专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09696328B2 Automated system for isolating, amplifying and detecting a target nucleic acid sequence 有权
公开(公告)号：US09696328B2
公开(公告)日：2017-07-04
申请号：US13551830
申请日：2012-07-18
申请人： Timothy R. Hansen , Matthew P. Collis , Bradley S. Thomas , Thomas L. Fort
发明人： Timothy R. Hansen , Matthew P. Collis , Bradley S. Thomas , Thomas L. Fort
IPC分类号： B01L3/00 , C12M1/00 , G01N35/00 , G01N35/02 , G01N35/10 , G01N35/04
CPC分类号： G01N35/0099 , B01L3/50855 , B01L2300/0829 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/1065 , G01N35/1074 , G01N2035/00366 , G01N2035/0405 , G01N2035/1025 , G01N2035/1053 , Y10T436/143333
摘要： A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases.

2. 发明授权

US06285450B1 Blood centrifugation device with movable optical reader 失效
标题翻译：具有可移动光学读取器的血液离心装置
公开(公告)号：US06285450B1
公开(公告)日：2001-09-04
申请号：US09033368
申请日：1998-03-02
申请人： Bradley S. Thomas , Michael A. Kelly , Michael R. Walters , Edward M. Skevington , Paul F. Gaidis
发明人： Bradley S. Thomas , Michael A. Kelly , Michael R. Walters , Edward M. Skevington , Paul F. Gaidis
IPC分类号： G01N2101
CPC分类号： B04B5/0407 , G01N15/042 , G01N2015/047
摘要： A centrifuge device that is used to centrifuge a fluid sample, such as a blood sample, to separate the fluid sample into its various component layers, and which is capable of measuring the length of the component layers to calculate cell counts for each layer. The centrifuge device includes a rotor assembly for rotating and thus centrifuging the fluid sample, and a movable optical reader device for reading the cell layers in the centrifuged sample. The centrifuge device is capable of accurately controlling the reading of the centrifuged sample based on the orientation of the rotor, so that the rotor can continue to rotate the centrifuged sample while the readings are being taken.
摘要翻译：离心机装置，其用于离心流体样品，例如血液样品，以将流体样品分离成其各种组分层，并且其能够测量组分层的长度以计算每层的细胞计数。离心机装置包括用于旋转和离心流体样品的转子组件和用于读取离心样品中的细胞层的可移动光学读取装置。离心机装置能够基于转子的取向精确地控制离心样品的读数，使得当读数被读取时，转子可以继续旋转离心样品。

3. 发明授权

US6074883A Method for using disposable blood tube holder 失效
标题翻译：使用一次性血管支架的方法
公开(公告)号：US6074883A
公开(公告)日：2000-06-13
申请号：US33119
申请日：1998-03-02
申请人： Michael A. Kelly , Edward G. King , Michael R. Walters , Bradley S. Thomas
发明人： Michael A. Kelly , Edward G. King , Michael R. Walters , Bradley S. Thomas
IPC分类号： B01L3/14 , B04B5/04 , G01N1/10 , B01L9/00
CPC分类号： B01L3/50215 , B04B5/0407 , Y10T436/2575
摘要： A carrier tube system and method for using the same includes a carrier tube that is configured to receive a capillary blood tube, and a cap which seals the carrier tube to isolate the blood in the capillary tube from the surrounding atmosphere. The carrier tube system can be placed in a centrifuge which separates the blood with its component parts and optically reads the resulting layer thicknesses. The cap of the carrier tube can include a gear portion which is adapted for engagement with an indexing mechanism of the centrifuge, so that the indexing mechanism can rotate the carrier tube system about its longitudinal axis during centrifugation, thus allowing the optical reader of the centrifuge to take layer thickness readings at various positions about the circumference of the capillary tube. The cap can also include a float holder which holds a float that is inserted automatically into the capillary tube when the cap is placed
摘要翻译：载体管系统及其使用方法包括配置为容纳毛细管血管的载体管和密封载体管以将毛细管中的血液与周围大气隔离的帽。载体管系统可以放置在离心机中，离心机将血液与其组分部分分离，并光学读取所得的层厚度。载体管的盖可以包括适于与离心机的分度机构接合的齿轮部分，使得分度机构可以在离心期间使载体管系统围绕其纵向轴线旋转，从而允许离心机的光学读取器以在毛细管周围的各个位置上取层厚读数。盖子还可以包括浮子保持器，该浮子保持器保持当盖子被放置时自动插入毛细管中的浮子

