专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060104916A1 Method and apparatus for enhanced size reduction of particles 有权
标题翻译：增加颗粒尺寸减小的方法和装置
公开(公告)号：US20060104916A1
公开(公告)日：2006-05-18
申请号：US10541909
申请日：2004-02-24
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger , Robert Huff
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger , Robert Huff
IPC分类号： A61K9/14 , A61L9/04 , B29B9/00
CPC分类号： B01F3/0853 , A61K9/146 , A61K9/1652 , A61K9/1694 , B01D3/06 , B01D11/0411 , B01F2003/0064 , B01J2/02 , C08J3/12 , C08J2305/00 , C08J2333/00 , C08J2367/00 , C08J2371/00 , C08J2389/00
摘要： The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composte particles.
摘要翻译：本发明提供了通过超临界流体处理生产颗粒的方法和装置。在一个实施方案中，该方法包括在压降下扩张超临界流体增塑的熔体，以形成同时分散，发泡和冷却的固体复合颗粒，并研磨生产的固体颗粒以达到所需的尺寸分布。在另一个实施方案中，将包含超临界流体增塑的熔体的压力容器减压以形成冷却的固体多孔质量块，然后将其研磨以获得固体堆肥颗粒。

2. 发明申请

US20060076293A1 Method and apparatus for producing composite particles using supercritical fluid as plasticizing and extracting agent 有权
标题翻译：使用超临界流体作为增塑剂和提取剂生产复合颗粒的方法和装置
公开(公告)号：US20060076293A1
公开(公告)日：2006-04-13
申请号：US10531008
申请日：2004-02-18
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： B01D11/02
CPC分类号： B01D11/0411 , B01D11/0203 , B01D11/0403
摘要： The present invention provides methods for producing composite particles using supercritical fluid as a plasticizing and extracting agent, composite particles formed in accordance with the methods and an apparatus for carrying out the methods. In accordance with the methods of the invention, a polymer, a wax and/or a lipid that is a solid at standard temperature and pressure is contacted with a supercritical fluid to form a melt, either before or after the polymer, wax and/or lipid has been contacted with a solution comprising a solute dissolved in a solvent. The supercritical fluid plasticizes the polymer, wax and/or lip and extracts the solvent from the solution, resulting in the formation of a two-fraction system including a first melt-rich fraction that includes the plasticized melt and fine particles of precipitated solute that are dispersed in the melt, and a second fraction that includes the supercritical fluid and the solvent. Expansion of the first fraction across a pressure drop results in the formation of composite particles that include the polymer, wax and/or lipid and the solute.
摘要翻译：本发明提供了使用超临界流体作为增塑萃取剂，根据所述方法形成的复合颗粒和用于实施所述方法的装置来生产复合颗粒的方法。根据本发明的方法，在标准温度和压力下作为固体的聚合物，蜡和/或脂质与超临界流体接触以形成熔体，在聚合物之前或之后，蜡和/或脂质已经与包含溶解在溶剂中的溶质的溶液接触。超临界流体使聚合物，蜡和/或脂肪增塑，并从溶液中提取溶剂，从而形成包括第一富熔体部分的双组分体系，其包括增塑的熔体和沉淀的溶质的细颗粒，分散在熔体中，第二部分包括超临界流体和溶剂。通过压降的第一级分的膨胀导致形成包括聚合物，蜡和/或脂质和溶质的复合颗粒。

3. 发明申请

US20060008531A1 METHOD FOR PRODUCING SOLID-LIPID COMPOSITE DRUG PARTICLES 审中-公开
标题翻译：生产固体脂肪复合药物颗粒的方法
公开(公告)号：US20060008531A1
公开(公告)日：2006-01-12
申请号：US11160367
申请日：2005-06-21
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Robert Huff
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Robert Huff
IPC分类号： A61K9/14
CPC分类号： A61K9/167 , A61K9/5123 , B01D11/0403 , B01D11/0407 , B01D11/0411 , B01D11/0484 , B01J13/02
摘要： A method of producing solid composite lipid/drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid/drug nanoparticles suspended or dispersed in the liquid.
摘要翻译：一种生产固体复合脂质/药物纳米颗粒的方法，其包括以下步骤：（1）将脂质和药物溶解在合适的有机溶剂中以形成溶液; （2）将溶液乳化在液体中以形成具有包含有机溶剂，药物和脂质的胶束不连续相的乳液和包含液体的连续相; 和（3）在适合于使超临界流体处于超临界状态的条件下使乳液与超临界流体接触，由此超临界流体从胶束中提取有机溶剂，导致它们作为无机溶剂固体复合脂质/药物沉淀悬浮或分散在液体中的纳米颗粒。

4. 发明申请

US20050178020A1 Lyophilization method and apparatus for producing particles 有权
公开(公告)号：US20050178020A1
公开(公告)日：2005-08-18
申请号：US11078554
申请日：2005-03-11
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： A61K9/16 , A61K9/19 , F25B9/02 , F25D3/10 , F26B5/06 , A23F5/00
CPC分类号： F25D3/102 , A61K9/1623 , A61K9/1694 , A61K9/19 , F25B9/02 , F26B5/065
摘要： A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.

