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1. 发明授权

US08153426B2 Preparation of antigen-presenting human gamma-delta T cells and use in immunotherapy 有权
标题翻译：抗原呈递人γ-δT细胞的制备和用于免疫治疗
公开(公告)号：US08153426B2
公开(公告)日：2012-04-10
申请号：US11573912
申请日：2005-08-11
申请人： Bernhard Moser , Marlene Brandes Kuchen
发明人： Bernhard Moser , Marlene Brandes Kuchen
IPC分类号： C12N5/071 , C12N5/0783 , C12N15/00
CPC分类号： C12N5/0636 , A61K2039/5154 , A61K2039/5158 , C12N2501/05 , C12N2501/23 , C12N2501/999
摘要： The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human γδ T cells process antigens and present antigenic peptides to αβ T cells and induce antigen-specific responses (proliferation and differentiation) in naïve αβ T cells. γδ T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The γδ T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.
摘要翻译：本发明涉及一种制备有效的抗原呈递人γδT细胞的方法，涉及通过这种方法制备的γδT细胞，以及它们在免疫治疗，疫苗接种，疫苗开发和诊断中的应用。这些人γδT细胞与效能和效力方面的树突状细胞（DC）类似，可以处理抗原并将抗原肽存在于α和bgr中。 T细胞，并在初始α和bgr中诱导抗原特异性应答（增殖和分化） T细胞。 γδT细胞从外周血中容易地纯化，在刺激的1天内获得“成熟”状态（必需粘附，共刺激和主要组织相容性复合物分子的表达），并诱导强的初级和辅助性T辅助细胞和细胞毒性 T细胞反应。 γδT细胞可用于治疗肿瘤或慢性或复发性感染性疾病，鉴定新型肿瘤或病原体衍生的抗原以及诊断患者免疫能力的方法。

2. 发明申请

US20090130074A1 PREPARATION OF ANTIGEN-PRESENTING HUMAN GAMMA DELTA T CELLS AND USE IN IMMUNOTHERAPY 有权
标题翻译：抗原呈递人类GAMMA DELTA T细胞的制备和在免疫学中的应用
公开(公告)号：US20090130074A1
公开(公告)日：2009-05-21
申请号：US12271576
申请日：2008-11-14
申请人： Bernhard Moser , Marlene Brandes Kuchen
发明人： Bernhard Moser , Marlene Brandes Kuchen
IPC分类号： A61K35/12 , C12N5/08 , A61P35/00 , A61P31/00
CPC分类号： A61K39/04 , A61K35/17 , A61K39/0011 , A61K2035/124 , A61K2039/5154 , C12N5/0636 , C12N2501/999 , C12N2502/11
摘要： Cytotoxic αβ T cells form an essential component in immunity to infections and tumors, and are also implicated in host defense against these challenges. The present disclosure demonstrates the ability of activated γδ T cells to cross-present exogenous antigens to CD8+ αβ T cells, a process previously thought to be mediated best by dendritic cells. In particular, the present disclosure provides a method for cross-presentation of antigen derived from tumor cell or microbial organisms such as viruses, bacteria, yeasts, parasites, and the like, or from cells infected with such organisms, to a CD8+ αβ T cell. Still further, the present disclosure provides a method for treatment of a tumor or a chronic or recurrent infectious disease, comprising delivering an antigen-presenting autologous γδ T cell population above into a patient requiring such treatment. Still yet further, a method is described for preparing a peptide-specific effector T cell.
摘要翻译：细胞毒性字母表T细胞是免疫感染和肿瘤的重要组成部分，也与宿主防御这些挑战有关。本公开内容显示了激活的Gammadelta T细胞将外源抗原交叉到CD8 +字母T细胞的能力，这是以前被认为是由树突细胞介导的过程。特别地，本公开提供了将衍生自肿瘤细胞或微生物生物例如病毒，细菌，酵母，寄生虫等的抗原或从这些生物感染的细胞的抗原交叉呈递到CD8 +字母表T细胞的方法。此外，本公开提供了治疗肿瘤或慢性或复发性传染病的方法，包括将上述抗原呈递自体Gammadelta T细胞群输送到需要这种治疗的患者中。更进一步地，描述了制备肽特异性效应T细胞的方法。

3. 发明申请

US20090208517A1 Preparation Of Antigen-Presenting Human Gamma-Delta T Cells And Use In Immunotherapy 审中-公开
标题翻译：抗原呈递的人γ-T细胞的制备和用于免疫治疗
公开(公告)号：US20090208517A1
公开(公告)日：2009-08-20
申请号：US12433030
申请日：2009-04-30
申请人： Bernhard Moser , Marlene Brandes Kuchen
发明人： Bernhard Moser , Marlene Brandes Kuchen
IPC分类号： A61K39/00 , A01N1/02
CPC分类号： C12N5/0636 , A61K2039/5158 , A61K2039/57
摘要： The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human γδ T cells process antigens and present antigenic peptides to αβ T cells and induce antigen-specific responses (proliferation and differentiation) in naïve αβ T cells. γδ T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell responses. The γδ T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.
摘要翻译：本发明涉及一种制备有效的抗原呈递人gammadelta T细胞的方法，用于通过这种方法制备的gammadelta T细胞，以及它们在免疫治疗，疫苗接种，疫苗开发和诊断中的应用。类似于树突状细胞（DCs）的效力和功效，这些人gammadelta T细胞处理抗原，并将抗原肽存在于字母表T细胞，并在天真的字母表T细胞中诱导抗原特异性反应（增殖和分化）。 gammadelta T细胞容易从外周血纯化，获得“成熟”状态（基本粘附表达，共同刺激和主要组织相容性复合物分子）在刺激的体外培养的1天内，诱导强的初级和辅助性T辅助细胞反应。 Gammadelta T细胞可用于治疗肿瘤或慢性或复发性感染性疾病，鉴定新型肿瘤或病原体衍生的抗原以及诊断患者免疫能力的方法。

