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1. 发明申请

US20030157021A1 Light imaging contrast agents 失效
公开(公告)号：US20030157021A1
公开(公告)日：2003-08-21
申请号：US10286988
申请日：2002-11-01
发明人： Jo Klaveness , Bjorn Fuglaas , Pal Rongved , Edvin Johannesen , Paul Mark Henrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
IPC分类号： A61K049/00
CPC分类号： B82Y5/00 , A61K49/001 , A61K49/0015 , A61K49/0032 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0078 , A61K49/0082 , A61K49/0084 , A61K49/0433 , A61K49/0461 , A61K49/0466 , A61K49/0485 , A61K49/223 , A61K49/227
摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

2. 发明授权

US06366801B1 Pharmaceutically enhanced low-energy radiosurgery 失效
标题翻译：药物强化低能放射外科手术
公开(公告)号：US06366801B1
公开(公告)日：2002-04-02
申请号：US09550498
申请日：2000-04-14
申请人： Webster C. Cash, Jr. , Michael D. Weil
发明人： Webster C. Cash, Jr. , Michael D. Weil
IPC分类号： A61B600
CPC分类号： A61N5/10 , A61K41/0085 , A61K49/006 , A61K49/0461 , A61N2005/1091 , A61N2005/1098
摘要： Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements from these contrast agents, even small quantities, leads to a major dose increase in target tissue. When combined with in vivo calibration of the amount of contrast agent, the procedure is quick, accurate, and safe. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue, up to 10:1.
摘要翻译：专为x射线诊断开发的造影剂可提供剂量增强的放射治疗和放射外科手术。来自这些造影剂的重元素甚至少量的存在导致靶组织中主要的剂量增加。结合造影剂量的体内校准时，手术快速，准确，安全。该技术还可以与诸如聚焦X射线的其它技术结合使用，以进一步提高治疗比。通过优化设备，可以在健康组织中达到非常大的剂量比例，达到10：1。

3. 发明申请

US20010022963A1 Light imaging contrast agents 失效
标题翻译：光成像造影剂
公开(公告)号：US20010022963A1
公开(公告)日：2001-09-20
申请号：US09732917
申请日：2000-12-11
申请人： Nycomed Imaging AS, a Oslo, Norway Corporation
发明人： Jo Klaveness , Bjorn Fuglass , Pal Rongved , Edvin Johannesen , Paul Mark Henrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
IPC分类号： A61B005/00
CPC分类号： B82Y5/00 , A61K49/001 , A61K49/0015 , A61K49/0032 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0078 , A61K49/0082 , A61K49/0084 , A61K49/0433 , A61K49/0461 , A61K49/0466 , A61K49/0485 , A61K49/223 , A61K49/227
摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.
摘要翻译：本发明涉及在体内光成像中使用颗粒材料作为造影剂。

4. 发明授权

US5741522A Ultrasmall, non-aggregated porous particles of uniform size for entrapping gas bubbles within and methods 失效
标题翻译：超细，非聚集的均匀尺寸的多孔颗粒，用于截留气泡和方法
公开(公告)号：US5741522A
公开(公告)日：1998-04-21
申请号：US460963
申请日：1995-06-05
申请人： Michael R. Violante , Kevin J. Parker
发明人： Michael R. Violante , Kevin J. Parker
IPC分类号： A61K49/00 , A61K49/04 , A61K49/22 , A61K9/14
CPC分类号： A61K49/0461 , A61K49/223 , Y10S514/951 , Y10S514/965
摘要： This invention relates to the preparation, composition and applications of suspensions of ultra-small, substantially non-aggregated, non-crystalline particles of predetermined uniform size which, when suspended in a liquid, contain entrapped gaseous bubbles. These gaseous bubble particles are prepared by simultaneous co-precipitation of two compounds. In accordance with the present invention, the two compounds chosen for co-precipitation are such that one is substantially more soluble than the other in a given vehicle. When this vehicle is used for washing the co-precipitated particles, part of the soluble material is dissolved leaving a porous matrix. The porous particles then are dried and stored. The porous particles, which can be resuspended immediately prior to use, contain entrapped gas in the evacuated crevices or pores which is not displaced for a period of time because of surface tension of the suspending vehicle. These ultrasmall, substantially non-aggregated porous particles therefore can be used to advantage as ultrasound contrast agents as well as other applications.
摘要翻译：本发明涉及预定均匀尺寸的超小型，基本上非聚集的非结晶颗粒的悬浮液的制备，组成和应用，当悬浮在液体中时，其含有截留的气泡。这些气泡颗粒通过两种化合物的同时共沉淀制备。根据本发明，选择用于共沉淀的两种化合物使得在给定的载体中一种化合物比其它化合物更可溶。当该载体用于洗涤共沉淀颗粒时，溶解的部分溶解物留下多孔基体。然后将多孔颗粒干燥并储存。可以在使用之前立即重新悬浮的多孔颗粒在被抽空的缝隙中包含夹带气体，或由于悬浮车辆的表面张力而不被移位一段时间的孔隙。因此，这些超小型，基本上非聚集的多孔颗粒可以用作超声造影剂以及其它应用。

