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1. 发明授权

US08232112B2 Optical microlabels: shapes and reflectors 失效
标题翻译：光学微标签：形状和反射镜
公开(公告)号：US08232112B2
公开(公告)日：2012-07-31
申请号：US12769169
申请日：2010-04-28
申请人： Richard C. Willson , Raul Ruchhoedft
发明人： Richard C. Willson , Raul Ruchhoedft
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y5/00 , C12Q1/6837 , Y10S436/805 , Y10S977/701 , Y10S977/702 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10S977/774 , Y10S977/834 , Y10S977/92 , C12Q2563/155
摘要： Labels and methods of producing labels for use in clinical, analytical and pharmaceutical development assays are provided. Labels may comprise shape-encoded particles which may be coupled to ligands such as DNA, RNA and antibodies, where different shapes are used to identify which ligand(s) are present. Labels may also comprise reflectors, including retroreflectors and retroreflectors susceptible to analyte-dependent assembly for efficient homogeneous assays.
摘要翻译：提供了生产用于临床，分析和药物开发测定的标签的标签和方法。标签可以包括可以与诸如DNA，RNA和抗体的配体偶联的形状编码的颗粒，其中使用不同的形状来鉴定哪些配体存在。标签还可以包括反射器，包括对分析物依赖性装配易于进行有效均匀测定的后向反射器和后向反射器。

2. 发明申请

US20120064255A1 VIBRATION DAMPING COATING 审中-公开
标题翻译：振动阻尼涂料
公开(公告)号：US20120064255A1
公开(公告)日：2012-03-15
申请号：US12878167
申请日：2010-09-09
申请人： Robert W. Willson , Michael C. Willson , John P. Henderson
发明人： Robert W. Willson , Michael C. Willson , John P. Henderson
IPC分类号： C23C4/04 , C03C8/20 , C03C8/14
CPC分类号： C03C8/20 , C23C4/02 , C23C4/11 , C23C4/134 , Y02T50/67 , Y02T50/6765
摘要： A method is disclosed for applying a vibration-damping surface to an article. The method includes providing a coating material comprising a ceramic, metallic or cermet material and a viscoelastic glass frit and plasma spraying the coating material onto an article. The coating material forms a plurality of ceramic, metallic or cermet microstructures having voids with the viscoelastic glass frit distributed to interact with the voids to provide vibration damping. Also disclosed are plasma spray coatings for damping vibrations that includes a ceramic-glass frit composite coating capable of reducing resonant vibrations in a substrate at temperatures between 700° F. to 1500° F. and said plasma spray coating as a coating on a substrate.
摘要翻译：公开了一种将减振表面施加到制品上的方法。该方法包括提供包括陶瓷，金属或金属陶瓷材料和粘弹性玻璃料的涂层材料和等离子体将涂层材料喷涂到制品上。涂层材料形成多个具有空隙的陶瓷，金属或金属陶瓷微结构，其中分布有粘弹性玻璃料以与空隙相互作用以提供振动阻尼。还公开了用于阻尼振动的等离子体喷涂涂层，其包括陶瓷 - 玻璃料复合涂层，其能够在700°F至1500°F之间的温度下降低衬底中的共振振动，并将所述等离子喷涂涂层作为衬底上的涂层。

3. 发明授权

US07598371B2 Nucleic acid separation using immobilized metal affinity chromatography 有权
标题翻译：使用固定化金属亲和色谱法进行核酸分离
公开(公告)号：US07598371B2
公开(公告)日：2009-10-06
申请号：US09994701
申请日：2001-11-06
申请人： Richard C. Willson , Jason C. Murphy
发明人： Richard C. Willson , Jason C. Murphy
IPC分类号： C07H21/00 , G01N30/02 , B01D15/08
CPC分类号： C12N15/101
摘要： An immobilized metal affinity chromatography (IMAC) method for separating and/or purifying compounds containing a non-shielded purine or pyrimidine moiety or group such as nucleic acid, presumably through interaction with the abundant aromatic nitrogen atoms in the purine or pyrimidine moiety. The method can also be used to purify compounds containing purine or pyrimidine moieties where the purine and pyrimidine moieties are shielded from interaction with the column matrix from compounds containing a non-shielded purine or pyrimidine moiety or group. Thus, double-stranded plasmid and genomic DNA, which has no low binding affinity can be easily separated from RNA and/or oligonucleotides which bind strongly to metal-charged chelating matrices. IMAC columns clarify plasmid DNA from bacterial alkaline lysates, purify a ribozyme, and remove primers and other contaminants from PCR reactions. The metal ion affinity of yeast RNA decreases in the order: copper (II), nickel (II), zinc (II), and cobalt (II).
摘要翻译：用于分离和/或纯化含有非屏蔽嘌呤或嘧啶部分或核酸的化合物的固定化金属亲和层析（IMAC）方法，可能通过与嘌呤或嘧啶部分中丰富的芳族氮原子相互作用来进行。该方法还可用于纯化含有嘌呤或嘧啶部分的化合物，其中嘌呤和嘧啶部分被屏蔽以免与含有非屏蔽嘌呤或嘧啶部分或基团的化合物与柱基质相互作用。因此，具有低结合亲和力的双链质粒和基因组DNA可以容易地从与金属电荷螯合基质强结合的RNA和/或寡核苷酸中分离出来。 IMAC色谱柱澄清细菌碱性裂解物的质粒DNA，纯化核酶，并从PCR反应中除去引物和其他污染物。酵母RNA的金属离子亲和力按照铜（II），镍（II），锌（II）和钴（II）的顺序降低。

