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1. 发明授权

US10384050B2 Implantable medical lead conductor having carbon nanotube wire 有权
公开(公告)号：US10384050B2
公开(公告)日：2019-08-20
申请号：US15316482
申请日：2015-06-24
申请人： Mallika Kamarajugadda , Mark Breyen , Suping Lyu , Bernard Q. Li , Qin Zhang , Jacob Popp , Medtronic, Inc.
发明人： Mallika Kamarajugadda , Mark Breyen , Suping Lyu , Bernard Q. Li , Qin Zhang , Jacob Popp
IPC分类号： A61N1/00 , G01R33/28 , A61N1/37 , A61N1/05 , A61N1/04 , A61N1/08
摘要： An implantable medical leads has a conductor that includes one or more metal wires and one or more carbon nanotube wires extending in substantially the same direction as the one or more metal wires. Such conductors may result in less MRI-induced heating at electrodes of leads than conductors that do not contain carbon nanotubes.

2. 发明授权

US09724784B2 Optical feedthrough for medical devices 有权
公开(公告)号：US09724784B2
公开(公告)日：2017-08-08
申请号：US12401239
申请日：2009-03-10
申请人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
发明人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
IPC分类号： B23K26/00 , B23K26/20 , B23K26/21 , A61N1/375 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/00 , B29C35/08 , G02B6/38 , G02B6/42
CPC分类号： B23K26/206 , A61N1/375 , B23K26/21 , B29C65/14 , B29C65/1406 , B29C65/16 , B29C65/4845 , B29C66/54 , B29C2035/0827 , G02B6/3897 , G02B6/4248
摘要： In general, the disclosure is directed toward transmitting radiant energy across a boundary of a medical device via an optical feedthrough. A system for transmitting radiant energy across a boundary of a medical device includes a first functional module of a medical device, a second functional module of the medical device, an optical feedthrough assembly coupled to the first functional module, and a radiant energy source that emits a beam through the optical feedthrough assembly to perform a manufacturing process on the first functional module and the second functional module.

3. 发明申请

US20120271386A1 CABLE CONFIGURATIONS FOR A MEDICAL DEVICE 有权
标题翻译：医疗设备的电缆配置
公开(公告)号：US20120271386A1
公开(公告)日：2012-10-25
申请号：US13092402
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/05 , B21F7/00
CPC分类号： A61N1/05 , A61B17/1215 , A61B17/1219 , A61N1/0529 , A61N1/0551 , C22C14/00 , C22F1/183 , H01B7/048
摘要： Techniques are disclosed related to cables that may be used within a medical device. According to one example, a cable may comprise multiple wires. Each wire may be formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements selected from a group of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. The cable may be heated to a stress-relieve temperature of the beta titanium alloy to allow the cable to retain a desired configuration while remaining ductile. The cable may be included within a medical device, such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电缆的技术。根据一个示例，电缆可以包括多根电线。每个线可以由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包括选自钛，钼，铌，钽，锆，铬，铁中的至少两种元素，以及锡。电缆可以被加热到β钛合金的应力释放温度，以允许电缆保持所需的构造，同时保持延性。电缆可以包括在医疗设备中，例如医疗电线。

4. 发明申请

US20120271385A1 LOW IMPEDANCE, LOW MODULUS WIRE CONFIGURATIONS FOR A MEDICAL DEVICE 有权
标题翻译：低阻抗，用于医疗设备的低模数电线配置
公开(公告)号：US20120271385A1
公开(公告)日：2012-10-25
申请号：US13092380
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/00 , C22F1/18
CPC分类号： B21C1/16 , A61N1/0551 , A61N1/056 , A61N1/375 , C22C14/00 , C22F1/183
摘要： Techniques are disclosed related to wires that may be used within a medical device. According to one example, a wire may include a core formed of a material having a resistivity of less than 25 micro-ohm-cm and a layer of a biocompatible beta titanium alloy surrounding the core. As one example, the beta titanium alloy has an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprises at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. In one embodiment, the core may be formed of silver, tantalum, a tantalum alloy, niobium, a niobium alloy, platinum, a platinum alloy, palladium, or a palladium alloy. In some examples, one or more wires may be incorporated into a coil or a cable and one or more such coils or cables may be carried by a medical device such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电线的技术。根据一个示例，线可以包括由电阻率小于25微欧姆-cm的材料形成的芯和围绕芯的生物相容性β钛合金层。作为一个实例，β钛合金的弹性模量范围为30千兆帕（GPa）至90GPa，并且包括来自钛，钼，铌，钽，锆，铬，铁和锡的至少两种元素。在一个实施例中，芯可以由银，钽，钽合金，铌，铌合金，铂，铂合金，钯或钯合金形成。在一些示例中，一个或多个电线可以结合到线圈或电缆中，并且一个或多个这样的线圈或电缆可以由诸如医疗电引线的医疗设备携带。

