专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5578601A Nonpeptide bradykinin antagonists 失效
标题翻译：非肽缓激肽拮抗剂
公开(公告)号：US5578601A
公开(公告)日：1996-11-26
申请号：US450062
申请日：1995-05-25
申请人： Peter R. Seoane , Joseph M. Salvino , Brent D. Douty , Mohamed M. A. Awad , Roland E. Dolle , David G. Sawutz , David M. Faunce , Wayne T. Houck
发明人： Peter R. Seoane , Joseph M. Salvino , Brent D. Douty , Mohamed M. A. Awad , Roland E. Dolle , David G. Sawutz , David M. Faunce , Wayne T. Houck
IPC分类号： C07C279/16 , C07D213/75 , C07D217/02 , C07D235/14 , C07D453/02 , C07F9/54 , C07F9/572 , C07F9/6553 , A01N43/42
CPC分类号： C07D213/75 , C07C279/16 , C07D217/02 , C07D235/14 , C07D453/02 , C07F9/5456 , C07F9/5728 , C07F9/6553 , C07F9/655345 , C07C2101/14
摘要： Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof therefor.
摘要翻译：公开了具有式（I）和（II）的缓激肽拮抗剂活性的非肽或其药学上可接受的盐。

2. 发明授权

US5466435A Compositions of iodophenoxy alkylene ethers and cellulose derivatives for visualization of the gastrointestinal tract 失效
标题翻译：碘苯氧基亚烷基醚和纤维素衍生物用于胃肠道可视化的组合物
公开(公告)号：US5466435A
公开(公告)日：1995-11-14
申请号：US222787
申请日：1994-04-04
申请人： Edward J. Baker , Edward R Bacon , Carl R. Illig , Thomas J. Caulfield , Brent D. Douty , Kurt A. Josef , John L. Toner , Robert W. Lee
发明人： Edward J. Baker , Edward R Bacon , Carl R. Illig , Thomas J. Caulfield , Brent D. Douty , Kurt A. Josef , John L. Toner , Robert W. Lee
IPC分类号： A61K49/04 , C07C43/225 , C07C43/23 , C07C69/92 , C07C255/54
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0461 , C07C43/225
摘要： Disclosed are contrast agents of the formula ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H or lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl;in an aqueous, pharmaceutically acceptable carrier comprising a cellulose derivative.
摘要翻译：公开了式IMA的造影剂，其中Z是H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，烷氧基羰基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R为C1-C25烷基，环烷基，低级或低级烷基; 其中每一个可以任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 - 烷氧基 - 羰氧基取代; （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C 3OND C-Q; R 1，R 2，R 3和R 4独立地为H或低级烷基，任选被卤素取代; x为1-4; n为1-4; m为1-15; p是1-20; Q为H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基; 在包含纤维素衍生物的水性药学上可接受的载体中。

3. 发明授权

US5385720A Compositions of iodobenzoic acid derivatives and cellulose derivatives for visualization of the gastrointestinal tract 失效
标题翻译：碘苯甲酸衍生物和纤维素衍生物用于胃肠道可视化的组合物
公开(公告)号：US5385720A
公开(公告)日：1995-01-31
申请号：US216988
申请日：1994-03-23
申请人： Edward J. Baker , Robert W. Lee , Carl R. Illig , Brent D. Douty , John L. Toner
发明人： Edward J. Baker , Robert W. Lee , Carl R. Illig , Brent D. Douty , John L. Toner
IPC分类号： A61K47/30 , A61K49/04 , C08K5/07 , A61K31/235 , A61K31/715
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p -- (CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -- C.dbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1--3y is 1--4;n is 1--5;m is 1--15;p is 1--10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl in a pharmaceutically acceptable carrier comprising a cellulose derivative.
摘要翻译：公开了用于胃肠道口服或逆行检查的x射线造影剂组合物，其包含下式的x射线产生剂或其药学上可接受的盐，其中Z为H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R是C 1 -C 25烷基，环烷基或卤代低级烷基，其各自可以任选被卤素，氟代低级烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级烷氧基羰基氧基; （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C = C-Q; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-3 y为1-4; n为1-5; m为1-15; p为1-10; Q为包含纤维素衍生物的药学上可接受的载体中的H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

4. 发明授权

US5344638A Compositions of iodobenzoic acid derivatives for visualization of the gastrointestinal tract 失效
标题翻译：碘苯甲酸衍生物用于胃肠道可视化的组合物
公开(公告)号：US5344638A
公开(公告)日：1994-09-06
申请号：US031384
申请日：1993-03-11
申请人： Carl R. Illig , Brent D. Douty
发明人： Carl R. Illig , Brent D. Douty
IPC分类号： A61K49/04 , C07C69/76 , C07C69/767 , C07C69/773 , C07C69/78 , C07C69/82 , C07C69/92
CPC分类号： A61K49/0433 , C07C69/76 , C07C69/92
摘要： Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinwhereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-3y is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylin an aqueous, pharmaceutically acceptable carrier.
摘要翻译：公开了含水组合物中含有的式“IMAGE”的造影剂及其用于胃肠道诊断放射学的方法，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R = C1-C25烷基，环烷基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级 - 烷氧基 - 羰氧基取代，（CR1R2 ）p - （CR 3 = CR 4）m Q或（CR 1 R 2） R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-3 y为1-4; n为1-5; m为1-15; p为1-10; 并且Q是在水性药学上可接受的载体中的H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

