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1. 发明申请

US20090061006A1 Layered Nanoparticles for Sustained Release of Small Molecules 审中-公开
标题翻译：分层纳米粒子用于持续释放小分子
公开(公告)号：US20090061006A1
公开(公告)日：2009-03-05
申请号：US12294359
申请日：2007-03-28
申请人： Carola Leuschner , Yuri M. Lvov , Challa S.S.R. Kumar
发明人： Carola Leuschner , Yuri M. Lvov , Challa S.S.R. Kumar
IPC分类号： A61K9/14 , A61K38/17 , A61K38/10
CPC分类号： A61K9/5115 , A61K9/5161 , A61K47/62
摘要： Nanoparticle compositions and methods are disclosed for the sustained release of small molecules, such as pharmaceutical compounds in vivo, for example ligand-lytic peptide conjugates. The construction of the nanoparticles helps to prevent self-aggregation of the molecules, and the consequent loss of effectiveness. The system employs layer-by-layer self-assembly of biocompatible polyelectrolyte layers, and layers of charged small molecules such as drug molecules, to form a multilayer nanoparticle in which the drug or other small molecule itself acts as one of the alternating charged layers in the multilayer assembly. The small molecules can then be released over time in a sustained manner. The LbL nano-assemblies can specifically target cancers, metastases, or other diseased tissues, while minimizing side effects.
摘要翻译：公开了纳米颗粒组合物和方法用于持续释放小分子，例如体内的药物化合物，例如配体 - 溶解肽缀合物。纳米颗粒的构建有助于防止分子的自聚集，从而导致有效性的丧失。该系统采用生物相容性聚电解质层和电荷小分子层（例如药物分子）的逐层自组装形成多层纳米颗粒，其中药物或其它小分子本身作为交替充电层之一多层组件。然后可以持续的方式随时间释放小分子。 LbL纳米组件可以特异性靶向癌症，转移瘤或其他患病组织，同时尽量减少副作用。

2. 发明申请

US20090169478A1 In Vivo Imaging and Therapy with Magnetic Nanoparticle Conjugates 审中-公开
标题翻译：用磁性纳米粒子缀合物进行体内成像和治疗
公开(公告)号：US20090169478A1
公开(公告)日：2009-07-02
申请号：US11997370
申请日：2006-08-04
申请人： Carola Leuschner , Challa S.S.R. Kumar , William Hansel , Josef Hormes
发明人： Carola Leuschner , Challa S.S.R. Kumar , William Hansel , Josef Hormes
IPC分类号： A61K49/18 , B32B1/00 , A61K49/04 , A61K49/22 , A61K9/14 , A61K39/395 , A61P35/00
CPC分类号： A61K49/1866 , B82Y5/00 , Y10T428/2982
摘要： A non-invasive in vivo technique is disclosed, useful for example in detecting cancers and micrometastases. The technique may be used to selectively deliver drugs to target cells such as tumors, metastases, micrometastases, and individual malignant cells. Ligands with specificity for a target cell receptor, and optionally drug molecules as well, are covalently bound to magnetic nanoparticles, either directly or through a spacer molecule. The ligand precludes the need for a separate coating layer. For example, human breast cancer cells express receptors both for luteinizing hormone/chorionic gonadotropin (LH/CG), and for luteinizing hormone releasing hormone (LHRH). These cells can be specifically targeted by iron oxide nanoparticles covalently linked to LH/CG or LHRH. The nanoparticles are incorporated into the cancer cells through receptor-mediated endocytosis. The specific accumulation in targeted cancer cells enhances resolution for imaging, therapy, or both. The ligand may, for example, be a hormone, receptor, or antibody, or a fragment thereof.
摘要翻译：公开了非侵入性体内技术，其可用于例如检测癌症和微转移。该技术可用于选择性地向靶细胞递送药物，例如肿瘤，转移瘤，微转移和个体恶性细胞。对靶细胞受体具有特异性的配体以及任选的药物分子也可直接或通过间隔分子与磁性纳米粒子共价结合。配体排除了对单独涂层的需要。例如，人乳腺癌细胞表达促黄体激素/绒毛膜促性腺激素（LH / CG）和黄体生成激素释放激素（LHRH）的受体。这些细胞可以与共价连接到LH / CG或LHRH的氧化铁纳米粒子特异性靶向。通过受体介导的胞吞作用将纳米颗粒掺入癌细胞。靶向癌细胞中的特异性积累增强了成像，治疗或两者的分辨率。配体可以是例如激素，受体或抗体或其片段。

