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1. 发明申请

US20080140014A1 Apparatus And Methods To Communicate Fluids And/Or Support Intraosseous Devices 有权
标题翻译：传播流体和/或支持骨内装置的装置和方法
公开(公告)号：US20080140014A1
公开(公告)日：2008-06-12
申请号：US11619390
申请日：2007-01-03
申请人： Larry J. Miller , David S. Bolleter , Robert W. Titkemeyer , Joseph J. Manno , Matthew T. Harmon , Bruce J. Richardson , Gary Emerson Hart
发明人： Larry J. Miller , David S. Bolleter , Robert W. Titkemeyer , Joseph J. Manno , Matthew T. Harmon , Bruce J. Richardson , Gary Emerson Hart
IPC分类号： A61M5/32
CPC分类号： A61M39/02 , A61B17/3472 , A61B17/3498 , A61B2017/3492 , A61M5/158 , A61M39/0247 , A61M39/10 , A61M39/26 , A61M2005/1581 , A61M2005/1585 , A61M2039/025 , A61M2039/0273 , A61M2039/0276 , A61M2210/02
摘要： Fluid communication devices and supporting structures may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.
摘要翻译：可以提供流体通信装置和支撑结构以用于骨内装置。还可以提供装置和方法以将流体与骨内装置进行通信。

2. 发明授权

US6066131A Contiguous, branched transmyocardial revascularization (TMR) channel, method and device 失效
标题翻译：连续分支的经心肌血运重建（TMR）通道，方法和装置
公开(公告)号：US6066131A
公开(公告)日：2000-05-23
申请号：US92798
申请日：1998-06-05
申请人： Richard L. Mueller , Stuart D. Harman , Robert L. Lathrop, Jr. , Bruce J. Richardson
发明人： Richard L. Mueller , Stuart D. Harman , Robert L. Lathrop, Jr. , Bruce J. Richardson
IPC分类号： A61B17/00 , A61B17/22 , A61B17/34 , A61B18/22 , A61B17/36
CPC分类号： A61B17/3403 , A61B18/22 , A61B2017/00247 , A61B2017/22075 , A61B2018/00392
摘要： Improved methods and devices related to laser-assisted transmyocardial revascularization (TMR), and more particularly, to improved methods and devices for creating branched TMR channels through myocardium in which a single opening is made in an epicardial surface with a plurality of channel branches, having predetermined geometries extending into and through myocardium, depending therefrom. A method of creating branched TMR channels comprises piercing an epicardial surface mechanically or with laser energy, directing laser energy through the opening in a first predetermined angular orientation with respect to the epicardial surface to create a first channel and delivering laser energy in a second predetermined angular orientation to create a second branch. A plurality of branches can thus be created in a single channel structure. A guide block device allows an opening to be made in an epicardial surface mechanically or with laser energy and provides a structure for directing laser energy into myocardium in a plurality of channels depending from the opening. Rotating guide devices and finger held devices with rotating head means include a hand held device with an elongated wand-like handle portion, a rotating head portion and a hollow guide needle means. Preferred embodiments further comprise a laser delivery means advancing mechanism and guide needle rotating means.
摘要翻译：改进的与激光辅助心肌血运重建（TMR）相关的方法和装置，更具体地说，涉及通过心肌产生分支TMR通道的改进方法和装置，其中在具有多个通道分支的心外膜表面中形成单个开口，预定的几何形状延伸到心肌中并通过心肌，这取决于它们。创建分支TMR通道的方法包括机械地或用激光能量刺穿心外膜表面，以相对于心外膜表面的第一预定角度方向引导激光能量通过开口，以产生第一通道并将激光能量传送到第二预定角度方向创建第二个分支。因此，可以在单个信道结构中创建多个分支。引导块装置允许以机械方式或用激光能量在心外膜表面制造开口，并且提供用于将激光能量引导到依赖于开口的多个通道中的心肌的结构。具有旋转头装置的旋转导向装置和手指保持装置包括具有细长的棒状手柄部分的手持装置，旋转头部分和中空导向针装置。优选实施例还包括激光输送装置前进机构和引导针旋转装置。

