 , B01D2257/91 , B01D2259/4533 , B01D2259/4541 , B01J20/28085
摘要： Preferred embodiments of the invention relate to systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same. The systems include adsorbents, odor adsorbing fabrics, masks, clean air members and clean air supply assemblies.
摘要翻译：本发明的优选实施方案涉及用于除去二甲基亚砜（DMSO）或相关化合物或与其相关的气味的系统。这些系统包括吸附剂，气味吸附织物，面罩，清洁空气构件和清洁空气供应组件。

6. 发明申请

US20110203585A1 ACTIVATED CARBON SYSTEMS FOR FACILITATING USE OF DIMETHYL SULFOXIDE (DMSO) BY REMOVAL OF SAME, RELATED COMPOUNDS, OR ASSOCIATED ODORS 有权
标题翻译：用于促进使用二甲基硅氧烷（DMSO）的活性炭体系，通过除去它们，相关化合物或相关的气味
公开(公告)号：US20110203585A1
公开(公告)日：2011-08-25
申请号：US13099120
申请日：2011-05-02
申请人： Jesse Cozean , Colette Cozean , Efrain Gonzales , Stanley W. Jacob
发明人： Jesse Cozean , Colette Cozean , Efrain Gonzales , Stanley W. Jacob
IPC分类号： A61M16/10
CPC分类号： A61M16/06 , A61M16/0093 , A61M16/105 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M16/208 , A61M2205/7527
摘要： Several embodiments of the invention relate to systems and methods for removing compositions comprising dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same. In several embodiments, the systems include activated carbon filters, adsorbents, odor adsorbing fabrics, masks, clean air members and clean air supply assemblies. Methods for reducing the concentration of a DMSO metabolite, or the odors associated with said DMSO metabolite are provided in some embodiments. In some embodiments the systems and methods facilitating the treatment of traumatic brain injury, ischemic stroke, atherosclerosis, spinal cord trauma, and neurodegenerative illnesses with compositions comprising DMSO.
摘要翻译：本发明的几个实施方案涉及用于除去包含二甲亚砜（DMSO）或相关化合物或与其相关的气味的组合物的组合物的系统和方法。在几个实施方案中，系统包括活性炭过滤器，吸附剂，气味吸附织物，掩模，清洁空气构件和清洁空气供应组件。在一些实施方案中提供了降低DMSO代谢物浓度或与所述DMSO代谢物相关的气味的方法。在一些实施方案中，使用包含DMSO的组合物促进治疗创伤性脑损伤，缺血性中风，动脉粥样硬化，脊髓创伤和神经变性疾病的系统和方法。

7. 发明授权

US07955418B2 Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same 有权
标题翻译：用于除去二甲基亚砜（DMSO）或与其相关的相关化合物或气味的系统
公开(公告)号：US07955418B2
公开(公告)日：2011-06-07
申请号：US12066485
申请日：2006-09-11
申请人： Harvey L. Claussen , Colette Cozean
发明人： Harvey L. Claussen , Colette Cozean
IPC分类号： A61L9/014 , A62B7/10
CPC分类号： A61M16/0087 , A41D13/1115 , A41D13/1123 , A41D13/1192 , A61L9/014 , A61M16/0093 , A61M16/06 , A61M16/105 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M16/208 , A61M2205/7527 , A62B23/00 , B01D53/02 , B01D53/04 , B01D53/508 , B01D2253/202 , B01D2253/311 , B01D2257/306 , B01D2257/90 , B01D2257/91 , B01D2259/4533 , B01D2259/4541 , B01J20/28085
摘要： Preferred embodiments of the invention relate to systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same. The systems include adsorbents, odor adsorbing fabrics, masks, clean air members and clean air supply assemblies.
摘要翻译：本发明的优选实施方案涉及用于除去二甲基亚砜（DMSO）或相关化合物或与其相关的气味的系统。这些系统包括吸附剂，气味吸附织物，面罩，清洁空气构件和清洁空气供应组件。