5. 发明申请

US20100256718A1 Wire Configuration and Method of Making for an Implantable Medical Apparatus 有权
标题翻译：电线配置和制造可植入医疗器械的方法
公开(公告)号：US20100256718A1
公开(公告)日：2010-10-07
申请号：US12419082
申请日：2009-04-06
申请人： Ling Wang , Bernard Q. Li
发明人： Ling Wang , Bernard Q. Li
IPC分类号： A61N1/05 , H01R43/00
CPC分类号： A61N1/05 , A61N1/0472 , A61N1/0488 , A61N1/0551 , Y10T29/49002
摘要： A filar includes an inner conductive core that is formed of a low-resistivity material such as silver having a resistivity of less than 20 μΩ per centimeter. A conductive coil is provided around the core to form a filar. This coil is formed of a biocompatible alloy or super alloy having an ultimate tensile strength (UTS) of between 150 kilo pounds per square inch (ksi) and 280 ksi at room temperature. Examples of such alloys include CoCrMo, CoFeCrMo, and CoFeNiCrMo. In one specific embodiment, the alloy is MP35N (CoNiCrMo), which may be low-titanium (“low-ti”) MP35N. One or more such filars may be included within a wire. This wire may be carried by an implantable medical apparatus such as a lead, lead extension, or catheter. The wire may electrically couple elements such as connector electrodes to conducting electrodes or sensors.
摘要翻译：丝状体包括由诸如银的低电阻率材料形成的内导电芯，其电阻率小于20μΩg; 每厘米在芯周围设置导电线圈以形成丝状体。该线圈由在室温下具有150千磅/平方英寸（ksi）和280ksi之间的极限拉伸强度（UTS）的生物相容性合金或超级合金形成。这种合金的实例包括CoCrMo，CoFeCrMo和CoFeNiCrMo。在一个具体实施方案中，合金是MP35N（CoNiCrMo），其可以是低钛（“低钛”）MP35N。一根或多根这样的丝状物可以包括在线内。该线可以由诸如铅，引线延伸或导管的可植入医疗设备携带。导线可以将诸如连接器电极的元件电耦合到导电电极或传感器。

6. 发明授权

US09409008B2 Cable configurations for a medical device 有权
标题翻译：医疗设备的电缆配置
公开(公告)号：US09409008B2
公开(公告)日：2016-08-09
申请号：US13092402
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/05 , C22C14/00 , C22F1/18 , H01B7/04 , A61B17/12
CPC分类号： A61N1/05 , A61B17/1215 , A61B17/1219 , A61N1/0529 , A61N1/0551 , C22C14/00 , C22F1/183 , H01B7/048
摘要： Techniques are disclosed related to cables that may be used within a medical device. According to one example, a cable may comprise multiple wires. Each wire may be formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements selected from a group of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. The cable may be heated to a stress-relieve temperature of the beta titanium alloy to allow the cable to retain a desired configuration while remaining ductile. The cable may be included within a medical device, such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电缆的技术。根据一个示例，电缆可以包括多根电线。每个线可以由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包括选自钛，钼，铌，钽，锆，铬，铁中的至少两种元素，以及锡。电缆可以被加热到β钛合金的应力释放温度，以允许电缆保持所需的构造，同时保持延性。电缆可以包括在医疗设备中，例如医疗电线。