4. 发明申请

US20070034600A1 Planarization Method of Patterning a Substratte 审中-公开
标题翻译：对子图案进行平面化的方法
公开(公告)号：US20070034600A1
公开(公告)日：2007-02-15
申请号：US11535889
申请日：2006-09-27
申请人： C. Willson , Britain Smith , Nicholas Stacey
发明人： C. Willson , Britain Smith , Nicholas Stacey
IPC分类号： B44C1/22
CPC分类号： B29C43/003 , B29C2043/025 , B81C99/0085 , B81C2201/0152 , B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F7/0955
摘要： The present invention includes a method for forming a pattern on a substrate with a composition by forming a cross-linked polymer from the composition upon exposing the same to radiation. The method includes depositing the composition to function as a planarization layer. Thereafter, a layer of polymerizable material into which a pattern is to be recorded is deposited.
摘要翻译：本发明包括通过在将组合物暴露于辐射时从组合物形成交联聚合物而在组合物上形成图案的方法。该方法包括沉积作为平坦化层的组合物。此后，沉积要记录图案的可聚合材料层。

5. 发明授权

US06908768B2 Process for testing catalysts using thermography 失效
标题翻译：使用热成像测试催化剂的方法
公开(公告)号：US06908768B2
公开(公告)日：2005-06-21
申请号：US10029891
申请日：2001-12-21
申请人： Richard C. Willson, III
发明人： Richard C. Willson, III
IPC分类号： G01N25/48 , B01J19/00 , B01J21/04 , C40B30/08 , C40B40/18 , G01N31/10 , G01N21/00 , G01N33/48
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/214 , Y10T436/24
摘要： Apparatus for testing catalyst candidates including a multi-cell holder e.g. a honeycomb or plate, or a collection of individual support particles that have been treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients and dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets. The apparatus also includes structure for contacting the catalyst candidates with a potentially reactive feed stream or batch e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g. by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g. by multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis e.g. spectral analysis, chromatography etc., or by observing temperature change in the vicinity of the catalyst e.g. by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.
摘要翻译：用于测试催化剂候选物的装置，包括多电池座，例如蜂窝或板，或已经用催化剂成分的溶液/悬浮液处理的单独的载体颗粒的集合，以产生保持成分的各种组合的各种组分的细胞，斑点或颗粒，并根据需要进行干燥，煅烧或处理以稳定细胞中的成分，斑点或颗粒。该装置还包括用于使催化剂候选物与潜在的反应性进料流或批料接触的结构，例如生物化学，瓦斯油，氢气加氧气，丙烯加氧气，CCl 2/2F 2 >和氢等。可以测量每个电池中发生的反应，例如通过红外热像仪，产物或残余反应物的光谱检测，或通过采样，例如，通过低体积管道从每个组合的附近进行多流，然后进行分析。光谱分析，色谱等，或通过观察催化剂附近的温度变化，通过热成像技术确定催化剂在每种组合中的相对功效。机器人技术可用于生产细胞，斑点，丸粒等。

6. 发明授权

US06623970B1 Process for testing catalysts using spectroscopy 有权
标题翻译：使用光谱法测试催化剂的方法
公开(公告)号：US06623970B1
公开(公告)日：2003-09-23
申请号：US09613877
申请日：2000-07-10
申请人： Richard C. Willson, III
发明人： Richard C. Willson, III
IPC分类号： G01N3110
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/214 , Y10T436/24
摘要： Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.
摘要翻译：用于评价催化剂的方法，其中多单元保持器例如蜂窝或板或各个支撑颗粒的集合用催化剂成分的溶液/悬浮液处理以产生保持各种各样的组合的细胞，斑点或颗粒根据需要将成分干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧， CCl 2 F 2和氢等。可以测量每个电池中发生的反应，例如通过红外热像仪，产物或残留反应物的光谱检测，或通过采样，例如通过低体积管道从每个组合的附近进行多流式化，随后通过分析，例如光谱分析，色谱法等，或通过观察催化剂附近的温度变化，例如通过热成像技术测定 e催化剂在每种组合中的相对功效。机器人技术可用于生产细胞，斑点，丸粒等。

