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1. 发明授权

US5760096A Potent penetration enhancers 失效
标题翻译：强效渗透增强剂
公开(公告)号：US5760096A
公开(公告)日：1998-06-02
申请号：US734053
申请日：1996-10-18
申请人： Carl R. Thornfeldt , Peter M. Elias
发明人： Carl R. Thornfeldt , Peter M. Elias
IPC分类号： A61K47/10 , A61K47/18 , A61K47/20 , A61K37/02
CPC分类号： A61K47/20 , A61K47/10 , A61K47/183 , A61K9/0014 , Y10S514/947
摘要： The epidermal permeability barrier to systemically and/or topically active agents or compositions designed for topical administration is enhanced to an unexpected degree by certain combinations of known penetration enhancing excipients. One group of combinations comprise a glycol and an alcohol at a weight ratio within the range of 1:0.1 to 1:10 with one or more further additives, selected from the excipient groups of branched-chain esters of fatty acids, surfactants, and membrane fluidizers. Another group of combinations comprise an alcohol of four or more carbon atoms and one or more further additives selected from the excipient groups of glycols and surfactants.
摘要翻译：全身和/或局部活性剂或设计用于局部给药的组合物的表皮渗透屏障通过已知的渗透增强赋形剂的某些组合增强到意想不到的程度。一组组合包括一种或多种其它添加剂，其重量比在1:0.1至1:10范围内的二醇和醇，其选自脂肪酸，表面活性剂和膜的支链酯的赋形剂基团流化器。另一组组合包括四个或更多个碳原子的醇和一种或多种另外的添加剂，其选自二醇和表面活性剂的赋形剂基团。

2. 发明授权

US5643899A Lipids for epidermal moisturization and repair of barrier function 失效
标题翻译：用于表皮保湿和修复屏障功能的脂质
公开(公告)号：US5643899A
公开(公告)日：1997-07-01
申请号：US347363
申请日：1995-02-27
申请人： Peter M. Elias , Kenneth R. Feingold , Carl R. Thornfeldt
发明人： Peter M. Elias , Kenneth R. Feingold , Carl R. Thornfeldt
IPC分类号： A61K8/55 , A61K8/00 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/42 , A61K8/58 , A61K8/63 , A61K8/68 , A61K31/047 , A61K31/20 , A61K31/23 , A61K31/575 , A61K31/59 , A61K31/593 , A61K31/70 , A61K31/715 , A61P17/00 , A61P29/00 , A61Q17/00 , A61Q19/00 , A61K31/16
CPC分类号： A61Q17/00 , A61K31/575 , A61K31/70 , A61K8/361 , A61K8/63 , A61K8/68 , A61Q19/00 , Y10S514/847
摘要： Disorders of the skin and mucous membrane that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of a formulation comprising certain of the three major epidermal lipid species or their structurally similar precursors, isomers, or analogs in certain proportion ranges. This invention utilizes the following lipid species in unique combinations of two or more components: cholesterol, an acylceramide, a ceramide, and essential and nonessential fatty acids. These combinations are effective both as moisturizing agents and agents for the restoration of barrier function. Some of these combinations are further enhanced by the addition of known moisturizers such as petrolatum and glycerine.
摘要翻译： PCT No.PCT / US93 / 05798 Sec。 371日期：1995年2月27日 102（e）日期1995年2月27日PCT提交1993年6月18日PCT公布。出版物WO94 / 00127 日期1994年1月6日通过局部施用包含某些三种主要表皮脂质或其结构上类似的前体，异构体或类似物的制剂来治疗或预防具有中断或功能失调的表皮屏障的皮肤和粘膜的疾病一定比例范围。本发明利用两种或多种组分的独特组合的以下脂质：胆固醇，酰基神经酰胺，神经酰胺以及必需和非必需的脂肪酸。这些组合作为保湿剂和用于恢复屏障功能的试剂都是有效的。这些组合中的一些通过加入已知的保湿剂如凡士林和甘油进一步增强。

