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1. 发明授权

US08639352B2 Wire configuration and method of making for an implantable medical apparatus 有权
标题翻译：电线配置和可植入医疗器械的制造方法
公开(公告)号：US08639352B2
公开(公告)日：2014-01-28
申请号：US12419082
申请日：2009-04-06
申请人： Ling Wang , Bernard Q. Li
发明人： Ling Wang , Bernard Q. Li
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/0472 , A61N1/0488 , A61N1/0551 , Y10T29/49002
摘要： A filar includes an inner conductive core that is formed of a low-resistivity material such as silver having a resistivity of less than 20 μΩ per centimeter. A conductive coil is provided around the core to form a filar. This coil is formed of a biocompatible alloy or super alloy having an ultimate tensile strength (UTS) of between 150 kilo pounds per square inch (ksi) and 280 ksi at room temperature. Examples of such alloys include CoCrMo, CoFeCrMo, and CoFeNiCrMo. In one specific embodiment, the alloy is MP35N (CoNiCrMo), which may be low-titanium (“low-ti”) MP35N. One or more such filars may be included within a wire. This wire may be carried by an implantable medical apparatus such as a lead, lead extension, or catheter. The wire may electrically couple elements such as connector electrodes to conducting electrodes or sensors.
摘要翻译：丝状物包括由诸如银的低电阻率材料形成的内导电芯，其电阻率小于每平方厘米20微米。在芯周围设置导电线圈以形成丝状体。该线圈由在室温下具有150千磅/平方英寸（ksi）和280ksi之间的极限拉伸强度（UTS）的生物相容性合金或超级合金形成。这种合金的实例包括CoCrMo，CoFeCrMo和CoFeNiCrMo。在一个具体实施方案中，合金是MP35N（CoNiCrMo），其可以是低钛（“低钛”）MP35N。一根或多根这样的丝状物可以包括在线内。该线可以由诸如铅，引线延伸或导管的可植入医疗设备携带。导线可以将诸如连接器电极的元件电耦合到导电电极或传感器。

2. 发明申请

US20120271386A1 CABLE CONFIGURATIONS FOR A MEDICAL DEVICE 有权
标题翻译：医疗设备的电缆配置
公开(公告)号：US20120271386A1
公开(公告)日：2012-10-25
申请号：US13092402
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/05 , B21F7/00
CPC分类号： A61N1/05 , A61B17/1215 , A61B17/1219 , A61N1/0529 , A61N1/0551 , C22C14/00 , C22F1/183 , H01B7/048
摘要： Techniques are disclosed related to cables that may be used within a medical device. According to one example, a cable may comprise multiple wires. Each wire may be formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements selected from a group of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. The cable may be heated to a stress-relieve temperature of the beta titanium alloy to allow the cable to retain a desired configuration while remaining ductile. The cable may be included within a medical device, such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电缆的技术。根据一个示例，电缆可以包括多根电线。每个线可以由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包括选自钛，钼，铌，钽，锆，铬，铁中的至少两种元素，以及锡。电缆可以被加热到β钛合金的应力释放温度，以允许电缆保持所需的构造，同时保持延性。电缆可以包括在医疗设备中，例如医疗电线。

3. 发明申请

US20120271385A1 LOW IMPEDANCE, LOW MODULUS WIRE CONFIGURATIONS FOR A MEDICAL DEVICE 有权
标题翻译：低阻抗，用于医疗设备的低模数电线配置
公开(公告)号：US20120271385A1
公开(公告)日：2012-10-25
申请号：US13092380
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/00 , C22F1/18
CPC分类号： B21C1/16 , A61N1/0551 , A61N1/056 , A61N1/375 , C22C14/00 , C22F1/183
摘要： Techniques are disclosed related to wires that may be used within a medical device. According to one example, a wire may include a core formed of a material having a resistivity of less than 25 micro-ohm-cm and a layer of a biocompatible beta titanium alloy surrounding the core. As one example, the beta titanium alloy has an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprises at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. In one embodiment, the core may be formed of silver, tantalum, a tantalum alloy, niobium, a niobium alloy, platinum, a platinum alloy, palladium, or a palladium alloy. In some examples, one or more wires may be incorporated into a coil or a cable and one or more such coils or cables may be carried by a medical device such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电线的技术。根据一个示例，线可以包括由电阻率小于25微欧姆-cm的材料形成的芯和围绕芯的生物相容性β钛合金层。作为一个实例，β钛合金的弹性模量范围为30千兆帕（GPa）至90GPa，并且包括来自钛，钼，铌，钽，锆，铬，铁和锡的至少两种元素。在一个实施例中，芯可以由银，钽，钽合金，铌，铌合金，铂，铂合金，钯或钯合金形成。在一些示例中，一个或多个电线可以结合到线圈或电缆中，并且一个或多个这样的线圈或电缆可以由诸如医疗电引线的医疗设备携带。