3. 发明授权

US09103757B2 Laser capture microdissection (LCM) extraction device and device carrier, and method for post-LCM fluid processing 有权
公开(公告)号：US09103757B2
公开(公告)日：2015-08-11
申请号：US12856182
申请日：2010-08-13
申请人： Thomas M. Baer , Robert H. Reamey , Keith E. Moravick , David F. Head , Bruce J. Richardson , Derrick A. Richardson
发明人： Thomas M. Baer , Robert H. Reamey , Keith E. Moravick , David F. Head , Bruce J. Richardson , Derrick A. Richardson
IPC分类号： G01N1/28 , G01N1/40
CPC分类号： G01N1/30 , G01N1/2813 , G01N1/40 , G01N2001/284 , Y10T436/25375 , Y10T436/255
摘要： The present invention generally discloses an extraction system that provides a locale for fluid processing and extraction on a post-microcapture transfer film. The extraction system includes a transfer film carrier and an extraction device forming a reservoir. The extraction system selectively excludes regions of the transfer film from the reservoir to advantageously reduce contamination due to matter adhered to the transfer film by non-specific transfer.

4. 发明申请

US20150104878A1 METHODS OF TRIGGERING ACTIVATION OF ENCAPSULATED SIGNAL-GENERATING SUBSTANCES AND APPARATUS UTILISING ACTIVATED SIGNAL-GENERATING SUBSTANCES 审中-公开
标题翻译：触发信号产生物质的激活方法和利用活化信号发生物质的装置
公开(公告)号：US20150104878A1
公开(公告)日：2015-04-16
申请号：US14241594
申请日：2012-08-30
申请人： Neil J. Campbell , Keith Edward Moravick , Joseph D. Penniman , Bruce J. Richardson
发明人： Neil J. Campbell , Keith Edward Moravick , Joseph D. Penniman , Bruce J. Richardson
IPC分类号： G01N33/53
CPC分类号： G01N33/5304 , G01N33/5432 , G01N33/558 , G01N33/586
摘要： Methods are disclosed for performing a bioassay, comprising activating capsules containing a signal precursor that is hydrolysable from a latent form in which substantially no signal is generated to a form in which it is able to generate a detectable signal, said activating comprising treating said capsules with heat and with an acid or a base catalysing solution, the combination of said heat and the pH of the catalysing solution being such as to hydrolyse said precursor to the form in which it is able to generate a detectable signal.
摘要翻译：公开了用于进行生物测定的方法，包括活化胶囊，所述胶囊含有信号前体，所述信号前体可潜在地从其中基本上不产生信号的潜在形式到能够产生可检测信号的形式，所述活化包括用加热和酸或碱催化溶液，所述加热和催化溶液的pH的组合使得将所述前体水解成能够产生可检测信号的形式。

5. 发明申请

US20130052749A1 METHODS OF TRIGGERING ACTIVATION OF ENCAPSULATED SIGNAL-GENERATING SUBSTANCES AND APPARATUS UTILISING ACTIVATED SIGNAL-GENERATING SUBSTANCES 有权
标题翻译：触发信号产生物质的激活方法和利用活化信号发生物质的装置
公开(公告)号：US20130052749A1
公开(公告)日：2013-02-28
申请号：US13221600
申请日：2011-08-30
申请人： Neil J. Campbell , Keith Edward Moravick , Joseph D. Penniman , Bruce J. Richardson
发明人： Neil J. Campbell , Keith Edward Moravick , Joseph D. Penniman , Bruce J. Richardson
IPC分类号： G01N21/64
CPC分类号： G01N33/5304 , G01N33/5432 , G01N33/558 , G01N33/586
摘要： A method of performing a bioassay comprising activating capsules containing a signal precursor that is hydrolysable from a latent form in which substantially no signal is generated to a form in which it is able to generate a detectable signal, said activating comprising treating said capsules with heat and with an acid or a base catalysing solution, the combination of said heat and the pH of the catalysing solution being such as to hydrolyse said precursor to the form in which it is able to generate a detectable signal.
摘要翻译：一种进行生物测定的方法，包括活化胶囊，所述胶囊含有可从潜在形式水解的信号前体，所述潜在形式基本上不产生任何信号而产生可产生可检测信号的形式，所述活化包括用热处理所述胶囊，使用酸或碱催化溶液，所述热和催化溶液的pH的组合使得将所述前体水解成能够产生可检测信号的形式。

