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1. 发明授权

US6140064A Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3 失效
标题翻译：检测或鉴定CXC趋化因子受体3的配体，抑制剂或启动子的方法
公开(公告)号：US6140064A
公开(公告)日：2000-10-31
申请号：US709838
申请日：1996-09-10
申请人： Marcel Loetscher , Bernhard Moser
发明人： Marcel Loetscher , Bernhard Moser
IPC分类号： A61K38/00 , A61K47/48 , C07K14/715 , C12N15/12 , G01N33/53 , C07K14/00 , C07K16/00 , C12N5/00
CPC分类号： C07K14/7158 , A61K47/48269 , A61K38/00
摘要： The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
摘要翻译：本发明涉及识别受体功能的配体和抑制剂（例如拮抗剂）或启动子（例如激动剂）的方法，包括其中将包含编码CXCR3或其变体的核酸的宿主细胞用于测定中的方法，鉴定和评估配体，抑制剂或启动子的功效。受体功能的抑制剂和启动子可用于调节受体活性，允许选择性抑制淋巴细胞功能，特别是效应细胞例如活化的T淋巴细胞和NK细胞用于治疗目的。

2. 发明申请

US20100061983A1 Method of inhibiting leukocytes with human cxc chemokine receptor 3 antibody 审中-公开
标题翻译：用人cxc趋化因子受体3抗体抑制白细胞的方法
公开(公告)号：US20100061983A1
公开(公告)日：2010-03-11
申请号：US11903330
申请日：2007-09-21
申请人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
发明人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
IPC分类号： A61K39/395 , C07H21/02 , G01N33/53
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
摘要翻译：本发明涉及称为CXC趋化因子受体3（CXCR3）及其变体的分离和/或重组哺乳动物（例如人）IP-10 / Mig受体蛋白质的蛋白质或多肽，包括特征在于选择性结合一种或多种趋化因子（例如，IP-10和/或Mig）和/或诱导细胞反应的能力（例如，趋化性，胞吐作用）。可以使用蛋白质或其变体或包含免疫原的宿主细胞产生与CXCR3受体反应的抗体。

3. 发明授权

US06184358B2 IP-10/Mig receptor designated CXCR3, antibodies, nucleic acids, and methods of use therefor 失效
标题翻译：称为CXCR3的IP-10 / Mig受体，抗体，核酸及其用途的方法
公开(公告)号：US06184358B2
公开(公告)日：2001-02-06
申请号：US08829839
申请日：1997-03-31
申请人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
发明人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
IPC分类号： C07K1600
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen. Another aspect of the invention relates to isolated and/or recombinant nucleic acids encoding a mammalian (e.g., human) CXCR3 protein and variants thereof, including antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, comprising a nucleic acid which encodes a protein of the present invention or variant thereof, and to host cells comprising a nucleic acid or construct, useful in the production of recombinant proteins. Also encompassed are methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
摘要翻译：本发明涉及称为CXC趋化因子受体3（CXCR3）及其变体的分离和/或重组哺乳动物（例如，人）IP-10 / Mig受体蛋白质的蛋白质或多肽，包括特征在于选择性结合一种或多种趋化因子（例如，IP-10和/或Mig）和/或诱导细胞反应的能力（例如，趋化性，胞吐作用）。可以使用蛋白质或其变体或与免疫原相同的宿主细胞产生与CXCR3受体反应的抗体。本发明的另一方面涉及编码哺乳动物（例如人）CXCR3蛋白及其变体的分离和/或重组核酸，包括反义核酸，重组核酸构建体，例如质粒或逆转录病毒载体，其包含编码本发明或其变体的蛋白质的核酸，以及宿主细胞，所述宿主细胞包含核酸或构建体，其可用于生产重组蛋白质。还包括鉴定受体功能的配体和抑制剂（例如拮抗剂）或启动子（例如激动剂）的方法，包括其中使用包含编码CXCR3或其变体的核酸的宿主细胞用于鉴定和评估配体，抑制剂或启动子的功效。受体功能的抑制剂和启动子可用于调节受体活性，允许选择性抑制淋巴细胞功能，特别是效应细胞例如活化的T淋巴细胞和NK细胞用于治疗目的。