4. 发明授权

US6002474A Method for using blood centrifugation device with movable optical reader 失效
标题翻译：使用可移动光学阅读器的血液离心装置的方法
公开(公告)号：US6002474A
公开(公告)日：1999-12-14
申请号：US32934
申请日：1998-03-02
申请人： Bradley S. Thomas , Michael A. Kelly , Michael R. Walters , Edward M. Skevington , Paul F. Gaidis
发明人： Bradley S. Thomas , Michael A. Kelly , Michael R. Walters , Edward M. Skevington , Paul F. Gaidis
IPC分类号： B04B5/04 , G01N15/04 , G01N21/07 , G01N21/01
CPC分类号： B04B5/0407 , G01N15/042 , G01N2015/047 , G01N21/07
摘要： A centrifuge device that is used to centrifuge a fluid sample, such as a blood sample, to separate the fluid sample into its various component layers, and which is capable of measuring the length of the component layers to calculate cell counts for each layer. The centrifuge device includes a rotor assembly for rotating and thus centrifuging the fluid sample, and a movable optical reader device for reading the cell layers in the centrifuged sample. The centrifuge device is capable of accurately controlling the reading of the centrifuged sample based on the orientation of the rotor, so that the rotor can continue to rotate the centrifuged sample while the readings are being taken.
摘要翻译：离心机装置，其用于离心流体样品，例如血液样品，以将流体样品分离成其各种组分层，并且其能够测量组分层的长度以计算每层的细胞计数。离心机装置包括用于旋转和离心流体样品的转子组件和用于读取离心样品中的细胞层的可移动光学读取装置。离心机装置能够基于转子的取向精确地控制离心样品的读数，使得当读数被读取时，转子可以继续旋转离心样品。

5. 发明授权

US5624849A Method and apparatus for filling glass capillary tubes 失效
标题翻译：填充玻璃毛细管的方法和装置
公开(公告)号：US5624849A
公开(公告)日：1997-04-29
申请号：US520998
申请日：1995-08-30
申请人： Bradley S. Thomas , Mark L. Sussman
发明人： Bradley S. Thomas , Mark L. Sussman
IPC分类号： G01N33/48 , A61B5/15 , A61J1/20 , G01N1/00 , G01N1/10 , B01L3/02
CPC分类号： B01L3/5635 , A61B5/15003 , A61B5/150305 , A61B5/150732 , A61B5/154 , A61J1/065 , B01L2300/0838 , B01L3/50825 , Y10T436/2575
摘要： The present invention relates to a method and apparatus for transferring fluid from a blood collection tube to a glass capillary tube. This eliminates the need for health care workers to open the blood collection tube, insert a glass capillary tube into the blood collection robe, pipet a fluid such as blood into the tube and be exposed to the excess fluid from the capillary tube. The apparatus of the present invention is directed to a transfer device, and a dispenser which can be used with the transfer device, for carrying out this method.
摘要翻译：本发明涉及将流体从采血管传送到玻璃毛细管的方法和装置。这消除了卫生保健工作者打开采血管的需要，将玻璃毛细管插入血液收集袍中，将诸如血液的流体移入管中并暴露于来自毛细管的多余的液体。本发明的装置涉及一种能够与传送装置一起使用的传送装置和分配器，用于执行该方法。

6. 发明授权

US5468022A Sample tube identification flag 失效
标题翻译：样品管识别标志
公开(公告)号：US5468022A
公开(公告)日：1995-11-21
申请号：US259444
申请日：1994-06-14
申请人： Benjamin Linder , Don Lee , Amy Battles , Bradley S. Thomas
发明人： Benjamin Linder , Don Lee , Amy Battles , Bradley S. Thomas
IPC分类号： G09F3/20 , B42D15/00
CPC分类号： G09F3/205 , Y10S283/90
摘要： The invention relates to an identification flag for a sample tube. The flag includes a longitudinally extending planar element, and tube connectors extending laterally from the planar element. The tube connectors are engageable with opposite portions of the tube to secure the planar element to the tube in a laterally spaced relationship with respect to an intermediate portion of the tube located between the opposite portions.
摘要翻译：本发明涉及用于样品管的识别标志。标志包括纵向延伸的平面元件和从平面元件横向延伸的管连接器。管连接器可与管的相对部分接合，以将平面元件相对于位于相对部分之间的管的中间部分以横向间隔的关系固定到管。

7. 发明授权

US4682806A Quadruple gripper 失效
标题翻译：四叉夹
公开(公告)号：US4682806A
公开(公告)日：1987-07-28
申请号：US688214
申请日：1985-01-02
申请人： Bradley S. Thomas , David J. Kargetta
发明人： Bradley S. Thomas , David J. Kargetta
IPC分类号： B25J15/00 , B25J15/06 , B66C1/00
CPC分类号： B25J15/0052 , B25J15/06
摘要： A central base of a gripper is adapted to be attached to a robot wrist flange. Carriage rods and stabilizing bars extend outwardly, on both sides of the central base. Sliding carriages, which move along the carriage rods on linear bearings, each carry two flexible urethane grippers which are capable of expanding and gripping a part from the inside when the flexible grippers are pressurized. Each carriage when slid from a first position to a second position by an air cylinder, causes the second flexible gripper of a carriage to occupy the same position in space that the first flexible gripper of the same carriage, previously occupied.
摘要翻译：夹持器的中心基座适于附接到机器人手腕法兰。支架杆和稳定杆在中心基座的两侧向外延伸。滑动滑架沿着直线轴承上的滑架杆移动，每个都带有两个柔性聚氨酯夹持器，当柔性夹持器被加压时，该滑动托架能够从内部扩展和夹紧零件。每个托架通过气缸从第一位置滑动到第二位置时，导致托架的第二柔性夹持器在与之前占据的相同托架的第一柔性夹持器的空间中占据相同的位置。