4. 发明申请

US20100256718A1 Wire Configuration and Method of Making for an Implantable Medical Apparatus 有权
标题翻译：电线配置和制造可植入医疗器械的方法
公开(公告)号：US20100256718A1
公开(公告)日：2010-10-07
申请号：US12419082
申请日：2009-04-06
申请人： Ling Wang , Bernard Q. Li
发明人： Ling Wang , Bernard Q. Li
IPC分类号： A61N1/05 , H01R43/00
CPC分类号： A61N1/05 , A61N1/0472 , A61N1/0488 , A61N1/0551 , Y10T29/49002
摘要： A filar includes an inner conductive core that is formed of a low-resistivity material such as silver having a resistivity of less than 20 μΩ per centimeter. A conductive coil is provided around the core to form a filar. This coil is formed of a biocompatible alloy or super alloy having an ultimate tensile strength (UTS) of between 150 kilo pounds per square inch (ksi) and 280 ksi at room temperature. Examples of such alloys include CoCrMo, CoFeCrMo, and CoFeNiCrMo. In one specific embodiment, the alloy is MP35N (CoNiCrMo), which may be low-titanium (“low-ti”) MP35N. One or more such filars may be included within a wire. This wire may be carried by an implantable medical apparatus such as a lead, lead extension, or catheter. The wire may electrically couple elements such as connector electrodes to conducting electrodes or sensors.
摘要翻译：丝状体包括由诸如银的低电阻率材料形成的内导电芯，其电阻率小于20μΩg; 每厘米在芯周围设置导电线圈以形成丝状体。该线圈由在室温下具有150千磅/平方英寸（ksi）和280ksi之间的极限拉伸强度（UTS）的生物相容性合金或超级合金形成。这种合金的实例包括CoCrMo，CoFeCrMo和CoFeNiCrMo。在一个具体实施方案中，合金是MP35N（CoNiCrMo），其可以是低钛（“低钛”）MP35N。一根或多根这样的丝状物可以包括在线内。该线可以由诸如铅，引线延伸或导管的可植入医疗设备携带。导线可以将诸如连接器电极的元件电耦合到导电电极或传感器。

5. 发明授权

US09409008B2 Cable configurations for a medical device 有权
标题翻译：医疗设备的电缆配置
公开(公告)号：US09409008B2
公开(公告)日：2016-08-09
申请号：US13092402
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/05 , C22C14/00 , C22F1/18 , H01B7/04 , A61B17/12
CPC分类号： A61N1/05 , A61B17/1215 , A61B17/1219 , A61N1/0529 , A61N1/0551 , C22C14/00 , C22F1/183 , H01B7/048
摘要： Techniques are disclosed related to cables that may be used within a medical device. According to one example, a cable may comprise multiple wires. Each wire may be formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements selected from a group of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. The cable may be heated to a stress-relieve temperature of the beta titanium alloy to allow the cable to retain a desired configuration while remaining ductile. The cable may be included within a medical device, such as a medical electrical lead.
摘要翻译：公开了可以在医疗装置内使用的电缆的技术。根据一个示例，电缆可以包括多根电线。每个线可以由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包括选自钛，钼，铌，钽，锆，铬，铁中的至少两种元素，以及锡。电缆可以被加热到β钛合金的应力释放温度，以允许电缆保持所需的构造，同时保持延性。电缆可以包括在医疗设备中，例如医疗电线。

6. 发明授权

US08660662B2 Low impedance, low modulus wire configurations for a medical device 有权
公开(公告)号：US08660662B2
公开(公告)日：2014-02-25
申请号：US13092380
申请日：2011-04-22
申请人： Bernard Q. Li , Ling Wang
发明人： Bernard Q. Li , Ling Wang
IPC分类号： A61N1/05 , H01B5/10
CPC分类号： B21C1/16 , A61N1/0551 , A61N1/056 , A61N1/375 , C22C14/00 , C22F1/183
摘要： Techniques are disclosed related to wires that may be used within a medical device. According to one example, a wire may include a core formed of a material having a resistivity of less than 25 micro-ohm-cm and a layer of a biocompatible beta titanium alloy surrounding the core. As one example, the beta titanium alloy has an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprises at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. In one embodiment, the core may be formed of silver, tantalum, a tantalum alloy, niobium, a niobium alloy, platinum, a platinum alloy, palladium, or a palladium alloy. In some examples, one or more wires may be incorporated into a coil or a cable and one or more such coils or cables may be carried by a medical device such as a medical electrical lead.

