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1. 发明授权

US08153426B2 Preparation of antigen-presenting human gamma-delta T cells and use in immunotherapy 有权
标题翻译：抗原呈递人γ-δT细胞的制备和用于免疫治疗
公开(公告)号：US08153426B2
公开(公告)日：2012-04-10
申请号：US11573912
申请日：2005-08-11
申请人： Bernhard Moser , Marlene Brandes Kuchen
发明人： Bernhard Moser , Marlene Brandes Kuchen
IPC分类号： C12N5/071 , C12N5/0783 , C12N15/00
CPC分类号： C12N5/0636 , A61K2039/5154 , A61K2039/5158 , C12N2501/05 , C12N2501/23 , C12N2501/999
摘要： The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human γδ T cells process antigens and present antigenic peptides to αβ T cells and induce antigen-specific responses (proliferation and differentiation) in naïve αβ T cells. γδ T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The γδ T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.
摘要翻译：本发明涉及一种制备有效的抗原呈递人γδT细胞的方法，涉及通过这种方法制备的γδT细胞，以及它们在免疫治疗，疫苗接种，疫苗开发和诊断中的应用。这些人γδT细胞与效能和效力方面的树突状细胞（DC）类似，可以处理抗原并将抗原肽存在于α和bgr中。 T细胞，并在初始α和bgr中诱导抗原特异性应答（增殖和分化） T细胞。 γδT细胞从外周血中容易地纯化，在刺激的1天内获得“成熟”状态（必需粘附，共刺激和主要组织相容性复合物分子的表达），并诱导强的初级和辅助性T辅助细胞和细胞毒性 T细胞反应。 γδT细胞可用于治疗肿瘤或慢性或复发性感染性疾病，鉴定新型肿瘤或病原体衍生的抗原以及诊断患者免疫能力的方法。

2. 发明授权

US06260637B1 Rock drill 有权
标题翻译：摇滚钻
公开(公告)号：US06260637B1
公开(公告)日：2001-07-17
申请号：US09297890
申请日：1999-05-11
申请人： August Haussmann , Mathias Fuss , Bernhard Moser , Thomas Wagegg
发明人： August Haussmann , Mathias Fuss , Bernhard Moser , Thomas Wagegg
IPC分类号： E21B1058
CPC分类号： E21B10/445
摘要： A rock drill which has a cutting tip of roof-shaped design at its front end is proposed. In order to achieve a reduction in the loading of the carbide cutting tip or an increased drilling capacity in particular in concrete, the flanks are subdivided into flank sections in order to achieve a slimmer embodiment of the drill head.
摘要翻译：提出了一种在其前端具有屋顶形设计的切割尖端的凿岩机。为了实现碳化物切削刀片的加载减小或特别是在混凝土中增加的钻孔能力，将侧翼细分为侧面部分，以实现钻头的较细的实施例。

3. 发明授权

US6140064A Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3 失效
标题翻译：检测或鉴定CXC趋化因子受体3的配体，抑制剂或启动子的方法
公开(公告)号：US6140064A
公开(公告)日：2000-10-31
申请号：US709838
申请日：1996-09-10
申请人： Marcel Loetscher , Bernhard Moser
发明人： Marcel Loetscher , Bernhard Moser
IPC分类号： A61K38/00 , A61K47/48 , C07K14/715 , C12N15/12 , G01N33/53 , C07K14/00 , C07K16/00 , C12N5/00
CPC分类号： C07K14/7158 , A61K47/48269 , A61K38/00
摘要： The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
摘要翻译：本发明涉及识别受体功能的配体和抑制剂（例如拮抗剂）或启动子（例如激动剂）的方法，包括其中将包含编码CXCR3或其变体的核酸的宿主细胞用于测定中的方法，鉴定和评估配体，抑制剂或启动子的功效。受体功能的抑制剂和启动子可用于调节受体活性，允许选择性抑制淋巴细胞功能，特别是效应细胞例如活化的T淋巴细胞和NK细胞用于治疗目的。

4. 发明授权

US6116827A Drilling tool 失效
标题翻译：钻孔工具
公开(公告)号：US6116827A
公开(公告)日：2000-09-12
申请号：US152513
申请日：1998-09-14
申请人： Bernhard Moser , Mathias Fuss
发明人： Bernhard Moser , Mathias Fuss
IPC分类号： E21B10/36 , B23B51/04 , B28D1/14 , E21B10/26 , B23B51/00
CPC分类号： E21B10/26 , B23B51/0473 , Y10T408/895 , Y10T408/8957 , Y10T408/906 , Y10T408/907
摘要： A drilling tool, in particular for rotary percussion drilling preferably of rock, is proposed, with a drill body preferably equipped with cutting tips toward the drilling side and with an axially arranged bore for receiving an exchangeable center drill. In order to carry out easy mounting and demounting of the center drill, the drilling tool is designed in two parts, the center drill being capable of being introduced into the drilling tool on the clamping side.
摘要翻译：提出了一种钻孔工具，特别是用于岩石的旋转冲击钻孔，其中钻体优选地配备有朝向钻孔侧的切割尖端以及用于接收可更换的中心钻的轴向布置的孔。为了实现中心钻的轻松安装和拆卸，钻具分为两部分设计，中心钻可以在夹紧侧被引入到钻具中。