8. 发明授权

US08329117B2 Microfluidic chip features for optical and thermal isolation 有权
标题翻译：微流控芯片功能用于光学和热隔离
公开(公告)号：US08329117B2
公开(公告)日：2012-12-11
申请号：US12779523
申请日：2010-05-13
申请人： Bradley S. Thomas , Johnathan S. Coursey , Kenton C. Hasson , Hongye Liang
发明人： Bradley S. Thomas , Johnathan S. Coursey , Kenton C. Hasson , Hongye Liang
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2300/0858 , B01L2300/18 , G01N21/0303 , Y10T436/11
摘要： A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip.
摘要翻译：微流体芯片包括微流体通道，用于热和光学隔离微流体通道的元件以及用于增强从微流体通道发射的光信号的检测的元件。热隔离元件和光学隔离元件可以包括插入在相邻布置的微流体通道对之间的阻挡通道，用于防止相邻的微流体通道之间的热和光学串扰。隔离元件可以可选地包括嵌入在相邻微流体通道之间的微流体芯片中的反射膜。信号增强元件包括邻近微流体通道设置的结构，其反射在朝向检测器的方向上通过微流体通道或从微流体通道发射的光。结构可以包括通过嵌入在微流体芯片中的全内反射或反射膜材料来重定向光的通道或多面的表面。

9. 发明申请

US20110022006A1 Method and apparatus for delivering a therapeutic substance through an injection port 有权
公开(公告)号：US20110022006A1
公开(公告)日：2011-01-27
申请号：US12923649
申请日：2010-09-30
申请人： Michael R. Walters , Bradley S. Thomas , Katherine Stanton
发明人： Michael R. Walters , Bradley S. Thomas , Katherine Stanton
IPC分类号： A61M5/00 , A61J1/20
CPC分类号： A61M5/3202 , A61J1/1406 , A61J1/201 , A61J1/2048 , A61J1/2055 , A61J1/2065 , A61J1/2096 , A61M5/001 , A61M5/158 , A61M5/3134 , A61M5/3287 , A61M39/0208 , A61M39/0247 , A61M2005/1587 , A61M2039/027 , A61M2039/0276 , A61M2039/0285 , A61M2039/0288 , A61M2039/0294
摘要： Adapters for utilizing a syringe or pen injector with a subcutaneous injection port to deliver a therapeutic substance through the injection port and methods of using the adapters are provided. A syringe adapter has a body having a first end and a second end. The first end of the body is configured to receive and engage the end of a syringe so that the cannula of the syringe is held at a fixed position with the respect to the adapter. The second end of the adapter configured to mate with a mating portion of the injection port. When the second end of the adapter engages the mating portion of the injection port, the adapter assures that the cannula of the syringe is properly aligned with the subcutaneous injection port and assures that the cannula penetrates the injection port to the proper depth. Adapters for use with pen style delivery systems are also disclosed. Additionally, an adapter to facilitate loading a syringe with a therapeutic substance from a vial is disclosed.

10. 发明申请

US20090155808A1 Automated system for isolating, amplifying and detecting a target nucleic acid sequence 审中-公开
标题翻译：用于分离，扩增和检测靶核酸序列的自动化系统
公开(公告)号：US20090155808A1
公开(公告)日：2009-06-18
申请号：US12379053
申请日：2009-02-11
申请人： Timothy R. Hansen , Matthew P. Collis , Bradley S. Thomas , Thomas L. Fort
发明人： Timothy R. Hansen , Matthew P. Collis , Bradley S. Thomas , Thomas L. Fort
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： G01N35/0099 , B01L3/50855 , B01L2300/0829 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/1065 , G01N35/1074 , G01N2035/00366 , G01N2035/0405 , G01N2035/1025 , G01N2035/1053 , Y10T436/143333
摘要： A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases.
摘要翻译：提出了一种用于制备和测试靶向核酸的系统和方法。该系统集成了移液器，提取器，测定读数器和其他组件，包括选择性兼容的铰接机器人臂（SCARA）。以前分离的诊断工具的这种协同整合创造了一种需要最少的人为干预的系统和方法。所得到的系统提供了用于诊断疾病的分离，扩增和检测靶核酸的基本更准确和精确的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式