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1. 发明授权

US5662849A Method and apparatus for forming compression dosage units within the product package 失效
标题翻译：用于在产品包装内形成压缩剂量单位的方法和装置
公开(公告)号：US5662849A
公开(公告)日：1997-09-02
申请号：US438239
申请日：1995-05-09
申请人： Beuford Arlie Bogue , Garry L. Myers
发明人： Beuford Arlie Bogue , Garry L. Myers
IPC分类号： A61J3/10 , A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , B30B11/08 , B30B11/10 , B30B11/14 , B30B15/30 , C13B30/02 , C13B50/00 , B29C43/08
CPC分类号： B30B15/302 , A23G3/10 , A23G3/346 , A23G3/368 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , B30B11/10 , B30B11/14 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： The present invention provides a method and apparatus for forming a compression dosage unit such as a tablet. The method of the present invention includes dispensing a premeasured volume of tableting feedstock into a product tray. The feedstock is compacted into a tablet within the product tray. The product tray may be further packaged for distribution and sale. The apparatus of the present invention includes a dossiter for dispensing the premeasured volume of feedstock into the product tray from a reservoir. A die is insertable into the product tray to form the tablet therein. The present invention also provides for the formation of the tablets within the product tray by use of the dossiter.
摘要翻译：本发明提供了一种用于形成诸如片剂的压缩剂量单位的方法和装置。本发明的方法包括将预先测量的压片原料分配到产品托盘中。原料在产品托盘内压实成片剂。产品托盘可以进一步包装以进行分销和销售。本发明的装置包括一个用于从储存器将预先测量的原料体积分配到产品托盘中的分配器。模具可插入产品托盘中以在其中形成片剂。本发明还提供了通过使用该装置在产品托盘内形成片剂。

2. 发明申请

US20080305173A1 AMORPHOUS DRUG BEADS 审中-公开
标题翻译：不规则药水珠
公开(公告)号：US20080305173A1
公开(公告)日：2008-12-11
申请号：US11623150
申请日：2007-01-15
申请人： Beuford Arlie Bogue
发明人： Beuford Arlie Bogue
IPC分类号： A61K9/14 , A61K31/496 , A61K31/337 , A61K31/7048 , A61K31/216 , A61K31/55 , A61K31/56 , A61K31/135 , A61K31/445
CPC分类号： A61K9/1617 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/2013 , A61K9/4866 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5089
摘要： The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods of preparing the amorphous drug beads, wherein molten drug beads are subject to a cooling step with or without shear.
摘要翻译：本发明主题涉及包含非晶形活性药物和具有改善的溶解性，吸收和润湿性特性的有机表面活性剂的无定形药物珠粒。本发明的主题还涉及制备无定形药物珠粒的方法，其中熔融药物珠粒经受有或没有剪切的冷却步骤。

3. 发明申请

US20080145438A1 Micro- and nano-particulate drugs and methods of making thereof 审中-公开
标题翻译：微粒和纳米颗粒药物及其制备方法
公开(公告)号：US20080145438A1
公开(公告)日：2008-06-19
申请号：US11823476
申请日：2007-06-26
申请人： Beuford Arlie Bogue
发明人： Beuford Arlie Bogue
IPC分类号： A61K9/51 , A61K9/50 , A61P43/00 , A61K31/522
CPC分类号： A61K31/522 , A61K9/5015 , A61K9/5146 , A61K9/5192
摘要： A micro and nano-particulate drug comprising a drug substance and a surfactant in which the drug and surfactant form a eutectic mixture. The matrix formed between the drug substance and the surfactant has a melting point less than the decomposition temperature of the drug substance and thus provides the advantages of reduced irritation due to the melting process without the prior art problem of decomposition of the drug substance. In one embodiment, crystals are formed while the mixture is cooled at room temperature under high shear conditions. In a second embodiment, a flowable material may be formed which also contains the drug and that may be incorporated into a pharmaceutical delivery system is also disclosed. Methods of preparing the micro and nano-particulate drug crystals and non-crystalline substance are also contemplated in the inventive subject matter.
摘要翻译：包含药物和表面活性剂的微纳米颗粒药物，其中药物和表面活性剂形成共晶混合物。在药物与表面活性剂之间形成的基质的熔点低于药物的分解温度，因此提供了由于熔融过程而导致的刺激性降低的优点，而没有现有技术的药物分解问题。在一个实施方案中，形成晶体，同时在高剪切条件下将混合物在室温下冷却。在第二个实施方案中，可以形成也含有药物的可流动的材料，并且还可以将其掺入到药物递送系统中。在本发明的主题中也考虑了制备微纳米颗粒药物晶体和非结晶物质的方法。