5. 发明申请

US20060074010A1 METHOD AND APPARATUS FOR PURIFYING PHARMACEUTICAL COMPOSITIONS USING SUPERCRITICAL FLUIDS 审中-公开
标题翻译：使用超临界流体净化药物组合物的方法和装置
公开(公告)号：US20060074010A1
公开(公告)日：2006-04-06
申请号：US11162698
申请日：2005-09-20
申请人： Pratibhash Chattopadhyay , Boris Shekunov
发明人： Pratibhash Chattopadhyay , Boris Shekunov
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K1/14 , Y02P20/544
摘要： The present invention provides a method and an apparatus for removing impurities from biodegradable polymers and/or pharmaceutical compounds. In accordance with the method, a stream of supercritical fluid and, optionally, a modifying co-solvent, is used to dissolve the impurities. The pressure and temperature of the supercritical fluid or supercritical fluid/co-solvent mixture is controlled such that the supercritical fluid or mixture acts as a solvent for the impurities, but not for the biodegradable polymers and/or pharmaceutical compounds.
摘要翻译：本发明提供了用于从可生物降解的聚合物和/或药物化合物中除去杂质的方法和装置。根据该方法，使用超临界流体和任选的改性共溶剂流来溶解杂质。控制超临界流体或超临界流体/共溶剂混合物的压力和温度，使得超临界流体或混合物用作杂质的溶剂，但不用作可生物降解的聚合物和/或药物化合物。

6. 发明申请

US20060039983A1 Nanoparticles from supercritical fluid antisolvent process using particle growth and agglomeration retardants 有权
标题翻译：纳米颗粒超临界流体反溶剂法使用颗粒生长和聚集阻滞剂
公开(公告)号：US20060039983A1
公开(公告)日：2006-02-23
申请号：US10531160
申请日：2004-05-28
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： A61K9/14
CPC分类号： A61K9/1694 , A61K9/1635 , A61K9/1641 , A61K9/1647
摘要： The present invention provides a method of forming particles using supercritical fluid (SCF). In accordance with the method, one or more growth retardant compounds having both SCF-philic and SCF-phobic groups are present when one or more solute materials reach a supersaturation point and begin to form particle nuclei. The growth retardant compounds can reduce the particle growth rate, increase the nucleation rate and also prevent particle agglomeration. Preferred growth retardant compounds include sugar acetates and fluorocarbons.
摘要翻译：本发明提供使用超临界流体（SCF）形成颗粒的方法。根据该方法，当一种或多种溶质材料达到过饱和点并开始形成粒子核时，存在一种或多种具有SCF亲和和SCF-疏水基团的生长阻滞化合物。生长阻滞化合物可以降低颗粒生长速率，增加成核速率，并且还可防止颗粒聚集。优选的生长阻滞化合物包括糖醋酸盐和碳氟化合物。

7. 发明申请

US20070158266A1 Method And Apparatus For Producing Particles Via Supercritical Fluid Processing 审中-公开
标题翻译：通过超临界流体处理生产颗粒的方法和装置
公开(公告)号：US20070158266A1
公开(公告)日：2007-07-12
申请号：US11687266
申请日：2007-03-16
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： B01D11/04
CPC分类号： B01J2/04 , A61K9/1688 , B01D11/0411 , B01F7/008 , B01F7/00908 , B01F2003/0064
摘要： An apparatus and method for producing particles using supercritical fluid with enhanced mixing. The process includes a vessel having an inner surface defining a chamber. A high-speed shear or turbulent mixer is incorporated inside the vessel in order to create a region of enhanced mixing (mixing zone). A supercritical fluid pump communicates with the first inlet, and supplies supercritical fluid into the mixing zone through the first inlet. A solution pump communicates with the second inlet, and supplies solution into the mixing zone through the second inlet. A mixer assembly includes a motor drive and a rotor. The rotor is in the mixing zone and can mix the solution and the supercritical fluid. Particles are produced when the solution and the supercritical fluid are pumped into the mixing zone while the rotor is mixing. The design of the mixer and the direction of the flow of materials into the chamber creates a plug flow in the mixing zone. The plug flow allows the particles to be removed from the mixing zone as soon as they are precipitated. Because of the high intensity homogeneous mixing and plug flow configuration, the particle uniformity is enhanced and production of composite particles facilitated.
摘要翻译：一种使用超临界流体加强混合生产颗粒的装置和方法。该方法包括具有限定室的内表面的容器。将高速剪切或湍流混合器并入容器内，以产生增强混合区域（混合区）。超临界流体泵与第一入口连通，并通过第一入口将超临界流体供应到混合区。溶液泵与第二入口连通，并通过第二入口将溶液供入混合区。混合器组件包括马达驱动器和转子。转子处于混合区，可以混合溶液和超临界流体。当溶液和超临界流体在转子混合时泵送到混合区域时产生颗粒。混合器的设计和材料流入腔室的方向在混合区域中产生塞子流。插塞流允许颗粒在沉淀时立即从混合区移除。由于高强度均匀混合和活塞流动配置，颗粒均匀性得到提高，并且复合颗粒的生产有助于。

