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1. 发明申请

US20070237836A1 Strontium compound for treatment of sub-dermal soft tissue pain 审中-公开
公开(公告)号：US20070237836A1
公开(公告)日：2007-10-11
申请号：US11808487
申请日：2007-06-11
申请人： Egil Jellum , Bjorn Fagerlund , Clas Kjolberg , Jo Klaveness
发明人： Egil Jellum , Bjorn Fagerlund , Clas Kjolberg , Jo Klaveness
IPC分类号： A61K33/14 , A61B18/18 , A61K33/00
CPC分类号： A61K33/14 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/198 , A61K31/20 , A61K31/28 , A61K31/375 , A61K31/60 , A61K33/24 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a subject in need thereof an effective amount of a physiologically tolerable strontium compound.

2. 发明授权

US06878365B2 Topical application for treating toenail fungus 失效
标题翻译：局部应用治疗趾甲真菌
公开(公告)号：US06878365B2
公开(公告)日：2005-04-12
申请号：US10077521
申请日：2002-02-15
申请人： James Edward Brehove
发明人： James Edward Brehove
IPC分类号： A61K9/70 , A61K31/69 , A61K7/04 , A01N55/02 , A01N59/00 , A01N59/14 , A61K6/00
CPC分类号： A61K31/69 , A61K9/7015 , Y10S514/936 , Y10S514/947
摘要： A topical applications is used to treat and prevent the spread of nail infections or onychomycosis caused by bacteria, fungi and other pathogens. The topical application has a composition that comprises, as an active ingredient, at least one species selected from the group consisting of 2,2′-(alkyldioxy)bis-(alkyl-1,3,2-dioxaborinane) and 2,2′-oxybis(alkyl-1,3,2-dioxaborinane). More specifically, the composition comprises, as an active ingredient, at least one member selected from the group consisting of 2,2′-(1-methyltrimethylenedioxy)bis-(4-methyl-1,3,2-dioxaborinane) and 2,2′-oxybis(4,4,6-trimethyl-1,3,2-dioxaborinane).
摘要翻译：使用局部应用来治疗和预防由细菌，真菌和其他病原体引起的指甲感染或甲真菌病的扩散。局部应用具有包含作为活性成分的至少一种选自2,2' - （烷基二氧基）双 - （烷基-1,3,2-二氧杂硼烷）和2,2' （烷基-1,3,2-二氧杂硼烷）。更具体地，组合物包含选自2,2' - （1-甲基三亚甲基二氧基）双 - （4-甲基-1,3,2-二氧杂硼烷）和2， 2,5-氧双（4,4,6-三甲基-1,3,2-二氧杂硼烷）。

3. 发明申请

US20030180379A1 Solutions and aerosols of metal-containing compounds 审中-公开
公开(公告)号：US20030180379A1
公开(公告)日：2003-09-25
申请号：US10277673
申请日：2002-10-22
发明人： Robert E. Burrell , Scott H. Gillis , Paul Schechter , John B. Wright , Kan Lam , Hua Qing Yin , Antony G. Naylor , Peter H. Moxham
IPC分类号： A61K033/38 , A61K033/26 , A61K033/24
CPC分类号： A61K9/0024 , A61K8/19 , A61K9/0019 , A61K9/0078 , A61K9/14 , A61K9/1682 , A61K9/51 , A61K9/7007 , A61K9/7023 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2800/413 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/63 , A61Q17/005 , A61Q19/00 , B82Y5/00 , Y10S514/858 , Y10S514/859 , Y10S514/865 , Y10S514/886 , Y10S514/887 , Y10S514/936 , Y10S514/937 , Y10S514/938 , Y10S514/946 , Y10S514/964 , A61K2300/00
摘要： Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

4. 发明授权

US5741527A Veterinary topical compositions and methods of use 失效
标题翻译：兽用局部组合物和使用方法
公开(公告)号：US5741527A
公开(公告)日：1998-04-21
申请号：US800563
申请日：1997-02-18
申请人： Paul K. Brown
发明人： Paul K. Brown
IPC分类号： A61K33/28 , A61K36/53 , A61K36/534 , A61K36/54 , A61K35/78
CPC分类号： A61K36/53 , A61K33/28 , A61K36/534 , A61K36/54 , Y10S514/887 , Y10S514/936 , Y10S514/947
摘要： The present invention relates to novel veterinary topical compositions, methods of making the compositions, and methods of using the compositions in the treatment of bone, muscle and connective tissue injuries, as well as respiratory ailments, in animals, particularly horses, dogs, and goats. The compositions comprise isopropyl alcohol, mercuric chloride and dimethylsulfoxide (DMSO), and may further comprise herbs. Light training can typically be resumed beginning about 24 hours after applying the composition to the injured area of the animal.
摘要翻译：本发明涉及新型兽用局部组合物，制备组合物的方法，以及使用组合物治疗骨骼，肌肉和结缔组织损伤以及动物，特别是马，狗和山羊中的呼吸道疾病的方法。组合物包含异丙醇，氯化汞和二甲基亚砜（DMSO），并且还可以包含草药。通常在将组合物施加到动物的受伤区域后约24小时开始轻度训练。