6. 发明申请

US20110290085A1 Dual Hex Pattern Open End Wrench 审中-公开
标题翻译：双十六进制图案开口扳手
公开(公告)号：US20110290085A1
公开(公告)日：2011-12-01
申请号：US13102025
申请日：2011-05-05
申请人： Perry James Richardson , Bruce J. Richardson
发明人： Perry James Richardson , Bruce J. Richardson
IPC分类号： B25B13/02
CPC分类号： B25B13/04 , B25B13/06 , B25B13/065 , B25B13/56
摘要： An open ended wrench incorporating both English (inch) and metric sizes. Two conventional single-size wrenches are replaced by a dual-size hex pattern wrench, reducing the number of wrenches likely to be needed to do a job. One hex pattern is sized to match preferably a metric component and the other hex pattern is sized to match preferably an English component. The two different sized hex patterns are preferably offset by 30 degrees.
摘要翻译：一种采用英制（公制）和公制尺寸的开口扳手。两个常规的单尺寸扳手由双尺寸六角扳手替代，减少了可能需要做的工作的扳手数量。一个六边形图案的尺寸被设计成优选地匹配一个度量元件，而另一个十六进制图案的尺寸被设计成优选地匹配英文分量。两个不同大小的六边形图案优选地偏移30度。

7. 发明授权

US07776273B2 Laser capture microdissection (LCM) extraction device and device carrier, and method for post-LCM fluid processing 有权
标题翻译：激光捕获显微解剖（LCM）提取装置和装置载体，以及后LCM流体处理方法
公开(公告)号：US07776273B2
公开(公告)日：2010-08-17
申请号：US09844187
申请日：2001-04-26
申请人： Thomas M. Baer , Robert H. Reamey , Keith E. Moravick , David F. Head , Bruce J. Richardson , Derrick A. Richardson
发明人： Thomas M. Baer , Robert H. Reamey , Keith E. Moravick , David F. Head , Bruce J. Richardson , Derrick A. Richardson
IPC分类号： B01L3/00
CPC分类号： G01N1/30 , G01N1/2813 , G01N1/40 , G01N2001/284 , Y10T436/25375 , Y10T436/255
摘要： The present invention generally discloses an extraction system that provides a locale for fluid processing and extraction on a post-microcapture transfer film. The extraction system includes a transfer film carrier and an extraction device forming a reservoir. The extraction system selectively excludes regions of the transfer film from the reservoir to advantageously reduce contamination due to matter adhered to the transfer film by non-specific transfer.
摘要翻译：本发明通常公开了一种提取系统，其提供用于后微量捕获转移膜上的流体处理和萃取的区域。提取系统包括转印膜载体和形成储存器的提取装置。提取系统选择性地从储存器排除转印膜的区域，以有利地减少由于通过非特异性转移附着在转印膜上的物质引起的污染。

8. 发明授权

US5604130A Releasable multiwell plate cover 失效
标题翻译：可拆卸的多孔板盖
公开(公告)号：US5604130A
公开(公告)日：1997-02-18
申请号：US451025
申请日：1995-05-31
申请人： Brian D. Warner , Benjamin T. Nordell , Bruce J. Richardson , Amer El-Hage
发明人： Brian D. Warner , Benjamin T. Nordell , Bruce J. Richardson , Amer El-Hage
IPC分类号： C12M1/00 , B01L3/00 , B01L3/14 , G01N1/10 , G01N35/02 , C12M1/02 , C12M1/38
CPC分类号： B01L3/50851 , B01L3/50825 , B01L3/50853
摘要： A cover effective to releasably seal a multiwell container, such as a microtitration plate, is disclosed. The cover contains a pad, fashioned from a flexible polymer sheet, and a plurality of resiliently compressible ridges formed on the sheet. The ridges are deformable, such that application of pressure applied to the cover is effective to form a fluid-tight seal between the pad and the well openings. The ridges extend from the pad sufficiently to break the seal upon release of the pressure.
摘要翻译：公开了一种有效地可释放地密封诸如微量滴定板的多孔容器的盖子。该盖包括由柔性聚合物片制成的垫，以及形成在片上的多个可弹性压缩的脊。脊可变形，使得施加到盖上的压力有效地在垫和孔开口之间形成流体密封。脊从垫充分延伸，以释放压力而破坏密封。

