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1. 发明授权

US08546535B2 Lytic domain fusion constructs and methods of making and using same 有权
标题翻译： Lytic域融合构建体及其使用方法
公开(公告)号：US08546535B2
公开(公告)日：2013-10-01
申请号：US12398965
申请日：2009-03-05
申请人： Carola Leuschner , Hector Alila
发明人： Carola Leuschner , Hector Alila
IPC分类号： C07K5/00
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
摘要翻译：本发明涉及融合构建体，使用融合构建体的方法和治疗不希望的或异常的细胞增殖或过度增殖性疾病如肿瘤，癌症，瘤形成和恶性肿瘤的方法。

2. 发明授权

US08318899B2 Lytic domain fusion constructs and methods of making and using same 有权
标题翻译： Lytic域融合构建体及其使用方法
公开(公告)号：US08318899B2
公开(公告)日：2012-11-27
申请号：US12359906
申请日：2009-01-26
申请人： Carola Leuschner , Hector Alila
发明人： Carola Leuschner , Hector Alila
IPC分类号： C07K14/00 , A61K38/16
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
摘要翻译：本发明涉及融合构建体，使用融合构建体的方法和治疗不期望的或异常的细胞增殖或过度增殖性疾病如肿瘤，癌症，瘤形成和恶性肿瘤的方法。

3. 发明申请

US20090233861A1 LYTIC DOMAIN FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME 有权
标题翻译：光学域熔融结构及其制造和使用方法
公开(公告)号：US20090233861A1
公开(公告)日：2009-09-17
申请号：US12398965
申请日：2009-03-05
申请人： CAROLA LEUSCHNER , HECTOR ALILA
发明人： CAROLA LEUSCHNER , HECTOR ALILA
IPC分类号： A61K38/16 , C07K14/00 , C07K7/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61K38/10
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
摘要翻译：本发明涉及融合构建体，使用融合构建体的方法和治疗不期望的或异常的细胞增殖或过度增殖性疾病如肿瘤，癌症，瘤形成和恶性肿瘤的方法。

4. 发明申请

US20130157961A1 LYTIC-PEPTIDE-HER2/NEU (HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2) LIGAND CONJUGATES AND METHODS OF USE 有权
标题翻译： LYTIC-PEPTIDE-HER2 / NEU（人类生殖因子受体2）配体结合体及使用方法
公开(公告)号：US20130157961A1
公开(公告)日：2013-06-20
申请号：US13695390
申请日：2011-04-28
申请人： Hector Alila , Carola Leuschner , Martha Juban , Ann Coulter
发明人： Hector Alila , Carola Leuschner , Martha Juban , Ann Coulter
IPC分类号： C07K14/00 , A61K38/16 , A61K45/00 , C07K7/08 , A61K38/10
CPC分类号： A61K38/10 , A61K38/16 , A61K45/00 , A61K47/64 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/526 , C07K2317/622
摘要： The invention relates to conjugates that bind to Her2/neu, methods of using conjugates that bind to Her2/neu and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express Her2/neu.
摘要翻译：本发明涉及结合Her2 / neu的缀合物，使用结合Her2 / neu的缀合物的方法和治疗不希望的或异常的细胞增殖或过度增殖性疾病（例如表达Her2 / neu的肿瘤，癌症，瘤形成和恶性肿瘤）的方法。

5. 发明申请

US20090233860A1 LYTIC DOMAIN FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：US20090233860A1
公开(公告)日：2009-09-17
申请号：US12398958
申请日：2009-03-05
申请人： CAROLA LEUSCHNER , HECTOR ALILA
发明人： CAROLA LEUSCHNER , HECTOR ALILA
IPC分类号： A61K38/16 , C07K14/00 , C07K7/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61K38/10
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.

6. 发明申请

US20090061006A1 Layered Nanoparticles for Sustained Release of Small Molecules 审中-公开
标题翻译：分层纳米粒子用于持续释放小分子
公开(公告)号：US20090061006A1
公开(公告)日：2009-03-05
申请号：US12294359
申请日：2007-03-28
申请人： Carola Leuschner , Yuri M. Lvov , Challa S.S.R. Kumar
发明人： Carola Leuschner , Yuri M. Lvov , Challa S.S.R. Kumar
IPC分类号： A61K9/14 , A61K38/17 , A61K38/10
CPC分类号： A61K9/5115 , A61K9/5161 , A61K47/62
摘要： Nanoparticle compositions and methods are disclosed for the sustained release of small molecules, such as pharmaceutical compounds in vivo, for example ligand-lytic peptide conjugates. The construction of the nanoparticles helps to prevent self-aggregation of the molecules, and the consequent loss of effectiveness. The system employs layer-by-layer self-assembly of biocompatible polyelectrolyte layers, and layers of charged small molecules such as drug molecules, to form a multilayer nanoparticle in which the drug or other small molecule itself acts as one of the alternating charged layers in the multilayer assembly. The small molecules can then be released over time in a sustained manner. The LbL nano-assemblies can specifically target cancers, metastases, or other diseased tissues, while minimizing side effects.
摘要翻译：公开了纳米颗粒组合物和方法用于持续释放小分子，例如体内的药物化合物，例如配体 - 溶解肽缀合物。纳米颗粒的构建有助于防止分子的自聚集，从而导致有效性的丧失。该系统采用生物相容性聚电解质层和电荷小分子层（例如药物分子）的逐层自组装形成多层纳米颗粒，其中药物或其它小分子本身作为交替充电层之一多层组件。然后可以持续的方式随时间释放小分子。 LbL纳米组件可以特异性靶向癌症，转移瘤或其他患病组织，同时尽量减少副作用。