7. 发明授权

US08340759B2 Large-pitch coil configurations for a medical device 有权
标题翻译：用于医疗设备的大节距线圈配置
公开(公告)号：US08340759B2
公开(公告)日：2012-12-25
申请号：US13092367
申请日：2011-04-22
申请人： Peter B. McIntyre , Bernard Q. Li , Ling Wang , Shangqian P. Zhang
发明人： Peter B. McIntyre , Bernard Q. Li , Ling Wang , Shangqian P. Zhang
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , C22C14/00 , C22F1/183 , Y10T29/49071
摘要： Techniques related to coils for medical device are disclosed. One example coil may comprise multiple filars, each being formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. At least one of the multiple filars may be electrically insulated one from another. A structural body, such as a lead body, may carry the coil. One or more filars may carry a low-resistance core.
摘要翻译：公开了与医疗装置的线圈有关的技术。一个示例性卷材可以包括多个丝状体，每个丝网由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包含由钛，钼，铌，钽等组成的组中的至少两种元素，锆，铬，铁和锡。多个丝线中的至少一个可以彼此电绝缘。诸如引线体的结构体可以承载线圈。一个或多个丝带可以携带低电阻芯。

8. 发明申请

US20120271381A1 LARGE-PITCH COIL CONFIGURATIONS FOR A MEDICAL DEVICE 有权
标题翻译：医疗设备的大型线圈配置
公开(公告)号：US20120271381A1
公开(公告)日：2012-10-25
申请号：US13092367
申请日：2011-04-22
申请人： Peter B. Mclntyre , Bernard Q. Li , Ling Wang , Shangqian P. Zhang
发明人： Peter B. Mclntyre , Bernard Q. Li , Ling Wang , Shangqian P. Zhang
IPC分类号： A61N1/36 , H01F5/06 , A61N1/05
CPC分类号： A61N1/05 , C22C14/00 , C22F1/183 , Y10T29/49071
摘要： Techniques related to coils for medical device are disclosed. One example coil may comprise multiple filars, each being formed of a biocompatible beta titanium alloy having an elastic modulus ranging from 30 GigaPascals (GPa) to 90 GPa and comprising at least two elements from a group consisting of titanium, molybdenum, niobium, tantalum, zirconium, chromium, iron and tin. At least one of the multiple filars may be electrically insulated one from another. A structural body, such as a lead body, may carry the coil. One or more filars may carry a low-resistance core.
摘要翻译：公开了与医疗装置的线圈有关的技术。一个示例性卷材可以包括多个丝状体，每个丝网由具有30千兆帕（GPa）至90GPa的弹性模量的生物相容性β钛合金形成，并且包含由钛，钼，铌，钽等组成的组中的至少两种元素，锆，铬，铁和锡。多个丝线中的至少一个可以彼此电绝缘。诸如引线体的结构体可以承载线圈。一个或多个丝带可以携带低电阻芯。

9. 发明申请

US20110172646A1 MULTI-MATERIAL SINGLE-PIECE ACTUATOR MEMBER FOR MINIATURE RECIPROCATING PISTON PUMP IN MEDICAL APPLICATIONS 有权
标题翻译：用于医疗应用的微型复合活塞泵的多功能单片执行机构
公开(公告)号：US20110172646A1
公开(公告)日：2011-07-14
申请号：US12684207
申请日：2010-01-08
申请人： Ahmed Elmouelhi , Bernard Q. Li , James M. Haase
发明人： Ahmed Elmouelhi , Bernard Q. Li , James M. Haase
IPC分类号： A61M5/145
CPC分类号： A61M5/14276 , A61M5/14212
摘要： An implantable medical device including a two piece actuator member which comprises a monocrystaline piston and a magnetizable pole. The monocrystalline piston is positioned within a piston channel having a surface having a titanium-oxide layer. The monocrystalline piston is selectively movable within the piston bore to permit intake and output of fluids.
摘要翻译：一种植入式医疗装置，包括一个包括单稳态活塞和一个可磁化极的两片致动器构件。单晶活塞位于具有氧化钛层表面的活塞通道内。单晶活塞可选择性地在活塞孔内移动以允许流体的进入和输出。

10. 发明申请

US20080103556A1 Housing for implantable medical device 有权
标题翻译：可植入医疗器械的外壳
公开(公告)号：US20080103556A1
公开(公告)日：2008-05-01
申请号：US11590250
申请日：2006-10-31
申请人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh
发明人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh
IPC分类号： A61N1/00
CPC分类号： A61L31/022 , A61N1/375
摘要： A housing for an implantable medical device includes a first portion formed from a first material and a second portion formed from a second material. The first material and the second material comprise titanium and the first material has a higher resistivity than the second material.
摘要翻译：用于可植入医疗装置的壳体包括由第一材料形成的第一部分和由第二材料形成的第二部分。第一材料和第二材料包括钛，并且第一材料具有比第二材料更高的电阻率。

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