5. 发明授权

US5738839A Gelled emulsion particles and the compositions in which they are present 失效
标题翻译：凝胶化乳剂颗粒及其存在的组合物
公开(公告)号：US5738839A
公开(公告)日：1998-04-14
申请号：US470493
申请日：1995-06-06
申请人： Anne Clement , Pierre Fodor , Gerard Guth , Nathalie Thiollet
发明人： Anne Clement , Pierre Fodor , Gerard Guth , Nathalie Thiollet
IPC分类号： A61K8/02 , A61K8/06 , A61K8/11 , A61K8/35 , A61K8/41 , A61K8/44 , A61K8/67 , A61K8/73 , A61K9/00 , A61K9/107 , A61K9/16 , A61K47/32 , A61Q19/00 , B01J13/00 , A61K9/10
CPC分类号： A61K9/1652 , A61K47/32 , A61K8/044 , A61K8/11 , A61K8/35 , A61K8/44 , A61K8/676 , A61K8/733 , A61K9/0014 , A61K9/107 , A61Q19/00 , A61K2800/412 , Y10S514/936 , Y10S514/939 , Y10S514/941 , Y10S514/944
摘要： The present invention relates to gelled emulsion particles obtained when predetermined volumes, especially drops, of an emulsion with an aqueous external phase, containing an appropriate reagent in solution in the said aqueous phase, are added to a gelling solution and left therein for a period of time which depends on the degree of gelling desired for the said particles. It further relates to compositions--especially solutions, gels or emulsions with an aqueous external phase--in which the said particles are present.
摘要翻译：本发明涉及当在含水相中的溶液中含有适当的试剂的预定体积，特别是含有外部水相的乳液的预定体积（特别是液滴）时，获得的胶凝乳液颗粒被加入到胶凝溶液中并保留一段时间时间取决于所述颗粒所需的胶凝程度。它还涉及具有外部水相的组合物，特别是溶液，凝胶或乳液，其中存在所述颗粒。

6. 发明授权

US4943307A Plant-protective pesticidal composition 失效
标题翻译：植物保护性农药成分
公开(公告)号：US4943307A
公开(公告)日：1990-07-24
申请号：US220018
申请日：1988-07-15
申请人： Tamas Detre , Sandor ngyan , Laszlo Pap , Andras Szego , Zoltan Karadi , Klara Bertus nee Bende , Katalin Marmarosi nee Kellner
发明人： Tamas Detre , Sandor ngyan , Laszlo Pap , Andras Szego , Zoltan Karadi , Klara Bertus nee Bende , Katalin Marmarosi nee Kellner
IPC分类号： A01N33/18 , A01N25/02 , A01N25/04 , A01N33/22 , A01N37/26 , A01N43/12 , A01N43/60 , A01N43/653 , A01N43/80 , A01N43/90 , A01N47/18 , A01N47/22 , A01N47/30 , A01N47/34 , A01N47/36 , A01N47/38 , A01N57/14 , A01N57/16 , A01P13/00
CPC分类号： A01N25/02 , A01N25/04 , Y10S514/918 , Y10S514/936 , Y10S514/937 , Y10S514/942 , Y10S514/95 , Y10S514/97 , Y10S514/973
摘要： The invention relates to a plant-protective solution containing 2.5 to 40 % by weight of one or more water-insoluble plant-protective ingredient(s) 20 to 71.5 % by weight of dimethylformamide and/or dimethylsulfoxide and/or acetone as water-miscible solvent, 10 to 71.5 % by weight of furfurol and/or furfuryl alcohol as partially water-miscible solvent, 1 to 15 % by weight of commonly used additives such as anionic and/or nonionic surface active agents and macromolecules.The invention also relates to the ready-for-use plant-protective suspension containing 0.2 to 10 % by weight of one or more water-insoluble plant-protective ingredient(s) with a particle size of 0.1 to 50 .mu.m, 0 to 60 % by weight of a fertilizer, 0.2 to 10 % by weight of dimethylformamide and/or dimethylsulfoxide and/or acetone as water-miscible solvent, 0.2 to 10 % by weight of furfurol and/or furfuryl alcohol as partially water-miscible solvent, 0.05 to 2.5 by weight of a commonly used additive such as anionic and/or nonionic surface active agents macromolecules and water in an amount supplementing up to 100 % by weight.

