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1. 发明申请

US20060257407A1 Anti-IL-6 antibodies, compositions, methods and uses 有权
标题翻译：抗IL-6抗体，组合物，方法和用途
公开(公告)号：US20060257407A1
公开(公告)日：2006-11-16
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David Knight , Michael Lark , Bailin Liang , David Shealy , Xiao-Yu Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Sheng-Jiun Wu , Jing Yang , David Marquis , Eric Smith , Alain Vasserot
发明人： Yan Chen , Debra Gardner , David Knight , Michael Lark , Bailin Liang , David Shealy , Xiao-Yu Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Sheng-Jiun Wu , Jing Yang , David Marquis , Eric Smith , Alain Vasserot
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

2. 发明授权

US08610411B2 High-voltage regulated power supply 有权
标题翻译：高压稳压电源
公开(公告)号：US08610411B2
公开(公告)日：2013-12-17
申请号：US13090128
申请日：2011-04-19
申请人： Eric Smith , P. Jeffrey Ungar , Heather R. Sullens
发明人： Eric Smith , P. Jeffrey Ungar , Heather R. Sullens
IPC分类号： G05F1/563
CPC分类号： H02M7/10
摘要： The disclosed embodiments relate to a power-supply circuit, an electronic device that includes the power-supply circuit, and a method for generating high-voltage DC power from AC line power using the power-supply circuit. This power-supply circuit includes a voltage multiplier and a low dropout (LDO) regulator, and does not include a step-up transformer. Conventional power supplies often use a custom step-up transformer, which is expensive unless the power supplies are manufactured in high quantities. In contrast, one embodiment of the present disclosure provides a solid-state implementation of a 700 V regulated power supply that can take up to a 1020 V input from an 6× voltage multiplier powered from the AC mains. Hence, the disclosed power-supply circuit eliminates the need for large, heavy and expensive step-up transformers and chokes that are used in conventional high-voltage DC power supplies.
摘要翻译：所公开的实施例涉及电源电路，包括电源电路的电子设备以及使用电源电路从AC线路电力产生高压DC电力的方法。该电源电路包括电压倍增器和低压差（LDO）调节器，并且不包括升压变压器。常规电源通常使用定制的升压变压器，这是非常昂贵的，除非电源大量生产。相比之下，本公开的一个实施例提供了700V稳压电源的固态实现，其可以从由AC电源供电的6×电压倍增器采用高达1020V的输入。因此，所公开的电源电路消除了对常规高压直流电源中使用的大型，重型和昂贵的升压变压器和扼流器的需要。

3. 发明授权

US08586713B2 Readily isolated bispecific antibodies with native immunoglobulin format 有权
标题翻译：用本地免疫球蛋白形式轻松分离双特异性抗体
公开(公告)号：US08586713B2
公开(公告)日：2013-11-19
申请号：US12823838
申请日：2010-06-25
申请人： Samuel Davis , Eric Smith , Douglas MacDonald , Kara Louise Olson
发明人： Samuel Davis , Eric Smith , Douglas MacDonald , Kara Louise Olson
IPC分类号： C07K16/00
CPC分类号： C07K1/22 , A61K2039/505 , C07K16/247 , C07K16/248 , C07K16/2809 , C07K16/2866 , C07K16/2887 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/56 , C07K2317/76
摘要： A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.
摘要翻译：提供提供易于分离的双特异性抗体形式，包括在CH3结构域中差异修饰的免疫球蛋白重链可变结构域，其中所述差异修饰是相对于CH3修饰的非免疫原性或基本上非免疫原性的，以及至少一种基于其对蛋白A的亲和力，所述修饰导致针对亲和试剂例如蛋白A的双特异性抗体的差异亲和力，并且双特异性抗体可从破坏的细胞，培养基或抗体混合物中分离。

4. 发明授权

US08547321B2 LED backlight driver synchronization and power reduction 有权
标题翻译： LED背光驱动器同步和功率降低
公开(公告)号：US08547321B2
公开(公告)日：2013-10-01
申请号：US12178471
申请日：2008-07-23
申请人： Eric Smith
发明人： Eric Smith
IPC分类号： G09G3/36
CPC分类号： G09G3/342 , G09G2330/021
摘要： A method and apparatus for providing a LED backlight to a LCD display screen is disclosed. In one embodiment, the apparatus includes: N LED strings, wherein N is an integer greater than or equal to two; a first circuit operable to synchronize a LED clock signal to a LCD timing signal; and a second circuit operable to generate N PWM drive signals synchronized with the LED clock signal, wherein the N PWM drive signals are phase offset from each other by a multiple of 360/N degrees and used to drive respective ones of the N LED strings.
摘要翻译：公开了一种用于向LCD显示屏提供LED背光的方法和装置。在一个实施例中，该装置包括：N个LED串，其中N是大于或等于2的整数; 第一电路，其可操作以将LED时钟信号与LCD定时信号同步; 以及第二电路，其可操作以产生与所述LED时钟信号同步的N个PWM驱动信号，其中所述N个PWM驱动信号彼此相位偏移360 / N度的倍数，并用于驱动所述N个LED串中的相应的一个。