7. 发明授权

US08660662B2 Low impedance, low modulus wire configurations for a medical device 有权
公开(公告)号：US08660662B2
公开(公告)日：2014-02-25
申请号：US13092380
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/05 , H01B5/10
CPC分类号： B21C1/16 , A61N1/0551 , A61N1/056 , A61N1/375 , C22C14/00 , C22F1/183
摘要： Techniques are disclosed related to wires that may be used within a medical device. According to one example, a wire may include a core formed of a material having a resistivity of less than 25 micro-ohm-cm and a layer of a biocompatible beta titanium alloy surrounding the core. As one example, the beta titanium alloy has an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprises at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. In one embodiment, the core may be formed of silver, tantalum, a tantalum alloy, niobium, a niobium alloy, platinum, a platinum alloy, palladium, or a palladium alloy. In some examples, one or more wires may be incorporated into a coil or a cable and one or more such coils or cables may be carried by a medical device such as a medical electrical lead.

8. 发明授权

US08380311B2 Housing for implantable medical device 有权
标题翻译：可植入医疗器械的外壳
公开(公告)号：US08380311B2
公开(公告)日：2013-02-19
申请号：US11590250
申请日：2006-10-31
申请人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh
发明人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh
IPC分类号： A61N1/375
CPC分类号： A61L31/022 , A61N1/375
摘要： A housing for an implantable medical device includes a first portion formed from a first material and a second portion formed from a second material. The first material and the second material comprise titanium and the first material has a higher resistivity than the second material.
摘要翻译：用于可植入医疗装置的壳体包括由第一材料形成的第一部分和由第二材料形成的第二部分。第一材料和第二材料包括钛，并且第一材料具有比第二材料更高的电阻率。

9. 发明授权

US08192418B2 Releasing a material within a medical device via an optical feedthrough 有权
标题翻译：通过光学馈通在医疗装置内释放材料
公开(公告)号：US08192418B2
公开(公告)日：2012-06-05
申请号：US12401267
申请日：2009-03-10
申请人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
发明人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
IPC分类号： A61M5/32
CPC分类号： A61M5/14276 , A61M5/1407 , A61M39/04 , A61M2205/368
摘要： In general, the disclosure is directed toward releasing material within a medical device via an optical feedthrough. A system for releasing material with a medical device comprises a cup that holds a material, wherein the cup includes a discharge port, a seal disc that seals the material within the cup, an optical feedthrough assembly coupled to the cup, a shell that defines a chamber within a medical device, wherein the optical feedthrough assembly is coupled to the shell, and a radiant energy source that shines a beam through the optical feedthrough assembly to puncture the seal disc to allow the material to enter the chamber via the discharge port.
摘要翻译：通常，本公开涉及经由光学馈通释放医疗装置内的材料。用于使用医疗装置释放材料的系统包括保持材料的杯，其中杯包括排出口，密封杯内的材料的密封盘，耦合到杯的光学馈通组件，其中所述光学馈通组件耦合到所述壳体，以及辐射能源，其将光束照射通过所述光学馈通组件以刺穿所述密封盘以允许所述材料经由所述排出口进入所述腔室。

10. 发明申请

US20120053514A1 DRUG INFUSION DEVICE WITH CONTROLLABLE VALVE 有权
标题翻译：具有可控阀的药物输注装置
公开(公告)号：US20120053514A1
公开(公告)日：2012-03-01
申请号：US13217981
申请日：2011-08-25
申请人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
发明人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
IPC分类号： A61M5/168 , A61M5/158 , A61M39/22
CPC分类号： A61M5/16827 , A61M5/14276 , A61M5/1684 , A61M39/223 , A61M2205/3523 , A61M2205/3569 , A61M2210/1003
摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the value to open and close the first fluid pathway and to open and close the second fluid pathway.
摘要翻译：通常描述包括至少一个可控阀的治疗流体输送装置。在一个示例中，可植入治疗流体递送系统包括构造成输送第一治疗流体的第一流体通路和构造成输送第二治疗流体的第二流体通路，第二流体通路与第一流体通路分离。治疗流体递送系统包括连接到第一流体通路和第二流体通路的阀，以及配置成控制该值的致动以打开和关闭第一流体通路并打开和关闭第二流体通路的处理器。

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