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1. 发明申请

US20120129259A1 METHOD FOR PRODUCING A COATED CELL CULTURE CARRIER 审中-公开
标题翻译：生产涂层细胞培养载体的方法
公开(公告)号：US20120129259A1
公开(公告)日：2012-05-24
申请号：US13321844
申请日：2010-05-18
申请人： Jürgen Köcher , Theresia Klose , Tilo Pompe , Philipp Seib , Carsten Werner
发明人： Jürgen Köcher , Theresia Klose , Tilo Pompe , Philipp Seib , Carsten Werner
IPC分类号： C12N5/071 , B05D5/00 , B05D3/00 , C12N5/0775
CPC分类号： C12N5/0068 , C12M23/20 , C12M25/06 , C12N2533/30
摘要： The present invention relates to a method for producing a coated cell culture carrier, wherein a solution comprising a polyurethane urea is applied to a cell carrier and dried. The polyurethane urea is produced beforehand by converting at least one polycarbonate polyol component, at least one polyisocyanate component, and at least one diamino component. The invention further relates to a cell culture carrier obtained according to the method and the use thereof for in-vitro cultivation of stem cells, particularly for cultivating mesenchymal stem cells.
摘要翻译：本发明涉及一种生产包被的细胞培养载体的方法，其中将包含聚氨酯脲的溶液施加到细胞载体上并干燥。通过转化至少一种聚碳酸酯多元醇组分，至少一种多异氰酸酯组分和至少一种二氨基组分，预先制备聚氨酯脲。本发明还涉及根据该方法获得的细胞培养载体及其用于体外培养干细胞的用途，特别是培养间充质干细胞。

2. 发明申请

US20090143792A1 Holding Device for a Membrane, Support for the Holding Device, and Method for Fixing the Membrane to an Eye by Means of the Holding Device 审中-公开
标题翻译：用于膜的保持装置，用于保持装置的支撑，以及通过保持装置将膜固定到眼睛的方法
公开(公告)号：US20090143792A1
公开(公告)日：2009-06-04
申请号：US12296679
申请日：2007-04-05
申请人： Katrin Engelmann , Heinz Korber , Carsten Werner
发明人： Katrin Engelmann , Heinz Korber , Carsten Werner
IPC分类号： A61F9/007
CPC分类号： A61F9/04 , A61F9/0017
摘要： The invention relates to a holding device (10) for an amnion membrane (20), wherein the amnion membrane can be mounted on the eye surface without a suture or any other securing means for medical application. For this purpose, the holding device comprises concentrically arranged rings (12, 14), wherein a first ring acting as inner ring (14) is accommodated in a receiving seat (12a) on the inner face of a second ring acting as outer ring (12), such that the two rings have a common frustoconical inner surface (12b), and wherein the amnion membrane (20) in the area of this receiving seat (12a) is clamped peripherally between the two rings (12, 14) and is arranged covering the common opening (18) of the two rings.
摘要翻译：本发明涉及一种用于羊膜（20）的保持装置（10），其中，羊膜可以安装在眼睛表面上，无需缝合线或用于医疗应用的任何其他固定装置。为此，保持装置包括同心布置的环（12,14），其中作为内圈（14）的第一环容纳在作为外圈的第二环的内表面上的接收座（12a）中使得两个环具有共同的截头圆锥形内表面（12b），并且其中在该接收座（12a）的区域中的羊膜（20）周向地夹在两个环（12,14）之间，并且是布置成覆盖两个环的公共开口（18）。

3. 发明申请

US20060031373A1 Spam filter with sender ranking system 失效
标题翻译：具有发送者排名系统的垃圾邮件过滤器
公开(公告)号：US20060031373A1
公开(公告)日：2006-02-09
申请号：US11150379
申请日：2005-06-10
申请人： Carsten Werner , Mark Usher
发明人： Carsten Werner , Mark Usher
IPC分类号： G06F15/16
CPC分类号： G06Q10/107 , H04L51/12 , H04L51/28
摘要： A spam detection system can monitor incoming and outgoing email messages and prevent email messages from being delivered. This spam detection system incorporates a sender ranking system that maintains prior sender's email addresses and an associated reliability value in a database. If an email message is categorized as spam, the system searches to see if the sender is located in the database. If the sender is located in the database and their reliability value is above a certain threshold, the sender's reliability value is decreased and the email message is treated as not spam. If the sender is not located in the database, the email message is discarded as spam. If an email message is not categorized as spam, prior users located in the database will have their reliability values increased, while new users will be entered into the database at a default level.
摘要翻译：垃圾邮件检测系统可以监控传入和传出的电子邮件消息，并防止传送电子邮件。该垃圾邮件检测系统包含一个发送者排名系统，该系统维护数据库中的先前发件人的电子邮件地址和相关的可靠性值。如果电子邮件消息被分类为垃圾邮件，系统将搜索发送者是否位于数据库中。如果发件人位于数据库中，并且其可靠性值高于某个阈值，则发送者的可靠性值会降低，电子邮件消息被视为非垃圾邮件。如果发件人不在数据库中，电子邮件将被丢弃为垃圾邮件。如果电子邮件消息未被分类为垃圾邮件，那么位于数据库中的先前用户将会增加其可靠性值，同时新用户将以默认级别输入数据库。