5. 发明授权

US08360486B2 Vehicle side door assembly 有权
标题翻译：车辆侧门总成
公开(公告)号：US08360486B2
公开(公告)日：2013-01-29
申请号：US12265674
申请日：2008-11-05
申请人： Jörg Gschweng , Andreas Heberer , Peter Eduard Schuessler , Thorsten Luedtke , Winfried Langendorf , Scott Charnesky , Eric Smith
发明人： Jörg Gschweng , Andreas Heberer , Peter Eduard Schuessler , Thorsten Luedtke , Winfried Langendorf , Scott Charnesky , Eric Smith
IPC分类号： E05B3/00 , E05C3/06
CPC分类号： E05B77/04 , E05B17/0062 , E05B77/44 , E05B79/12 , Y10T292/1076 , Y10T292/57
摘要： A side door of a motorized vehicle is provided that includes, but is not limited to a latch mechanism adapted to cooperate with a latch member disposed at a door frame, an actuator for locking and/or unlocking the latch mechanism and a coupling means for mechanically coupling (i.e., a mechanical coupling) the actuator and the latch mechanism. A disengagement apparatus is adapted to mechanically disengage the coupling between the actuator and the latch mechanism in response to an external force effect.
摘要翻译：提供了一种机动车辆的侧门，其包括但不限于适于与设置在门框处的闩锁构件配合的闩锁机构，用于锁定和/或解锁闩锁机构的致动器以及用于机械地连接的联接装置联动（即，机械联接）执行器和闩锁机构。分离装置适于响应于外力效应而机械地脱离致动器和闩锁机构之间的联接。

6. 发明申请

US20120086426A1 SINGLE-INDUCTOR MULTIPLE-OUTPUT POWER SUPPLY WITH DEFAULT PATH 审中-公开
标题翻译：单电源多路输出电源与默认路径
公开(公告)号：US20120086426A1
公开(公告)日：2012-04-12
申请号：US12903078
申请日：2010-10-12
申请人： Eric Smith
发明人： Eric Smith
IPC分类号： G05F3/16
CPC分类号： H02M3/1588 , H02M3/1584 , H02M2001/008 , Y02B70/1466
摘要： The disclosed embodiments relate to a power supply for a portable electronic device. This power supply includes a power source, an inductor, a control circuit, and an input switch that couples the input terminal of the inductor to either the power source or a reference voltage. The power supply also includes a first output path that produces a first output voltage and a second output path that produces a second output voltage. The first output path includes a first diode coupled between the output terminal of the inductor and the first output voltage, and a first output capacitor coupled between the first output voltage and the reference voltage. The second output path includes a second diode and an output switch coupled between the output terminal and the second output voltage, and a second output capacitor coupled between the second output voltage and the reference voltage.
摘要翻译：所公开的实施例涉及便携式电子设备的电源。该电源包括电源，电感器，控制电路和将电感器的输入端子耦合到电源或参考电压的输入开关。电源还包括产生第一输出电压的第一输出路径和产生第二输出电压的第二输出路径。第一输出路径包括耦合在电感器的输出端和第一输出电压之间的第一二极管和耦合在第一输出电压和参考电压之间的第一输出电容器。第二输出路径包括耦合在输出端和第二输出电压之间的第二二极管和输出开关，以及耦合在第二输出电压和参考电压之间的第二输出电容器。

