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1. 发明授权

US09885092B2 Materials and methods for detection of HPV nucleic acids 有权
公开(公告)号：US09885092B2
公开(公告)日：2018-02-06
申请号：US13403759
申请日：2012-02-23
申请人： Brian Lowe , Anna K. Fulbright , Irina Nazarenko
发明人： Brian Lowe , Anna K. Fulbright , Irina Nazarenko
IPC分类号： C12P19/34 , C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/708 , C12Q1/6825 , C12Q2563/131
摘要： Provided are nucleic acids capable of hybridizing to HPV 16 and/or HPV 18 nucleic acids, in particular, mRNA encoding E2 and E6-7 gene products. Such nucleic acids are useful in methods of isolating RNA from a biological sample, methods and means for determining the presence of particular RNA splice-form variants in a biological sample, methods and means for determining the relative ratio of RNA ratios in a biological sample, methods and means for predicting the progression of precancerous cervical lesions, and methods and means for detecting disruption of genes or gene expression.

2. 发明授权

US09797000B2 Non-target amplification method for detection of RNA splice-forms in a sample 有权
公开(公告)号：US09797000B2
公开(公告)日：2017-10-24
申请号：US12771042
申请日：2010-04-30
申请人： Brian Lowe , Anna K. Fulbright , Irina Nazarenko
发明人： Brian Lowe , Anna K. Fulbright , Irina Nazarenko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/682 , C12Q2537/125 , C12Q2537/143 , C12Q2563/125 , C12Q2565/531 , C12Q2563/131
摘要： Provided are methods of isolating RNA from a biological sample, methods and means for determining the presence of particular RNA splice-form variants in a biological sample, methods and means for determining the relative ratio of RNA ratios in a biological sample, and methods and means for predicting the progression of precancerous cervical lesions.

3. 发明授权

US09422593B2 Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids 有权
标题翻译：用于核酸序列特异性纯化和多重分析的方法和组合物
公开(公告)号：US09422593B2
公开(公告)日：2016-08-23
申请号：US13110660
申请日：2011-05-18
申请人： Thomas Rothmann , Irina Nazarenko , Dominic O'Neil , Arvind Virmani , Brian Lowe , Shiuli Agarwal , Holly Basham
发明人： Thomas Rothmann , Irina Nazarenko , Dominic O'Neil , Arvind Virmani , Brian Lowe , Shiuli Agarwal , Holly Basham
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6806 , C12Q1/689 , Y02A50/52 , Y02A50/59 , Y02A50/60 , C12Q2537/143 , C12Q2563/107 , C12Q2565/518
摘要： Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step comprising contacting the target nucleic acid with a plurality of detectably labeled nucleic acid detection probes, wherein each (a) bears a different detectable label from the other detection probes, and/or (b) has a different melting temperature from probes bearing the same detectable label. Also disclosed are compositions and kits for use in such a method.
摘要翻译：提供了用于确定样品中至少一种核酸存在的方法和材料，所述方法包括（1）使用序列特异性杂交捕获的纯化步骤; （2）扩增步骤; （3）检测步骤，包括使目标核酸与多个可检测标记的核酸检测探针接触，其中每个（a）与其它检测探针具有不同的可检测标记，和/或（b）具有不同的熔点带有相同可检测标签的探针的温度。也公开了用于这种方法的组合物和试剂盒。

4. 发明授权

US08901287B2 Detection of nucleic acids by target-specific hybrid capture method 有权
标题翻译：通过目标特异性杂交捕获方法检测核酸
公开(公告)号：US08901287B2
公开(公告)日：2014-12-02
申请号：US12576425
申请日：2009-10-09
申请人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
发明人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/708 , C12Q1/6804 , C12Q1/6834 , C12Q1/6876 , C12Q2565/519 , C12Q2525/186 , C12Q2565/543 , C12Q2537/143 , C12Q2525/121 , C12Q2537/119 , C12Q2522/101
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
摘要翻译：目标特异性杂交捕获（TSHC）提供了一种核酸检测方法，其不仅快速且灵敏，而且还具有高度特异性并且能够区分高度同源的核酸靶序列。该方法产生可通过多种方法检测的DNA：RNA杂交体。

