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1. 发明申请

US20120014835A1 OPTICAL SYSTEM FOR CHEMICAL AND/OR BIOCHEMICAL REACTIONS 审中-公开
标题翻译：化学和/或生物化学反应的光学系统
公开(公告)号：US20120014835A1
公开(公告)日：2012-01-19
申请号：US13143720
申请日：2010-01-08
申请人： James Richard Howell , Benjamin Masterman Webster , Mark Quentin Clark , Richard Alfred Howell
发明人： James Richard Howell , Benjamin Masterman Webster , Mark Quentin Clark , Richard Alfred Howell
IPC分类号： G01N21/76
CPC分类号： B01J19/0046 , G01N21/253 , G01N21/6452 , G01N2201/0826 , G01N2201/0833
摘要： An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light dispersing device (8) for dispersing the light from each waveguide (7) into a dispersed spectrum. A light detecting device (10) detects specific spectra in the dispersed spectra of light substantially simultaneously. In one embodiment, the apertures (6) are substantially smaller in size than the emitting area of the reaction vessel, but in another embodiment, the apertures (6) are substantially similar in size to the emitting area of the reaction vessel and the light waveguides (7) have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter. In an alternative embodiment, the light waveguides are not used, when light from the small apertures is directed straight at the light dispersing device. In a further alternative embodiment, several light waveguides are provided for each reaction vessel, each waveguide directing light to a different detector for detecting a different specific spectrum.
摘要翻译：公开了一种用于检测在多个反应容器（3）中发生的化学或生物化学反应产生的光中的光谱的装置。每个反应容器（3）具有容纳部分，该容器部分具有能够发出光的发射区域。该装置可以包括具有孔（6）阵列的掩模元件（5），来自每个反应容器（3）的光可以通过该孔排出。多个光波导（7）布置成将来自掩模元件（5）中的孔（6）的光引导到用于将来自每个波导（7）的光分散到分散光谱中的光分散装置（8）。光检测装置（10）基本上同时检测光的分散光谱中的特定光谱。在一个实施例中，孔（6）的尺寸基本上小于反应容器的发射面积，但是在另一个实施例中，孔（6）的大小与反应容器的发射面积基本相似，并且光波导（7）的直径从直径基本上类似于反应容器顶部的面积的第一端逐渐变细到直径基本上较小的第二端。在替代实施例中，当来自小孔的光直接指向光分散装置时，不使用光波导。在另一替代实施例中，为每个反应容器提供几个光波导，每个波导将光引导到不同的检测器以检测不同的特定光谱。

2. 发明授权

US10029227B2 Optical system for chemical and/or biochemical reactions 有权
公开(公告)号：US10029227B2
公开(公告)日：2018-07-24
申请号：US13143720
申请日：2010-01-08
申请人： James Richard Howell , Benjamin Masterman Webster , Mark Quentin Clark , Richard Alfred Howell
发明人： James Richard Howell , Benjamin Masterman Webster , Mark Quentin Clark , Richard Alfred Howell
IPC分类号： B01J19/00 , G01N21/25 , G01N21/64
摘要： An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light dispersing device (8) for dispersing the light from each waveguide (7) into a dispersed spectrum. A light detecting device (10) detects specific spectra in the dispersed spectra of light substantially simultaneously. In one embodiment, the apertures (6) are substantially smaller in size than the emitting area of the reaction vessel, but in another embodiment, the apertures (6) are substantially similar in size to the emitting area of the reaction vessel and the light waveguides (7) have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter. In an alternative embodiment, the light waveguides are not used, when light from the small apertures is directed straight at the light dispersing device. In a further alternative embodiment, several light waveguides are provided for each reaction vessel, each waveguide directing light to a different detector for detecting a different specific spectrum.

3. 发明授权

US09377407B2 Reaction monitoring 有权
标题翻译：反应监测
公开(公告)号：US09377407B2
公开(公告)日：2016-06-28
申请号：US12297261
申请日：2007-04-18
申请人： Benjamin Masterman Webster , James Richard Howell
发明人： Benjamin Masterman Webster , James Richard Howell
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2021/6421 , G01N2021/6441
摘要： The invention provides a method and apparatus for detecting a signal of a specific spectrum emitted in the course of a chemical or biochemical reaction. The method comprises conducting the reaction in a reaction vessel, which is arranged so that light emanating from the reaction vessel is received by a detector comprising a plurality of photosensors in an array, wherein each photosensor is activated by light falling within a particular waveband range only, and where photosensors activated by light in different waveband ranges are distributed throughout the array. Output from one or more subsets of those photosensors which receive wavebands which contribute to the said specific spectrum is monitored and the output from a subset, or the relationship between the outputs of each subset are used to determine the signal in the specific spectrum.
摘要翻译：本发明提供一种用于检测在化学或生物化学反应过程中发射的特定光谱的信号的方法和装置。该方法包括在反应容器中进行反应，该反应容器被设置为使得由反应容器发出的光被包括阵列中的多个光电传感器的检测器所接收，其中每个光传感器由仅在特定波段范围内的光激活，并且其中由不同波段范围内的光激活的光电传感器分布在整个阵列中。监视那些接收有助于所述特定频谱的波段的光电传感器的一个或多个子集的输出，并且使用来自子集的输出或每个子集的输出之间的关系来确定特定频谱中的信号。