7. 发明授权

US06623968B1 Parallel flow reactor and apparatus for testing catalysts 有权
标题翻译：平行流动反应器和催化剂测试装置
公开(公告)号：US06623968B1
公开(公告)日：2003-09-23
申请号：US09612857
申请日：2000-07-10
申请人： Richard C. Willson, III
发明人： Richard C. Willson, III
IPC分类号： G01N3110
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/214 , Y10T436/24
摘要： Apparatus for evaluating catalysts, including a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.
摘要翻译：用于评价催化剂的装置，包括多单元保持器，例如蜂窝或板，或各个支撑颗粒的集合，用催化剂成分的溶液/悬浮液处理，以产生保持各种各样的组合的细胞，斑点或颗粒成分，干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧，CCl 2 F 2 和氢气等。可以测量每个电池中发生的反应，例如通过红外热成像，产物或残余反应物的光谱检测，或通过从每个组合的附近采样，例如通过低体积管进行多流，然后是分析，例如光谱分析，色谱等，或通过观察催化剂附近的温度变化，例如通过热成像技术来阻止在每种组合中我们的催化剂的相对功效。机器人技术可用于生产细胞，斑点，丸粒等。

8. 发明授权

US06605470B1 Process for testing catalysts using detection agents 有权
标题翻译：使用检测剂测试催化剂的方法
公开(公告)号：US06605470B1
公开(公告)日：2003-08-12
申请号：US09613084
申请日：2000-07-10
申请人： Richard C. Willson, III
发明人： Richard C. Willson, III
IPC分类号： G01N3300
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/214 , Y10T436/24
摘要： Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.
摘要翻译：用于评价催化剂的方法，其中多单元保持器例如蜂窝或板或各个支撑颗粒的集合用催化剂成分的溶液/悬浮液处理以产生保持各种各样的组合的细胞，斑点或颗粒根据需要将成分干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧， CCl 2 F 2和氢等。可以测量每个电池中发生的反应，例如通过红外热成像，产物或残余反应物的光谱检测，或通过采样，例如通过低体积管道从每个组合的附近进行多流式化，随后通过分析，例如光谱分析，色谱法等，或通过观察催化剂附近的温度变化，例如通过热成像技术测定 e催化剂在每种组合中的相对功效。机器人技术可用于生产细胞，斑点，丸粒等。

9. 发明授权

US06514764B1 Catalyst testing process with in situ synthesis 有权
标题翻译：催化剂测试过程与原位合成
公开(公告)号：US06514764B1
公开(公告)日：2003-02-04
申请号：US09727890
申请日：2000-11-28
申请人： Richard C. Willson, III
发明人： Richard C. Willson, III
IPC分类号： G01N3110
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/214 , Y10T436/24
摘要： A multicell holder e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g. by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g. by multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis e.g. spectral analysis, chromatography etc, or by observing temperature change in the vicinity of the catalyst e.g. by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.
摘要翻译：用催化剂成分的溶液/悬浮液处理多单元载体，例如蜂窝或板，或各个载体颗粒的集合，以产生保持成分各种组合的各种组分的细胞，斑点或颗粒，干燥，煅烧或根据需要进行处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批料例如生化，瓦斯油，氢加氧，丙烯加氧，CCl 2 F 2和氢等接触。发生反应在每个单元格中可以测量，例如通过红外热像仪，产物或残余反应物的光谱检测，或通过采样，例如，通过低体积管道从每个组合的附近进行多流，然后进行分析。光谱分析，色谱分析等，或者通过观察催化剂附近的温度变化。通过热成像技术确定催化剂在每种组合中的相对功效。机器人技术可用于生产细胞，斑点，丸粒等。

10. 发明授权

US6063633A Catalyst testing process and apparatus 失效
标题翻译：催化剂测试过程和仪器
公开(公告)号：US6063633A
公开(公告)日：2000-05-16
申请号：US664836
申请日：1996-06-17
申请人： Richard C. Willson, III
发明人： Richard C. Willson, III
IPC分类号： G01N25/48 , B01J19/00 , B01J21/04 , C40B30/08 , C40B40/18 , G01N31/10 , G01N21/75 , G01N21/76 , G01N25/20
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/214 , Y10T436/24
摘要： A multicell holder e.g. a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CC12F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g. by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g. by multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis e.g. spectral analysis, chromatography etc, or by observing temperature change in the vicinity of the catalyst e.g. by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.
摘要翻译：多单元座用催化剂成分的溶液/悬浮液处理蜂窝状或板状或单独的载体颗粒的集合，以产生保持成分各种组合的细胞，斑点或颗粒，根据需要进行干燥，煅烧或处理以稳定然后将细胞，斑点或丸粒中的成分与潜在的反应性进料流或批料例如生化，瓦斯油，氢加氧，丙烯加氧，CC12F2和氢等接触。每个电池中发生的反应可以是测量，例如通过红外热像仪，产物或残余反应物的光谱检测，或通过采样，例如，通过低体积管道从每个组合的附近进行多流，然后进行分析。光谱分析，色谱分析等，或者通过观察催化剂附近的温度变化。通过热成像技术确定催化剂在每种组合中的相对功效。机器人技术可用于生产细胞，斑点，丸粒等。

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