4. 发明授权

US5881853A Arrangement for actuating a change-speed gearbox shift mechanism and for engaging and disengaging a main clutch 失效
标题翻译：用于致动变速齿轮箱换档机构并用于接合和分离主离合器的装置
公开(公告)号：US5881853A
公开(公告)日：1999-03-16
申请号：US923870
申请日：1997-09-04
申请人： Carsten Werner Peuster , Martin Stengel , Guenter Woerner
发明人： Carsten Werner Peuster , Martin Stengel , Guenter Woerner
IPC分类号： B60W10/02 , B60K23/02 , B60W10/08 , B60W10/10 , B60W30/18 , F16D27/00 , F16H61/26 , F16H61/28 , F16H61/32 , F16H63/02 , F16H63/20 , F16H63/46 , B60K41/22
CPC分类号： F16H63/46 , B60W10/02 , B60W10/10 , B60W30/1819 , F16D28/00 , F16H61/32 , Y10T74/19251
摘要： An arrangement actuates the shift mechanism of a change-speed gearbox and engages and disengages a main clutch via a common servomotor. The shift mechanism, with the interposition of an auxiliary clutch which can be engaged and disengaged by a servomotor, can be actuated independently of the main clutch.
摘要翻译：一种装置致动变速齿轮箱的变速机构，并通过公共伺服电机使主离合器接合和脱离。可以独立于主离合器来致动换档机构，其中插入可由伺服电动机接合和分离的辅助离合器。

5. 发明授权

US07552186B2 Method and system for filtering spam using an adjustable reliability value 失效
标题翻译：使用可调节可靠性值过滤垃圾邮件的方法和系统
公开(公告)号：US07552186B2
公开(公告)日：2009-06-23
申请号：US11150379
申请日：2005-06-10
申请人： Carsten Werner , Mark Usher
发明人： Carsten Werner , Mark Usher
IPC分类号： G06F15/16
CPC分类号： G06Q10/107 , H04L51/12 , H04L51/28
摘要： A spam detection system can monitor incoming and outgoing email messages and prevent email messages from being delivered. This spam detection system incorporates a sender ranking system that maintains prior sender's email addresses and an associated reliability value in a database. If an email message is categorized as spam, the system searches to see if the sender is located in the database. If the sender is located in the database and their reliability value is above a certain threshold, the sender's reliability value is decreased and the email message is treated as not spam. If the sender is not located in the database, the email message is discarded as spam. If an email message is not categorized as spam, prior users located in the database will have their reliability values increased, while new users will be entered into the database at a default level.
摘要翻译：垃圾邮件检测系统可以监控传入和传出的电子邮件消息，并防止传送电子邮件。该垃圾邮件检测系统包含一个发送者排名系统，该系统维护数据库中的先前发件人的电子邮件地址和相关的可靠性值。如果电子邮件消息被分类为垃圾邮件，系统将搜索发送者是否位于数据库中。如果发件人位于数据库中，并且其可靠性值高于某个阈值，则发送者的可靠性值会降低，电子邮件消息被视为非垃圾邮件。如果发件人不在数据库中，电子邮件将被丢弃为垃圾邮件。如果电子邮件消息未被分类为垃圾邮件，那么位于数据库中的先前用户将会增加其可靠性值，同时新用户将以默认级别输入数据库。