4. 发明授权

US07163700B2 Amorphous drug beads 失效
标题翻译：无定形药物珠粒
公开(公告)号：US07163700B2
公开(公告)日：2007-01-16
申请号：US10207975
申请日：2002-07-31
申请人： Beuford Arlie Bogue
发明人： Beuford Arlie Bogue
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K9/14 , A61K9/145 , A61K9/146 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5089
摘要： The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods of preparing the amorphous drug beads, wherein molten drug beads are subject to a cooling step with or without shear.
摘要翻译：本发明主题涉及包含非晶形活性药物和具有改善的溶解性，吸收和润湿性特性的有机表面活性剂的无定形药物珠粒。本发明的主题还涉及制备无定形药物珠粒的方法，其中熔融药物珠粒经受有或没有剪切的冷却步骤。

5. 发明授权

US5653926A Method and apparatus for forming compression dosage units 失效
标题翻译：用于形成压缩剂量单位的方法和装置
公开(公告)号：US5653926A
公开(公告)日：1997-08-05
申请号：US437300
申请日：1995-05-09
申请人： Beuford Arlie Bogue , Garry L. Myers
发明人： Beuford Arlie Bogue , Garry L. Myers
IPC分类号： A61J3/10 , A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , B30B11/08 , B30B11/10 , B30B11/14 , B30B15/30 , C13B30/02 , C13B50/00 , B29C43/04
CPC分类号： B30B15/302 , A23G3/10 , A23G3/346 , A23G3/368 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , B30B11/10 , B30B11/14 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： A method and apparatus provides for the formation of compression dosage units from tableting feedstock. A feedstock dossiter is provided including an open ended chamber for insertion into a reservoir containing the tableting feedstock. The dossiter includes a movable die punch which is movable within the chamber between at least two positions. A first position away from the open end of the chamber provides for the collection of a preselected volume of tableting feedstock from the reservoir. The die punch is movable to a second position which effects formation of the tablet within the accumulation chamber. The dossiter shown herein may be used in combination with a fixed die punch to form the tablet.
摘要翻译：一种方法和装置提供从压片原料形成压缩剂量单位。提供了一种原料分布器，包括用于插入到含有压片原料的储存器中的开口端室。该装置包括一个活动模具冲头，它可在室内至少在两个位置之间移动。离开室的开口端的第一位置提供从储存器收集预选量的压片原料。模具冲头可移动到第二位置，其实现在积聚室内形成片剂。本文所示的装置可以与固定模具冲头组合使用以形成片剂。

6. 发明授权

US5648033A Method and apparatus for retaining a formed compression dosage unit within a die cavity 失效
标题翻译：用于将形成的压缩剂量单元保持在模腔内的方法和装置
公开(公告)号：US5648033A
公开(公告)日：1997-07-15
申请号：US438165
申请日：1995-05-09
申请人： Beuford Arlie Bogue , Garry L. Myers
发明人： Beuford Arlie Bogue , Garry L. Myers
IPC分类号： A61J3/10 , A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , B30B11/02 , B30B11/08 , B30B11/10 , B30B11/14 , C13B30/02 , C13B50/00 , B29C43/08
CPC分类号： A23G3/10 , A23G3/346 , A23G3/368 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , B30B11/027 , B30B11/10 , B30B11/14 , C13B30/021 , C13B50/00 , A23G2200/06
摘要： A method and apparatus is provided for the formation of a tablet from tableting feedstock. An elongate die is provided which has a cavity defined by an inner wall. A pair of die punches are insertably positioned within the cavity. The die punches include opposed facing surfaces for supporting therebetween tableting feedstock. The die punches are relatively movable within the cavity to a tablet forming position to compress the feedstock into a tablet. The tablet forming positions defined by the facing die punch surfaces are spaced apart sufficient distance so as to maintain the formed tablet in contact with the inner wall of the cavity so as to retain the tablet within the cavity upon removal of the die punches.
摘要翻译：提供了一种从压片原料形成片剂的方法和装置。提供具有由内壁限定的空腔的细长模具。一对模冲头可插入腔内。冲模包括相对的相对的表面，用于在其间支撑压片原料。冲模在空腔内相对移动到片剂形成位置，以将原料压缩成片剂。由面对的模具冲头表面限定的片剂形成位置间隔开足够的距离，以便保持形成的片剂与空腔的内壁接触，以便在去除模具冲头时将片剂保持在空腔内。

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