4. 发明授权

US07029862B1 Method for identifying ligands, inhibitors or promoters of CXC chemokine receptor 3 失效
标题翻译：识别CXC趋化因子受体3的配体，抑制剂或启动子的方法
公开(公告)号：US07029862B1
公开(公告)日：2006-04-18
申请号：US09633541
申请日：2000-08-07
申请人： Marcel Loetscher , Bernhard Moser
发明人： Marcel Loetscher , Bernhard Moser
IPC分类号： G01N33/53
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
摘要翻译：本发明涉及鉴定受体功能的配体和抑制剂（例如拮抗剂）或启动子（例如激动剂）的方法，包括其中使用包含编码CXCR3或其变体的核酸的宿主细胞用于鉴定并评估配体，抑制剂或启动子的功效。受体功能的抑制剂和启动子可用于调节受体活性，允许选择性抑制淋巴细胞功能，特别是效应细胞例如活化的T淋巴细胞和NK细胞用于治疗目的。

5. 发明授权

US06686175B1 IP-10/MIG receptor designated CXCR3, nucleic acids, and methods of use therefor 失效
标题翻译：称为CXCR3的IP-10 / MIG受体，核酸及其用途的方法
公开(公告)号：US06686175B1
公开(公告)日：2004-02-03
申请号：US09624594
申请日：2000-07-25
申请人： Marcel Loetscher , Bernhard Moser
发明人： Marcel Loetscher , Bernhard Moser
IPC分类号： C12N1512
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The invention relates to isolated and/or recombinant nucleic acids encoding a mammalian (e.g., human) CXCR3 protein and variants thereof, including antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, comprising a nucleic acid which encodes a protein of the present invention or variant thereof, and to host cells comprising a nucleic acid or construct, useful in the production of recombinant proteins. The invention also relates to a method for producing a mammalian (e.g., human) CXCR3 protein.
摘要翻译：本发明涉及编码哺乳动物（例如人）CXCR3蛋白及其变体的分离和/或重组核酸，包括反义核酸，重组核酸构建体，例如质粒或逆转录病毒载体，其包含编码蛋白质的核酸本发明或其变体，以及宿主包含可用于重组蛋白质生产的核酸或构建体的细胞。本发明还涉及一种用于产生哺乳动物（例如人）CXCR3蛋白的方法。

6. 发明授权

US07407655B2 Method of inhibiting leukocytes with human CXC chemokine receptor 3 antibody 失效
标题翻译：用人CXC趋化因子受体3抗体抑制白细胞的方法
公开(公告)号：US07407655B2
公开(公告)日：2008-08-05
申请号：US10251686
申请日：2002-09-20
申请人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
发明人： Marcel Loetscher , Bernhard Moser , Shixin Qin , Charles R. Mackay
IPC分类号： A61K39/395
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
摘要翻译：本发明涉及称为CXC趋化因子受体3（CXCR3）及其变体的分离和/或重组哺乳动物（例如，人）IP-10 / Mig受体蛋白质的蛋白质或多肽，包括特征在于选择性结合一种或多种趋化因子（例如，IP-10和/或Mig）和/或诱导细胞反应的能力（例如，趋化性，胞吐作用）。可以使用蛋白质或其变体或包含免疫原的宿主细胞产生与CXCR3受体反应的抗体。

7. 发明授权

US06833439B1 IP-10/MIG receptor designated CXCR3, nucleic acids and methods of use therefor 失效
标题翻译：称为CXCR3的IP-10 / MIG受体，核酸及其使用方法
公开(公告)号：US06833439B1
公开(公告)日：2004-12-21
申请号：US09607156
申请日：2000-06-29
申请人： Marcel Loetscher , Bernhard Moser
发明人： Marcel Loetscher , Bernhard Moser
IPC分类号： C07K1400
CPC分类号： C07K14/7158 , A61K38/00 , A61K47/642
摘要： The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.
摘要翻译：本发明涉及称为CXC趋化因子受体3（CXCR3）及其变体的分离和/或重组哺乳动物（例如，人）IP-10 / Mig受体蛋白质的蛋白质或多肽，包括特征在于选择性结合一种或多种趋化因子（例如，IP-10和/或Mig）和/或诱导细胞反应的能力（例如，趋化性，胞吐作用）。可以使用蛋白质或其变体或包含免疫原的宿主细胞产生与CXCR3受体反应的抗体。

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