7. 发明授权

US4937230A Method of healing wounds in horses 失效
标题翻译：治疗马匹伤口的方法
公开(公告)号：US4937230A
公开(公告)日：1990-06-26
申请号：US128738
申请日：1987-12-04
申请人： Loren R. Pickart
发明人： Loren R. Pickart
IPC分类号： A61K38/00 , A61K38/06 , C07K5/08 , C07K5/10 , C07K7/06
CPC分类号： C07K7/06 , A61K38/06 , C07K5/0827 , C07K5/1027 , Y10S514/886 , Y10S514/887 , Y10S514/936 , Y10S514/947
摘要： Methods are disclosed for enhancing the healing of a variety of wounds in horses. The methods generally comprise administering to the wound a therapeutically effective amount of a composition comprising GHL:Cu or a derivative thereof in combination with a physiologically acceptable carrier or diluent.
摘要翻译：公开了用于增强马中各种伤口愈合的方法。所述方法通常包括向伤口施用治疗有效量的包含GHL：Cu或其衍生物与生理上可接受的载体或稀释剂组合的组合物。

8. 发明授权

US4857334A Synthetic resin matrix system incorporating healing enhancer 失效
标题翻译：合成树脂基体系结合愈合增强剂
公开(公告)号：US4857334A
公开(公告)日：1989-08-15
申请号：US199375
申请日：1988-05-27
申请人： Bernard Korol , Paul Nathan
发明人： Bernard Korol , Paul Nathan
IPC分类号： A61K9/22 , A61L15/24 , A61L15/44 , A61L26/00
CPC分类号： A61L26/008 , A61L15/24 , A61L15/44 , A61L26/0014 , A61L2300/40 , A61L2300/414 , A61L2300/602 , Y10S514/936 , Y10S514/946 , Y10S514/965
摘要： An apparatus and method is described for applying epidermal growth factor (EGF) for achieving healing enhancement at a wound site. The human source of epidermal growth factor, designated as hEGF, is applied from the synthetic resin matrix system of this invention, and which comprises a polymer, such as poly(2-hydroxyl ethyl methyl methacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin, so that the more plasticizer present, the shorter the set-up time. The dressing, once formed, and having the healing enhancer contained therein, may be sealed within various backing sheets, in order to preserve its aseptic condition. When ready for use, one of the backing sheets may be peeled away to expose the resin pad with the emobodied healing enhancer, ready for application to the wound site.
摘要翻译：描述了一种用于在伤口部位应用表皮生长因子（EGF）用于实现愈合增强的装置和方法。称为hEGF的人表皮生长因子来源于本发明的合成树脂基质体系，其包含聚合物，例如聚（2-羟乙基甲基丙烯酸甲酯），称为PHEMA，有机溶剂，例如聚乙二醇（PEG）和氢结合增塑剂如二甲基亚砜（DMSO）。增塑剂调节合成树脂的安装时间，使得存在的增塑剂越多，安装时间越短。一旦形成并且其中含有愈合增强剂的敷料可以被密封在各种背衬片内，以便保持其无菌状态。当准备使用时，其中一个背衬片可能被剥离，以暴露树脂垫与表面的愈合增强剂，准备应用于伤口部位。

9. 发明授权

US4833158A Method of combating termites 失效
标题翻译：防治白蚁的方法
公开(公告)号：US4833158A
公开(公告)日：1989-05-23
申请号：US133983
申请日：1987-12-17
申请人： Roland S. Twydell , Jennifer M. Radcliffe
发明人： Roland S. Twydell , Jennifer M. Radcliffe
IPC分类号： A01N47/34 , B27K3/40
CPC分类号： A01N47/34 , B27K3/40 , Y10S514/936 , Y10S514/946
摘要： This invention provides a method of combating termites at a locus, which comprises treating the locus e.g. soil or timber with an acyl urea of the formula ##STR1## wherein one substituent X is a halogen atom or a merthyl group and the other is a halogen atom, a hydrogen atom or a methyl group, and each of R.sup.1, R.sup.2 and R.sup.3 independently represents a hydrogen or fluorine atom; the use of acyl ureas of formula I for combating termites; and compositions for protecting timber against termite attack.

10. 发明授权

US4689230A Contraceptive composition for external application 失效
标题翻译：外用避孕药组合物
公开(公告)号：US4689230A
公开(公告)日：1987-08-25
申请号：US561527
申请日：1983-12-15
申请人： Nabeel H. Ayoub
发明人： Nabeel H. Ayoub
IPC分类号： A61K9/00 , A61K9/70 , A61K36/48 , A61K36/9068 , A61K47/20 , A61L15/44 , A61K35/78
CPC分类号： A61K9/0014 , A61K36/48 , A61K36/9068 , A61K47/20 , A61K9/70 , A61L15/44 , A61L2300/30 , A61L2300/45 , Y10S424/14 , Y10S514/843 , Y10S514/899 , Y10S514/936
摘要： Plant extracts are employed to provide a menses inducing composition for topical application. Common commercially available fenugreek seeds and commercially available ginger are mixed in a preferred range of ratios and combined in a dry powder form for topical application to the outside of the abdomen of the female to induce menses.
摘要翻译：植物提取物用于提供用于局部施用的月经诱导组合物。将常见的市售的葫芦巴种子和市售的姜以优选的比例混合，并以干粉形式混合，用于局部施用到雌性腹部的外部以诱导月经。

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