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1. 发明申请

US20120302619A1 Novel 1-aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders 有权
标题翻译：新型1-芳基-3-氮杂双环[3.1.0]己烷：制备和用于治疗神经精神障碍
公开(公告)号：US20120302619A1
公开(公告)日：2012-11-29
申请号：US13366219
申请日：2012-02-03
申请人： Phil SKOLNICK , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil SKOLNICK , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： A61K31/403 , A61P25/22 , A61P25/24 , C07D209/52 , A61P25/00
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
摘要翻译：本发明提供新的多取代的1-芳基-3-氮杂双环[3.1.0]己烷，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物用于治疗和/或预防中枢的组合物和方法神经系统（CNS）障碍，包括抑郁和焦虑。

2. 发明申请

US20090233978A1 Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders 审中-公开
标题翻译：新型1-芳基-3-氮杂双环[3.1.0]己烷：制备和用于治疗神经精神障碍
公开(公告)号：US20090233978A1
公开(公告)日：2009-09-17
申请号：US12334432
申请日：2008-12-12
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： A61K31/40 , C07D209/02 , A61P25/00
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
摘要翻译：本发明提供新的多取代的1-芳基-3-氮杂双环[3.1.0]己烷，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物用于治疗和/或预防中枢的组合物和方法神经系统（CNS）障碍，包括抑郁和焦虑。

3. 发明申请

US20080234354A1 Methods And Compositions For Controlling Body Weight And Appetite 审中-公开
标题翻译：用于控制体重和食欲的方法和组合
公开(公告)号：US20080234354A1
公开(公告)日：2008-09-25
申请号：US11943552
申请日：2007-11-20
申请人： Arnold S. LIPPA , Joseph W. Epstein , Joseph T. Tizzano , Anthony Basile
发明人： Arnold S. LIPPA , Joseph W. Epstein , Joseph T. Tizzano , Anthony Basile
IPC分类号： A61K31/403 , A61P3/04 , A61P3/10
CPC分类号： A61K31/40 , A61K31/403 , A61K45/06 , C07D209/52 , A61K2300/00
摘要： The present invention provides novel compositions and methods for the controlling appetite and weight and/or treating obesity using a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound. The invention also provides novel compositions and methods for treating or preventing disorders related to or complicated by excessive body weight or obesity, including coronary heart disease, osteoarthritis, osteoporosis, dislipidemias, gout, atherosclerosis, joint pain, sexual and fertility problems, respiratory problems, gall bladder disease, skin conditions, hypertension, diabetes, stroke, pulmonary embolism, sleep apnea, idiopathic intracranial hypertension, lower extremity venous stasis disease, gastro-esophageal reflux, urinary stress incontinence, metabolic syndrome, insulin resistance and cancer. The methods and compositions of the invention may employ a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound alone, or in combination with a second anti-appetite or anti-obesity agent.
摘要翻译：本发明提供了使用（+）-1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或相关化合物来控制食欲和体重和/或治疗肥胖症的新型组合物和方法。本发明还提供了用于治疗或预防与体重过重或肥胖相关或复杂的疾病的新型组合物和方法，包括冠心病，骨关节炎，骨质疏松症，血脂异常，痛风，动脉粥样硬化，关节疼痛，性和生殖问题，呼吸问题，胆囊疾病，皮肤病，高血压，糖尿病，中风，肺栓塞，睡眠呼吸暂停，特发性颅内高压，下肢静脉淤滞疾病，胃食管反流，尿失禁，代谢综合征，胰岛素抵抗和癌症。本发明的方法和组合物可以单独使用（+）-1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或相关化合物，或与第二抗食欲或抗 - 肥胖剂。

4. 发明申请

US20070082940A1 Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders 审中-公开
标题翻译：新型1-芳基-3-氮杂双环[3.1.0]己烷：制备和用于治疗神经精神障碍
公开(公告)号：US20070082940A1
公开(公告)日：2007-04-12
申请号：US11493431
申请日：2006-07-25
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
IPC分类号： A61K31/403
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
摘要翻译：本发明提供新的多取代的1-芳基-3-氮杂双环[3.1.0]己烷，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物用于治疗和/或预防中枢的组合物和方法神经系统（CNS）障碍，包括抑郁和焦虑。