3. 发明授权

US10093961B2 Methods for diagnosis of and predicting treatment efficacy of hormone receptor expressing tumors, cancers and neoplasias 有权
公开(公告)号：US10093961B2
公开(公告)日：2018-10-09
申请号：US12975058
申请日：2010-12-21
申请人： Carola Leuschner , Hector Alila
发明人： Carola Leuschner , Hector Alila
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574
摘要： The invention relates to diagnosis, detection, screening, identifying and predicting methods. In various embodiments, methods of the invention include diagnosis, detection, or screening for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject; identifying a subject that will or is likely to respond to a therapy for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia); and predicting therapeutic efficacy of a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) treatment in a subject.

4. 发明授权

US08546535B2 Lytic domain fusion constructs and methods of making and using same 有权
标题翻译： Lytic域融合构建体及其使用方法
公开(公告)号：US08546535B2
公开(公告)日：2013-10-01
申请号：US12398965
申请日：2009-03-05
申请人： Carola Leuschner , Hector Alila
发明人： Carola Leuschner , Hector Alila
IPC分类号： C07K5/00
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
摘要翻译：本发明涉及融合构建体，使用融合构建体的方法和治疗不希望的或异常的细胞增殖或过度增殖性疾病如肿瘤，癌症，瘤形成和恶性肿瘤的方法。

5. 发明授权

US08318899B2 Lytic domain fusion constructs and methods of making and using same 有权
标题翻译： Lytic域融合构建体及其使用方法
公开(公告)号：US08318899B2
公开(公告)日：2012-11-27
申请号：US12359906
申请日：2009-01-26
申请人： Carola Leuschner , Hector Alila
发明人： Carola Leuschner , Hector Alila
IPC分类号： C07K14/00 , A61K38/16
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
摘要翻译：本发明涉及融合构建体，使用融合构建体的方法和治疗不期望的或异常的细胞增殖或过度增殖性疾病如肿瘤，癌症，瘤形成和恶性肿瘤的方法。

6. 发明申请

US20130157961A1 LYTIC-PEPTIDE-HER2/NEU (HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2) LIGAND CONJUGATES AND METHODS OF USE 有权
标题翻译： LYTIC-PEPTIDE-HER2 / NEU（人类生殖因子受体2）配体结合体及使用方法
公开(公告)号：US20130157961A1
公开(公告)日：2013-06-20
申请号：US13695390
申请日：2011-04-28
申请人： Hector Alila , Carola Leuschner , Martha Juban , Ann Coulter
发明人： Hector Alila , Carola Leuschner , Martha Juban , Ann Coulter
IPC分类号： C07K14/00 , A61K38/16 , A61K45/00 , C07K7/08 , A61K38/10
CPC分类号： A61K38/10 , A61K38/16 , A61K45/00 , A61K47/64 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/526 , C07K2317/622
摘要： The invention relates to conjugates that bind to Her2/neu, methods of using conjugates that bind to Her2/neu and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express Her2/neu.
摘要翻译：本发明涉及结合Her2 / neu的缀合物，使用结合Her2 / neu的缀合物的方法和治疗不希望的或异常的细胞增殖或过度增殖性疾病（例如表达Her2 / neu的肿瘤，癌症，瘤形成和恶性肿瘤）的方法。

7. 发明授权

US09586996B2 Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use 有权
标题翻译： Lytic-peptide-Her2 / neu（人表皮生长因子受体2）配体缀合物及其使用方法
公开(公告)号：US09586996B2
公开(公告)日：2017-03-07
申请号：US13695390
申请日：2011-04-28
申请人： Hector Alila , Carola Leuschner
发明人： Hector Alila , Carola Leuschner
IPC分类号： C07K16/00 , C07K7/08 , A61K39/00 , A61K38/03 , C07K14/00 , A61K47/48 , A61K38/10 , A61K38/16 , A61K45/00
CPC分类号： A61K38/10 , A61K38/16 , A61K45/00 , A61K47/64 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/526 , C07K2317/622
摘要： The invention relates to conjugates that bind to Her2/neu, methods of using conjugates that bind to Her2/neu and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express Her2/neu.
摘要翻译：本发明涉及结合Her2 / neu的缀合物，使用结合Her2 / neu的缀合物的方法和治疗不希望的或异常的细胞增殖或过度增殖性疾病（例如表达Her2 / neu的肿瘤，癌症，瘤形成和恶性肿瘤）的方法。

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