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1. 发明授权

US07373255B2 Method and system for determination of molecular interaction parameters 有权
标题翻译：测定分子相互作用参数的方法和系统
公开(公告)号：US07373255B2
公开(公告)日：2008-05-13
申请号：US10861098
申请日：2004-06-04
申请人： Robert Karlsson , Karl Andersson , Christina Wass
发明人： Robert Karlsson , Karl Andersson , Christina Wass
IPC分类号： G01N7/00
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

2. 发明授权

US08321152B2 Method and system for determination of molecular interaction parameters 有权
标题翻译：测定分子相互作用参数的方法和系统
公开(公告)号：US08321152B2
公开(公告)日：2012-11-27
申请号：US13038432
申请日：2011-03-02
申请人： Robert Karlsson , Karl Andersson , Christina Wass
发明人： Robert Karlsson , Karl Andersson , Christina Wass
IPC分类号： G06F7/00
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

3. 发明申请

US20110152118A1 METHOD AND SYSTEM FOR DETERMINATION OF MOLECULAR INTERACTION PARAMETERS 有权
标题翻译：用于确定分子相互作用参数的方法和系统
公开(公告)号：US20110152118A1
公开(公告)日：2011-06-23
申请号：US13038432
申请日：2011-03-02
申请人： ROBERT KARLSSON , Karl Andersson , Christina Wass
发明人： ROBERT KARLSSON , Karl Andersson , Christina Wass
IPC分类号： C40B30/04
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

4. 发明授权

US07642058B2 Method and apparatus for characterization of interactions 有权
标题翻译：用于表征相互作用的方法和装置
公开(公告)号：US07642058B2
公开(公告)日：2010-01-05
申请号：US10861099
申请日：2004-06-04
申请人： Karl Andersson , Christina Wass
发明人： Karl Andersson , Christina Wass
IPC分类号： C12N33/53 , G01N33/48 , C12M1/36
CPC分类号： G01N35/085 , G01N21/553 , G01N21/658 , G01N35/08 , G01N2035/0097 , Y10T436/117497
摘要： The invention relates to a method of characterizing interaction between two species in a liquid environment, wherein a liquid comprising said at least one species is passed as a flow through a measurement system, and wherein the interaction takes place within said measurement system. The method comprises generating a concentration gradient of at least a first one of said species or of at least one other species having an influence on the interaction or on interacted components. The flow of liquid is passed through a sensor device, and a result of interaction between said at least two species is detected. The flow of liquid is intersected at least once with a further liquid before the flow is passed through said sensor, so as to create at least two separated liquid segments having different concentrations of at least one of said species forming the concentration gradient.
摘要翻译：本发明涉及一种在液体环境中表征两种物质之间的相互作用的方法，其中包含所述至少一种物质的液体作为流动通过测量系统，并且其中所述相互作用发生在所述测量系统内。所述方法包括产生至少第一种所述物种或至少一种对相互作用或相互作用的组分具有影响的其它物质的浓度梯度。液体的流动通过传感器装置，并且检测所述至少两种之间的相互作用的结果。在流过所述传感器之前，液体的流动与另外的液体相交至少一次，以便产生具有不同浓度的至少一种形成浓度梯度的物质的至少两个分离的液体段。

5. 发明申请

US20080227206A1 METHOD AND SYSTEM FOR DETERMINATION OF MOLECULAR INTERACTION PARAMETERS 有权
标题翻译：用于确定分子相互作用参数的方法和系统
公开(公告)号：US20080227206A1
公开(公告)日：2008-09-18
申请号：US12105355
申请日：2008-04-18
申请人： ROBERT KARLSSON , KARL ANDERSSON , CHRISTINA WASS
发明人： ROBERT KARLSSON , KARL ANDERSSON , CHRISTINA WASS
IPC分类号： G01N33/00
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

6. 发明申请

US20050019933A1 Method and apparatus for characterization of interactions 有权
标题翻译：用于表征相互作用的方法和装置
公开(公告)号：US20050019933A1
公开(公告)日：2005-01-27
申请号：US10861099
申请日：2004-06-04
申请人： Karl Andersson , Christina Wass
发明人： Karl Andersson , Christina Wass
IPC分类号： G01N20060101 , G01N21/55 , G01N35/00 , G01N35/08
CPC分类号： G01N35/085 , G01N21/553 , G01N21/658 , G01N35/08 , G01N2035/0097 , Y10T436/117497
摘要： The invention relates to a method of characterizing interaction between two species in a liquid environment, wherein a liquid comprising said at least one species is passed as a flow through a measurement system, and wherein the interaction takes place within said measurement system. The method comprises generating a concentration gradient of at least a first one of said species or of at least one other species having an influence on the interaction or on interacted components. The flow of liquid is passed through a sensor device, and a result of interaction between said at least two species is detected. The flow of liquid is intersected at least once with a further liquid before the flow is passed through said sensor, so as to create at least two separated liquid segments having different concentrations of at least one of said species forming the concentration gradient.
摘要翻译：本发明涉及一种在液体环境中表征两种物质之间的相互作用的方法，其中包含所述至少一种物质的液体作为流动通过测量系统，并且其中所述相互作用发生在所述测量系统内。所述方法包括产生至少第一种所述物种或至少一种对相互作用或相互作用的组分具有影响的其它物质的浓度梯度。液体的流动通过传感器装置，并且检测所述至少两种之间的相互作用的结果。在流过所述传感器之前，液体的流动与另外的液体相交至少一次，以便产生具有不同浓度的至少一种形成浓度梯度的物质的至少两个分离的液体段。

7. 发明申请

US20050014179A1 Method and system for determination of molecular interaction parameters 有权
标题翻译：测定分子相互作用参数的方法和系统
公开(公告)号：US20050014179A1
公开(公告)日：2005-01-20
申请号：US10861098
申请日：2004-06-04
申请人： Robert Karlsson , Karl Andersson , Christina Wass
发明人： Robert Karlsson , Karl Andersson , Christina Wass
IPC分类号： B01L3/00 , G01N33/543 , G01N35/08 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/542 , G06F19/00
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

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