4. 发明申请

US20080075732A1 Preparation of Antigen-Presenting Human Gamma-Delta T Cells and Use in Immunotherapy 有权
标题翻译：抗原呈递的人γ-T细胞的制备及其在免疫治疗中的应用
公开(公告)号：US20080075732A1
公开(公告)日：2008-03-27
申请号：US11573912
申请日：2005-08-11
申请人： Bernhard Moser , Marlene Brandes Kuchen
发明人： Bernhard Moser , Marlene Brandes Kuchen
IPC分类号： A61K39/00 , A61K35/00 , A61K39/395 , A61P43/00 , C12N13/00 , C12N15/87 , C12N5/06 , C40B30/04 , G01N33/574
CPC分类号： C12N5/0636 , A61K2039/5154 , A61K2039/5158 , C12N2501/05 , C12N2501/23 , C12N2501/999
摘要： The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human γδ T cells process antigens and present antigenic peptides to αβ T cells and induce antigen-specific responses (proliferation and differentiation) in naïve αβ T cells. γδ T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The γδ T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.
摘要翻译：本发明涉及一种制备有效的抗原呈递人gammadelta T细胞的方法，用于通过这种方法制备的gammadelta T细胞，以及它们在免疫治疗，疫苗接种，疫苗开发和诊断中的应用。类似于树突状细胞（DCs）的效力和功效，这些人gammadelta T细胞处理抗原，并将抗原肽存在于字母表T细胞，并在天真的字母表T细胞中诱导抗原特异性反应（增殖和分化）。 gammadelta T细胞容易从外周血纯化，在刺激前1天内获得“成熟”状态（基本粘附，共刺激和主要组织相容性复合物分子的表达），并诱导强的初级和辅助性T辅助细胞和细胞毒性 T细胞反应。 Gammadelta T细胞可用于治疗肿瘤或慢性或复发性感染性疾病，鉴定新型肿瘤或病原体衍生的抗原以及诊断患者免疫能力的方法。

5. 发明授权

US08338173B2 Preparation of antigen-presenting human γδ T cells and use in immunotherapy 有权
标题翻译：抗原呈递人γδT细胞的制备及其在免疫治疗中的应用
公开(公告)号：US08338173B2
公开(公告)日：2012-12-25
申请号：US12271576
申请日：2008-11-14
申请人： Bernhard Moser , Marlene Brandes Kuchen
发明人： Bernhard Moser , Marlene Brandes Kuchen
IPC分类号： C12N5/071 , C12N5/0783 , C12N15/00
CPC分类号： A61K39/04 , A61K35/17 , A61K39/0011 , A61K2035/124 , A61K2039/5154 , C12N5/0636 , C12N2501/999 , C12N2502/11
摘要： Cytotoxic αβ T cells form an essential component in immunity to infections and tumors, and are also implicated in host defense against these challenges. The present disclosure demonstrates the ability of activated γδ T cells to cross-present exogenous antigens to CD8+ αβ T cells, a process previously thought to be mediated best by dendritic cells. In particular, the present disclosure provides a method for cross-presentation of antigen derived from tumor cell or microbial organisms such as viruses, bacteria, yeasts, parasites, and the like, or from cells infected with such organisms, to a CD8+ αβ T cell. Still further, the present disclosure provides a method for treatment of a tumor or a chronic or recurrent infectious disease, comprising delivering an antigen-presenting autologous γδ T cell population above into a patient requiring such treatment. Still yet further, a method is described for preparing a peptide-specific effector T cell.
摘要翻译：细胞毒性α＆bgr T细胞在感染和肿瘤的免疫中形成必不可少的组成部分，并且也涉及宿主防御这些挑战。本公开内容表明活化的γδT细胞将外源抗原交叉存在于CD8 +α和bgr的能力; T细胞，以前被认为是由树突细胞介导最好的过程。特别地，本公开提供了将衍生自肿瘤细胞或微生物生物（例如病毒，细菌，酵母，寄生虫等）的抗原或从这些生物体感染的细胞交叉呈递至CD8 +α和bgr的方法。 T细胞。此外，本公开提供了治疗肿瘤或慢性或复发感染性疾病的方法，包括将上述抗原呈递自体γδT细胞群输送到需要这种治疗的患者中。更进一步地，描述了制备肽特异性效应T细胞的方法。

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