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1. 发明申请

US20110152118A1 METHOD AND SYSTEM FOR DETERMINATION OF MOLECULAR INTERACTION PARAMETERS 有权
标题翻译：用于确定分子相互作用参数的方法和系统
公开(公告)号：US20110152118A1
公开(公告)日：2011-06-23
申请号：US13038432
申请日：2011-03-02
申请人： ROBERT KARLSSON , Karl Andersson , Christina Wass
发明人： ROBERT KARLSSON , Karl Andersson , Christina Wass
IPC分类号： C40B30/04
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

2. 发明申请

US20080227206A1 METHOD AND SYSTEM FOR DETERMINATION OF MOLECULAR INTERACTION PARAMETERS 有权
标题翻译：用于确定分子相互作用参数的方法和系统
公开(公告)号：US20080227206A1
公开(公告)日：2008-09-18
申请号：US12105355
申请日：2008-04-18
申请人： ROBERT KARLSSON , KARL ANDERSSON , CHRISTINA WASS
发明人： ROBERT KARLSSON , KARL ANDERSSON , CHRISTINA WASS
IPC分类号： G01N33/00
CPC分类号： G01N33/6854 , B01L3/5027 , G01N33/53 , G01N33/543 , G01N35/08 , G01N2333/912 , G01N2333/936 , G01N2333/974 , G01N2333/988 , G01N2500/04 , G01N2500/20 , Y10S707/99943
摘要： A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
摘要翻译：确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地，不经过固定配体的中间再生或更新，流过多个含有在固体支持物表面上结合配偶体的不同已知浓度，监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据，并通过全局拟合来确定动力学参数用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型，该模型允许在固体支持物表面的质量传递限制。还公开了用于执行该方法的分析系统，计算机程序，计算机程序产品和用于执行该方法的计算机系统。

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