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1. 发明授权

US10130951B2 Open-ended conical tube for recovering cells from a microfludic chip 有权
公开(公告)号：US10130951B2
公开(公告)日：2018-11-20
申请号：US14428252
申请日：2013-09-11
申请人： Robert Shartle , Behrad Vahidi , William M. Strauss
发明人： Robert Shartle , Behrad Vahidi , William M. Strauss
IPC分类号： B01L3/00 , B01D21/26
摘要： Provided are devices for recovery of cells from a microfluidic device. In particular, provided are open-ended conical tubes for recovery of cells from a microfluidic device and methods of use. In some embodiments, the open-ended conical tubes comprise: i) a nipple portion (7), wherein the nipple portion (7) comprises a length in the range of 0.2 to 0.3 inches, a diameter in the range of 0.2 to 0.3 inches, wherein the nipple portion (7) comprises a narrow orifice; ii) a conical portion (5) attached to and in fluid communication with the nipple portion, wherein the conical portion (5) has a length in the range of 1.0 to 1.5 inches and the angle of the outer surface of the conical portion (5) of the tube in relation to the outer surface of a cylindrical portion (1) of the tube is between 30° to 45° , wherein an outer circumferential surface of the conical portion (5) is attached to a flange (6) comprising a cylindrical cavity (12), wherein the cylindrical cavity (12) is formed into the surface of the flange (6), and the flange (6) is attached to the outer circumferential surface of the conical portion (5) of the tube such that the opening of the cylindrical cavity (12) extends perpendicularly with respect to the longitudinal axis of the tube, wherein a cap of a PCR tube fits into the cylindrical cavity (12) in the flange (6); iii) the cylindrical portion (1) attached to and in fluid communication with the conical portion (5) and having an axis substantially co-linear with an axis of the conical portion (5), wherein the cylindrical portion (1) comprises a wide orifice and threads (8) on the outer surface abutting the wide orifice to accommodate a cap for the conical tube, wherein the cylindrical portion (1) comprises a length in the range of 2.2 to 2.8 inches, an outer diameter in the range of 1.10 to 1.19 inches along its entire length and an inner diameter configured to accommodate one or more microfluidic chips or slides.

2. 发明申请

US20150231632A1 SPIN ELUTE TUBE 审中-公开
标题翻译：旋压管
公开(公告)号：US20150231632A1
公开(公告)日：2015-08-20
申请号：US14428252
申请日：2013-09-11
申请人： Robert SHARTLE , Behrad VAHIDI , William M. STRAUSS
发明人： Robert Shartle , Behrad Vahidi , William M. Strauss
IPC分类号： B01L3/00 , B01D21/26
CPC分类号： B01L3/50825 , B01D21/262 , B01L3/5021 , B01L3/5027 , B01L7/52 , B01L2300/04 , B01L2300/042 , B01L2400/0409
摘要： Provided are devices for recovery of cells from a microfluidic device.
摘要翻译：提供了用于从微流体装置回收细胞的装置。

3. 发明申请

US20190283022A1 HIGHLY PARALLEL MICROFLUIDIC BLOOD SEPARATION DEVICE 审中-公开
公开(公告)号：US20190283022A1
公开(公告)日：2019-09-19
申请号：US15922322
申请日：2018-03-15
申请人： Behrad Vahidi , Dongjing Tang , Xin Ye , Xianjun Fan , Yanling Zhou
发明人： Behrad Vahidi , Dongjing Tang , Xin Ye , Xianjun Fan , Yanling Zhou
IPC分类号： B01L3/00 , B03C1/32 , G01N33/50 , G01N33/543
摘要： A highly parallel microfluidic blood separation device for isolation of variety of analytes for large-scale clinical trials. The device can be utilized for isolation of number of different target analytes, which may be the starting materials for variety of diagnostic methods including NGS, PCR, FISH, IHC, and others. Separation is achieved via magnetic sheath flow principals and is highly parallel. The separation device achieves effective magnetic separation, functions during sample flow in a vertical geometry and may fasten to standard multi-well plates for highly multiplexed sample recovery. Operating in vertical orientation allows multiplexing, more cards/slot/bay on instrument, allows effective use of real estate on instruments and bench tops.

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