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1. 发明申请

US20090061006A1 Layered Nanoparticles for Sustained Release of Small Molecules 审中-公开
标题翻译：分层纳米粒子用于持续释放小分子
公开(公告)号：US20090061006A1
公开(公告)日：2009-03-05
申请号：US12294359
申请日：2007-03-28
申请人： Carola Leuschner , Yuri M. Lvov , Challa S.S.R. Kumar
发明人： Carola Leuschner , Yuri M. Lvov , Challa S.S.R. Kumar
IPC分类号： A61K9/14 , A61K38/17 , A61K38/10
CPC分类号： A61K9/5115 , A61K9/5161 , A61K47/62
摘要： Nanoparticle compositions and methods are disclosed for the sustained release of small molecules, such as pharmaceutical compounds in vivo, for example ligand-lytic peptide conjugates. The construction of the nanoparticles helps to prevent self-aggregation of the molecules, and the consequent loss of effectiveness. The system employs layer-by-layer self-assembly of biocompatible polyelectrolyte layers, and layers of charged small molecules such as drug molecules, to form a multilayer nanoparticle in which the drug or other small molecule itself acts as one of the alternating charged layers in the multilayer assembly. The small molecules can then be released over time in a sustained manner. The LbL nano-assemblies can specifically target cancers, metastases, or other diseased tissues, while minimizing side effects.
摘要翻译：公开了纳米颗粒组合物和方法用于持续释放小分子，例如体内的药物化合物，例如配体 - 溶解肽缀合物。纳米颗粒的构建有助于防止分子的自聚集，从而导致有效性的丧失。该系统采用生物相容性聚电解质层和电荷小分子层（例如药物分子）的逐层自组装形成多层纳米颗粒，其中药物或其它小分子本身作为交替充电层之一多层组件。然后可以持续的方式随时间释放小分子。 LbL纳米组件可以特异性靶向癌症，转移瘤或其他患病组织，同时尽量减少副作用。

2. 发明授权

US08764938B1 Method for the manufacture of smart paper and smart wood fibers 有权
标题翻译：智能纸和智能木纤维的制造方法
公开(公告)号：US08764938B1
公开(公告)日：2014-07-01
申请号：US13735442
申请日：2013-01-07
申请人： Mangilal Agarwal , Yuri M. Lvov , Khodadad Varahramyan
发明人： Mangilal Agarwal , Yuri M. Lvov , Khodadad Varahramyan
IPC分类号： D21F11/00
CPC分类号： D21F11/00
摘要： A method is provided for making “smart” paper and “smart” microfibers by means of nanotechnology layer-by-layer techniques. The method comprises forming an aqueous pulp of lignocellulose fibers and nanocoating it by alternatively adsorbing onto the fibers multiple consecutively-applied layers of organized ultra thin and oppositely-charged polyelectrolytes, at least one of which is an electrically conductive polymer or nanoparticle (or a magnetically active polymer or nanoparticle, or an optically active polymer or nanoparticle), and another one of which has a charge opposite of said electrically conductive polymer or nanoparticle (or magnetically active polymer or nanoparticle, or optically active polymer or nanoparticle), thereby making a modified aqueous pulp of electrically conductive (or magnetically active, or optically active) multi-layer nanocoated lignocellulose fibers. A finished paper is manufactured by drying sheets of the modified fibers and processing the dried sheets to make a smart paper having enhanced electrical conductivity, magnetic and/or optical properties.
摘要翻译：提供了一种通过纳米技术逐层技术制造“智能”纸和“智能”微纤维的方法。该方法包括形成木质纤维素纤维的水性纸浆并通过交替地吸附到纤维上多次连续施加的有序的超薄和相反电荷的聚电解质的层中进行纳米胶化，其中至少一种是导电聚合物或纳米颗粒（或磁性的）活性聚合物或纳米颗粒，或光学活性聚合物或纳米颗粒），并且另一个具有与所述导电聚合物或纳米颗粒（或磁性活性聚合物或纳米颗粒或光学活性聚合物或纳米颗粒）相反的电荷，导电（或磁性活性或光学活性）多层纳米涂层木质纤维素纤维的水性纸浆。通过将改性纤维的片材干燥并加工干燥的片材以制造具有增强的导电性，磁性和/或光学性质的智能纸来制造成品纸。

