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1. 发明申请

US20100273260A1 CELL CULTURE SUBSTRATE AND PROCESS FOR PRODUCING THE SAME AND METHOD FOR CULTURING CELLS 审中-公开
标题翻译：细胞培养基底及其生产方法和培养细胞的方法
公开(公告)号：US20100273260A1
公开(公告)日：2010-10-28
申请号：US12600037
申请日：2008-07-10
申请人： Chiharu Odane , Sakura Toshikawa , Atsuko Mizuike , Hiroyuki Nishii , Takuji Shintani , Carsten Werner , Mirko Nitschke , Walter Eevers
发明人： Chiharu Odane , Sakura Toshikawa , Atsuko Mizuike , Hiroyuki Nishii , Takuji Shintani , Carsten Werner , Mirko Nitschke , Walter Eevers
IPC分类号： C12N5/02 , C12M1/00 , C08G65/00 , C08G63/08
CPC分类号： C12N5/0068 , C08G65/33306 , C08G81/00 , C08G81/024 , C08G2650/50 , C08G2650/58 , C08L51/06 , C08L67/00 , C08L71/02 , C08L2205/05 , C12M23/20 , C12N2533/30 , C12N2533/40 , C08L2666/24 , C08L2666/18
摘要： The present invention relates to a cell culture substrate in which a polymer chain having a hydrophilic skeleton is grafted onto a surface of polystyrene or poly(ε-caprolactone) having a water contact angle of from 75° to 100°. This cell culture substrate has excellent efficiency of cell culture without the necessity of immobilization and adsorption of a cell adhesion substance on a surface of a substrate.
摘要翻译：本发明涉及具有亲水性骨架的聚合物链接枝在聚苯乙烯或具有75°〜100°的水接触角的聚（ε-己内酯）表面上的细胞培养基质。该细胞培养基质的细胞培养效率优异，不需要在基材表面固定化和吸附细胞粘附物质。

2. 发明授权

US08563194B2 Electrolyte membrane for polymer electrolyte fuel cell and method of manufacturing the same 失效
标题翻译：聚合物电解质燃料电池用电解质膜及其制造方法
公开(公告)号：US08563194B2
公开(公告)日：2013-10-22
申请号：US12988572
申请日：2009-04-22
申请人： Hiroyuki Nishii , Tooru Sugitani , Otoo Yamada , Sakura Toshikawa
发明人： Hiroyuki Nishii , Tooru Sugitani , Otoo Yamada , Sakura Toshikawa
IPC分类号： H01M8/10 , B05D5/12
CPC分类号： H01B1/122 , C08G73/1042 , C08G73/1046 , C08G73/105 , C08G73/1067 , C08G73/1071 , C08J5/20 , C08J5/2275 , C08J2379/08 , C08L79/08 , H01M8/1004 , H01M8/1011 , H01M8/1023 , H01M8/103 , H01M8/1044 , H01M8/1053 , H01M2300/0082 , H01M2300/0094 , Y02E60/523 , Y02P70/56
摘要： An electrolyte membrane (1) includes a base material layer (1) containing a hydrocarbon-based electrolyte as a main component, and a surface layer (5) laminated with the base material layer (1). The surface layer (5) is a layer containing, as a main component, a polymeric material having a hydroxyl group and a proton conductive group. The polymeric material that constitutes the surface layer (5) contains, for example, a first polymer having a hydroxyl group, and a second polymer having a proton conductive group. A matrix is formed by cross-linking the first polymer, and the second polymer can be held in the matrix.
摘要翻译：电解质膜（1）包括以烃系电解液为主要成分的基材层（1）和层叠有基材层（1）的表层（5）。表面层（5）是含有具有羟基和质子传导性基团的聚合物材料作为主要成分的层。构成表面层（5）的聚合物材料包含例如具有羟基的第一聚合物和具有质子传导性基团的第二聚合物。通过交联第一聚合物形成基质，第二聚合物可以保持在基质中。