8. 发明申请

US20050255053A1 Compositions and methods for preventing tooth decay 审中-公开
标题翻译：防止蛀牙的组合物和方法
公开(公告)号：US20050255053A1
公开(公告)日：2005-11-17
申请号：US11185380
申请日：2005-07-20
申请人： Colette Cozean , Lynn Powell , Samir Nammour
发明人： Colette Cozean , Lynn Powell , Samir Nammour
IPC分类号： A61C1/00 , A61C5/00 , A61K8/21 , A61Q11/00 , A61K7/16 , A61K7/18
CPC分类号： A61K8/21 , A61C1/0046 , A61K2800/81 , A61Q11/00 , Y10S514/835
摘要： A method for preventing tooth decay by initially treating the tooth surface with a laser with a coherent or incoherent light source is provided. In one embodiment, this process makes the tooth more resistant to acid and more able to bond fluoride, thus requiring a lower concentration of fluoride. In one embodiment, the method allows for a deeper penetration of the tooth then previously accomplished with other methods. Low concentration fluoride compositions are also provided.
摘要翻译：提供了一种通过用具有相干或非相干光源的激光器首先处理牙齿表面来防止蛀牙的方法。在一个实施方案中，该方法使得牙齿更耐酸，更能够结合氟化物，因此需要较低浓度的氟化物。在一个实施例中，该方法允许以前用其它方法完成的牙齿的较深穿透。还提供了低浓度的氟化物组合物。

9. 发明授权

US5741245A Corneal sculpting using laser energy 失效
标题翻译：使用激光能量的角膜造型
公开(公告)号：US5741245A
公开(公告)日：1998-04-21
申请号：US384243
申请日：1995-02-06
申请人： Colette Cozean , Robert J. Freiberg , HeeJung Koh Wescoat
发明人： Colette Cozean , Robert J. Freiberg , HeeJung Koh Wescoat
IPC分类号： A61B18/20 , A61B17/00 , A61F9/007 , A61F9/01 , A61M1/00 , A61N5/06
CPC分类号： A61F9/008 , A61F9/00804 , A61B2017/00172 , A61B2017/00973 , A61B2018/204 , A61F2009/00844 , A61F2009/00872 , A61F2009/00882
摘要： A corneal sculpting system utilized for performing surgery to reshape the cornea of the eye. The system includes a laser delivery system that is coupled to a filter positioning system and a corneal topography system. The filter positioning system suspends a sculpting filter above the surface of the cornea. The sculpting filter controls the level of tissue removal that occurs in each area of the cornea by absorbing a certain percentage of the incident laser energy in various areas of the filter. The positioning system also has a conduit for delivering water to the corneal surface. A thin layer of water is heated by the application of the laser to cause microexplosions that dislodge and propel the tissue to ablate the cornea. The corneal topography system provides real time feedback on the curvature of the cornea, before during and after the surgery.
摘要翻译：用于进行手术以重塑眼睛角膜的角膜造型系统。该系统包括耦合到过滤器定位系统和角膜地形系统的激光传送系统。过滤器定位系统将雕刻过滤器悬挂在角膜表面上方。雕刻过滤器通过在过滤器的各个区域吸收一定百分比的入射激光能量来控制在角膜的每个区域中发生的组织去除水平。定位系统还具有用于将水输送到角膜表面的导管。通过施加激光来加热薄层的水，导致微小的爆炸物移动并推动组织以烧蚀角膜。角膜地形系统在手术之前和之后提供角膜曲率的实时反馈。

10. 发明授权

US5688261A Transparent laser surgical probe 失效
标题翻译：透明激光手术探针
公开(公告)号：US5688261A
公开(公告)日：1997-11-18
申请号：US419511
申请日：1995-04-07
申请人： Varouj D. Amirkhanian , Colette Cozean
发明人： Varouj D. Amirkhanian , Colette Cozean
IPC分类号： A61B18/22 , A61B18/24 , A61F9/011 , A61B17/36
CPC分类号： A61F9/008 , A61B18/22 , A61B18/24 , A61B2018/2266 , A61B2018/2272 , A61F2009/00868 , A61F2009/0087 , A61F2009/00872 , A61F2009/00887 , A61F2009/00889 , A61F2009/00891
摘要： A laser surgical apparatus is disclosed in which laser energy can be directed at an angle relative to the longitudinal axis of the probe. The probe includes a reflecting surface directing the laser energy. The reflecting surface is transparent to visible light. In a preferred embodiment, the reflecting surface is on a rod cut at an angle to form a wedge, and a collimator is used to collimate the light beam before it reaches the reflecting surface.
摘要翻译：公开了一种激光手术装置，其中可以相对于探针的纵向轴线以一定角度引导激光能量。探针包括引导激光能量的反射表面。反射面对可见光透明。在优选实施例中，反射表面处于以一定角度切割的杆上以形成楔形物，并且准直器用于在光束到达反射表面之前准直光束。

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