5. 发明授权

US08133163B2 Apparatus for forming a barrel from a blank 有权
标题翻译：用于从坯料形成桶的装置
公开(公告)号：US08133163B2
公开(公告)日：2012-03-13
申请号：US11538342
申请日：2006-10-03
申请人： Benjamin Strong , Brian Lowe
发明人： Benjamin Strong , Brian Lowe
IPC分类号： B31B1/28
CPC分类号： B31B1/28 , B31B50/28 , B31B50/81 , B65D5/029 , B65D5/10
摘要： A barrel formed from a sheet of blank material includes a plurality of side wall panels for forming sides of the barrel including a front panel, a rear panel, two opposing end panels, and at least one diagonal corner panel, at least one bottom flap for forming a bottom of the barrel, and a plurality of top flaps for forming a top of the barrel including a top front flap foldably connected to the front panel, a top rear flap foldably connected to the rear panel, and two opposing top end flaps each foldably connected to one of the end panels. The top front flap and the top rear flap include at least one closure slot. Each of the two opposing top end flaps includes at least one locking finger. The locking fingers are inserted within the closure slots for securing the top of the barrel in a closed position.
摘要翻译：由一片坯料形成的桶包括多个用于形成桶的侧面的侧壁板，包括前板，后板，两个相对的端板和至少一个对角角板，至少一个底板，用于形成筒的底部，以及多个用于形成筒的顶部的顶部折板，包括可折叠地连接到前面板的顶部前翼片，可折叠地连接到后面板的顶部后翼片和每个相对的顶端翼片可折叠地连接到端板之一。顶部前翼片和顶部后翼片包括至少一个封闭槽。两个相对的顶端折翼中的每一个包括至少一个锁定指状物。锁定指状物插入封闭槽内，用于将桶的顶部固定在关闭位置。

6. 发明申请

US20120045756A1 METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC PURIFICATION AND MULTIPLEX ANALYSIS OF NUCLEIC ACIDS 有权
标题翻译：核酸的序列特异性纯化和多重分析的方法和组合物
公开(公告)号：US20120045756A1
公开(公告)日：2012-02-23
申请号：US13110660
申请日：2011-05-18
申请人： Thomas ROTHMANN , Irina NAZARENKO , Dominic O'NEIL , Arvind VIRMANI , Brian LOWE , Shiuli AGARWAL , Holly BASHAM
发明人： Thomas ROTHMANN , Irina NAZARENKO , Dominic O'NEIL , Arvind VIRMANI , Brian LOWE , Shiuli AGARWAL , Holly BASHAM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/689 , Y02A50/52 , Y02A50/59 , Y02A50/60 , C12Q2537/143 , C12Q2563/107 , C12Q2565/518
摘要： Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step comprising contacting the target nucleic acid with a plurality of detectably labeled nucleic acid detection probes, wherein each (a) bears a different detectable label from the other detection probes, and/or (b) has a different melting temperature from probes bearing the same detectable label. Also disclosed are compositions and kits for use in such a method.
摘要翻译：提供了用于确定样品中至少一种核酸存在的方法和材料，所述方法包括（1）使用序列特异性杂交捕获的纯化步骤; （2）扩增步骤; （3）检测步骤，包括使目标核酸与多个可检测标记的核酸检测探针接触，其中每个（a）与其它检测探针具有不同的可检测标记，和/或（b）具有不同的熔点带有相同可检测标签的探针的温度。还公开了用于这种方法的组合物和试剂盒。

7. 发明申请

US20110287701A1 Portable Wheel Rim Polisher 有权
标题翻译：便携式轮圈抛光机
公开(公告)号：US20110287701A1
公开(公告)日：2011-11-24
申请号：US13109575
申请日：2011-05-17
申请人： Brian Lowe McKee
发明人： Brian Lowe McKee
IPC分类号： B24B23/00
CPC分类号： B24B29/02 , B24B27/0007 , B60S3/042
摘要： The specification discloses a portable vehicle wheel polisher (10) having a rotatable polishing head (23) adapted to rotate about a substantially horizontal axis (15), the polisher (10) including a drive motor and gear reduction arrangement (14) connected to a drive shaft (17) for the rotatable polishing head (23), adjustable suspension means (18) enabling the horizontal rotation axis (15) to be selectably raised or lowered relative to an installed vehicle wheel on a vehicle, ground engaging wheels (12) carrying the adjustable suspension means (18) enabling the portable vehicle wheel polisher (10) to be moved to a position that engages the polishing head (23) with the installed vehicle wheel and to a separate position disengaged from the installed vehicle wheel.
摘要翻译：本说明书公开了一种便携式车轮抛光机（10），其具有适于围绕基本上水平的轴线（15）旋转的可旋转抛光头（23），所述抛光机（10）包括驱动马达和齿轮减速装置（14）用于可旋转抛光头（23）的驱动轴（17），使得水平旋转轴线（15）相对于车辆上安装的车轮可选地升高或降低的可调节悬挂装置（18），地面接合轮（12）携带可调节悬挂装置（18），使得便携式车轮抛光机（10）能够移动到与安装的车轮接合抛光头（23）的位置以及与安装的车轮车轮脱离的单独位置。