3. 发明授权

US4816478A Treatment of acquired immunodeficiency syndrome 失效
标题翻译：治疗获得性免疫缺陷综合征
公开(公告)号：US4816478A
公开(公告)日：1989-03-28
申请号：US88437
申请日：1987-08-24
申请人： Carl R. Thornfeldt
发明人： Carl R. Thornfeldt
IPC分类号： A61K31/335
CPC分类号： A61K31/335
摘要： A treatment of Acquired Immunodeficiency Syndrome (AIDS) and AIDS Related Complex (ARC) with therapeutically effective amounts of semisynthetic derivatives of dihydroartemesinin and synthetic compounds with a sesquiterpene structure.
摘要翻译：获得性免疫缺陷综合征（AIDS）和AIDS相关复合物（ARC）的治疗，其具有治疗有效量的二氢青蒿素的半合成衍生物和具有倍半萜烯结构的合成化合物。

4. 发明授权

US06482839B1 Pyridine-thiols for treatment of a follicular dermatosis 失效
标题翻译：用于治疗滤泡性皮肤病的吡啶硫醇
公开(公告)号：US06482839B1
公开(公告)日：2002-11-19
申请号：US09145822
申请日：1998-09-02
申请人： Carl R. Thornfeldt
发明人： Carl R. Thornfeldt
IPC分类号： A61K314402
CPC分类号： A61Q19/08 , A61K8/19 , A61K8/20 , A61K8/23 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/368 , A61K8/4933 , A61K31/00 , A61Q19/00 , A61Q19/02 , Y10S514/859
摘要： This invention provides compositions and methods for treatment of skin and mucous membranes suffering from a follicular dermatosis. The compositions include one or more pyridine-thiols and tautomers with attached metallic moieties. Administration of the compounds to aging skin and mucous membranes in topical formulations, either as the only active ingredient or in combination with other known active ingredients to treat a follicular dermatosis. Additional compositions for treating follicular dermatosis contain one or more sulfides and oxides of these same metallic ions, either alone or in combination with other molecules. Topical formulations containing both a pyridine-thiol and tautomers with attached metallic moiety and a metallic sulfide and/or metallic oxide effectively treat skin and mucous membranes suffering from a follicular dermatosis.
摘要翻译：本发明提供了治疗患有滤泡性皮肤病的皮肤和粘膜的组合物和方法。组合物包括一种或多种具有连接的金属部分的吡啶硫醇和互变异构体。在局部制剂中施用化合物以老化皮肤和粘膜，作为唯一的活性成分或与其它已知的活性成分组合以治疗滤泡性皮肤病。用于治疗滤泡性皮肤病的附加组合物含有一种或多种这些相同金属离子的硫化物和氧化物，单独或与其它分子组合。含有吡啶硫醇和具有连接的金属部分的互变异构体和金属硫化物和/或金属氧化物的局部制剂有效地治疗患有滤泡性皮肤病的皮肤和粘膜。

5. 发明授权

US4978676A Treatment of skin diseases with artemisinin and derivatives 失效
标题翻译：用青蒿素及其衍生物治疗皮肤病
公开(公告)号：US4978676A
公开(公告)日：1990-12-18
申请号：US335615
申请日：1989-04-10
申请人： Carl R. Thornfeldt
发明人： Carl R. Thornfeldt
IPC分类号： A61K31/335 , A61K31/365 , A61K31/39 , C08G67/04 , C08G69/08 , C08G69/10
CPC分类号： A61K31/335 , A61K31/365 , A61K31/39 , C08G67/04 , C08G69/08 , C08G69/10 , Y10S514/863
摘要： Psoriasis, ultraviolet light induced skin conditions and tumors are successfully treated with topical or oral administration of artemisinin, dihydroartemisinin, its semisynthetic derivatives and its synthetic analogs. Viral tumors/diseases, hemorrhoids, and bullous skin diseases are also successfully treated with these topical compositions.