5. 发明申请

US20060173064A1 (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders 审中-公开
标题翻译：（ - ） - 1-（3,4-二氯苯基）-3-氮杂环[3.1.0]己烷及其组合物，以及用于治疗酒精相关疾病
公开(公告)号：US20060173064A1
公开(公告)日：2006-08-03
申请号：US11254242
申请日：2005-10-18
申请人： Arnold Lippa , Anthony Basile , Joseph Epstein
发明人： Arnold Lippa , Anthony Basile , Joseph Epstein
IPC分类号： C07D209/52 , A61K31/403
CPC分类号： C07D209/52 , A61K31/403
摘要： The present invention relates to (−)-1-(3,4-dichlorophenyl )-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing a disorder alleviated by inhibiting dopamine reuptake. In certain embodiments the methods and compositions of the invention are effective for treating attention-deficit disorder, depression, obesity, Parkinson's disease, a tic disorder, and/or an addictive disorder. In more detailed embodiments, methods and compositions of the invention are provided for treating an alcohol-related addictive disorder, for example alcohol abuse, alcohol dependence, excess alcohol consumption, and/or alcohol withdrawal. The (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof may be employed within the methods and compositions of the invention in a form or composition that is substantially free of its corresponding (+)-enantiomer.
摘要翻译：本发明涉及（ - ） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷及其药学上可接受的盐，其包含（ - ） - 1-（3,4-二氯苯基） 3-氮杂双环[3.1.0]己烷或其药学上可接受的盐，以及用于治疗或预防通过抑制多巴胺再摄取而减轻的病症的方法。在某些实施方案中，本发明的方法和组合物对于治疗注意力缺陷障碍，抑郁症，肥胖，帕金森病，抽动障碍和/或成瘾性障碍是有效的。在更详细的实施方案中，提供本发明的方法和组合物用于治疗醇相关的成瘾症，例如酒精滥用，酒精依赖，过量饮酒和/或戒酒。（ - ） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或其药学上可接受的盐可以在本发明的方法和组合物中以基本上不含其对应的（+） - 对映异构体。

6. 发明申请

US20070225351A1 Methods and compositions for controlling body weight and appetite 审中-公开
标题翻译：用于控制体重和食欲的方法和组合物
公开(公告)号：US20070225351A1
公开(公告)日：2007-09-27
申请号：US11603974
申请日：2006-11-21
申请人： Arnold Lippa , Joseph Epstein , Anthony Basile , Joseph Tizzano
发明人： Arnold Lippa , Joseph Epstein , Anthony Basile , Joseph Tizzano
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D209/52 , A61K31/403
摘要： The present invention provides novel compositions and methods for the controlling appetite and weight and/or treating obesity using a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound. The invention also provides novel compositions and methods for treating or preventing disorders related to or complicated by excessive body weight or obesity, including coronary heart disease, osteoarthritis, osteoporosis, dislipidemias, gout, atherosclerosis, joint pain, sexual and fertility problems, respiratory problems, gall bladder disease, skin conditions, hypertension, diabetes, stroke, pulmonary embolism, sleep apnea, idiopathic intracranial hypertension, lower extremity venous stasis disease, gastro-esophageal reflux, urinary stress incontinence, metabolic syndrome, insulin resistance and cancer. The methods and compositions of the invention may employ a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound alone, or in combination with a second anti-appetite or anti-obesity agent.
摘要翻译：本发明提供了使用（+）-1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或相关化合物来控制食欲和体重和/或治疗肥胖症的新型组合物和方法。本发明还提供了用于治疗或预防与体重过重或肥胖相关或复杂的疾病的新型组合物和方法，包括冠心病，骨关节炎，骨质疏松症，血脂异常，痛风，动脉粥样硬化，关节疼痛，性和生殖问题，呼吸问题，胆囊疾病，皮肤病，高血压，糖尿病，中风，肺栓塞，睡眠呼吸暂停，特发性颅内高压，下肢静脉淤滞疾病，胃食管反流，尿失禁，代谢综合征，胰岛素抵抗和癌症。本发明的方法和组合物可以单独使用（+）-1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或相关化合物，或与第二抗食欲或抗 - 肥胖剂。