3. 发明授权

US08304135B2 Proton-conductive polymer electrolyte membrane, method of manufacturing the proton-conductive polymer electrolyte membrane, and membrane-electrode assembly and polymer electrolyte fuel cell using the proton-conductive polymer electrolyte membrane 失效
标题翻译：质子导电聚合物电解质膜，质子传导聚合物电解质膜的制造方法以及使用质子传导性聚合物电解质膜的膜 - 电极组件和聚合物电解质燃料电池
公开(公告)号：US08304135B2
公开(公告)日：2012-11-06
申请号：US12936658
申请日：2009-03-03
申请人： Tooru Sugitani , Hiroyuki Nishii , Otoo Yamada , Sakura Toshikawa
发明人： Tooru Sugitani , Hiroyuki Nishii , Otoo Yamada , Sakura Toshikawa
IPC分类号： H01M8/10
CPC分类号： C08J5/2275 , C08J5/2287 , C08J2329/04 , H01B1/122 , H01M8/04253 , H01M8/1011 , H01M8/1023 , H01M8/1025 , H01M8/1027 , H01M8/1069 , Y02E60/523 , Y02P70/56
摘要： A method of manufacturing a proton-conductive polymer electrolyte membrane using polyvinyl alcohol (PVA) as a base material and having excellent proton conductivity and methanol blocking properties is provided. The method includes: heat-treating a precursor membrane including PVA and a water-soluble polymer electrolyte having a proton conductive group to proceed crystallization of the PVA; and chemically crosslinking the heat-treated precursor membrane with a crosslinking agent reactive with the PVA, to form a polymer electrolyte membrane in which a crosslinked PVA is a base material and protons are conducted through the electrolyte retained in the base material. The content of a water-soluble polymer except the PVA and the water-soluble polymer electrolyte in the precursor membrane is in a weight ratio of less than 0.1 with respect to the PVA.
摘要翻译：提供了使用聚乙烯醇（PVA）作为基材并具有优异的质子传导性和甲醇阻断性质的质子传导性聚合物电解质膜的制造方法。该方法包括：对包含PVA的前体膜和具有质子传导基团的水溶性聚合物电解质进行热处理，以进行PVA的结晶化; 并且用与PVA反应的交联剂将热处理的前体膜化学交联，形成聚合物电解质膜，其中交联的PVA是基材，质子通过保留在基材中的电解质导入。前体膜中PVA以外的水溶性聚合物和水溶性聚合物电解质的含量相对于PVA的重量比小于0.1。

4. 发明申请

US20110039185A1 ELECTROLYTE MEMBRANE FOR POLYMER ELECTROLYTE FUEL CELL AND METHOD OF MANUFACTURING THE SAME 失效
标题翻译：聚合物电解质燃料电池用电解质膜及其制造方法
公开(公告)号：US20110039185A1
公开(公告)日：2011-02-17
申请号：US12988572
申请日：2009-04-22
申请人： Hiroyuki Nishii , Tooru Sugitani , Otoo Yamada , Sakura Toshikawa
发明人： Hiroyuki Nishii , Tooru Sugitani , Otoo Yamada , Sakura Toshikawa
IPC分类号： H01M8/10 , B05D5/12
CPC分类号： H01B1/122 , C08G73/1042 , C08G73/1046 , C08G73/105 , C08G73/1067 , C08G73/1071 , C08J5/20 , C08J5/2275 , C08J2379/08 , C08L79/08 , H01M8/1004 , H01M8/1011 , H01M8/1023 , H01M8/103 , H01M8/1044 , H01M8/1053 , H01M2300/0082 , H01M2300/0094 , Y02E60/523 , Y02P70/56
摘要： An electrolyte membrane (1) includes a base material layer (1) containing a hydrocarbon-based electrolyte as a main component, and a surface layer (5) laminated with the base material layer (1). The surface layer (5) is a layer containing, as a main component, a polymeric material having a hydroxyl group and a proton conductive group. The polymeric material that constitutes the surface layer (5) contains, for example, a first polymer having a hydroxyl group, and a second polymer having a proton conductive group. A matrix is formed by cross-linking the first polymer, and the second polymer can be held in the matrix.
摘要翻译：电解质膜（1）包括以烃系电解液为主要成分的基材层（1）和层叠有基材层（1）的表层（5）。表面层（5）是含有具有羟基和质子传导性基团的聚合物材料作为主要成分的层。构成表面层（5）的聚合物材料包含例如具有羟基的第一聚合物和具有质子传导性基团的第二聚合物。通过交联第一聚合物形成基质，第二聚合物可以保持在基质中。