3. 发明授权

US09192912B1 Ceramic nanotube composites with sustained drug release capability for implants, bone repair and regeneration 有权
标题翻译：陶瓷纳米复合材料具有持续的植入物释放能力，骨修复和再生
公开(公告)号：US09192912B1
公开(公告)日：2015-11-24
申请号：US13446775
申请日：2012-04-13
申请人： David Mills , Yuri M. Lvov
发明人： David Mills , Yuri M. Lvov
IPC分类号： B01J20/16 , C08L33/12 , A61C5/08
CPC分类号： A61L24/0089 , A61C8/0012 , A61C8/0016 , B01J20/16 , C08K3/34 , C08K9/10 , C08K2201/003 , C08K2201/004 , C08K2201/011 , C08L33/12
摘要： An augmented ceramic composite including aluminosilicate nanotubes may be added to a biocompatible polymer matrix. Aluminosilicate nanotubes have a surprisingly high biocompatibility, radio opaqueness, and suitability for storing therapeutic compounds for release over time. These surprising advantages make aluminosilicate nanotubes, such as halloysite nanotubes, a good candidate for use in various medical applications from bone and dental prosthetics to cancer treatment and prevention. Furthermore, unlike other additives, the addition of certain quantities of halloysite nanotubes increases the strength of the polymer matrix to which it is added.
摘要翻译：包括铝硅酸盐纳米管的增强陶瓷复合材料可以加入到生物相容的聚合物基质中。硅铝酸盐纳米管具有令人惊奇的高生物相容性，无线电不透明度和适用于随时间释放的治疗化合物的储存。这些令人惊奇的优点使铝硅酸盐纳米管（如多水高岭土纳米管）成为用于从骨骼和牙科假肢到癌症治疗和预防的各种医学应用的良好候选物。此外，与其他添加剂不同，加入一定量的多水高岭土纳米管增加了加入其中的聚合物基质的强度。

4. 发明申请

US20110297038A1 Microreservoir with End Plugs for Controlled Release of Corrosion Inhibitor 有权
标题翻译：具有用于控制释放腐蚀抑制剂的端塞的微储存器
公开(公告)号：US20110297038A1
公开(公告)日：2011-12-08
申请号：US12795984
申请日：2010-06-08
申请人： Yuri M. Lvov , Elshad Abdullayev
发明人： Yuri M. Lvov , Elshad Abdullayev
IPC分类号： C09D1/04 , C09D1/02
CPC分类号： C09D5/082 , B05D5/005 , B05D7/14 , C08K3/346 , C08K5/3437 , C08K5/3447 , C08K5/3475 , C09D7/48 , C09D7/67 , C09D7/68 , Y10T428/13
摘要： A corrosion inhibiting structure includes a mineral tubule having a first end, a second end, and a lumen extending from the first end to the second end. The lumen terminates in a first opening at the first end and a second opening at the second end. The corrosion inhibiting structure also includes an anticorrosion deposit disposed within the lumen, and first and second precipitate stoppers covering the first and second openings, respectively. A coating composition includes a population of corrosion inhibiting structures and a coating material. A method of inhibiting corrosion includes loading anticorrosion agent deposits into lumens, forming stoppers at first and second openings by mixing loaded mineral tubules with a solution containing a predetermined concentration of transition metal ions, mixing the loaded mineral tubules having stoppers with a coating material to form a composite material, and applying the composite material to a metal surface.
摘要翻译：腐蚀抑制结构包括具有第一端，第二端和从第一端延伸到第二端的内腔的矿物管。内腔终止于第一端的第一开口和第二端的第二开口。腐蚀抑制结构还包括设置在内腔内的防腐沉积物，以及分别覆盖第一和第二开口的第一和第二沉淀物塞子。涂料组合物包括一组腐蚀抑制结构和涂料。抑制腐蚀的方法包括将防腐蚀剂沉积物加载到内腔中，通过将负载的矿物小管与含有预定浓度的过渡金属离子的溶液混合，在第一和第二开口处形成塞子，将具有塞子的加载的矿物小管与涂料混合形成复合材料，并将复合材料施加到金属表面。