6. 发明申请

US20100273260A1 CELL CULTURE SUBSTRATE AND PROCESS FOR PRODUCING THE SAME AND METHOD FOR CULTURING CELLS 审中-公开
标题翻译：细胞培养基底及其生产方法和培养细胞的方法
公开(公告)号：US20100273260A1
公开(公告)日：2010-10-28
申请号：US12600037
申请日：2008-07-10
申请人： Chiharu Odane , Sakura Toshikawa , Atsuko Mizuike , Hiroyuki Nishii , Takuji Shintani , Carsten Werner , Mirko Nitschke , Walter Eevers
发明人： Chiharu Odane , Sakura Toshikawa , Atsuko Mizuike , Hiroyuki Nishii , Takuji Shintani , Carsten Werner , Mirko Nitschke , Walter Eevers
IPC分类号： C12N5/02 , C12M1/00 , C08G65/00 , C08G63/08
CPC分类号： C12N5/0068 , C08G65/33306 , C08G81/00 , C08G81/024 , C08G2650/50 , C08G2650/58 , C08L51/06 , C08L67/00 , C08L71/02 , C08L2205/05 , C12M23/20 , C12N2533/30 , C12N2533/40 , C08L2666/24 , C08L2666/18
摘要： The present invention relates to a cell culture substrate in which a polymer chain having a hydrophilic skeleton is grafted onto a surface of polystyrene or poly(ε-caprolactone) having a water contact angle of from 75° to 100°. This cell culture substrate has excellent efficiency of cell culture without the necessity of immobilization and adsorption of a cell adhesion substance on a surface of a substrate.
摘要翻译：本发明涉及具有亲水性骨架的聚合物链接枝在聚苯乙烯或具有75°〜100°的水接触角的聚（ε-己内酯）表面上的细胞培养基质。该细胞培养基质的细胞培养效率优异，不需要在基材表面固定化和吸附细胞粘附物质。

7. 发明申请

US20120058943A1 Bioactive Hydrogel 有权
标题翻译：生物活性水凝胶
公开(公告)号：US20120058943A1
公开(公告)日：2012-03-08
申请号：US13131295
申请日：2008-11-28
申请人： Carsten Werner , Uwe Freudenberg , Dorit Meinhold , Marie-Francoise Gouzy , Petra Welzel
发明人： Carsten Werner , Uwe Freudenberg , Dorit Meinhold , Marie-Francoise Gouzy , Petra Welzel
IPC分类号： A61K38/18 , B29D7/01 , A61K47/42 , A61K47/36 , C12N5/071 , A61L31/06
CPC分类号： A61K9/107 , A61K31/727 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/602 , C08B37/0075 , C08B37/0081 , C08J3/075 , C08J3/246 , C08J5/18 , C08J2305/10 , C08J2371/02 , C08L5/10
摘要： The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.
摘要翻译：本发明涉及作为具有官能化端基的肝素和星形支链聚乙二醇的混合材料的生物活性水凝胶，其中肝素通过与1-乙基-3-（3-二甲基氨基丙基）碳二亚胺活化的羧基反应而直接结合 / N-羟基磺基琥珀酰亚胺（EDC / s-NHS）与聚乙二醇的末端氨基通过酰胺键共价。

8. 发明申请

US20110183405A1 MODIFIED MULTIWELL PLATE FOR BIOCHEMICAL ANALYSES AND CELL CULTURE EXPERIMENTS. 审中-公开
标题翻译：用于生物化学分析和细胞培养实验的改性多孔板。
公开(公告)号：US20110183405A1
公开(公告)日：2011-07-28
申请号：US12809211
申请日：2008-12-16
申请人： Tilo Pompe , Kristina Lehmann , Mirko Nitschke , Carsten Werner
发明人： Tilo Pompe , Kristina Lehmann , Mirko Nitschke , Carsten Werner
IPC分类号： C12M1/00
CPC分类号： C08J7/047 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/163 , C08F8/00 , C08J7/12 , C08J2323/12 , C08J2423/08 , C08J2423/14 , C08J2425/08 , G01N33/54353 , C08F8/12 , C08F222/06 , C08F222/08 , C08F210/02 , C08F210/06 , C08F212/08
摘要： The invention relates to a modified multi-well plate for biochemical analyses and cell culture experiments, which can be obtained through a method for functionalization. The method comprises the following process steps: a) Treatment of the multi-well plate by means of an ammonia low-pressure plasma, so that reactive amino groups are formed on the plate surface; b) Application of an aqueous or alcoholic solution of a maleic anhydride copolymer; c) Drying the solution of the maleic anhydride copolymer on the surface; d) Heat treatment for the covalent bonding of the maleic anhydride copolymer to the multi-well plate; e) Rinsing with aqueous solution to eliminate unbound and water-soluble maleic anhydride copolymer f) Heat treatment to reestablish the reactivity of the anhydride groups on the maleic anhydride copolymer.
摘要翻译：本发明涉及用于生物化学分析和细胞培养实验的改良多孔板，其可以通过官能化方法获得。该方法包括以下工艺步骤：a）通过氨低压等离子体处理多孔板，从而在板表面上形成反应性氨基; b）马来酸酐共聚物的水溶液或醇溶液的应用; c）将马来酸酐共聚物的溶液干燥在表面上; d）马来酸酐共聚物与多孔板的共价键合的热处理; e）用水溶液冲洗以消除未结合和水溶性马来酸酐共聚物f）热处理以重新建立马来酸酐共聚物上酸酐基团的反应性。