6. 发明授权

US4713394A Treatment of nonacne inflammatory and infectious dermatoses and hair loss 失效
标题翻译：治疗非炎性和感染性皮肤病和脱发
公开(公告)号：US4713394A
公开(公告)日：1987-12-15
申请号：US873859
申请日：1986-06-11
申请人： Carl R. Thornfeldt
发明人： Carl R. Thornfeldt
IPC分类号： A61K8/00 , A61K8/30 , A61K8/36 , A61K8/362 , A61K8/46 , A61K31/185 , A61K31/19 , A61K31/20 , A61K31/265 , A61P17/00 , A61P29/00 , A61P31/04 , A61Q5/00 , A61Q7/00 , A61Q19/00 , C07C55/02
CPC分类号： A61Q19/008 , A61K31/185 , A61K31/19 , A61K31/20 , A61K31/265 , A61K8/362 , A61Q19/00 , A61Q5/00 , A61Q7/00 , Y10S514/887
摘要： Dermatoses involving nonacne inflammatory dermatoses, infectious cutaneous diseases, and hair loss resulting from inflammation or hormonal anomalies are treated with dicarboxylic acids containing 7 to 13 carbon atoms, or certain mercapto derivatives or salts thereof.
摘要翻译：涉及非痤疮性炎性皮肤病，感染性皮肤疾病和由炎症或激素异常引起的脱发的皮肤病是用含有7至13个碳原子的二羧酸或某些巯基衍生物或其盐处理的。

7. 发明授权

US06071543A Pyridine-thiols reverse mucocutaneous aging 失效
标题翻译：吡啶硫醇反向粘膜皮肤老化
公开(公告)号：US06071543A
公开(公告)日：2000-06-06
申请号：US89302
申请日：1998-06-01
申请人： Carl R. Thornfeldt
发明人： Carl R. Thornfeldt
IPC分类号： A61K8/19 , A61K8/20 , A61K8/23 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/368 , A61K8/49 , A61K31/00 , A61K31/44 , A61K33/00 , A61Q5/10 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K33/32 , A61K33/04
CPC分类号： A61Q19/08 , A61K31/00 , A61K8/19 , A61K8/20 , A61K8/23 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/368 , A61K8/4933 , A61Q19/00 , A61Q19/02
摘要： This invention provides compositions and methods for preventing and reversing the signs and symptoms of intrinsic and photo aging. The compositions include one or more pyridine-thiols and tautomers with attached metallic moieties. Administration of the compounds to aging skin and mucous membranes in topical formulations, either as the only active ingredient or in combination with other known active ingredients, prevents and reverses aging symptoms. Additional compositions for preventing and reversing aging contain one or more sulfides and oxides of these same metallic ions, either alone or in combination with other molecules known or suspected to exhibit age reversing properties. Topical formulations containing both a pyridine-thiol and tautomers with attached metallic moiety and a metallic sulfide and/or metallic oxide effectively prevent and reverse the signs and symptoms of mucocutaneous aging.
摘要翻译：本发明提供用于预防和逆转内在和照片老化的体征和症状的组合物和方法。组合物包括一种或多种具有连接的金属部分的吡啶硫醇和互变异构体。作为唯一活性成分或与其它已知活性成分组合的局部制剂中化合物老化皮肤和粘膜的施用可预防和逆转老化症状。用于预防和逆转老化的其它组合物包含一种或多种这些相同金属离子的硫化物和氧化物，单独或与已知或怀疑具有年龄反转性能的其它分子组合。含有吡啶硫醇和具有附着金属部分的互变异构体和金属硫化物和/或金属氧化物的局部制剂有效地预防和逆转粘膜皮肤老化的体征和症状。

8. 发明授权

US5885565A Methods for inducing phase separation of epithelial lipid bilayers 失效
标题翻译：诱导上皮脂双层相分离的方法
公开(公告)号：US5885565A
公开(公告)日：1999-03-23
申请号：US638302
申请日：1996-04-26
申请人： Peter M. Elias , Stephen Grayson , Carl R. Thornfeldt
发明人： Peter M. Elias , Stephen Grayson , Carl R. Thornfeldt
IPC分类号： A61K47/18 , A61K47/22 , A61K47/26 , A61K47/46 , A61K9/06
CPC分类号： A61K47/46 , A61K47/183 , A61K47/22 , A61K47/26 , A61K9/0014 , Y10S424/15 , Y10S514/936 , Y10S514/937 , Y10S514/944 , Y10S514/946 , Y10S514/947 , Y10S514/969
摘要： A method for enhancing penetration of a therapeutic or prophylactic agent in a host in need of the topical administration thereof which comprises applying to the epithelium of the host, an effective amount of one or more penetration enhancing epithelial sterols and the therapeutic or prophylactic agent.
摘要翻译：一种用于增强治疗或预防剂在需要局部施用的宿主中的渗透的方法，其包括向宿主的上皮施用有效量的一种或多种渗透增强上皮甾醇和治疗或预防剂。