5. 发明授权

US08507056B2 Microreservoir with end plugs for controlled release of corrosion inhibitor 有权
标题翻译：具有用于控制释放腐蚀抑制剂的端塞的微型储存器
公开(公告)号：US08507056B2
公开(公告)日：2013-08-13
申请号：US12795984
申请日：2010-06-08
申请人： Yuri M. Lvov , Elshad Abdullayev
发明人： Yuri M. Lvov , Elshad Abdullayev
IPC分类号： B29D22/00 , C04B9/02
CPC分类号： C09D5/082 , B05D5/005 , B05D7/14 , C08K3/346 , C08K5/3437 , C08K5/3447 , C08K5/3475 , C09D7/48 , C09D7/67 , C09D7/68 , Y10T428/13
摘要： A corrosion inhibiting structure includes a mineral tubule having a first end, a second end, and a lumen extending from the first end to the second end. The lumen terminates in a first opening at the first end and a second opening at the second end. The corrosion inhibiting structure also includes an anticorrosion deposit disposed within the lumen, and first and second precipitate stoppers covering the first and second openings, respectively. A coating composition includes a population of corrosion inhibiting structures and a coating material. A method of inhibiting corrosion includes loading anticorrosion agent deposits into lumens, forming stoppers at first and second openings by mixing loaded mineral tubules with a solution containing a predetermined concentration of transition metal ions, mixing the loaded mineral tubules having stoppers with a coating material to form a composite material, and applying the composite material to a metal surface.
摘要翻译：腐蚀抑制结构包括具有第一端，第二端和从第一端延伸到第二端的内腔的矿物管。内腔终止于第一端的第一开口和第二端的第二开口。腐蚀抑制结构还包括设置在内腔内的防腐沉积物，以及分别覆盖第一和第二开口的第一和第二沉淀物塞子。涂料组合物包括一组腐蚀抑制结构和涂料。抑制腐蚀的方法包括将防腐蚀剂沉积物加载到内腔中，通过将负载的矿物小管与含有预定浓度的过渡金属离子的溶液混合，在第一和第二开口处形成塞子，将具有塞子的加载的矿物小管与涂料混合形成复合材料，并将复合材料施加到金属表面。