5. 发明授权

US5336484A Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastronintestinal tract 失效
标题翻译：碘苯基酯和碘苯基磺酸盐在成膜材料中用于胃肠道可视化的组合物
公开(公告)号：US5336484A
公开(公告)日：1994-08-09
申请号：US040702
申请日：1993-03-31
申请人： Edward R. Bacon , Sol J. Daum , Kimberly G. Estep , Kurt A. Josef , Brent D. Douty , Carl R. Illig
发明人： Edward R. Bacon , Sol J. Daum , Kimberly G. Estep , Kurt A. Josef , Brent D. Douty , Carl R. Illig
IPC分类号： A61K9/107 , A61K47/02 , A61K47/36 , A61K47/38 , A61K49/04 , C07C69/63 , A61K31/075 , A61K31/715
CPC分类号： A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,n is 1-5;y is 0-4; andw is 1-4.
摘要翻译：公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法的胃肠道，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R = C 1 -C 25烷基，环烷基，芳基或卤代低级烷基，任选被卤素，氟代低级烷基，低级烷氧基，羟基，羧基或低级烷氧基羰基，低级烯基，低级炔基，低级 - 亚烷基或低级 - 烷氧基 - 羰氧基，n为1-5; y为0-4; w为1-4。

6. 发明授权

US5316755A Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract 失效
标题翻译：碘苯氧基烷烃和碘苯醚的组合物，用于胃肠道的可视化
公开(公告)号：US5316755A
公开(公告)日：1994-05-31
申请号：US12189
申请日：1993-02-02
申请人： Carl R. Illig , Eugene R. Cooper , John L. Toner , Donald A. Upson , Brent D. Douty , Thomas J. Caulfield , Edward R. Bacon , Kimberly G. Estep , Kurt A. Josef , Shaughnessy Robinson , Paul P. Spara
发明人： Carl R. Illig , Eugene R. Cooper , John L. Toner , Donald A. Upson , Brent D. Douty , Thomas J. Caulfield , Edward R. Bacon , Kimberly G. Estep , Kurt A. Josef , Shaughnessy Robinson , Paul P. Spara
IPC分类号： A61K49/00 , A61K49/04 , C07C43/225 , C07C43/247 , C07C255/54 , A61K31/085
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy,(CR.sub.1 R.sub.2).sub.p -(CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -C.ident.C-Q; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
摘要翻译：公开了含水组合物中含有的式“IMAGE”的造影剂及其用于胃肠道诊断放射学的方法，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基基团可以被卤素或卤代低级烷基取代; R = C1-C25烷基，环烷基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级 - 烷氧基 - 羰氧基取代，（CR1R2 ）p（CR 3 = CR 4）mQ，或（CR 1 R 2）p C = CQ; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-4; n为1-5; m为1-15; p为1-10; 并且Q是H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

7. 发明授权

US07112601B2 Cycloalkyl heterocycles for treating hepatitis C virus 有权
标题翻译：用于治疗丙型肝炎病毒的环烷基杂环
公开(公告)号：US07112601B2
公开(公告)日：2006-09-26
申请号：US10922096
申请日：2004-08-19
申请人： Peter W. Glunz , Brent D. Douty , Scott W. Martin , Jeffrey Romine
发明人： Peter W. Glunz , Brent D. Douty , Scott W. Martin , Jeffrey Romine
IPC分类号： A61K31/415 , C07D231/12 , C07D231/14 , C07D231/16
CPC分类号： C07D231/12 , C07D231/14
摘要： Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also disclosed
摘要翻译：公开了抑制丙型肝炎NS5B RNA依赖性RNA聚合酶并可用于治疗丙型肝炎的式I化合物。也公开了使用这些化合物的组合物和方法