9. 发明授权

US5723114A Penetration enhancing compositions and methods of their use 失效
标题翻译：渗透增强组合物及其使用方法
公开(公告)号：US5723114A
公开(公告)日：1998-03-03
申请号：US639212
申请日：1996-04-26
申请人： Carl R. Thornfeldt , Peter M. Elias , Stephen Grayson
发明人： Carl R. Thornfeldt , Peter M. Elias , Stephen Grayson
IPC分类号： A61K47/18 , A61K47/22 , A61K47/26 , A61K47/46 , A61K9/06 , A61K9/10
CPC分类号： A61K47/46 , A61K47/183 , A61K47/22 , A61K47/26 , A61K9/0014 , Y10S424/15 , Y10S514/936 , Y10S514/937 , Y10S514/944 , Y10S514/946 , Y10S514/947 , Y10S514/969
摘要： A method for enhancing penetration of a therapeutic or prophylactic agent in a host in need of the topical administration thereof which comprises applying to the epithelium of the host, the agent and an effective amount of one or more penetration enhancing epithelial proton pump inhibitors.
摘要翻译：一种用于增强需要局部给药的宿主中治疗性或预防性药物穿透的方法，其包括向宿主的上皮，所述药剂和有效量的一种或多种渗透增强上皮质子泵抑制剂施用。

10. 发明授权

US5326790A Administration of skin medications by use of dicarboxylic acids and derivatives 失效
标题翻译：使用二羧酸及其衍生物给药皮肤药物
公开(公告)号：US5326790A
公开(公告)日：1994-07-05
申请号：US869920
申请日：1992-04-16
申请人： Carl R. Thornfeldt
发明人： Carl R. Thornfeldt
IPC分类号： A61K31/19 , A61K31/20 , A61K31/34 , A61K31/35 , A61K31/455 , A01N37/02 , A01N25/00
CPC分类号： A61K31/19 , A61K31/20 , A61K31/34 , A61K31/35 , A61K31/455 , Y10S514/946 , Y10S514/947
摘要： The topical administration of therapeutic agents to a variety of disease conditions, both cutaneous and systemic, is enhanced by combining the therapeutic agents with dicarboxylic acids or analogs of such acids, which include mono- and dimercapto derivatives, salts, esters, amides and anhydrides. Preferred dicarboxylic acids are azelaic and dodecanedioic acids and their monoglyceride and sucrose salts. Preferred therapeutic agents are antiinflammatory compounds, antihistamine compounds, antineoplastic compounds, vitamin D and retinoid agents. Specific examples of some of these compounds are 5-fluorouracil, methotrexate, bleomycin, carmustine and nitrogen mustard. The acids and analogs of this invention enhance the penetration capabilities of the therapeutic agents and are thus effective in promoting the therapeutic effect of these agents inside diseased cells, particularly for diseases such as inflammatory skin diseases and premalignant and non-melanoma malignant skin tumors.
摘要翻译：通过将治疗剂与这些酸的二羧酸或类似物组合，其包括单和二巯基衍生物，盐，酯，酰胺和酸酐，可将治疗剂局部施用于多种疾病状况，包括皮肤和全身。优选的二羧酸是壬二酸和十二烷二酸及其单甘油酯和蔗糖盐。优选的治疗剂是抗炎化合物，抗组胺剂化合物，抗肿瘤化合物，维生素D和类视色素。一些这些化合物的具体实例是5-氟尿嘧啶，甲氨蝶呤，博来霉素，卡莫司汀和氮芥。本发明的酸和类似物增强治疗剂的渗透能力，因此有效地促进这些药物在病变细胞内的治疗效果，特别是对于疾病如炎症性皮肤疾病，恶化前和非黑色素瘤恶性皮肤肿瘤。

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