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1. 发明授权

US09593366B2 Individually synthesized primers to be used in whole genome amplification 有权
标题翻译：单独合成的引物用于全基因组扩增
公开(公告)号：US09593366B2
公开(公告)日：2017-03-14
申请号：US13126165
申请日：2009-10-26
申请人： Irina Nazarenko , Dominic O'Neil , Ha Thai , Attila Lorincz
发明人： Irina Nazarenko , Dominic O'Neil , Ha Thai , Attila Lorincz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2525/179
摘要： Disclosed are compositions and methods for random amplification of nucleic acid sequences of interest using random-G-deficient primers. Also disclosed are methods of randomly amplifying a target nucleic acid sequence using random G-deficient primers alone or in combination with random, partially random, or specific primers.
摘要翻译：公开了使用随机G缺陷引物随机扩增感兴趣的核酸序列的组合物和方法。还公开了使用随机G缺陷引物单独或与随机，部分随机或特异性引物组合随机扩增靶核酸序列的方法。

2. 发明申请

US20140051587A1 CANCER MARKERS 审中-公开
标题翻译：癌症标志
公开(公告)号：US20140051587A1
公开(公告)日：2014-02-20
申请号：US14008182
申请日：2012-03-30
申请人： Attila Lorincz
发明人： Attila Lorincz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154
摘要： Hence, the invention relates to a method for diagnosis and/or prognosis of cancer, comprising the steps of analyzing in a sample of a subject the DNA methylation status of a genomic region of at least one member of the group of, (i) SFN according to SEQ ID NO. 1, (ii) SLIT2 according to SEQ ID NO. 2, (iii) SERPINB5 according to SEQ ID NO. 3; and (iv) TWIST 1 according to SEQ ID NO 4; wherein, if (i) SFN shows a methylation cut off value of above 80% and/or, (ii) SLIT2 shows a methylation cut-off value of above 45% and/or, (iii) SERPBINB5 shows a methylation cut-off value of above 70%, and/or (iv) TWIST 1 shows a methylation level below 15% the sample is categorized as a sample from a patient with cancer and/of a poor prognosis.
摘要翻译：因此，本发明涉及一种用于癌症的诊断和/或预后的方法，包括以下步骤：在受试者的样品中分析以下组中至少一个成员的基因组区域的DNA甲基化状态：（i）SFN 根据SEQ ID NO。 1，（ii）根据SEQ ID NO。 2，（iii）SEQ ID NO：5的SERPINB5。 3; 和（iv）根据SEQ ID NO 4的TWIST 1; 其中，如果（i）SFN显示高于80％的甲基化切断值和/或（ii）SLIT2显示高于45％的甲基化截止值和/或（iii）SERPBINB5显示甲基化截止值值高于70％，和/或（iv）TWIST 1显示甲基化水平低于15％，样品被分类为患有癌症和/或预后不良的患者的样品。

3. 发明申请

US20110059542A1 DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD 有权
标题翻译：通过目标特异性混合捕获方法检测核酸
公开(公告)号：US20110059542A1
公开(公告)日：2011-03-10
申请号：US12904459
申请日：2010-10-14
申请人： James Anthony , Attila Lorincz , John Troy , Yanglin Tan
发明人： James Anthony , Attila Lorincz , John Troy , Yanglin Tan
IPC分类号： G01N33/50 , C07H21/04
CPC分类号： C12Q1/6832 , C12Q1/6834 , C12Q1/6886 , C12Q1/705 , C12Q1/708 , Y10T436/143333 , C12Q2565/543 , C12Q2525/186 , C12Q2565/519
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
摘要翻译：目标特异性杂交捕获（TSHC）提供了一种核酸检测方法，其不仅是快速和敏感的，而且是高度特异性的并能够区分高度同源的核酸靶序列。该方法产生可通过多种方法检测的DNA-RNA杂交体。

4. 发明申请

US20060051809A1 Detection of nucleic acids by target-specific hybrid capture method 有权
公开(公告)号：US20060051809A1
公开(公告)日：2006-03-09
申请号：US11269003
申请日：2005-11-07
申请人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
发明人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/708 , C12Q1/6804 , C12Q1/6834 , C12Q1/6876 , C12Q2565/519 , C12Q2525/186 , C12Q2565/543 , C12Q2537/143 , C12Q2525/121 , C12Q2537/119 , C12Q2522/101
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.

5. 发明授权

US08901287B2 Detection of nucleic acids by target-specific hybrid capture method 有权
标题翻译：通过目标特异性杂交捕获方法检测核酸
公开(公告)号：US08901287B2
公开(公告)日：2014-12-02
申请号：US12576425
申请日：2009-10-09
申请人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
发明人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/708 , C12Q1/6804 , C12Q1/6834 , C12Q1/6876 , C12Q2565/519 , C12Q2525/186 , C12Q2565/543 , C12Q2537/143 , C12Q2525/121 , C12Q2537/119 , C12Q2522/101
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
摘要翻译：目标特异性杂交捕获（TSHC）提供了一种核酸检测方法，其不仅快速且灵敏，而且还具有高度特异性并且能够区分高度同源的核酸靶序列。该方法产生可通过多种方法检测的DNA：RNA杂交体。