7. 发明授权

US6032446A Densification method and apparatus for harvested cotton or other similar fibrous material 失效
标题翻译：采收棉或其他类似纤维材料的致密化方法和装置
公开(公告)号：US6032446A
公开(公告)日：2000-03-07
申请号：US56259
申请日：1998-04-06
申请人： John Anthony Gola , Peter Anthony Basile , Timothy Arthur Deutsch
发明人： John Anthony Gola , Peter Anthony Basile , Timothy Arthur Deutsch
IPC分类号： A01D46/08 , A01F15/00 , A01D39/00
CPC分类号： A01D46/084 , A01F15/00
摘要： A method and apparatus for densification of fibrous material such as harvested cotton, preferably by a movement of the cotton continuously through a compacting zone on the harvester. In one aspect of the invention, the fibers are locked by differential translation of portions of the mass of compacted material to prevent a layer of material from springing back after compression. A continuous mat of compressed material with locked fibers is formed into a uniform, high density bale or module on the harvester. A cotton harvester compacting system includes an air system feeding harvested cotton into an accumulation area and to the compacting zone on the harvester. The cotton is compressed and fed through a shear zone which differentially translates the cotton and locks the cotton fibers into a uniform, compact mat. In one embodiment, the mat of compacted cotton is fed to a round baler on the harvester to form a dense round bale or module. In another embodiment, the mat is layered into a rectangular bale or module on the harvester. An in-line horizontal compaction zone allows any existing voids in the in-feed section or voids resulting from compaction or shearing to be closed. A brake zone can be provided after the shear zone to provide adjustable back pressure for improved locked in compaction and web handling integrity. The brake is adjustable to fine tune the system for various cotton types and for different moisture and trash conditions. The accumulation area allows continued harvester operation during brief compacting interruptions, such as during module unloading.
摘要翻译：纤维材料如收获的棉花致密化的方法和装置，优选地通过棉花连续通过收割机上的压实区域的运动。在本发明的一个方面，纤维通过压实材料块的部分的差速平移被锁定，以防止一层材料在压缩后弹回。具有锁定纤维的连续的压缩材料垫在收割机上形成均匀的高密度捆包或模块。棉花收割机压实系统包括将收获的棉花送入收集区域和收割机上的压实区域的空气系统。棉花被压缩并通过剪切带进给，差异地翻转棉花并将棉纤维锁定成均匀的紧密垫。在一个实施例中，将压实棉花的垫料送入收割机上的圆形打捆机以形成致密的圆包或模块。在另一个实施例中，垫被分层成收割机上的矩形包或模块。在线水平压实区域允许进料部分中的任何现有空隙或由于压实或剪切而导致的空隙被关闭。可以在剪切区域之后提供制动区域，以提供可调节的背压，以改善锁定的压实和幅材处理的完整性。制动器是可调节的，以微调系统的各种棉花类型和不同的水分和垃圾条件。累积区域允许在短暂的压实中断期间继续收割机操作，例如在模块卸载期间。

8. 发明授权

US08461196B2 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders 有权
公开(公告)号：US08461196B2
公开(公告)日：2013-06-11
申请号：US13366219
申请日：2012-02-03
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

9. 发明申请

US20060100263A1 Antipyretic compositions and methods 审中-公开
标题翻译：解热组合物和方法
公开(公告)号：US20060100263A1
公开(公告)日：2006-05-11
申请号：US11263045
申请日：2005-10-31
申请人： Anthony Basile , Warren Stern
发明人： Anthony Basile , Warren Stern
IPC分类号： A61K31/403
CPC分类号： A61K31/445 , A61K31/403 , A61K45/06 , A61K2300/00
摘要： Methods and compositions containing bicifadine are provided for the treatment and prevention of hyperthermia in mammalian subjects. The methods and compositions may be used to prevent or treat fever, pyresis, menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot flashes, hot flashes caused by anti-estrogen therapy, hot flashes secondary to surgical removal of estrogen producing tissue, hot flashes caused by radiation therapy, malignant hyperthermia, serotonin syndrome, heat stroke, febrile seizures, and neuroleptic malignant syndrome, among other conditions. Additional compositions and methods are provided employing bicifadine to treat pyresis and simultaneously elicit an analgesic response in mammalian subjects. Yet additional compositions and methods are provided which employ bicifadine in combination with a second antipyretic agent, a second analgesic agent, or a different therapeutic agent to yield more effective antipyretic treatment tools, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperthermia and one or more additional symptoms (e.g., pain, or depression) in mammalian subjects.
摘要翻译：提供含有二西他汀的方法和组合物用于治疗和预防哺乳动物受试者的热疗。所述方法和组合物可用于预防或治疗发烧，发热，绝经期潮热; 绝经期潮热，绝经后潮热，抗雌激素治疗引起的热潮红，继发于产生雌激素的组织的手术切除的热潮红，放射治疗引起的潮热，恶性高热，血清素综合征，中暑，发热性惊厥和精神安定药恶性综合征等。提供了另外的组合物和方法，其采用二西他准来治疗吡啶并同时在哺乳动物受试者中引发止痛反应。还提供了另外的组合物和方法，其使用二西他定与第二解热剂，第二止痛剂或不同治疗剂组合产生更有效的解热治疗工具，和/或可用于预防或减少的双重活性治疗方法和制剂热疗和哺乳动物受试者中的一种或多种另外的症状（例如疼痛或抑郁症）。

10. 发明申请

US20130345439A1 Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders 有权
公开(公告)号：US20130345439A1
公开(公告)日：2013-12-26
申请号：US13887367
申请日：2013-05-05
申请人： Phil SKOLNICK , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil SKOLNICK , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： C07D209/52
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

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