5. 发明申请

US20110027692A1 PROTON-CONDUCTIVE POLYMER ELECTROLYTE MEMBRANE, METHOD OF MANUFACTURING THE PROTON-CONDUCTIVE POLYMER ELECTROLYTE MEMBRANE, AND MEMBRANE-ELECTRODE ASSEMBLY AND POLYMER ELECTROLYTE FUEL CELL USING THE PROTON-CONDUCTIVE POLYMER ELECTROLYTE MEMBRANE 失效
标题翻译：导电聚合物电解质膜，制备导电聚合物电解质膜的方法和使用导电聚合物电解质膜的膜 - 电极组件和聚合物电解质燃料电池
公开(公告)号：US20110027692A1
公开(公告)日：2011-02-03
申请号：US12936658
申请日：2009-03-03
申请人： Tooru Sugitani , Hiroyuki Nishii , Otoo Yamada , Sakura Toshikawa
发明人： Tooru Sugitani , Hiroyuki Nishii , Otoo Yamada , Sakura Toshikawa
IPC分类号： H01M8/10 , C08J5/20
CPC分类号： C08J5/2275 , C08J5/2287 , C08J2329/04 , H01B1/122 , H01M8/04253 , H01M8/1011 , H01M8/1023 , H01M8/1025 , H01M8/1027 , H01M8/1069 , Y02E60/523 , Y02P70/56
摘要： A method of manufacturing a proton-conductive polymer electrolyte membrane using polyvinyl alcohol (PVA) as a base material and having excellent proton conductivity and methanol blocking properties is provided. The method includes: heat-treating a precursor membrane including PVA and a water-soluble polymer electrolyte having a proton conductive group to proceed crystallization of the PVA; and chemically crosslinking the heat-treated precursor membrane with a crosslinking agent reactive with the PVA, to form a polymer electrolyte membrane in which a crosslinked PVA is a base material and protons are conducted through the electrolyte retained in the base material. The content of a water-soluble polymer except the PVA and the water-soluble polymer electrolyte in the precursor membrane is in a weight ratio of less than 0.1 with respect to the PVA.
摘要翻译：提供了使用聚乙烯醇（PVA）作为基材并具有优异的质子传导性和甲醇阻断性质的质子传导性聚合物电解质膜的制造方法。该方法包括：对包含PVA的前体膜和具有质子传导基团的水溶性聚合物电解质进行热处理，以进行PVA的结晶化; 并且用与PVA反应的交联剂将热处理的前体膜化学交联，形成聚合物电解质膜，其中交联的PVA是基材，质子通过保留在基材中的电解质导入。前体膜中PVA以外的水溶性聚合物和水溶性聚合物电解质的含量相对于PVA的重量比小于0.1。