4. 发明申请

US20110039711A1 THERMAL CONTROL SYSTEM AND METHOD FOR CHEMICAL AND BIOCHEMICAL REACTIONS 有权
标题翻译：化学与生物化学反应的热控制系统及方法
公开(公告)号：US20110039711A1
公开(公告)日：2011-02-17
申请号：US12936307
申请日：2009-04-03
申请人： James Richard Howell , Benjamin Masterman Webster
发明人： James Richard Howell , Benjamin Masterman Webster
IPC分类号： C40B30/00 , C40B60/00 , C12M1/38 , C12Q1/68
CPC分类号： B01L7/52 , B01L2300/1805 , B01L2300/185 , B01L2300/1894
摘要： A system (20) for a PCR reaction includes an array of reaction vessels mounted on a thermal mount (21). The thermal mount (21) is provided with a liquid path therein coupled to a cooling liquid input port (22), a heating liquid input port (23) and a liquid output port (24). A pump (38) is used to pump liquid from cooling liquid source (29) either along a cooling liquid path (28) to the cooling liquid input port (22), or via a heating liquid source (31), where the liquid is heated, and along a heating liquid path (30) to the heating liquid input port (23). A temperature sensor (34) measures the temperature of the thermal mount (21) and a processor (27) controls the pump, valves (26) at the input and output ports and valves (41-44) at either side of the pump (38), to control whether heating or cooling liquid is input to the thermal mount, and at what flow rate, in order to obtain the correct temperature of the thermal block (21).
摘要翻译：用于PCR反应的系统（20）包括安装在热座（21）上的反应容器阵列。热固定装置（21）设置有与冷却液体输入口（22），加热液体输入端口（23）和液体输出端口（24）连接的液体通路。泵（38）用于将液体从冷却液体源（29）沿着冷却液路径（28）泵送到冷却液输入端口（22），或者通过加热液体源（31）将液体从液体源加热，并且沿着加热液体路径（30）加热到加热液体输入端口（23）。温度传感器（34）测量热装置（21）的温度，处理器（27）控制泵，输入和输出端口处的阀（26）和泵的任一侧的阀（41-44） 38），以控制加热或冷却液体是否输入到热安装座，以及以什么流量，以获得热块（21）的正确温度。

5. 发明申请

US20100303690A1 THERMAL CONTROL APPARATUS FOR CHEMICAL AND BIOCHEMICAL REACTIONS 有权
标题翻译：化学和生化反应的热控制装置
公开(公告)号：US20100303690A1
公开(公告)日：2010-12-02
申请号：US12676805
申请日：2008-09-05
申请人： James Richard Howell , Benjamin Masterman Webster
发明人： James Richard Howell , Benjamin Masterman Webster
IPC分类号： B01J19/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L7/52 , B01L9/00 , B01L2200/12 , B01L2300/12 , B01L2300/1827
摘要： An apparatus (40) for a PCR reaction includes an array (41) of reaction vessels (42) is mounted on a thermal mount (43). The thermal mount (43) is positioned on a on a heater/cooler (45), such as a Peltier module. The array (41) is covered by a sealing film (44), which is sealed to the upper rims (49) of the vessels (42) to keep the reagents and reaction products within each vessel (42). A heated lid (50) is used to heat the underside of the sealing film to reduce condensation thereon of reagents vaporised during the reaction. The reaction vessels (42) are formed of an upper, thermally insulating part (25) and a lower, thermally conducting part (21) so as to facilitate accurate temperature control within the vessels but so as to reduce the amount of thermal energy conducted from the heated lid to the vessels, which would reduce the accuracy of the temperature control. The heated lid (50) may include a conformal layer (51) on its lower surface to conform to any variations in the configuration of the upper rims (49) of the vessels (42). The apparatus may include a thermal barrier between the lower portion (21) of the reaction vessels (42) and the heated lid (50).
摘要翻译：用于PCR反应的装置（40）包括反应容器（42）的阵列（41）安装在热座（43）上。热安装座（43）位于加热器/冷却器（45）上，如珀耳帖模块。阵列（41）由密封膜（44）覆盖，密封膜（44）密封到容器（42）的上边缘（49），以将试剂和反应产物保持在每个容器（42）内。加热盖（50）用于加热密封膜的下侧以减少在反应期间蒸发的试剂上的冷凝。反应容器（42）由上绝热部件（25）和下导热部件（21）形成，以便于在容器内精确的温度控制，以便减少从加热的盖子到容器，这将降低温度控制的精度。加热的盖（50）可以在其下表面上包括适形层（51），以符合容器（42）的上边缘（49）的构型的任何变化。该装置可以包括在反应容器（42）的下部（21）和加热盖（50）之间的热障碍。