6. 发明授权

US08349131B1 Method for the manufacture of smart paper and smart wood microfibers 有权
标题翻译：智能纸和智能木材微纤维的制造方法
公开(公告)号：US08349131B1
公开(公告)日：2013-01-08
申请号：US11928626
申请日：2007-10-30
申请人： Mangilal Agarwal , Yuri M. Lvov , Khodadad Varahramyan
发明人： Mangilal Agarwal , Yuri M. Lvov , Khodadad Varahramyan
IPC分类号： D21F11/00
CPC分类号： D21F11/00
摘要： A method is provided for making “smart” paper and “smart” microfibers by means of nanotechnology layer-by-layer techniques. The method comprises forming an aqueous pulp of lignocellulose fibers and nanocoating it by alternatively adsorbing onto the fibers multiple consecutively-applied layers of organized ultra thin and oppositely-charged polyelectrolytes, at least one of which is an electrically conductive polymer or nanoparticle (or a magnetically active polymer or nanoparticle, or an optically active polymer or nanoparticle), and another one of which has a charge opposite of said electrically conductive polymer or nanoparticle (or magnetically active polymer or nanoparticle, or optically active polymer or nanoparticle), thereby making a modified aqueous pulp of electrically conductive (or magnetically active, or optically active) multi-layer nanocoated lignocellulose fibers; then draining the water out of the modified aqueous pulp to form sheets of smart microfibers. A finished paper is manufactured by drying the sheets of the nanocoated multi-layer fibers and processing the dried sheets to make a smart paper having enhanced electrical conductivity, magnetic and/or optical properties.
摘要翻译：提供了一种通过纳米技术逐层技术制造智能纸和智能微纤维的方法。该方法包括形成木质纤维素纤维的水性纸浆并通过交替地吸附到纤维上多次连续施加的有序的超薄和相反电荷的聚电解质的层中进行纳米涂层，其中至少一个是导电聚合物或纳米颗粒（或磁性的）活性聚合物或纳米颗粒，或光学活性聚合物或纳米颗粒），并且另一个具有与所述导电聚合物或纳米颗粒（或磁性活性聚合物或纳米颗粒或光学活性聚合物或纳米颗粒）相反的电荷，导电（或磁性活性或光学活性）多层纳米碳酸化木质纤维素纤维的水性纸浆; 然后将水从改性的含水纸浆中排出以形成柔性微纤维片。通过干燥纳米多层纤维的片材并加工干燥的片材以制造具有增强的导电性，磁性和/或光学性质的智能纸来制造成品纸。

7. 发明授权

US07842162B1 Layer-by-layer nanocoating for paper fabrication 有权
标题翻译：用于纸张制造的逐层纳米涂层
公开(公告)号：US07842162B1
公开(公告)日：2010-11-30
申请号：US11372945
申请日：2006-03-11
申请人： Yuri M. Lvov , George Grozdits
发明人： Yuri M. Lvov , George Grozdits
IPC分类号： D21F11/00
CPC分类号： D21H17/22 , D21H17/20 , D21H17/33 , D21H17/67 , D21H19/38 , D21H21/20
摘要： A method is provided for manufacturing paper by means of layer-by-layer nanocoating techniques. The method comprises the sequential processing of an aqueous pulp of lignocellulose fibers which is first subjected to nanocoating by alternatively adsorbing onto the fibers multiple consecutively-applied layers of oppositely-charged nanoparticles, polymers and/or proteins thereby making a modified aqueous pulp of multi-layer nanocoated lignocellulose fibers, then draining the water out of the modified pulp to form sheets of multi-layer nanocoated fibers, and drying the formed sheets of multi-layer nanocoated fibers. The resulting dried sheets are then processed to make a finished paper that has superior physical strength and improved surface properties. In a preferred embodiment the starting aqueous pulp of lignocellulose fibers is divided into is separate portions which are separately nanocoated with opposite charges, and then blended to form a complex aggregate pulp of nanocoated fibers before draining and drying it. The method is particularly applicable to the treatment of broken (mill broke) recycled fibers in order to facilitate their usage in paper production.
摘要翻译：提供了一种通过逐层纳米涂覆技术制造纸的方法。该方法包括对木质纤维素纤维的水性纸浆进行连续加工，首先通过交替地吸附到纤维上多次连续施加的相反电荷的纳米颗粒，聚合物和/或蛋白质层，进行纳米涂层，层纳米碳酸纤维素纤维，然后将水从改性纸浆中排出以形成多层纳米填充纤维片，并干燥多层纳米填充纤维的成形片材。然后将所得的干燥片材加工成具有优异的物理强度和改进的表面性能的成品纸。在一个优选的实施方案中，将木质纤维素纤维的起始含水纸浆分成独立的部分，这些部分用相反的电荷单独地纳米化，然后在排干和干燥之前共混以形成纳米填充纤维的复合聚集纸浆。该方法特别适用于破碎（破碎）回收纤维的处理，以便于其在纸张生产中的使用。

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