6. 发明申请

US20140165837A1 METHOD FOR MANUFACTURING CARBON DIOXIDE SEPARATION MEMBRANE, AND CARBON DIOXIDE SEPARATION MEMBRANE 审中-公开
标题翻译：二氧化碳分离膜的制造方法和二氧化碳分离膜
公开(公告)号：US20140165837A1
公开(公告)日：2014-06-19
申请号：US14238771
申请日：2012-08-13
申请人： Naomichi Kimura , Hideyuki Emori , Hiroyuki Nishii , Takuji Shintani
发明人： Naomichi Kimura , Hideyuki Emori , Hiroyuki Nishii , Takuji Shintani
IPC分类号： B01D71/34 , B01D67/00
CPC分类号： B01D71/34 , B01D53/228 , B01D67/009 , B01D67/0093 , B01D71/82 , B01D2323/385 , C08J7/18 , Y02P20/152
摘要： The present invention provides a carbon dioxide separation membrane having a grafted chain into which a substituent having high selective affinity for carbon dioxide is introduced and thus having high carbon dioxide separation capability. The present invention is a method for producing a carbon dioxide separation membrane. This method includes the steps of: (1) irradiating a polymer film with radiation; (2) forming, in the irradiated polymer film, a grafted chain containing a repeating unit of a monomer having a substituent capable of forming a salt with a fluoride ion; and (3) subjecting the substituent capable of forming a salt with a fluoride ion to treatment with a fluoride salt so as to form a salt with a fluoride ion in the substituent.
摘要翻译：本发明提供了具有接枝链的二氧化碳分离膜，其中引入了对二氧化碳具有高选择性亲和力的取代基，因此具有高的二氧化碳分离能力。本发明是二氧化碳分离膜的制造方法。该方法包括以下步骤：（1）用辐射照射聚合物膜; （2）在被照射的聚合物膜中形成含有能够与氟离子形成盐的取代基的单体的重复单元的接枝链; 和（3）使能够与氟离子形成盐的取代基用氟化物盐处理，从而与取代基中的氟离子形成盐。

7. 发明授权

US08980499B2 Proton-conductive polymer electrolyte membrane, and membrane-electrode assembly and polymer electrolyte fuel cell using the same 有权
标题翻译：质子导电聚合物电解质膜和膜电极组件和聚合物电解质燃料电池使用相同
公开(公告)号：US08980499B2
公开(公告)日：2015-03-17
申请号：US13322073
申请日：2010-05-21
申请人： Tooru Sugitani , Hiroyuki Nishii , Akira Shimazu
发明人： Tooru Sugitani , Hiroyuki Nishii , Akira Shimazu
IPC分类号： H01M8/10 , H01B1/12 , H01M8/04
CPC分类号： H01B1/122 , H01M8/04197 , H01M8/1011 , H01M8/1027 , H01M8/103 , H01M8/1067 , Y02E60/523
摘要： Provided is a polyimide-based proton-conductive polymer electrolyte membrane having high methanol permeation resistance property (methanol blocking property). The proton-conductive polymer electrolyte membrane includes, as a main component, a polyimide resin formed by polycondensation of a tetracarboxylic dianhydride, a first aromatic diamine having a proton-conductive group, and a second aromatic diamine having no proton-conductive group. The second aromatic diamine has a fused ring skeleton composed of three or more rings. This electrolyte membrane is suitable for use in a polymer electrolyte fuel cell (PEFC), in particular in a direct methanol fuel cell (DMFC).
摘要翻译：本发明提供具有高甲醇渗透性（甲醇阻断性）的聚酰亚胺系质子传导性高分子电解质膜。质子传导性高分子电解质膜以四羧酸二酐，具有质子传导性基团的第一芳香族二胺和不具有质子传导性基团的第二芳香族二胺缩聚形成的聚酰亚胺树脂为主要成分。第二芳族二胺具有由三个以上环构成的稠环骨架。该电解质膜适用于聚合物电解质燃料电池（PEFC），特别是在直接甲醇燃料电池（DMFC）中。

8. 发明授权

US08475554B2 Permeable member, and permeable casing and electrical component using the same 有权
标题翻译：可渗透构件，以及可渗透套管和使用其的电气部件
公开(公告)号：US08475554B2
公开(公告)日：2013-07-02
申请号：US11792158
申请日：2005-12-01
申请人： Kouji Furuuchi , Hiroyuki Nishii
发明人： Kouji Furuuchi , Hiroyuki Nishii
IPC分类号： B01D46/00
CPC分类号： F21V31/03 , F21S45/33 , H05K5/0213
摘要： The present invention provides a permeable member which can attain both a pullout strength and following property (sealing property) and provides a permeable casing and an electrical component using the permeable member. The present invention includes a permeable film through which a gas passing an opening passes when the permeable film is fixed to the opening of a casing, and a tubular support that supports the permeable film. The support includes a first resin part that contacts the casing with the support fixed to the opening, and a second resin part composed of a material having a higher elastic modulus than that of a material constituting the first resin part, and the first resin part and the second resin part are laminated at least partly in a transverse section of the support.
摘要翻译：本发明提供一种能够获得拉拔强度和跟随性（密封性）两者的可渗透构件，并且提供使用该可渗透构件的可渗透外壳和电气部件。本发明包括当透气膜固定到壳体的开口时通过开口的气体通过的渗透膜和支撑可渗透膜的管状支撑件。所述支撑体包括：第一树脂部分，其与固定到所述开口的支撑体接触所述壳体;以及第二树脂部件，其由具有比构成所述第一树脂部件的材料的弹性模量高的材料构成;以及所述第一树脂部件，第二树脂部分至少部分地层压在支撑件的横截面中。