7. 发明申请

US20110147208A1 SODIUM/MOLYBDENUM METAL ARTICLES AND METHODS FOR MAKING THE SAME 失效
标题翻译： SODIUM / MOLYBDENUM METAL ARTICLES AND METHODS FOR MAKING THE SAME
公开(公告)号：US20110147208A1
公开(公告)日：2011-06-23
申请号：US13038578
申请日：2011-03-02
申请人： Naresh Goel , Carl Cox , Dave Honecker , Eric Smith , Chris Michaluk , Adam DeBoskey , Sunil Chandra Jha
发明人： Naresh Goel , Carl Cox , Dave Honecker , Eric Smith , Chris Michaluk , Adam DeBoskey , Sunil Chandra Jha
IPC分类号： C23C14/34 , B22F1/00 , B22F3/02 , B22F3/12 , B22F3/15
CPC分类号： H01L31/02167 , B22F3/15 , B22F2998/10 , B22F2999/00 , C22C1/045 , C23C4/08 , C23C14/14 , C23C14/3414 , H01L31/022425 , H01L31/0322 , H01L31/03923 , H01L31/0749 , Y02E10/541 , Y02P70/521 , Y10T428/12 , Y10T428/31678 , B22F3/1007 , B22F2201/013 , B22F9/026 , B22F3/04
摘要： A method for producing a metal article may include: Producing a supply of a composite metal powder by: providing a supply of molybdenum metal powder; providing a supply of a sodium compound; combining the molybdenum metal powder and the sodium compound with a liquid to form a slurry; feeding the slurry into a stream of hot gas; and recovering the composite metal powder; and consolidating the composite metal powder to form the metal article, the metal article comprising a sodium/molybdenum metal matrix. Also disclosed is a metal article produced accordance with this method.
摘要翻译：金属制品的制造方法可以包括：通过以下方式制造复合金属粉末的供给：提供钼金属粉末的供给; 提供钠化合物的供应; 将钼金属粉末和钠化合物与液体结合以形成浆料; 将浆料送入热气流中; 并回收复合金属粉末; 并且将所述复合金属粉末固结以形成所述金属制品，所述金属制品包含钠/钼金属基体。还公开了根据该方法制造的金属制品。

8. 发明申请

US20100316636A1 Method of Treating Rheumatoid Arthritis with an IL-6R Antibody 有权
标题翻译：用IL-6R抗体治疗类风湿关节炎的方法
公开(公告)号：US20100316636A1
公开(公告)日：2010-12-16
申请号：US12780006
申请日：2010-05-14
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译：本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。

9. 发明申请

US20100316627A1 Human antibodies to human IL-6 receptor 有权
标题翻译：人类IL-6受体的抗体
公开(公告)号：US20100316627A1
公开(公告)日：2010-12-16
申请号：US12501657
申请日：2009-07-13
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395 , C07K16/28 , A61P29/00 , A61P1/00 , A61P1/04 , A61P37/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
摘要翻译：以约500pM以下的KD结合人IL-6受体（hIL-6R）的人抗体或抗原结合片段，并以200pM以下的IC 50阻断IL-6活性。在优选的实施方案中，抗体抗体或抗原结合片段以相对于其结合猴IL-6R至少高2倍的亲和力结合hIL-6R。

10. 发明申请

US20100095107A1 METHOD AND APPARATUS FOR DEVICE DETECTION AND MULTI-MODE SECURITY IN A CONTROL NETWORK 有权
标题翻译：用于设备检测和控制网络中的多模式安全的方法和装置
公开(公告)号：US20100095107A1
公开(公告)日：2010-04-15
申请号：US12549305
申请日：2009-08-27
申请人： Eric Smith , James Gist
发明人： Eric Smith , James Gist
IPC分类号： H04L29/06 , H04L9/08
CPC分类号： H04L12/2803 , H04L12/2809 , H04L12/281 , H04L63/0428 , H04L63/061 , H04L2012/2841 , H04L2012/285 , H04W12/02 , H04W12/04
摘要： A method and apparatus for device discovery and multi-mode security in a wired and/or wireless control network are described. A controlled device is configured with discovery-level instructions and application-level control instructions. The controlled device includes a user-configurable parameter for selecting between multiple security modes. In one or more security modes, the controlled device may ignore application-level messages until encrypted communications are established with a controller. In one mode, the encrypted communication is established with an encryption key exchange using a predetermined security key. In another mode, a specific key is manually entered into the controller by the user/administrator to facilitate the encryption key exchange. Additionally, for control applications where security is not important, an unencrypted security mode may be implemented. A driver ID provided by the controlled device facilitates loading of a preferred device driver by the controller.
摘要翻译：描述了有线和/或无线控制网络中的设备发现和多模式安全性的方法和装置。受控设备配置有发现级指令和应用级控制指令。受控设备包括用于在多个安全模式之间进行选择的用户可配置参数。在一种或多种安全模式中，受控设备可以忽略应用级消息，直到与控制器建立加密通信。在一种模式中，使用预定的安全密钥通过加密密钥交换建立加密的通信。在另一种模式下，用户/管理员手动将特定密钥输入到控制器中以便于加密密钥交换。另外，对于安全性不重要的控制应用，可以实现未加密的安全模式。由受控设备提供的驾驶员ID便于控制器加载优选的设备驱动程序。

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