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1. 发明授权

US6063775A Retardation of metalloproteinase incidental to HIV and/or AIDS 失效
标题翻译：与HIV和/或艾滋病有关的金属蛋白酶的延迟
公开(公告)号：US6063775A
公开(公告)日：2000-05-16
申请号：US848290
申请日：1997-04-29
申请人： Charles L. Berman
发明人： Charles L. Berman
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： The instant invention provides a product of manufacture for retarding the biochemical formation of metalloproteinase, including gelatinase, elastase, collaginase, and the like, within the tissues of the body of a patient who has been inflicted with the HIV virus and/or the HIV virus which has advance to the AIDS virus, through the administration of an effective amount of a non-antimicrobial/non-antibiotic/non-antibacterial, chemically modified tetracycline (CMT) analog, its salts, cojugates and/or derivatives, and combinations thereof.
摘要翻译：本发明提供了一种制造产品，用于在已经施用HIV病毒和/或HIV病毒的患者的身体的组织内延缓金属蛋白酶的生化形成，包括明胶酶，弹性蛋白酶，胶原蛋白酶等。其通过施用有效量的非抗微生物/非抗生素/非抗菌化学修饰的四环素（CMT）类似物，其盐，缀合物和/或衍生物及其组合而向AIDS病毒发展。

2. 发明授权

US06384081B2 Treatment of diseases of the eye characterized by the formation of metalloproteinase 失效
标题翻译：治疗以金属蛋白酶形成为特征的眼睛疾病
公开(公告)号：US06384081B2
公开(公告)日：2002-05-07
申请号：US09169660
申请日：1998-10-09
申请人： Charles L. Berman
发明人： Charles L. Berman
IPC分类号： A61K31165
CPC分类号： A61K45/06 , A61K31/00 , A61K31/65 , Y10S514/912
摘要： The instant invention provides a method of inhibiting the formation of metalloproteinase and its species, within the eyes of a patient inflicted with at least one form of retinitis characterized by the presence of metalloproteinase, through the administration of an effective dosage that includes an a tetracycline analog, its salts, conjugates or derivatives. In an alternate preferred embodiment of the invention, the dosage includes at least one other therapeutic substance in effective combination with a tetracyline analog.
摘要翻译：本发明提供一种抑制金属蛋白酶及其物质形成的方法，所述方法通过施用包含四环素类似物的有效剂量，在患有至少一种以金属蛋白酶存在为特征的视网膜炎形式的患者的眼睛内，其盐，缀合物或衍生物。在本发明的替代优选实施方案中，剂量包括与四环素类似物有效组合的至少一种其它治疗物质。

3. 发明授权

US06224635B1 Implantation of surgical implants with calcium sulfate 失效
标题翻译：用硫酸钙植入外科植入物
公开(公告)号：US06224635B1
公开(公告)日：2001-05-01
申请号：US09187584
申请日：1998-11-06
申请人： John Ricci , Harold Alexander , Charles L. Berman , Sally Frenkel , Bruce Hollander , Gabriele Pecora
发明人： John Ricci , Harold Alexander , Charles L. Berman , Sally Frenkel , Bruce Hollander , Gabriele Pecora
IPC分类号： A61K608
CPC分类号： A61K6/0625 , A61C8/0012 , A61F2/28 , A61F2/30767 , A61F2002/30062 , A61F2002/4631 , A61F2210/0004 , A61F2310/00023 , A61F2310/00089 , A61F2310/00131 , A61F2310/00796 , A61F2310/00952 , A61L24/0089 , A61L24/02
摘要： The present invention relates to techniques for the preparation and implantation of implants with surgical cements composed primarily of calcium sulfate (“CS”). The first of these novel techniques involves the steps of: (1.) precoating an implant with CS; (2.) permitting the implant to dry, and, (3.) thereafter grouting the implant in place with wet CS. The second embodiment involves: (1.) grouting an uncoated implant in place with wet CS. Finally, the third embodiment involves: (1.) precoating an implant with CS; (2.) permitting it to dry; and, (2.) subsequently press-fitting the implant in place without grouting.
摘要翻译：本发明涉及用主要由硫酸钙（“CS”）组成的手术水泥制备和植入植入物的技术。这些新技术中的第一个涉及以下步骤：（1）用CS预处理植入物; （2.）允许植入物干燥，和（3.）此后用湿CS将植入物灌浆就位。第二实施例涉及：（1）用湿CS将未涂覆的植入物注入适当位置。最后，第三实施例涉及：（1）用CS预涂植入物; （2）允许干燥; 和（2.）随后将植入物按压在适当位置而不进行灌浆。