8. 发明申请

US20060145375A1 Method and apparatus for supercritical fluid assisted particle production 有权
标题翻译：用于超临界流体辅助颗粒生产的方法和装置
公开(公告)号：US20060145375A1
公开(公告)日：2006-07-06
申请号：US10541292
申请日：2004-01-30
申请人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
发明人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
IPC分类号： A61K9/14 , B29B9/00
CPC分类号： C08J3/16 , A61K9/145 , A61K9/1617 , A61K9/1694 , B01F3/0807 , B01F7/22 , B01F2003/0064 , B01J2/04 , C08J3/02 , C08J2391/00 , Y02P20/544
摘要： The present invention provides an apparatus and methods of producing particles that include a polymer, a wax and/or lipid and, optionally, a biologically active substance. In accordance with the methods of the invention, a load stock including a polymer, a wax and/or a lipid that is a solid at standard temperature and pressure and, optionally, a biologically active substance is provided. The load stock is contacted with a supercritical fluid to form a melt. The melt is contacted with a polar solvent under suitable conditions to form an emulsion. The emulsion is expanded across a pressure drop to form solid particles that include the load stock. The methods and apparatus facilitate the production of very small particles that have a narrow particle size distribution.
摘要翻译：本发明提供了一种生产包括聚合物，蜡和/或脂质以及任选的生物活性物质的颗粒的装置和方法。根据本发明的方法，提供了包含聚合物，蜡和/或在标准温度和压力下为固体的脂质和任选的生物活性物质的负载储备。负载原料与超临界流体接触以形成熔体。在合适的条件下使熔体与极性溶剂接触以形成乳液。乳液在压降下膨胀以形成包括负载原料的固体颗粒。该方法和装置有助于生产具有窄粒度分布的非常小的颗粒。

9. 发明申请

US20070267768A1 Production of Porous Materials by Supercritical Fluid Processing 有权
标题翻译：超临界流体加工生产多孔材料
公开(公告)号：US20070267768A1
公开(公告)日：2007-11-22
申请号：US10552008
申请日：2005-06-21
申请人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
发明人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
IPC分类号： B29B9/00
CPC分类号： A61K9/1688 , A61K9/0073 , A61K9/1647
摘要： The present invention provides a method of producing porous structures, particles or matrixes, which may be comprised of one or a plurality of components, an apparatus for carrying out the method and particles formed in accordance with the method. The method is particularly suitable for producing porous composite or pure particles for pharmaceutical applications. In accordance with the method, a composite comprising a material such as a pharmaceutical, a biodegradable polymers and/or a biological agent is formed. The composite must further comprise a material that is soluble in supercritical fluid. Extraction of the supercritical fluid soluble material produces porous structures, which may be in the form of particles or matrixes.
摘要翻译：本发明提供一种生产可由一种或多种组分组成的多孔结构，颗粒或基体的方法，用于实施根据该方法形成的方法和颗粒的装置。该方法特别适用于生产用于药物应用的多孔复合物或纯颗粒。根据该方法，形成包含诸如药物，可生物降解的聚合物和/或生物试剂的材料的复合材料。复合材料还必须包含可溶于超临界流体的材料。超临界流体可溶物质的提取产生多孔结构，其可以是颗粒或基体的形式。

10. 发明申请

US20060153921A1 Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions 有权
标题翻译：从超临界流体或压缩气体乳液制备颗粒的方法
公开(公告)号：US20060153921A1
公开(公告)日：2006-07-13
申请号：US10534665
申请日：2004-06-02
申请人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
发明人： Pratibhash Chattopadhyay , Boris Shekunov , Jeffrey Seitzinger
IPC分类号： A61K48/00 , A61K39/12 , A61K9/14 , A61K36/18 , B29B9/02
CPC分类号： A61K48/00 , A61K9/1605 , A61K9/19 , B01J2/04
摘要： The present invention provides a method of producing particles from solution-in-supercritical fluid or compressed gas emulsions. In accordance with the method of the invention, a solution that includes a solute dissolved in a solvent is contacted with supercritical fluid or compressed gas to form a solution-in-super critical fluid or compressed gas emulsion. The emulsion is sprayed through an orifice to create spray droplets. The supercritical fluid or compressed gas and the solvent are removed from the spray droplets resulting in the formation of particles that include the solute. In one embodiment of the invention, the solvent is removed from the spray droplets by lyophilization. In another embodiment of the invention, the solvent is removed from the spray droplets by evaporation.
摘要翻译：本发明提供了一种从超临界流体或压缩气体乳液中制备颗粒的方法。根据本发明的方法，将包含溶解在溶剂中的溶质的溶液与超临界流体或压缩气体接触以形成超临界流体或压缩气体乳液。通过孔喷雾乳液以产生喷雾液滴。从喷雾液滴中除去超临界流体或压缩气体和溶剂，导致形成包括溶质的颗粒。在本发明的一个实施方案中，通过冷冻干燥从喷雾液滴中除去溶剂。在本发明的另一个实施方案中，通过蒸发从喷雾液滴中除去溶剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式