8. 发明申请

US20110053143A1 METHODS AND KITS FOR DETERMINING VIRAL LOAD IN CLINICAL SAMPLES 审中-公开
标题翻译：用于确定临床样本中病毒载量的方法和工具
公开(公告)号：US20110053143A1
公开(公告)日：2011-03-03
申请号：US12875533
申请日：2010-09-03
申请人： Brian Lowe , Dominic O'Neil , Irina Nazarenko , Dirk Loeffert
发明人： Brian Lowe , Dominic O'Neil , Irina Nazarenko , Dirk Loeffert
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： Methods and kits for determining load of an infectious agent in a sample are described, comprising performing at least one hybridization assay and calculating the load of the infectious agent in the sample from a detected nucleic acid. In particular, the methods and kits disclosed determine the load of human papillomavirus (HPV) in a sample.
摘要翻译：描述了用于确定样品中感染剂负荷的方法和试剂盒，包括进行至少一种杂交测定并从检测到的核酸计算样品中感染剂的载量。特别地，所公开的方法和试剂盒确定样品中人乳头瘤病毒（HPV）的负荷。

9. 发明申请

US20100311039A1 NON-TARGET AMPLIFICATION METHOD FOR DETECTION OF RNA SPLICE-FORMS IN A SAMPLE 有权
标题翻译：用于检测样品中RNA片段的非目标扩增方法
公开(公告)号：US20100311039A1
公开(公告)日：2010-12-09
申请号：US12771042
申请日：2010-04-30
申请人： Brian Lowe , Anna K. Fulbright , Irina Nazarenko
发明人： Brian Lowe , Anna K. Fulbright , Irina Nazarenko
IPC分类号： C12Q1/70 , C12Q1/68 , C07H21/02 , G01N33/566
CPC分类号： C12Q1/6804 , C12Q1/682 , C12Q2537/125 , C12Q2537/143 , C12Q2563/125 , C12Q2565/531 , C12Q2563/131
摘要： Provided are methods of isolating RNA from a biological sample, methods and means for determining the presence of particular RNA splice-form variants in a biological sample, methods and means for determining the relative ratio of RNA ratios in a biological sample, and methods and means for predicting the progression of precancerous cervical lesions.
摘要翻译：提供从生物样品中分离RNA的方法，用于确定生物样品中特定RNA剪接形式变体的存在的方法和手段，用于确定生物样品中RNA比率的相对比例的方法和手段，以及方法和手段用于预测癌前期宫颈病变的进展。

10. 发明申请

US20080091230A1 CENTERING INTRAVASCULAR FILTERS AND DEVICES AND METHODS FOR DEPLOYING AND RETRIEVING INTRAVASCULAR FILTERS 有权
标题翻译：中心静脉过滤器和装置以及用于分配和检索血管内滤器的方法
公开(公告)号：US20080091230A1
公开(公告)日：2008-04-17
申请号：US11955966
申请日：2007-12-13
申请人： Brian Lowe
发明人： Brian Lowe
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/848 , A61F2002/011 , A61F2002/016 , A61F2230/005
摘要： An intravascular expandable filter which has centering members that work to center the filter in a body vessel, the centering member creating a zone at the radial extent of the filter substantially parallel to the longitudinal axis of the filter. A device to deploy the filter consisting of an inner sheath with radially expandable distal arms having slots in them to receive the elongate members of the filter. A device to receive the filter consisting of a member to push a central portion of the filter into a receiving portion of the device.
摘要翻译：一种血管内可膨胀过滤器，其具有工作以将过滤器居中在身体容器中的定心构件，定心构件在过滤器的径向范围处基本上平行于过滤器的纵向轴线产生区域。一种用于将由内护套组成的过滤器的装置，其具有径向可扩展的远端臂，其中具有狭槽以容纳过滤器的细长构件。接收由构件构成的过滤器的装置，以将过滤器的中心部分推入设备的接收部分。

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