6. 发明申请

US20110256591A1 INDIVIDUALLY SYNTHESIZED PRIMERS TO BE USED IN WHOLE GENOME AMPLIFICATION 有权
标题翻译：在全基因组扩增中使用个体合成的引物
公开(公告)号：US20110256591A1
公开(公告)日：2011-10-20
申请号：US13126165
申请日：2009-10-26
申请人： Irina Nazarenko , Dominic O'Neil , Ha Thai , Attila Lorincz
发明人： Irina Nazarenko , Dominic O'Neil , Ha Thai , Attila Lorincz
IPC分类号： C12P19/34
CPC分类号： C12Q1/6844 , C12Q2525/179
摘要： Disclosed are compositions and methods for random amplification of nucleic acid sequences of interest using random-G-deficient primers. Also disclosed are methods of randomly amplifying a target nucleic acid sequence using random G-deficient primers alone or in combination with random, partially random, or specific primers.
摘要翻译：公开了使用随机G缺陷引物随机扩增感兴趣的核酸序列的组合物和方法。还公开了使用随机G缺陷引物单独或与随机，部分随机或特异性引物组合随机扩增靶核酸序列的方法。

7. 发明申请

US20090162851A1 DETECTION OF NUCLEIC ACIDS BY TYPE SPECIFIC HYBRID CAPTURE METHOD 有权
标题翻译：通过类型特异性混合捕获方法检测核酸
公开(公告)号：US20090162851A1
公开(公告)日：2009-06-25
申请号：US12253976
申请日：2008-10-19
申请人： JAMES ANTHONY , ATTILA LORINCZ , JOHN TROY , YANGLIN TAN
发明人： JAMES ANTHONY , ATTILA LORINCZ , JOHN TROY , YANGLIN TAN
IPC分类号： C12Q1/68 , G01N33/00 , G01N33/543 , C07H21/04
CPC分类号： C12Q1/6832 , C12Q1/6834 , C12Q1/6886 , C12Q1/705 , C12Q1/708 , Y10T436/143333 , C12Q2565/543 , C12Q2525/186 , C12Q2565/519
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
摘要翻译：目标特异性杂交捕获（TSHC）提供了一种核酸检测方法，其不仅快速且灵敏，而且还具有高度特异性并且能够区分高度同源的核酸靶序列。该方法产生可通过多种方法检测的DNA-RNA杂交体。

8. 发明申请

US20070243552A1 Novel approach to molecular diagnosis of human papillomavirus-related diseases 有权
标题翻译：人类乳头瘤病毒相关疾病分子诊断的新方法
公开(公告)号：US20070243552A1
公开(公告)日：2007-10-18
申请号：US11753454
申请日：2007-05-24
申请人： Inna Williams , Attila Lorincz , Aisling O'Hara
发明人： Inna Williams , Attila Lorincz , Aisling O'Hara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708
摘要： The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognostic assessments of HPV-based disease. The method of the invention comprises a primary screen of a sample for HPV nucleic acids, followed by a secondary screen for molecular markers, such as proliferation and cell cycle control group protein markers. The sequential or concurrently sequential method significantly reduces the number of false positive results.
摘要翻译：本发明涉及用于人乳头状瘤病毒（HPV）的疾病的分子诊断的准确，灵敏和有效的顺序或同时顺序的方法，其中该方法提高了基于HPV的疾病的诊断和预后评估的准确性和可靠性。本发明的方法包括用于HPV核酸的样品的主筛选，随后是用于分子标记的次级筛选，例如增殖和细胞周期对照组蛋白质标记。顺序或同时顺序的方法显着减少了假阳性结果的数量。

9. 发明授权

US08557973B2 Detection of nucleic acids by target-specific hybrid capture method 有权
标题翻译：通过目标特异性杂交捕获方法检测核酸
公开(公告)号：US08557973B2
公开(公告)日：2013-10-15
申请号：US12904459
申请日：2010-10-14
申请人： James Anthony , Attila Lorincz , John Troy , Yanglin Tan
发明人： James Anthony , Attila Lorincz , John Troy , Yanglin Tan
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6834 , C12Q1/6886 , C12Q1/705 , C12Q1/708 , Y10T436/143333 , C12Q2565/543 , C12Q2525/186 , C12Q2565/519
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
摘要翻译：目标特异性杂交捕获（TSHC）提供了一种核酸检测方法，其不仅快速且灵敏，而且还具有高度特异性并且能够区分高度同源的核酸靶序列。该方法产生可通过多种方法检测的DNA-RNA杂交体。

10. 发明申请

US20100036104A1 DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD 有权
标题翻译：通过目标特异性混合捕获方法检测核酸
公开(公告)号：US20100036104A1
公开(公告)日：2010-02-11
申请号：US12576425
申请日：2009-10-09
申请人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
发明人： Irina Nazarenko , Attila Lorincz , Paul Eder , Brian Lowe , Richard Mallonee , Ha Thai
IPC分类号： C07H21/04
CPC分类号： C12Q1/708 , C12Q1/6804 , C12Q1/6834 , C12Q1/6876 , C12Q2565/519 , C12Q2525/186 , C12Q2565/543 , C12Q2537/143 , C12Q2525/121 , C12Q2537/119 , C12Q2522/101
摘要： Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
摘要翻译：目标特异性杂交捕获（TSHC）提供了一种核酸检测方法，其不仅快速且灵敏，而且还具有高度特异性并且能够区分高度同源的核酸靶序列。该方法产生可通过多种方法检测的DNA：RNA杂交体。

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