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    • 4. 发明授权
    • Transcription factor having zinc finger domains
    • 具有锌指结构域的转录因子
    • US08058408B2
    • 2011-11-15
    • US12363650
    • 2009-01-30
    • Chiaki SenooMariko Numata
    • Chiaki SenooMariko Numata
    • C07K14/47C07K14/00
    • C07K14/4705
    • Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.
    • 使用未分化的小鼠CL6细胞系,加入DMSO以诱导其分化为心肌细胞,以获得其诱导表达升高的基因片段。 分离的基因具有锌指结构域,并显示与Sp1家族基因的显着同源性。 此外,分离与该小鼠基因相对应的人类基因。 由该基因编码的蛋白质存在于细胞核中并结合到GC盒上。 显示蛋白质以抑制CMV启动子的转录调节活性,从而作为转录因子。