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1. 发明授权

US06534540B2 Combination and method of treatment of cancer utilizing a COX-2 inhibitor and a 3-hydroxy-3-methylglutaryl-coenzyme-a (HMG-CoA) reductase inhibitor 失效
公开(公告)号：US06534540B2
公开(公告)日：2003-03-18
申请号：US09912703
申请日：2001-07-25
申请人： George Kindness , Brooke Schumm, III , F. Timothy Guilford
发明人： George Kindness , Brooke Schumm, III , F. Timothy Guilford
IPC分类号： A61K3134
CPC分类号： A61K45/06 , A61K31/195 , A61K31/198 , A61K31/22 , A61K31/225 , A61K31/34 , A61K31/35 , A61K31/355 , A61K31/365 , A61K31/366 , A61K31/385 , A61K31/415 , A61K33/04 , A61K33/38 , A61K2300/00
摘要： The inventors propose a combination of an HMG-CoA reductase inhibitor (also referred to as “HMG-CoA inhibitor(s)”), and COX-2 inhibitor for the treatment of cancer especially prostate cancer and a method of treatment of cancer by that combination, especially prostate cancer. The inventors propose a combination of an HMG-CoA reductase inhibitor, COX-2 inhibitor, and glutathione pathway enhancing and detoxifying compound, particularly cystine, for the treatment of cancer especially prostate cancer and a method of treatment of cancer by that combination, especially prostate cancer. Based on the clinical results of retardation, but not cure of cancer, the combination has the characteristic of sufficiently interfering with replication and apparently restoring the immune system capacity to manage cancer.

2. 发明申请

US20100233193A1 SYSTEMIC ADMINISTRATION OF NAC FOR VACCINATION PROPHYLAXIS 审中-公开
标题翻译： NAC用于疫苗预防的系统管理
公开(公告)号：US20100233193A1
公开(公告)日：2010-09-16
申请号：US12486971
申请日：2009-06-18
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K39/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and /or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

3. 发明授权

US08679530B2 Liposomally encapsulated reduced glutathione, including with other pharmacologic preparation, capable of administration as an oral, topical, intraoral or transmucosal, prepartion, for reversal and prevention of oxidation of cholesterol and of low density lipoprotein 有权
标题翻译：脂质体包裹的还原型谷胱甘肽，包括与其他药理学制剂，能够作为口服，局部，口内或经粘膜的预处理，用于逆转和预防胆固醇和低密度脂蛋白的氧化
公开(公告)号：US08679530B2
公开(公告)日：2014-03-25
申请号：US12092628
申请日：2006-10-26
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/4808 , A61K31/122 , A61K31/198 , A61K31/366 , A61K33/04 , A61K38/00 , A61K38/05 , A61K38/063 , A61K45/06 , A61K2300/00
摘要： The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.
摘要翻译：本发明提出在脂质体（脂质体还原型谷胱甘肽）中确保还原型谷胱甘肽以口服给药治疗有效量以改善血管疾病进展，包括动脉粥样硬化，糖尿病，高血压，导致血流减少的动脉狭窄，缺血性事件，血栓形成，血小板聚集异常和血栓形成事件，减少氧化胆固醇，氧化型HDL和氧化LDL的量和作用。本发明还提出将脂质体包封的谷胱甘肽与他汀类药物组合以改善不仅降低胆固醇而且降低氧化的胆固醇以及氧化的HDL和氧化的LDL的作用。本发明还提出将脂质体包封的谷胱甘肽与CoQ10组合作为血管疾病的治疗和他汀类药物治疗的副作用的管理。

4. 发明授权

US08114913B1 Systemic administration of NAC as an adjunct in the treatment of bioterror exposures such as smallpox and use in combination with DHEA for the treatment of smallpox 有权
标题翻译：系统地施用NAC作为治疗天花等生物错误暴露的辅助物质，并与DHEA联合用于治疗天花
公开(公告)号：US08114913B1
公开(公告)日：2012-02-14
申请号：US12486851
申请日：2009-06-18
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A01N33/08 , A61K31/33
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

5. 发明申请

US20120087994A1 SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF BIOTERROR EXPOSURES SUCH AS SMALLPOX AND USE IN COMBINATION WITH DHEA FOR THE TREATMENT OF SMALLPOX 审中-公开
标题翻译： NAC作为治疗生物暴露的补充剂的系统管理，如小细胞病毒，并与DHEA联合用于治疗小细胞肺炎
公开(公告)号：US20120087994A1
公开(公告)日：2012-04-12
申请号：US13329900
申请日：2011-12-19
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K31/198 , A61P31/20 , A61K33/04
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