5. 发明授权

US5445811A Organ specific emulsion 失效
标题翻译：器官特异性乳剂
公开(公告)号：US5445811A
公开(公告)日：1995-08-29
申请号：US137061
申请日：1993-12-07
申请人： Bjorn Norrlind , Arvid Wretlind
发明人： Bjorn Norrlind , Arvid Wretlind
IPC分类号： A61K9/107 , A61K36/87 , A61K47/06 , A61K49/04
CPC分类号： A61K49/0461 , A61K9/1075 , Y10S514/938 , Y10S514/943
摘要： Disclosed are emulsions for intravenous administration based on lipophilic iodized and/or bromated substances with emulsifiers and containing derivatives of cyclopenta-phenanthrene, wherein the weight ratio between emulsifier and derivative in the emulsion is between 10:1 and 1:2. These emulsions are intended for use as X-ray contrast agent, particularly for visibilizing the presence of tumors, metastases and the like in liver and spleen. The derivative of cyclopenta-phenanthrene is preferably cholesterol, phytosterol, sitosterol, sigmasterol and/or campesterol. The invention also relates to a method for preparing the emulsion and to the use of the emulsion in the preparation of an X-ray contrast medium for computed tomographic examinations.
摘要翻译： PCT No.PCT / SE92 / 00261 Sec。 371日期：1993年12月7日 102（e）日期1993年12月7日PCT提交1992年4月22日PCT公布。 WO92 / 18169 PCT出版物日期为1992年10月29日。公开是基于亲脂性碘化和/或溴化物质与乳化剂并含有环戊二烯衍生物的静脉内施用的乳剂，其中乳化剂与乳液中的衍生物之间的重量比为10:1至1:1 ：2。这些乳剂旨在用作X射线造影剂，特别是用于在肝脏和脾脏中显现肿瘤，转移灶等的存在。环戊菲的衍生物优选为胆固醇，植物甾醇，谷甾醇，西格米醇和/或菜油甾醇。本发明还涉及一种制备该乳液的方法以及该乳液在用于计算机断层摄影检查的X射线造影剂的制备中的应用。

6. 发明授权

US5334370A Compositions of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract 失效
标题翻译：用于胃肠道可视化的成膜材料中烷基苯的组成
公开(公告)号：US5334370A
公开(公告)日：1994-08-02
申请号：US13459
申请日：1993-02-04
申请人： Kurt A. Josef , Edward R. Bacon , Kimberly G. Estep , Carl R. Illig , Brent D. Douty
发明人： Kurt A. Josef , Edward R. Bacon , Kimberly G. Estep , Carl R. Illig , Brent D. Douty
IPC分类号： A61K49/04 , C07C17/12 , C07C17/26 , C07C17/354 , C07C25/02 , C07C69/65 , C07C22/00 , C07C25/00 , C07C69/76
CPC分类号： C07C17/12 , A61K49/0461 , C07C17/2635 , C07C17/354 , C07C25/02 , C07C69/65
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinR=C.sub.1 -C.sub.25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, lower-alkyl, optionally substituted with halo;n is 1-5;m is 1-5;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
摘要翻译：公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法的胃肠道，其中R = C 1 -C 25烷基，环烷基，不饱和烯丙基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级（CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p C 3 B 3 CQ; R 1，R 2，R 3和R 4独立地为H，低级烷基，任选被卤素取代; n为1-5; m为1-5; p为1-10; 并且Q是H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