4. 发明授权

US5257201A Method to efficiently reduce the number of connections in a circuit 失效
标题翻译：有效减少电路中连接数量的方法
公开(公告)号：US5257201A
公开(公告)日：1993-10-26
申请号：US394247
申请日：1989-08-14
申请人： Charles L. Berman , Louise H. Trevillyan
发明人： Charles L. Berman , Louise H. Trevillyan
IPC分类号： G06F17/50 , G06F15/60
CPC分类号： G06F17/505
摘要： A provided logic circuitry implementation in a given technology includes n signals and m nodes. A final logic circuitry implementation is produced therefrom which is the functional equivalent of, and contains fewer connections than, the provided logic circuitry implementation. A given one of the n signals is first processed, and global information is computed for this signal. A graphical representation of connections between the m nodes is derived from the computed global information. A list of nodes that form a cut-set is produced from the graphical representation, and an optimized logic circuitry implementation is provided as a function thereof. Each of the remaining ones of the n signals are processed sequentially, as above, to form successive optimized logic circuitry implementations, with the processing of the nth signal resulting in the final logic circuitry implementation.
摘要翻译：在给定技术中提供的逻辑电路实现包括n个信号和m个节点。由此产生最终逻辑电路实现，其与所提供的逻辑电路实现的功能等同于并且包含更少的连接。首先对n个信号中的一个信号进行处理，并计算该信号的全局信息。从所计算的全局信息中导出m个节点之间的连接的图形表示。从图形表示产生形成剪切集的节点的列表，并且作为其功能提供优化的逻辑电路实现。如上所述，依次对n个信号中的剩余信号中的每一个进行处理，以形成连续优化的逻辑电路实现，第n个信号的处理产生最终的逻辑电路实现。

5. 发明授权

US4816999A Method of detecting constants and removing redundant connections in a logic network 失效
标题翻译：在逻辑网络中检测常量并去除冗余连接的方法
公开(公告)号：US4816999A
公开(公告)日：1989-03-28
申请号：US052672
申请日：1987-05-20
申请人： Charles L. Berman , Daniel Brand , Louse H. Trevillyan
发明人： Charles L. Berman , Daniel Brand , Louse H. Trevillyan
IPC分类号： G06F17/50 , G06F15/60
CPC分类号： G06F17/505
摘要： A method of reducing the number of connections in, and increasing the testability of, a logic network. This is accomplished by propagating global controlling information through a graphical representation of the logic network. Logically redundant connections are detected and removed by means of this information.

6. 再颁专利

USRE38386E1 Retardation of metalloproteinase incidental to HIV and/or AIDS 失效
标题翻译：与HIV和/或艾滋病有关的金属蛋白酶的延迟
公开(公告)号：USRE38386E1
公开(公告)日：2004-01-13
申请号：US09973331
申请日：2001-10-09
申请人： Charles L. Berman
发明人： Charles L. Berman
IPC分类号： A61K3165
CPC分类号： A61K31/65
摘要： The instant invention provides a product of manufacture for retarding the biochemical formation of metalloproteinase, including gelatinase, elastase, collaginase, and the like, within the tissues of the body of a patient who has been inflicted with the HIV virus and/or the HIV virus which has advance to the AIDS virus, through the administration of an effective amount of a non-antimicrobial/non-antibiotic/non-antibacterial, chemically modified tetracycline (CMT) analog, its salts, cojugates and/or derivatives, and combinations thereof.

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