8. 发明授权

US5620677A Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract 失效
标题翻译：碘苯氧基烷烃和碘苯醚的组合物，用于胃肠道的可视化
公开(公告)号：US5620677A
公开(公告)日：1997-04-15
申请号：US189949
申请日：1994-02-01
申请人： Carl R. Illig , Eugene R. Cooper , John L. Toner , Donald A. Upson , Brent D. Douty , Thomas J. Caulfield , Edward R. Bacon , Kimberly G. Estep , Kurt A. Josef , Shaughnessy Robinson , Paul P. Spara
发明人： Carl R. Illig , Eugene R. Cooper , John L. Toner , Donald A. Upson , Brent D. Douty , Thomas J. Caulfield , Edward R. Bacon , Kimberly G. Estep , Kurt A. Josef , Shaughnessy Robinson , Paul P. Spara
IPC分类号： A61K49/00 , A61K49/04 , C07C43/225 , C07C43/247 , C07C255/54
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
摘要翻译：公开了含水组合物中含有的式“IMAGE”的造影剂及其用于胃肠道诊断放射学的方法，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基基团可以被卤素或卤代低级烷基取代; R = C1-C25烷基，环烷基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级 - 烷氧基 - 羰氧基取代，（CR1R2 ）p - （CR 3 = CR 4）m Q或（CR 1 R 2） R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-4; n为1-5; m为1-15; p为1-10; 并且Q是H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

9. 发明授权

US5385721A Compositions of alkylbenzenes and cellulose derivatives for visualization of the gastrointestinal tract 失效
标题翻译：用于胃肠道可视化的烷基苯和纤维素衍生物的组合物
公开(公告)号：US5385721A
公开(公告)日：1995-01-31
申请号：US217138
申请日：1994-03-22
申请人： Edward J. Baker , Kurt A. Josef , Edward R. Bacon , Kimberly G. Estep , Carl R. Illig , Brent D. Douty , John L. Toner , Robert W. Lee
发明人： Edward J. Baker , Kurt A. Josef , Edward R. Bacon , Kimberly G. Estep , Carl R. Illig , Brent D. Douty , John L. Toner , Robert W. Lee
IPC分类号： A61K49/00 , A61K49/04 , C07C17/00 , C07C17/12 , C07C17/26 , C07C25/02 , C07C25/13 , C07C25/24 , C07C33/46 , C07C43/225 , C07C69/65 , C07C69/76 , C07C69/92 , A61K31/715 , A61K31/02
CPC分类号： C07C17/354 , A61K49/04 , A61K49/0404 , A61K49/0409 , A61K49/0433 , C07C17/12 , C07C17/2635 , C07C25/02 , C07C25/24 , C07C69/65
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein R is methyl, ethyl, n-propyl, C.sub.4 -C.sub.25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, lower-alkyl, optionally substituted with halo;n is 2-5;m is 2-5;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl;in a pharmaceutically acceptable carrier comprising a cellulose derivative.
摘要翻译：公开了用于口服或逆行检查胃肠道的x射线造影剂组合物，其包含下式的x射线产生剂或其药学上可接受的盐，其中R是甲基，乙基，正丙基，C 4 -C 25烷基，环烷基，不饱和烯丙基或卤代低级烷基，其各自可以任选被卤素，氟代低级烷基，芳基，低级烷氧基，羟基，羧基或低级烷氧基羰基取代; （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C 3OND C-Q; R 1，R 2，R 3和R 4独立地为H，低级烷基，任选被卤素取代; n为2-5; m为2-5; p为1-10; Q为H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基; 在包含纤维素衍生物的可药用载体中。

10. 发明授权

US5348727A Compositions of iodophenoxy alkylene ethers for visualization of the gastrointestinal tract 失效
标题翻译：用于可视化胃肠道的碘苯氧基亚烷基醚的组合物
公开(公告)号：US5348727A
公开(公告)日：1994-09-20
申请号：US29485
申请日：1993-03-11
申请人： Edward R. Bacon , Carl R. Illig , Thomas J. Caulfield , Brent D. Douty , Kurt A. Josef
发明人： Edward R. Bacon , Carl R. Illig , Thomas J. Caulfield , Brent D. Douty , Kurt A. Josef
IPC分类号： A61K49/04 , C07C43/225 , C07C43/23 , C07C69/92 , C07C255/54 , A61B5/055 , A61K31/075 , C07C41/00
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0461 , C07C43/225
摘要： A compound of the formula: ##STR1## wherein Z.dbd.H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, wherein thealkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.dbd.C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p -(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C-Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, or lower-alkyl, optionally substituted with halo;x is 1-4;n is [1-5]1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, these compounds are useful as X-ray contrast agents or aryl-lower alkyl.
摘要翻译：其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，烷氧基羰基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R = C 1 -C 25烷基，环烷基，或低级烷基; 羟基，羧基，低级烷氧基羰基或低级烷氧基 - 羰基氧基（CR 1 R 2）p - （CR 3 = CR 4）m Q或任选被卤素，氟 - 低级 - 烷基，芳基，（CR1R2）pC 3BOND CQ; R 1，R 2，R 3和R 4独立地为H或被卤素取代的低级烷基; x为1-4; n是[1-5] 1-4; m为1-15; p是1-20; Q为H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基，这些化合物可用作X射线造影剂或芳基 - 低级烷基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式