6. 发明授权

US10919042B2 Biochemical reaction system 有权
公开(公告)号：US10919042B2
公开(公告)日：2021-02-16
申请号：US15301765
申请日：2015-04-07
申请人： James Richard Howell , Benjamin Masterman Webster
发明人： James Richard Howell , Benjamin Masterman Webster
IPC分类号： B01L7/00 , G01N21/03 , B01L9/06 , G01N21/27
摘要： A chemical and/or biochemical apparatus (10) for receiving a plurality of reaction vessels in which chemical and/or biochemical reactions may take place includes a thermal mount (14) having a plurality of wells (26) for receiving the reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and a plurality of thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) is provided for delivering excitation light to a reaction vessel, and a second set of light waveguides (38) is provided for receiving light from a reaction vessel and for delivering the light to the light sensor (52). The first heat sink (18) comprises an interior space (5) and the printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within the interior space (5).

7. 发明申请

US20170113225A1 BIOCHEMICAL REACTION SYSTEM 审中-公开
公开(公告)号：US20170113225A1
公开(公告)日：2017-04-27
申请号：US15301765
申请日：2015-04-07
申请人： James Richard HOWELL , Benjamin Masterman WEBSTER
发明人： James Richard HOWELL , Benjamin Masterman WEBSTER
IPC分类号： B01L7/00 , G01N21/27
CPC分类号： B01L7/52 , B01L9/06 , B01L2300/02 , B01L2300/041 , B01L2300/0654 , B01L2300/0663 , B01L2300/0681 , B01L2300/0832 , B01L2300/087 , B01L2300/123 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , G01N21/0332 , G01N21/272 , G01N2201/0231 , G01N2201/0846
摘要： A chemical and/or biochemical apparatus (10) for receiving a plurality of reaction vessels in which chemical and/or biochemical reactions may take place includes a thermal mount (14) having a plurality of wells (26) for receiving the reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and a plurality of thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) is provided for delivering excitation light to a reaction vessel, and a second set of light waveguides (38) is provided for receiving light from a reaction vessel and for delivering the light to the light sensor (52). The first heat sink (18) comprises an interior space (5) and the printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within the interior space (5).

8. 发明授权

US09266109B2 Thermal control system and method for chemical and biochemical reactions 有权
标题翻译：热控系统及化学反应及生化反应方法
公开(公告)号：US09266109B2
公开(公告)日：2016-02-23
申请号：US12936307
申请日：2009-04-03
申请人： James Richard Howell , Benjamin Masterman Webster
发明人： James Richard Howell , Benjamin Masterman Webster
IPC分类号： C12M1/36 , C12Q1/68 , B01L7/00
CPC分类号： B01L7/52 , B01L2300/1805 , B01L2300/185 , B01L2300/1894
摘要： A system (20) for a PCR reaction includes an array of reaction vessels mounted on a thermal mount (21). The thermal mount (21) is provided with a liquid path therein coupled to a cooling liquid input port (22), a heating liquid input port (23) and a liquid output port (24). A pump (38) is used to pump liquid from cooling liquid source (29) either along a cooling liquid path (28) to the cooling liquid input port (22), or via a heating liquid source (31), where the liquid is heated, and along a heating liquid path (30) to the heating liquid input port (23). A temperature sensor (34) measures the temperature of the thermal mount (21) and a processor (27) controls the pump, valves (26) at the input and output ports and valves (41-44) at either side of the pump (38), to control whether heating or cooling liquid is input to the thermal mount, and at what flow rate, in order to obtain the correct temperature of the thermal block (21).
摘要翻译：用于PCR反应的系统（20）包括安装在热座（21）上的反应容器阵列。热固定装置（21）设置有与冷却液体输入口（22），加热液体输入端口（23）和液体输出端口（24）连接的液体通路。泵（38）用于将液体从冷却液体源（29）沿着冷却液路径（28）泵送到冷却液输入端口（22），或者通过加热液体源（31）将液体从液体源加热，并且沿着加热液体路径（30）加热到加热液体输入端口（23）。温度传感器（34）测量热装置（21）的温度，处理器（27）控制泵，输入和输出端口处的阀（26）和泵的任一侧的阀（41-44） 38），以控制加热或冷却液体是否输入到热安装座，以及以什么流量，以获得热块（21）的正确温度。