7. 发明授权

US10093961B2 Methods for diagnosis of and predicting treatment efficacy of hormone receptor expressing tumors, cancers and neoplasias 有权
公开(公告)号：US10093961B2
公开(公告)日：2018-10-09
申请号：US12975058
申请日：2010-12-21
申请人： Carola Leuschner , Hector Alila
发明人： Carola Leuschner , Hector Alila
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574
摘要： The invention relates to diagnosis, detection, screening, identifying and predicting methods. In various embodiments, methods of the invention include diagnosis, detection, or screening for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject; identifying a subject that will or is likely to respond to a therapy for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia); and predicting therapeutic efficacy of a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) treatment in a subject.

8. 发明申请

US20110124564A1 NUCLEOLIN-BINDING PEPTIDES, NUCLEOLIN- BINDING LYTIC PEPTIDES, FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：核蛋白结合肽，核蛋白结合胶原蛋白，融合构造及其制备和使用方法
公开(公告)号：US20110124564A1
公开(公告)日：2011-05-26
申请号：US12868353
申请日：2010-08-25
申请人： Hector ALILA , Carola LEUSCHNER
发明人： Hector ALILA , Carola LEUSCHNER
IPC分类号： A61K38/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K19/00 , C07K16/18 , A61K38/08 , A61K38/02 , C12N5/071 , A61P35/00
CPC分类号： C07K14/43563 , A61K38/00 , C07K14/4702 , C07K2319/30
摘要： The invention relates to nucleolin binding peptides, nucleolin binding peptides and anti-nucleolin antibody conjugates with cytotoxic activity, fusion constructs, methods of using nucleolin binding peptides and antibodies and fusion constructs thereof, and methods of treating various disorders, undesirable conditions and diseases treatable with nucleolin binding peptides and fusion constructs, such as undesirable or aberrant cell proliferation (hyperproliferation) or hyperproliferative disorders, including tumors, cancers, neoplasia and malignancies, angiogenesis related or dependent diseases, and inflammatory diseases and inflammation.
摘要翻译：本发明涉及具有细胞毒活性的核仁林结合肽，核仁结合肽和抗核蛋白抗体缀合物，融合构建体，使用核仁核苷结合肽和抗体的方法及其融合构建体，以及治疗各种疾病，不良状况和可治疗的疾病的方法核仁素结合肽和融合构建体，例如不期望的或异常的细胞增殖（过度增殖）或过度增殖性疾病，包括肿瘤，癌症，瘤形成和恶性肿瘤，血管发生相关或依赖性疾病，炎性疾病和炎症。

9. 发明申请

US20090269341A1 LYTIC DOMAIN FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME 有权
公开(公告)号：US20090269341A1
公开(公告)日：2009-10-29
申请号：US12359906
申请日：2009-01-26
申请人： CAROLA LEUSCHNER , Hector Alila
发明人： CAROLA LEUSCHNER , Hector Alila
IPC分类号： A61K39/395 , C07K16/18 , C07K14/00 , A61P35/00
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.

10. 发明申请

US20110217702A1 METHODS FOR DIAGNOSIS OF AND PREDICTING TREATMENT EFFICACY OF HORMONE RECEPTOR EXPRESSING TUMORS, CANCERS AND NEOPLASIAS 审中-公开
标题翻译：用于诊断和预测激素受体表达肿瘤，癌症和神经细胞的治疗效果的方法
公开(公告)号：US20110217702A1
公开(公告)日：2011-09-08
申请号：US12975058
申请日：2010-12-21
申请人： CAROLA LEUSCHNER , Hector Alila
发明人： CAROLA LEUSCHNER , Hector Alila
IPC分类号： C12Q1/68 , G01N33/566 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574
摘要： The invention relates to diagnosis, detection, screening, identifying and predicting methods. In various embodiments, methods of the invention include diagnosis, detection, or screening for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject; identifying a subject that will or is likely to respond to a therapy for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia); and predicting therapeutic efficacy of a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) treatment in a subject.
摘要翻译：本发明涉及诊断，检测，筛选，鉴定和预测方法。在各种实施方案中，本发明的方法包括对受试者中的过度增殖性疾病（例如肿瘤，癌症或瘤形成）的诊断，检测或筛选; 识别将会或可能对过度增殖性疾病（例如肿瘤，癌症或瘤形成）的治疗作出反应的对象; 并预测受试者中过度增殖性疾病（例如肿瘤，癌症或瘤形成）治疗的治疗功效。

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