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1. 发明申请

US20050250144A1 Novel genes encoding protein kinase/protein phosphatase 审中-公开
标题翻译：编码蛋白激酶/蛋白磷酸酶的新基因
公开(公告)号：US20050250144A1
公开(公告)日：2005-11-10
申请号：US11109156
申请日：2005-04-19
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Chiaki Senoo , Jin-Ichi Nezu
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Chiaki Senoo , Jin-Ichi Nezu
IPC分类号： A61K38/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N9/12 , C12N9/16 , C12N15/09 , C12P21/06
CPC分类号： C07K14/4702 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C12N2799/021
摘要： Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.
摘要翻译：已经在螺旋研究所（螺旋克隆，日本专利申请2000-183767）中确定了已经分离的克隆的克隆和/或磷酸酶样结构的克隆及其结构的选择。通过使用已知的激酶和磷酸酶的氨基酸序列作为查询，通过对所有螺旋克隆进行同源性检索来提供两个新基因。这些基因预期参与细胞内信号转导。可以通过使用能够检测信号转导的报告基因测定系统来测试本发明基因的生理功能。本发明的蛋白质可用作药物发现和开发新药物中的靶分子。

2. 发明授权

US08110662B2 Antibody directed to protein involved in maintaining differentiation of smooth muscle cells 有权
标题翻译：涉及保持平滑肌细胞分化的蛋白质的抗体
公开(公告)号：US08110662B2
公开(公告)日：2012-02-07
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： C07K16/00 , A61K39/00
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

3. 发明申请

US20080069826A1 Novel Genes Associated with the Maintenance of Differentiation of Smooth Muscle Cells 有权
标题翻译：与维持平滑肌细胞分化相关的新基因
公开(公告)号：US20080069826A1
公开(公告)日：2008-03-20
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： A61K39/00 , A61P43/00 , C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

4. 发明授权

US07279558B2 Genes associated with the maintenance of differentiation of smooth muscle cells 有权
标题翻译：与维持平滑肌细胞分化相关的基因
公开(公告)号：US07279558B2
公开(公告)日：2007-10-09
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： C12N9/02 , C12N15/70 , C12N5/16 , C12Q1/68 , C12P21/06 , A61K38/00 , C07H21/04
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

5. 发明申请

US20050164934A1 Novel genes associated with the maintenance of differentiation of smooth muscle cells 有权
标题翻译：与维持平滑肌细胞分化相关的新基因
公开(公告)号：US20050164934A1
公开(公告)日：2005-07-28
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07K14/705 , C07K16/28
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

6. 发明授权

US06908748B2 Genes associated with the maintenance of differentiation of smooth muscle cells 有权
标题翻译：与维持平滑肌细胞分化相关的基因
公开(公告)号：US06908748B2
公开(公告)日：2005-06-21
申请号：US10058518
申请日：2002-01-28
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

7. 发明申请

US20070105122A1 Primers for synthesizing full-length cDNA and their use 审中-公开
标题翻译：用于合成全长cDNA的引物及其用途
公开(公告)号：US20070105122A1
公开(公告)日：2007-05-10
申请号：US10917503
申请日：2004-08-13
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Saito , Junichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Saito , Junichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47
摘要： Primers for synthesizing full-length cDNAs and their use are provided. 5602 cDNA encoding a human protein has been isolated and nucleotide sequences of 5′-, and 3′-ends of the cDNA have been determined. Furthermore, primers for synthesizing the full-length cDNA have been provided to clarify the function of the protein encoded by the cDNA. The full-length cDNA of the present invention containing the translation start site provides information useful for analyzing the functions of the protein.
摘要翻译：提供了用于合成全长cDNA的引物及其用途。已经分离了编码人蛋白质的cDNA，已经确定了cDNA的5'和3'末端的核苷酸序列。此外，提供了用于合成全长cDNA的引物以阐明由cDNA编码的蛋白质的功能。含有翻译起始位点的本发明的全长cDNA提供了可用于分析蛋白质功能的信息。

8. 发明申请

US20070082345A1 Secretory protein or membrane protein 审中-公开
标题翻译：分泌蛋白或膜蛋白
公开(公告)号：US20070082345A1
公开(公告)日：2007-04-12
申请号：US11429594
申请日：2006-05-08
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C07K14/505 , C07K14/47
摘要： Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides of the present invention are used to produce these proteins.
摘要翻译：提供新的人类分泌蛋白或膜蛋白，以及编码蛋白质的全长cDNA。已经分离了173种新型蛋白质和编码这些蛋白质的多核苷酸。本发明的蛋白质可用作药物的候选物或用作开发药物的靶分子。本发明的多核苷酸用于制备这些蛋白质。

9. 发明授权

US07129338B1 Secretory protein or membrane protein 失效
标题翻译：分泌蛋白或膜蛋白
公开(公告)号：US07129338B1
公开(公告)日：2006-10-31
申请号：US10305278
申请日：2002-11-27
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Kawai , Tomoyasu Sugiyama , Koji Hayashi
IPC分类号： C07H19/167 , C07H19/173
CPC分类号： C07K14/47 , C07K14/505
摘要： Human cDNA encoding a secretory or membrane protein useful as a candidate for developing medicine or as a target molecule for developing medicine. The expression level of the polynucleotide of the present invention increased in NT2 cells after retinoic acid-treatment. Accordingly, this cDNA is associated neurological disease.
摘要翻译：编码分泌蛋白或膜蛋白的人类cDNA可用作开发药物或用作开发药物的靶分子。在视黄酸处理后，本发明的多核苷酸的表达量在NT2细胞中增加。因此，该cDNA与神经系统疾病相关。

10. 发明授权

US09127886B2 Multistage furnace system 有权
标题翻译：多级炉系统
公开(公告)号：US09127886B2
公开(公告)日：2015-09-08
申请号：US13826688
申请日：2013-03-14
申请人： Koji Hayashi , Taichi Shimizu
发明人： Koji Hayashi , Taichi Shimizu
IPC分类号： F27D3/06 , F27B1/02 , F27B9/02 , F27D9/00 , F27B1/20 , F27B9/24 , F27B9/38 , F27B9/39 , F27B9/40
CPC分类号： F27B1/02 , F27B1/20 , F27B9/021 , F27B9/028 , F27B9/2469 , F27B9/38 , F27B9/39 , F27B9/40 , F27D9/00
摘要： The invention provides a multistage heating system including a compact multistage furnace of which the installation area in a factory is decreased and a work carrier machine. A multistage furnace is configured by piling up a plurality of furnace units in the vertical direction. Each of the furnace units includes an upper heater and a lower heater, support pipes disposed on the upper heater and extending in the horizontal direction, and a plurality of work support bars mounted over the support pipes. A work carrier machine includes work carrier bars extending in the horizontal direction, a horizontal motion mechanism connecting the ends of the work carrier bars and move the work carrier bars on horizontal rails, and a vertical motion mechanism moving the body of the work carrier machine including the horizontal rails on vertical rails.
摘要翻译：本发明提供了一种多级加热系统，其包括紧凑型多级炉，其中工厂的安装面积减小，工作承载机。多级炉通过在垂直方向上堆叠多个炉单元构成。每个炉单元包括上加热器和下加热器，设置在上加热器上并在水平方向上延伸的支撑管，以及安装在支撑管上的多个工作支撑杆。工作载体机器包括沿水平方向延伸的工作承载杆，连接工作承载杆的端部并将工作承载杆移动到水平轨道上的水平运动机构，以及使工作承载机的主体移动的垂直运动机构，包括垂直导轨上的水平导轨。

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