5. 发明授权

US5791424A Drill bit for the rotary-percussive drilling of preferably rock, concrete or the like 失效
标题翻译：钻头用于优选岩石，混凝土等的旋转冲击钻孔
公开(公告)号：US5791424A
公开(公告)日：1998-08-11
申请号：US610404
申请日：1996-03-04
申请人： Bernhard Moser , Hans Peter Meyen
发明人： Bernhard Moser , Hans Peter Meyen
IPC分类号： E21B10/02 , B28D1/04 , B28D1/14 , E21B7/24 , E21B10/04 , E21B10/44 , E21B10/48
CPC分类号： B28D1/041 , E21B10/04 , E21B10/445 , E21B10/485 , E21B7/24
摘要： A drill bit is proposed, in particular for the rotary-percussive drilling of preferably rock, concrete or the like, which includes a thin-walled cylindrical drilling body (106) open to the drilling side and a drill-bit base (20) extending essentially radially and having an axially arranged drill-bit shank (101) for fastening the drill bit. The drill-bit base (20) has an outer contour in the radial direction, which outer contour follows a curve shape which has at least one inflection point. Furthermore, a drill bit is proposed whose drill-bit base (20) has an outer contour which passes through a minimum in the radial direction, the drill-bit base being connected in the rising radially outer curve section of its outer contour to the cylindrical drilling body. Further independent features of the drill bit according to the invention are at least one prominence (19) on the inside of the drill-bit base for crushing the material to be drilled, which prominence (19) projects from the contour of the inside, or a cuttings-discharge flute (109) having a variable helix angle on the outer contour of the drilling body (106).
摘要翻译：提出了一种钻头，特别是用于优选岩石，混凝土等的旋转冲击式钻孔，其包括向钻孔侧开口的薄壁圆柱形钻体（106）和钻头底座（20），所述钻头底座延伸基本上径向地具有用于紧固钻头的轴向布置的钻头柄（101）。钻头基座（20）在径向上具有外轮廓，该外轮廓遵循具有至少一个拐点的曲线形状。此外，提出了一种钻头，其钻头基座（20）具有沿径向方向通过最小的外轮廓，钻头基座在其外轮廓的上升径向外弯曲部分中连接到圆柱形钻体。根据本发明的钻头的其它独立特征是在钻头基座的内侧上的至少一个突出部（19），用于破碎待钻孔的材料，该突起（19）从内部的轮廓突出，或在所述钻孔体（106）的外轮廓上具有可变螺旋角的切屑排出槽（109）。

6. 发明授权

US4750572A Drilling tool with an interchangeable conveying spiral 失效
标题翻译：钻具具有可互换的输送螺旋
公开(公告)号：US4750572A
公开(公告)日：1988-06-14
申请号：US862244
申请日：1986-05-12
申请人： Bernhard Moser
发明人： Bernhard Moser
IPC分类号： E21B17/04 , E21B17/046 , E21B17/22
CPC分类号： E21B17/046 , E21B17/04 , E21B17/22
摘要： A drilling tool is proposed which is provided with an interchangeable conveying spiral and an axial supporting device of the conveying spiral. To achieve a cost-effective and simply constructed, but at the same time reliable axial support of the conveying spiral (14), an elastic sleeve (15) is held in a recessed groove (19) in the drill shank (11) against axial slipping by a support ring (17).
摘要翻译：提出了一种具有可交换输送螺旋和输送螺旋的轴向支撑装置的钻具。为了实现成本有效且简单地构造，但是同时可靠地轴向支撑输送螺旋（14），弹性套筒（15）被保持在钻杆（11）中的凹槽（19）中以抵抗轴向通过支撑环（17）滑动。

7. 发明授权

US4729441A Rock drill 失效
标题翻译：摇滚钻
公开(公告)号：US4729441A
公开(公告)日：1988-03-08
申请号：US753629
申请日：1985-07-10
申请人： Wolfgang Peetz , Bernhard Moser
发明人： Wolfgang Peetz , Bernhard Moser
IPC分类号： E21B10/40 , E21B10/54 , E21B10/58 , E21B10/46 , E21B10/26
CPC分类号： E21B10/58 , E21B10/40 , E21B10/54
摘要： A rock drill in which the depth of the recessed groove for accommodating the cutting body is made greater than the axial brazing-in depth of the cutting body whereby a largely stress-free seating of the cutting body results. In particular, for rock drills for making break-throughs, this recessed groove extended in the radial direction into lobes of a drill head can be used for locating cutting bodies in the lobes.
摘要翻译：一种凿岩机，其中用于容纳切割体的凹槽的深度大于切割体的轴向钎焊深度，由此导致切割体的基本上无应力的就座。特别地，对于用于穿透的岩石钻头，该凹槽在径向方向上延伸成钻头的凸角可用于将切割体定位在凸角中。