9. 发明申请

US20090186083A1 METHOD FOR STABILIZATION OF ISOXAZOLE COMPOUND 审中-公开
标题翻译： ISOXAZOLE化合物稳定化方法
公开(公告)号：US20090186083A1
公开(公告)日：2009-07-23
申请号：US12090668
申请日：2006-10-18
申请人： Hiroyuki Nishii , Makoto Matsuoka
发明人： Hiroyuki Nishii , Makoto Matsuoka
IPC分类号： A61K9/28 , C07D413/12 , A61K31/5377
CPC分类号： A61K47/10 , A61K9/1611 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/20 , A61K47/22 , C07D261/14
摘要： 3-[(1S)-1-(2-fluorobiphenyl-4-yl)ethyl]-5-[[amino(morpholin-4-yl)methylene]amino]isoxazole is an isoxazole compound useful as a therapeutic agent for an autoimmune disease. The isoxazole compound can be stabilized by using an antioxidant such as a metabisulfite, bisulfite, sulfite or dibutylhydroxytoluene. A pharmaceutical composition for oral administration comprising the isoxazole compound and the antioxidant is an excellent pharmaceutical composition, since the isoxazole compound contained in the composition is stabilized.
摘要翻译： 3 - [（1S）-1-（2-氟联苯-4-基）乙基] -5 - [[氨基（吗啉-4-基）亚甲基]氨基]异恶唑是可用作自身免疫的治疗剂的异恶唑化合物疾病。异恶唑化合物可以通过使用抗氧化剂如偏亚硫酸氢盐，亚硫酸氢盐，亚硫酸盐或二丁基羟基甲苯来稳定化。包含异恶唑化合物和抗氧化剂的口服药物组合物是优异的药物组合物，因为组合物中所含的异恶唑化合物是稳定的。

10. 发明申请

US20080092741A1 Permeable Member, And Permeable Casing And Electrical Component Using The Same 有权
标题翻译：可渗透构件，透气套管和电气部件使用它
公开(公告)号：US20080092741A1
公开(公告)日：2008-04-24
申请号：US11792158
申请日：2005-12-01
申请人： Kouji Furuuchi , Hiroyuki Nishii
发明人： Kouji Furuuchi , Hiroyuki Nishii
IPC分类号： B01D53/22
CPC分类号： F21V31/03 , F21S45/33 , H05K5/0213
摘要： The present invention provides a permeable member which can attain both a pullout strength and following property (sealing property) and provides a permeable casing and an electrical component using the permeable member. The present invention includes a permeable film through which a gas passing an opening passes when the permeable film is fixed to the opening of a casing, and a tubular support that supports the permeable film. The support includes a first resin part that contacts the casing with the support fixed to the opening, and a second resin part composed of a material having a higher elastic modulus than that of a material constituting the first resin part, and the first resin part and the second resin part are laminated at least partly in a transverse section of the support.
摘要翻译：本发明提供一种能够获得拉拔强度和跟随性（密封性）两者的可渗透构件，并且提供使用该可渗透构件的可渗透外壳和电气部件。本发明包括当透气膜固定到壳体的开口时通过开口的气体通过的渗透膜和支撑可渗透膜的管状支撑件。所述支撑体包括：第一树脂部分，其与固定到所述开口的支撑体接触所述壳体;以及第二树脂部件，其由具有比构成所述第一树脂部件的材料的弹性模量高的材料构成;以及所述第一树脂部件，第二树脂部分至少部分地层压在支撑件的横截面中。

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