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1. 发明授权

US09034184B2 Inexpensive fourth world primitive water cleanser with key parts transportable in suitcase size packaging 有权
标题翻译：廉价的第四世界原始水清洁剂，带有手提包尺寸包装的关键零件
公开(公告)号：US09034184B2
公开(公告)日：2015-05-19
申请号：US13930974
申请日：2013-06-28
申请人： Brooke Schumm, III
发明人： Brooke Schumm, III
IPC分类号： C02F1/78 , C02F1/32 , C02F9/00 , C02F1/00
CPC分类号： C02F9/005 , C02F1/001 , C02F1/32 , C02F1/78 , C02F9/00 , C02F2201/009 , C02F2201/782 , Y02A20/212
摘要： This is a scalable water cleansing system intended for very low technology primitive communities buildable for between $600 and $1,000 of parts. A gravity feed system is contemplated with one or more of an initial filtering stage(s), a settling stage, a UV treatment stage, and an ozonator stage. A stand-alone power system with solar power needing no infrastructure is contemplated to enhance purification. The system can improve the worst of water quality, including for small groups; and under some conditions to end up with clean water of a quality found in developed countries with mature water systems.For water to the site in communities with low precipitation, the water brought in would be emptied into the initial stage of the water cleansing system, and the person who brought the water would draw from the last stage most or all of the amount of water carried in.
摘要翻译：这是一个可扩展的水清洁系统，旨在为非常低的技术原始社区建造600至1,000美元的零件。考虑了重力进料系统中的一个或多个初始过滤阶段，沉降阶段，UV处理阶段和臭氧发生阶段。考虑到一个独立的太阳能发电系统不需要基础设施来增强净化。该系统可以改善最差的水质，包括小团体; 在某些条件下，最终得到具有成熟水系统的发达国家质量清洁水。对于降水较少的社区的水域，进水的水将被清空到水清洗系统的初始阶段，带水的人从最后阶段抽取大部分或全部的水量在。

2. 发明授权

US08920300B2 Direct visualization robotic intra-operative radiation therapy device with radiation ablation capsule 有权
标题翻译：直接可视化机器人放射治疗装置与放射消融胶囊
公开(公告)号：US08920300B2
公开(公告)日：2014-12-30
申请号：US12886493
申请日：2010-09-20
申请人： Walter A. Roberts , Mason Gibbs , Thomas Cender , Brooke Schumm, III
发明人： Walter A. Roberts , Mason Gibbs , Thomas Cender , Brooke Schumm, III
IPC分类号： A61F5/00 , A61N5/10
CPC分类号： A61N5/1001 , A61N2005/1052 , A61N2005/1055 , A61N2005/1061
摘要： This invention proposes a robotic applicator device to be deployed internally to a patient having a capsule (also referred to as a cassette) and aperture with a means of alternately occluding and exposing a radioactive source through the aperture. The capsule and aperture will be integrated with a surgical robot to create a robotic IORT (intra-operative radiation therapy) applicator device as more fully described below. The capsule, radiation source, and IORT applicator arm would be integrated to enable a physician, physicist or technician to interactively internally view and select tissue for exposure to ionizing radiation in sufficient quantities to deliver therapeutic radiation doses to tissue. Via the robotic manipulation device, the physician and physicist would remotely apply radiation to not only the tissue to be exposed, but also control the length of time of the exposure. Control means would be added to identify and calculate margin and depth of tissue to be treated and the proper radiation source or radioactive isotope (which can be any particle emitter, including neutron, x-ray, alpha, beta or gamma emitter) to obtain the desired therapeutic effects. The invention enables stereotactical surgery and close confines radiation therapy adjacent to radiosensitive tissue.
摘要翻译：本发明提出一种机器人涂抹器装置，其内部部署到具有胶囊（也称为盒式磁带）的患者和具有通过孔径交替地封闭和暴露放射源的装置的孔。胶囊和孔将与外科手术机器人集成以创建如下面更充分描述的机器人IORT（手术中放射治疗）施用器装置。胶囊，辐射源和IORT施加器臂将被整合，以使医师，物理学家或技术人员以交互方式内部地观察和选择组织以暴露于足够数量的电离辐射以将治疗辐射剂量递送至组织。通过机器人操纵装置，医师和物理学家将远程地对不仅要暴露的组织施加辐射，而且还控制曝光时间的长短。将添加控制装置以识别和计算要处理的组织的边缘和深度，以及适当的辐射源或放射性同位素（其可以是任何颗粒发射体，包括中子，x射线，α，β或γ发射体），以获得所需治疗效果。本发明能够进行立体定向手术并且紧密地限制与放射敏感组织相邻的放射治疗。