9. 发明授权

US09492825B2 Thermal control apparatus for chemical and biochemical reactions 有权
标题翻译：用于化学和生化反应的热控制装置
公开(公告)号：US09492825B2
公开(公告)日：2016-11-15
申请号：US12676805
申请日：2008-09-05
申请人： James Richard Howell , Benjamin Masterman Webster
发明人： James Richard Howell , Benjamin Masterman Webster
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L7/52 , B01L9/00 , B01L2200/12 , B01L2300/12 , B01L2300/1827
摘要： An apparatus (40) for a PCR reaction includes an array (41) of reaction vessels (42) is mounted on a thermal mount (43). The thermal mount (43) is positioned on a on a heater/cooler (45), such as a Peltier module. The array (41) is covered by a sealing film (44), which is sealed to the upper rims (49) of the vessels (42) to keep the reagents and reaction products within each vessel (42). A heated lid (50) is used to heat the underside of the sealing film to reduce condensation thereon of reagents vaporized during the reaction. The reaction vessels (42) are formed of an upper, thermally insulating part (25) and a lower, thermally conducting part (21) so as to facilitate accurate temperature control within the vessels but so as to reduce the amount of thermal energy conducted from the heated lid to the vessels, which would reduce the accuracy of the temperature control. The heated lid (50) may include a conformal layer (51) on its lower surface to conform to any variations in the configuration of the upper rims (49) of the vessels (42). The apparatus may include a thermal barrier between the lower portion (21) of the reaction vessels (42) and the heated lid (50).
摘要翻译：用于PCR反应的装置（40）包括反应容器（42）的阵列（41）安装在热座（43）上。热安装座（43）位于加热器/冷却器（45）上，如珀耳帖模块。阵列（41）由密封膜（44）覆盖，密封膜（44）密封到容器（42）的上边缘（49），以将试剂和反应产物保持在每个容器（42）内。加热盖（50）用于加热密封膜的下侧以减少在反应期间蒸发的试剂上的冷凝。反应容器（42）由上绝热部件（25）和下导热部件（21）形成，以便于在容器内精确的温度控制，以便减少从加热的盖子到容器，这将降低温度控制的精度。加热的盖（50）可以在其下表面上包括适形层（51），以符合容器（42）的上边缘（49）的构型的任何变化。该装置可以包括在反应容器（42）的下部（21）和加热盖（50）之间的热障碍。

10. 发明申请

US20100015611A1 REACTION MONITORING 有权
标题翻译：反应监测
公开(公告)号：US20100015611A1
公开(公告)日：2010-01-21
申请号：US12297261
申请日：2007-04-18
申请人： Benjamin Masterman Webster , James Richard Howell
发明人： Benjamin Masterman Webster , James Richard Howell
IPC分类号： C12Q1/68 , C12M1/34 , G01J3/00
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2021/6421 , G01N2021/6441
摘要： The invention provides a method and apparatus for detecting a signal of a specific spectrum emitted in the course of a chemical or biochemical reaction. The method comprises conducting the reaction in a reaction vessel, which is arranged so that light emanating from the reaction vessel is received by a detector comprising a plurality of photosensors in an array, wherein each photosensor is activated by light falling within a particular waveband range only, and where photosensors activated by light in different waveband ranges are distributed throughout the array. Output from one or more subsets of those photosensors which receive wavebands which contribute to the said specific spectrum is monitored and the output from a subset, or the relationship between the outputs of each subset are used to determine the signal in the specific spectrum.
摘要翻译：本发明提供一种用于检测在化学或生物化学反应过程中发射的特定光谱的信号的方法和装置。该方法包括在反应容器中进行反应，该反应容器被设置为使得由反应容器发出的光被包括阵列中的多个光电传感器的检测器所接收，其中每个光传感器由仅在特定波段范围内的光激活，并且其中由不同波段范围内的光激活的光电传感器分布在整个阵列中。监视那些接收有助于所述特定频谱的波段的光电传感器的一个或多个子集的输出，并且使用来自子集的输出或每个子集的输出之间的关系来确定特定频谱中的信号。

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