6. 发明申请

US20110129523A1 Liposomally Encapsulated Reduced Glutathione, including with Other Pharmacologic Preparation, Capable of Administration as an Oral, Topical, Intraoral or Transmucosal, Prepartion, for Reversal and Prevention of Oxidation of Cholesterol and of Low Density Lipoprotein 有权
标题翻译：脂质体包被的还原型谷胱甘肽，包括与其他药理学准备，能够作为口服，局部，口内或透粘膜，预防，用于逆转和预防胆固醇和低密度脂蛋白氧化的药物制剂
公开(公告)号：US20110129523A1
公开(公告)日：2011-06-02
申请号：US12092628
申请日：2006-10-26
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K9/127 , A61K38/06 , A61K33/04 , A61K31/12 , A61P9/00 , A61P3/06
CPC分类号： A61K9/127 , A61K9/4808 , A61K31/122 , A61K31/198 , A61K31/366 , A61K33/04 , A61K38/00 , A61K38/05 , A61K38/063 , A61K45/06 , A61K2300/00
摘要： The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.
摘要翻译：本发明提出在脂质体（脂质体还原型谷胱甘肽）中确保还原型谷胱甘肽以口服给药治疗有效量以改善血管疾病进展，包括动脉粥样硬化，糖尿病，高血压，导致血流减少的动脉狭窄，缺血性事件，血栓形成，血小板聚集异常和血栓形成事件，减少氧化胆固醇，氧化型HDL和氧化LDL的量和作用。本发明还提出将脂质体包封的谷胱甘肽与他汀类药物组合以改善不仅降低胆固醇而且降低氧化的胆固醇以及氧化的HDL和氧化的LDL的作用。本发明还提出将脂质体包封的谷胱甘肽与CoQ10组合作为血管疾病的治疗和他汀类药物治疗的副作用的管理。

7. 发明申请

US20100233297A1 SYSTEMIC ADMINISTRATION OF NAC AS AN ADJUNCT IN THE TREATMENT OF TERRORISM EXPOSURES SUCH AS RADIATION AND FOR PROPHYLAXIS 审中-公开
标题翻译：作为放射治疗恐怖主义暴力行为的民主化的系统管理如辐射和预防
公开(公告)号：US20100233297A1
公开(公告)日：2010-09-16
申请号：US12486993
申请日：2009-06-18
申请人： F. Timothy Guilford , Brooke Schumm, III
发明人： F. Timothy Guilford , Brooke Schumm, III
IPC分类号： A61K33/04 , A61K31/195 , A61K31/566 , A61P17/16 , A61P43/00
CPC分类号： A61K45/06 , A61K31/221 , A61K33/04 , A61K38/063 , A61K2300/00
摘要： The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
摘要翻译：本发明涉及N-乙酰半胱氨酸口服，吸入或静脉内或谷胱甘肽吸入或静脉内的组合和相关方法，通常与抗生素和/或抗病毒治疗组合以改善用于Bioterror中的材料感染的毒性作用事件如炭疽芽孢杆菌和天花病毒，或者在暴露于辐射，测试和接种期间，作为治疗之前用抗生素或抗病毒治疗来改善感染和暴露于这些生物体的毒性作用。

8. 发明授权

US06575719B2 Planetary rotary machine using apertures, volutes and continuous carbon fiber reinforced peek seals 失效
标题翻译：行星旋转机使用孔，蜗壳和连续碳纤维增强的窥视密封
公开(公告)号：US06575719B2
公开(公告)日：2003-06-10
申请号：US09916561
申请日：2001-07-27
申请人： David B. Manner , Kevin R. Kirtley , Brooke Schumm, III
发明人： David B. Manner , Kevin R. Kirtley , Brooke Schumm, III
IPC分类号： F03C200
CPC分类号： F01C1/22 , F01C11/004 , F02B53/00 , F02B2053/005 , F05C2225/04
摘要： Apertures through each face of a planetary rotor, volutes for low loss delivery and collection of fluid to and from the working volumes of a planetary rotary pump, compressor, or turbine, and zero clearance seals by using continuous carbon fiber reinforced polyetheretherketone (PEEK) or other self-lubricating materials significantly improve the volumetric flow rate of such rotary pumps compressors or turbines. By establishing a means to vent each working volume to an intake or exhaust port at arbitrary rotor positions, apertures linking working volumes to intake or exhaust ports allows each working volume of a multilobe planetary rotary pump to function independently near peak volumetric efficiency. An additional means to improve the performance of planetary rotary pumps has been established by using scroll-like volutes which collect and deliver the exhaust and intake flow for each working volume in a manner which reduces the fluid dynamic loss associated with conventional sudden expansions and contractions found at the inlet and exit of a plenum. To minimize leakage between the separate working volumes and improve performance, self lubricated continuous carbon fiber reinforced polyetheretherketone seals are employed for components in high speed sliding contact. The continuous carbon fiber reinforced PEEK can withstand high sliding speeds, high temperatures with low wear and excellent foreign object impact resistance.
摘要翻译：通过行星转子的每个表面的孔径，用于低损失输送的蜗壳，并且将流体收集到行星旋转泵，压缩机或涡轮机的工作容积和通过使用连续碳纤维增强聚醚醚酮（PEEK）或零间隙密封其他自润滑材料显着提高了这种旋转泵压缩机或涡轮机的体积流量。通过建立将任何工作体积排放到任意转子位置的进气口或排气口的装置，将工作体积连接到进气口或排气口允许每个多叶行星式旋转泵的工作容积独立起作用，接近峰值容积效率。已经通过使用涡卷状蜗壳来建立增加行星旋转泵性能的附加手段，该涡卷状蜗壳以减少与传统的突然膨胀和收缩相关联的流体动态损失的方式收集并输送每个工作体积的排气和进气流量在集气室的入口和出口处。为了最大限度地减少分离的工作量之间的泄漏并提高性能，自润滑连续碳纤维增强聚醚醚酮密封件用于高速滑动接触的部件。连续碳纤维增强PEEK可以承受高滑动速度，高温，低磨损和优异的异物耐冲击性。