3. 发明申请

US20120087994A1 SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF BIOTERROR EXPOSURES SUCH AS SMALLPOX AND USE IN COMBINATION WITH DHEA FOR THE TREATMENT OF SMALLPOX 审中-公开
标题翻译： NAC作为治疗生物暴露的补充剂的系统管理，如小细胞病毒，并与DHEA联合用于治疗小细胞肺炎
公开(公告)号：US20120087994A1
公开(公告)日：2012-04-12
申请号：US13329900
申请日：2011-12-19
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K31/198 , A61P31/20 , A61K33/04
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

4. 发明申请

US20110129523A1 Liposomally Encapsulated Reduced Glutathione, including with Other Pharmacologic Preparation, Capable of Administration as an Oral, Topical, Intraoral or Transmucosal, Prepartion, for Reversal and Prevention of Oxidation of Cholesterol and of Low Density Lipoprotein 有权
标题翻译：脂质体包被的还原型谷胱甘肽，包括与其他药理学准备，能够作为口服，局部，口内或透粘膜，预防，用于逆转和预防胆固醇和低密度脂蛋白氧化的药物制剂
公开(公告)号：US20110129523A1
公开(公告)日：2011-06-02
申请号：US12092628
申请日：2006-10-26
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K9/127 , A61K38/06 , A61K33/04 , A61K31/12 , A61P9/00 , A61P3/06
CPC分类号： A61K9/127 , A61K9/4808 , A61K31/122 , A61K31/198 , A61K31/366 , A61K33/04 , A61K38/00 , A61K38/05 , A61K38/063 , A61K45/06 , A61K2300/00
摘要： The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.
摘要翻译：本发明提出在脂质体（脂质体还原型谷胱甘肽）中确保还原型谷胱甘肽以口服给药治疗有效量以改善血管疾病进展，包括动脉粥样硬化，糖尿病，高血压，导致血流减少的动脉狭窄，缺血性事件，血栓形成，血小板聚集异常和血栓形成事件，减少氧化胆固醇，氧化型HDL和氧化LDL的量和作用。本发明还提出将脂质体包封的谷胱甘肽与他汀类药物组合以改善不仅降低胆固醇而且降低氧化的胆固醇以及氧化的HDL和氧化的LDL的作用。本发明还提出将脂质体包封的谷胱甘肽与CoQ10组合作为血管疾病的治疗和他汀类药物治疗的副作用的管理。

5. 发明申请

US20100112418A1 MULTICAPABILITY PRINTED MICROACTUATORS (WITH SPIRAL OR FERROMAGNETIC ACTION) AND FUEL AND OXIDIZER CONTROL DEVICE GROUP 审中-公开
标题翻译：多功能打印微处理器（具有螺旋或FERROMAGNETIC动作）和燃料和氧化剂控制装置组
公开(公告)号：US20100112418A1
公开(公告)日：2010-05-06
申请号：US11909358
申请日：2006-03-21
申请人： Brooke Schumm, JR. , Brooke Schumm, III
发明人： Brooke Schumm, JR. , Brooke Schumm, III
IPC分类号： H01M2/36 , H01M10/52 , H01M4/82 , H01M2/00
CPC分类号： H01M6/50 , H01M12/06 , Y10T29/49115
摘要： The invention proposes resealable, electrically responsive, thermally actuated valves in conjunction with a battery of cells, a case containing a battery, or a cell which valves have certain rotational characteristics that preferably operate spirally and away from an initial plane allowing entry of fluid, and then, on inactivation of a circuit, return to a resting sealed position. A further proposal is to provide the microactuation valve action with a micro ferromagnetic device either printed or otherwise deposited on a substrate to be included in the fuel cell or battery porting system. A further proposal is to increase the current supplying capability of small fuel cells and batteries by providing a metal, semiconductor or polymer barrier membrane containing metal oxides or other advantageous materials to allow increased fuel or oxygen diffusion into the fuel or oxygen depolarized cell or battery.
摘要翻译：本发明提出了可重新密封的，电响应的热致动阀，其与电池单体，容纳电池的壳体或电池具有一些旋转特性的电池，该旋转特性优选地螺旋地操作并远离允许流体进入的初始平面;以及然后，在电路失活时，返回到静止的密封位置。进一步的提议是提供微致动器作用与微型铁磁装置，印刷或以其他方式沉积在待包括在燃料电池或电池端口系统中的基板上。进一步的提议是通过提供含有金属氧化物或其它有利材料的金属，半导体或聚合物屏障膜来增加小燃料电池和电池的电流供应能力，以允许增加燃料或氧气扩散到燃料或氧去极化电池或电池中。