8. 发明授权

US4202420A Rock drill with hard metal drilling head 失效
标题翻译：钻石钻头与硬金属钻头
公开(公告)号：US4202420A
公开(公告)日：1980-05-13
申请号：US929269
申请日：1978-07-31
申请人： Wolfgang Peetz , Siegfried Klaissle , Bernhard Moser
发明人： Wolfgang Peetz , Siegfried Klaissle , Bernhard Moser
IPC分类号： E21B10/00 , B23B51/00 , B23B51/04 , E21B10/44 , E21B10/48 , E21C13/08
CPC分类号： B23B51/00 , B23B51/0406 , E21B10/445 , E21B10/48 , B23B2226/75 , B23B2251/408 , B23B2260/132 , Y10S173/02
摘要： A rock drill for rotary blow drilling with a drilling head arranged at the free end of the drill shaft, which at least partially consists of hard metal. The drilling head the end face of which is circular disc shaped or circular ring shaped includes a formed piece of solid hard metal. Cutting bodies are machined out of the end of this piece of hard metal which cutting bodies have the shape of pyramids or truncated pyramids and taper with increasing distance from the drill shank.
摘要翻译：一种用于旋转钻孔的钻石钻头，其具有布置在钻杆轴的自由端处的钻头，其至少部分地由硬质金属组成。钻头的端面为圆形或圆环状的钻头包括成形的固体硬质金属片。切割体从这块硬金属的末端加工出来，切割体具有金字塔形或截锥形的锥体，并且与钻柄的距离增加。

9. 发明授权

US07740089B2 Drilling tool with a cutting element that is configured as a plate or head 有权
标题翻译：钻具具有配置为板或头的切割元件
公开(公告)号：US07740089B2
公开(公告)日：2010-06-22
申请号：US10589317
申请日：2005-08-04
申请人： Bernhard Moser , Rainer Widmann
发明人： Bernhard Moser , Rainer Widmann
IPC分类号： E21B10/58
CPC分类号： E21B10/58 , B23B51/02 , B23B2226/75 , B23B2251/14 , B23B2251/50 , Y10T408/909
摘要： The invention relates to a drilling tool, especially for percussion drilling, which comprises a cutting element (3) that is configured as a plate (3) or head and that has at least one cutting edge (11) defined by a cutting face (6) and a free face (10). The cutting edge (11) is associated with a first free face section (10a) which is limited in a cutting plane at a right angle to the cutting edge (11) and parallel to the longitudinal axis (L) of the drilling tool (1) by a convex bulge (13) or a convex polygon outline. The vertical height of a rib (14) defined by the first free face section (10a) and an associated first cutting face section (6a) ranges from 0.1 mm to 1.0 mm.
摘要翻译：本发明涉及一种特别用于冲击钻孔的钻具，其包括构造为板（3）或头部的切割元件（3），并且具有由切割面（6）限定的至少一个切割刃（11））和自由面（10）。刀刃（11）与第一自由面部分（10a）相关联，第一自由面部分（10a）在与切削刃（11）成直角并且平行于钻具（1）的纵向轴线（L）的切割平面中被限制）通过凸凸起（13）或凸多边形轮廓。由第一自由面部分（10a）和相关联的第一切割面部分（6a）限定的肋（14）的垂直高度为0.1mm至1.0mm。

10. 发明申请

US20100061983A1 Method of inhibiting leukocytes with human cxc chemokine receptor 3 antibody 审中-公开
标题翻译：用人cxc趋化因子受体3抗体抑制白细胞的方法
公开(公告)号：US20100061983A1
公开(公告)日：2010-03-11
申请号：US11903330
申请日：2007-09-21
申请人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
发明人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
IPC分类号： A61K39/395 , C07H21/02 , G01N33/53
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
摘要翻译：本发明涉及称为CXC趋化因子受体3（CXCR3）及其变体的分离和/或重组哺乳动物（例如人）IP-10 / Mig受体蛋白质的蛋白质或多肽，包括特征在于选择性结合一种或多种趋化因子（例如，IP-10和/或Mig）和/或诱导细胞反应的能力（例如，趋化性，胞吐作用）。可以使用蛋白质或其变体或包含免疫原的宿主细胞产生与CXCR3受体反应的抗体。

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