9. 发明授权

US08460119B2 Combination for passing an object through a three dimensional true color image 有权
标题翻译：通过三维真彩色图像传递对象的组合
公开(公告)号：US08460119B2
公开(公告)日：2013-06-11
申请号：US13184972
申请日：2011-07-18
申请人： Brooke Schumm, Jr. , Brooke Schumm, III
发明人： Brooke Schumm, Jr. , Brooke Schumm, III
IPC分类号： A63G31/16 , A63J5/00
CPC分类号： G02B27/2292 , G02B17/061
摘要： The combination of a truly realistic three dimensional real image in color and a second device to produce a repetitive passage of a solid object through the real image creates the illusion of one solid body passing through another. A simple method of accomplishing this is to mount a clock with a pendulum over or under the image and allow a pendulum end to pass periodically through the real image. Other means such as a device running on a circular track could accomplish the same illusory effect. The pendulum end or the device can take various forms as can the real image. In principle the designs are not limited in size. The invention creates an exciting visual and illusory moment of a second object passing through an apparently solid object.
摘要翻译：真正逼真的三维真实图像在颜色和第二装置中的组合以通过真实图像产生固体物体的重复通过产生穿过另一实体的一个实体的错觉。实现这一点的一个简单方法是将钟摆安装在图像之上或之下，并使摆钟端部周期性地穿过真实图像。诸如在圆形轨道上运行的设备的其他方式可以实现相同的虚幻效果。摆式终端或设备可以采用各种形式，如实像。原则上，设计的尺寸不受限制。本发明创造出通过明显固体物体的第二物体的激动人心的视觉和虚幻时刻。

10. 发明申请

US20160184605A1 Direct visualization Robotic Intra-Operative Radiation Therapy Device with Radiation Ablation Capsule and Shutter System 审中-公开
标题翻译：直接可视化放射消融胶囊和快门系统的机器人手术内放射治疗装置
公开(公告)号：US20160184605A1
公开(公告)日：2016-06-30
申请号：US14685435
申请日：2015-04-13
申请人： Walter A. Roberts , Brooke Schumm III
发明人： Walter A Roberts , Brooke Schumm, III
IPC分类号： A61N5/10 , A61B19/00
CPC分类号： A61N5/1083 , A61N5/1014 , A61N5/1042
摘要： This invention proposes a robotic applicator device to be deployed internally to a patient having a capsule (also referred to as a cassette) and aperture with a means of alternately occluding and exposing a radioactive source through the aperture. The capsule and aperture will be integrated with a surgical robot to create a robotic IORT (intra-operative radiation therapy) applicator device as more fully described below. The capsule, radiation source, and IORT applicator arm would be integrated to enable a physician, physicist or technician to interactively internally view and select tissue for exposure to ionizing radiation in sufficient quantities to deliver therapeutic radiation doses to tissue. Via the robotic manipulation device, the physician and physicist would remotely apply radiation to not only the tissue to be exposed, but also control the length of time of the exposure. Control means would be added to identify and calculate margin and depth of tissue to be treated and the proper radiation source or radioactive isotope (which can be any particle emitter, including neutron, x-ray, alpha, beta or gamma emitter) to obtain the desired therapeutic effects. The invention enables stereotactical surgery and close confines radiation therapy adjacent to radiosensitive tissue.
摘要翻译：本发明提出一种机器人涂抹器装置，其内部部署到具有胶囊（也称为盒式磁带）的患者和具有通过孔径交替地封闭和暴露放射源的装置的孔。胶囊和孔将与外科手术机器人集成以创建如下面更充分描述的机器人IORT（手术中放射治疗）施用器装置。胶囊，辐射源和IORT施加器臂将被整合，以使医师，物理学家或技术人员以交互方式内部地观察和选择组织以暴露于足够数量的电离辐射以将治疗辐射剂量递送至组织。通过机器人操纵装置，医师和物理学家将远程地对不仅要暴露的组织施加辐射，而且还控制曝光时间的长短。将添加控制装置以识别和计算要处理的组织的边缘和深度，以及适当的辐射源或放射性同位素（其可以是任何颗粒发射体，包括中子，x射线，α，β或γ发射体），以获得所需治疗效果。本发明能够进行立体定向手术并且紧密地限制与放射敏感组织相邻的放射治疗。

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