7. 发明授权

US5330740A Compositions of iodoaniline derivatives in film-forming materials for visualization of the gastrointestinal tract 失效
标题翻译：用于胃肠道可视化的成膜材料中的碘苯胺衍生物的组合物
公开(公告)号：US5330740A
公开(公告)日：1994-07-19
申请号：US24714
申请日：1993-03-01
申请人： Carl R. Illig , Thomas J. Caulfield
发明人： Carl R. Illig , Thomas J. Caulfield
IPC分类号： A61K9/107 , A61K49/04 , C08K5/315 , C08L101/00 , C08L101/06 , G01N21/00
CPC分类号： A61K49/0404 , A61K49/0409 , A61K49/0461
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.25 alkyl, cycloalkyl acetyl, or halo-lower-alkyl, wherein said C.sub.1 -C.sub.25 alkyl, cycloalkyl, acetyl and halo-lower-alkyl are optionally substituted with, fiuoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;n is 1-5;y is 1-4; andx is 1 or 2in a pharmaceutically acceptable carrier.
摘要翻译：公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法的胃肠道，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R 1和R 2独立地为H，C 1 -C 25烷基，环烷基乙酰基或卤代低级烷基，其中所述C 1 -C 25烷基，环烷基，乙酰基和卤代低级烷基任选被氟低级烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级烷氧基 - 羰基氧基; n为1-5; y为1-4; 并且x在药学上可接受的载体中为1或2。

8. 发明授权

US4917880A Iodine-containing emulsion 失效
标题翻译：含碘乳液
公开(公告)号：US4917880A
公开(公告)日：1990-04-17
申请号：US204718
申请日：1988-06-10
申请人： Karl A. J. Wretlind , Bengt M. Ajaxon
发明人： Karl A. J. Wretlind , Bengt M. Ajaxon
IPC分类号： A61K49/04
CPC分类号： A61K49/0461
摘要： The invention relates to an emulsion for use as an X-ray contrast agent and containing one or more iodinated lipids emulsified in an aqueous phase. The emulsion contains one or more amino acids, fatty acids or their salts, fat-soluble vitamins and/or urea for increasing its stability. Furthermore, the emulsion may contain one or more pharmacologically acceptable oils or fats.By the stability-increasing agent, it has been possible to prepare emulsions of iodinated lipids which can be sterilized in an autoclave and be stored for a long time without the emulsion breaking.

9. 发明授权

US4873075A Polyiodinated triglyceride analogs as radiologic agents 失效
标题翻译：多碘化甘油三酯类似物作为放射剂
公开(公告)号：US4873075A
公开(公告)日：1989-10-10
申请号：US774498
申请日：1985-09-10
申请人： Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert , Susan P. Schwendner
发明人： Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert , Susan P. Schwendner
IPC分类号： A61K49/04 , A61K51/04 , A61K51/12 , C07C237/20
CPC分类号： C07C237/20 , A61K49/0433 , A61K49/0438 , A61K49/0461 , A61K51/0406 , A61K51/1217 , A61K2123/00
摘要： Novel iodinated arylaliphatic triglyceride analogs, as radiologic agents are liver and hepatocyte site-specific. The triglyceride backbone structure is preferably 1,3-disubstituted or 1,2,3-trisubstituted with, in some embodiments, a 3-substituted-2,4,6-triiodophenyl aliphatic chain wherein the chain has a structure similar to naturally occurring fatty acids. In another embodiment, a monoiodophenyl aliphatic chain is utilized. Any position remaining on the triglyceride backbone is substituted with a saturated or unsaturated aliphatic hydrocarbon chain of the type found in naturally occurring fatty acids. The triglyceride analogs can be radioiodinated. In a preferred embodiment, a lipid emulsion is provided as the carrier vehicle.
摘要翻译：新型碘化芳基脂肪酸甘油三酯类似物，作为放射剂是肝和肝细胞位点特异性。甘油三酯主链结构优选在一些实施方案中被3-取代-2,4,6-三碘苯基脂族链进行1,3-二取代或1,2,3-三取代，其中链具有类似于天然存在的脂肪酸。在另一个实施方案中，使用单碘苯基脂族链。在甘油三酯主链上残留的任何位置被天然存在的脂肪酸中所发现类型的饱和或不饱和脂族烃链所取代。甘油三酯类似物可以放射性碘化。在优选的实施方案中，提供脂质乳剂作为载体载体。

10. 发明授权

US2921884A Pharmaceutical compositions 失效
公开(公告)号：US2921884A
公开(公告)日：1960-01-19
申请号：US68716557
申请日：1957-09-30
申请人： STERLING DRUG INC
发明人： NACHOD FREDERICK C , HOPPE JAMES O , BUCK PHILLIS G
IPC分类号： A61K9/10 , A61K38/00 , A61K49/04
CPC分类号： A61K31/70 , A61K9/10 , A61K49/0433 , A61K49/0461 , Y10S424/90

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