9. 发明申请

US20090142596A1 METHOD FOR PRODUCING MULTI-LAYERED SURFACE STRUCTURES, PARTICLES OR FIBRES 审中-公开
标题翻译：生产多层表面结构，颗粒或纤维的方法
公开(公告)号：US20090142596A1
公开(公告)日：2009-06-04
申请号：US11718048
申请日：2005-10-20
申请人： Uwe Freudenberg , Stefan Zschoche , Carsten Werner , Kati Schmidt , Sven Holger Behrens , Helmut Auweter
发明人： Uwe Freudenberg , Stefan Zschoche , Carsten Werner , Kati Schmidt , Sven Holger Behrens , Helmut Auweter
IPC分类号： B05D3/10 , B05D7/00 , B32B27/06 , B32B15/02 , D02G3/00
CPC分类号： C08G77/388 , B05D1/185 , B05D3/142 , B05D5/04 , B05D7/52 , D06M15/05 , D06M15/263 , D06M2200/00 , Y10T428/2938 , Y10T428/2998 , Y10T428/3179
摘要： The process for producing multilayered sheetlike structures, particles or fibers comprises the steps of (a) applying a reactive polycarboxylic acid or one of its derivatives atop a sheetlike, particulate or fibrous carrier material already comprising, or previously provided with, groups reactive toward, capable of covalent bonding with, the polycarboxylic acid or one of its derivatives, (b) if appropriate heating the carrier material treated in step (a) to a temperature in the range from 60° C. to 130° C. and preferably to a temperature in the range from 80° C. to 120° C. to hasten, complete or further optimize the covalent bonds, (c) applying atop the carrier material a cellulose capable of covalent bonding with the polycarboxylic acid or its derivatives. The present invention further relates to the use of the present invention's process for production of multilayered sheetlike structures, particles or fibers for hydrophilicizing surfaces, in particular for adhesion promotion between hydrophobic and hydrophilic materials and for improving the washability of synthetic fibers, the surfaces which are hydrophilicized by the process forming the sheetlike, particulate or fibrous carrier material.
摘要翻译：生产多层片状结构物，颗粒或纤维的方法包括以下步骤：（a）将具有反应活性的多元羧酸或其衍生物施加在片状，颗粒状或纤维状载体材料上，与多元羧酸或其衍生物之一共价键合，（b）如果将步骤（a）中处理的载体材料适当加热至60℃至130℃，优选温度在80℃至120℃的范围内加速，完成或进一步优化共价键，（c）在载体材料上方施加能与多元羧酸或其衍生物共价键合的纤维素。本发明还涉及本发明的用于生产用于亲水化表面的多层片状结构，颗粒或纤维的方法的用途，特别是用于疏水和亲水材料之间的粘合促进和用于改善合成纤维的可洗性，通过形成片状，颗粒或纤维载体材料的方法亲水化。

10. 发明授权

US08859706B2 Bioactive hydrogel 有权
标题翻译：生物活性水凝胶
公开(公告)号：US08859706B2
公开(公告)日：2014-10-14
申请号：US13131295
申请日：2008-11-28
申请人： Carsten Werner , Uwe Freudenberg , Dorit Meinhold , Marie-Francoise Gouzy , Petra Welzel
发明人： Carsten Werner , Uwe Freudenberg , Dorit Meinhold , Marie-Francoise Gouzy , Petra Welzel
IPC分类号： A61L33/08 , A61L33/10 , A61L33/12 , A61K38/18 , A61K47/42 , A61K47/36 , C08B37/10 , C08J5/18 , C08J3/075 , C08B37/00 , C08L5/10 , A61L27/54 , A61L27/52 , C08J3/24
CPC分类号： A61K9/107 , A61K31/727 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/602 , C08B37/0075 , C08B37/0081 , C08J3/075 , C08J3/246 , C08J5/18 , C08J2305/10 , C08J2371/02 , C08L5/10
摘要： The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.
摘要翻译：本发明涉及作为具有官能化端基的肝素和星形支链聚乙二醇的混合材料的生物活性水凝胶，其中肝素通过与1-乙基-3-（3-二甲基氨基丙基）碳二亚胺活化的羧基反应而直接结合 / N-羟基磺基琥珀酰亚胺（EDC / s-NHS）与聚乙二醇的末端氨基通过酰胺键共价。

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