9. 发明授权

US09103785B2 Method and apparatus for melting curve analysis of nucleic acids in microarray format 有权
标题翻译：以微阵列形式融化核酸曲线分析的方法和装置
公开(公告)号：US09103785B2
公开(公告)日：2015-08-11
申请号：US13001036
申请日：2009-06-25
申请人： Michael Okura , Bruce J. Richardson
发明人： Michael Okura , Bruce J. Richardson
IPC分类号： G01N21/64 , C12Q1/68 , B01L7/00 , C40B60/12 , G01N21/03
CPC分类号： G01N21/6408 , B01J2219/00529 , B01J2219/00722 , B01L7/00 , B01L2300/0636 , B01L2300/0822 , B01L2300/088 , B01L2300/1822 , B01L2300/1838 , B01L2400/0487 , C12Q1/68 , G01N21/0332 , G01N21/6428 , G01N21/6452 , G01N2021/6441
摘要： A method and apparatus for performing melting curve analyses of nucleic acids on a microarray is described. The present method includes varying the temperature of a fluid on a microarray to dissociate and remove target DNA, scanning the mircoarray for fluorescence, collecting the target DNA removed from the microarray, and reusing the collected target DNA and the microarray. The apparatus of the present disclosure includes a microarray stage, a light source and detector, and a temperature controller, wherein the temperature controller is configured to adjust the temperature of a fluid within a sample chamber on the microarray such that the temperature of the fluid is varied during the analysis such that target DNA is dissociated from the microarray, and wherein the light source is directed to the microarray and the resulting fluorescence is perceived by the detector.
摘要翻译：描述了在微阵列上进行核酸的熔解曲线分析的方法和装置。本发明的方法包括改变微阵列上的流体的温度以解离和去除目标DNA，扫描微阵列进行荧光，收集从微阵列中去除的靶DNA，并重新使用收集的靶DNA和微阵列。本公开的装置包括微阵列级，光源和检测器以及温度控制器，其中温度控制器被配置为调节微阵列上的样品室内的流体的温度，使得流体的温度为在分析期间变化，使得靶DNA从微阵列解离，并且其中光源被引导到微阵列，并且所得到的荧光被检测器感知。

10. 发明授权

US08974410B2 Apparatus and methods to communicate fluids and/or support intraosseous devices 有权
标题翻译：用于传播流体和/或支持骨内装置的装置和方法
公开(公告)号：US08974410B2
公开(公告)日：2015-03-10
申请号：US11619390
申请日：2007-01-03
申请人： Larry J. Miller , David S. Bolleter , Robert W. Titkemeyer , Joseph J. Manno , Matthew T. Harmon , Bruce J. Richardson , Gary Emerson Hart
发明人： Larry J. Miller , David S. Bolleter , Robert W. Titkemeyer , Joseph J. Manno , Matthew T. Harmon , Bruce J. Richardson , Gary Emerson Hart
IPC分类号： A61M5/00 , A61B17/34 , A61M5/158 , A61M39/26 , A61M39/10 , A61M39/02
CPC分类号： A61M39/02 , A61B17/3472 , A61B17/3498 , A61B2017/3492 , A61M5/158 , A61M39/0247 , A61M39/10 , A61M39/26 , A61M2005/1581 , A61M2005/1585 , A61M2039/025 , A61M2039/0273 , A61M2039/0276 , A61M2210/02
摘要： Fluid communication devices and supporting structures may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.
摘要翻译：可以提供流体通信装置和支撑结构以用于骨内装置。还可以提供装置和方法以将流体与骨内装置进行通信。

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