6. 发明授权

US06799658B2 Mobile outrigger scaffolding system 失效
标题翻译：移动支腿脚手架系统
公开(公告)号：US06799658B2
公开(公告)日：2004-10-05
申请号：US09747648
申请日：2000-12-26
申请人： Terry W. Cogar , Brooke Schumm, III
发明人： Terry W. Cogar , Brooke Schumm, III
IPC分类号： E04G300
CPC分类号： E04G5/04 , E04G3/20 , E04G5/045 , E04G5/06
摘要： Specially designed plates and/or mounting apparatus against and on the standard vertical column used in construction of office structures or other structures including bridges. Each set of plates has a clamping mechanism design to fit around or on the vertical column and has protrusions onto which are mounted a bracket with holes fitting on the protrusions. The brackets project outside the skin of a building and deck planks or pics can be mounted on the brackets to allow workmen to safely walk and work on the deck planks to perform work on a floor-by-floor basis. The system can be dissembled quickly and moved to another part of the same floor, to a new floor, and can be used around the outside corner of a structure or from an overhang or from a horizontal beam. The system can be used with steel tube construction with or without fireproofing.
摘要翻译：专门设计的板和/或安装设备抵抗和用于办公结构或其他结构（包括桥梁）的建筑中使用的标准垂直柱。每组板具有夹紧机构设计，以适合在垂直柱上或垂直柱上，并且具有凸起，其上安装有安装在突起上的孔的托架。支架在建筑物皮肤外部进行投影，甲板板或图片可以安装在支架上，以使工作人员能够安全地行走和在甲板板上工作，以逐层的方式进行工作。该系统可以快速拆卸并移动到同一楼层的另一部分，到新的地板上，并且可以在结构的外角或从悬垂或水平梁周围使用。该系统可与钢管结构一起使用，具有或不具有防火性。

7. 发明授权

US06534540B2 Combination and method of treatment of cancer utilizing a COX-2 inhibitor and a 3-hydroxy-3-methylglutaryl-coenzyme-a (HMG-CoA) reductase inhibitor 失效
公开(公告)号：US06534540B2
公开(公告)日：2003-03-18
申请号：US09912703
申请日：2001-07-25
申请人： George Kindness , Brooke Schumm, III , F. Timothy Guilford
发明人： George Kindness , Brooke Schumm, III , F. Timothy Guilford
IPC分类号： A61K3134
CPC分类号： A61K45/06 , A61K31/195 , A61K31/198 , A61K31/22 , A61K31/225 , A61K31/34 , A61K31/35 , A61K31/355 , A61K31/365 , A61K31/366 , A61K31/385 , A61K31/415 , A61K33/04 , A61K33/38 , A61K2300/00
摘要： The inventors propose a combination of an HMG-CoA reductase inhibitor (also referred to as “HMG-CoA inhibitor(s)”), and COX-2 inhibitor for the treatment of cancer especially prostate cancer and a method of treatment of cancer by that combination, especially prostate cancer. The inventors propose a combination of an HMG-CoA reductase inhibitor, COX-2 inhibitor, and glutathione pathway enhancing and detoxifying compound, particularly cystine, for the treatment of cancer especially prostate cancer and a method of treatment of cancer by that combination, especially prostate cancer. Based on the clinical results of retardation, but not cure of cancer, the combination has the characteristic of sufficiently interfering with replication and apparently restoring the immune system capacity to manage cancer.

8. 发明申请

US20120141608A1 SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF BIOTERROR EXPOSURES SUCH AS ANTHRAX, VIRUS OR RADIATION AND USE IN COMBINATION WITH DHEA FOR THE TREATMENT OF VIRUSES 审中-公开
标题翻译： NAC作为治疗生物暴露的补充剂的系统管理，例如ANTHRAX，病毒或辐射，并与DHEA联合用于治疗病毒
公开(公告)号：US20120141608A1
公开(公告)日：2012-06-07
申请号：US12487036
申请日：2009-06-18
申请人： F. Timothy GUILFORD , Brooke SCHUMM, III
发明人： F. Timothy GUILFORD , Brooke SCHUMM, III
IPC分类号： A61K33/04 , A61P31/12 , A61P31/16 , A61K31/56
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

9. 发明申请

US20100233193A1 SYSTEMIC ADMINISTRATION OF NAC FOR VACCINATION PROPHYLAXIS 审中-公开
标题翻译： NAC用于疫苗预防的系统管理
公开(公告)号：US20100233193A1
公开(公告)日：2010-09-16
申请号：US12486971
申请日：2009-06-18
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K39/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and /or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

10. 发明申请

US20070248533A1 Stabilized and Lyophilized Radiopharmaceutical Agents For Destroying Tumors 审中-公开
标题翻译：稳定和冻干放射性药物用于破坏肿瘤
公开(公告)号：US20070248533A1
公开(公告)日：2007-10-25
申请号：US11570771
申请日：2005-06-17
申请人： John Kuperus , Robert McKenzie Jr. , Brooke Schumm III
发明人： John Kuperus , Robert McKenzie Jr. , Brooke Schumm III
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/10 , A61K51/1241
摘要： A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置，以稳定的，可运输的冻干形式制备放射性诊断性放射性药物的新方法。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重构，以使放射性药物复合物以所需浓度进入溶液。

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